ABSTRACT:
A smart transport procedure known as "Phytosome advancement" has been created to concede phospholipid and water-dissolvable phytoconstituent the capacity to cooperate synergistically. The phospholipid molecule, made out of two fat-dissolvable tails and a water-solvent head, assumes a pivotal part in this cycle. Going about as an emulsifying subject matter expert, it uses its double dissolvability qualities to work with the mix with natural concentrates. The consequence of this blend is the upgrade of the bioavailability of lipid-dissolvable drugs, empowering quicker and more successful assimilation. The meaning of this article lies in its compact outline of both a unique drug conveyance framework and vesicular prescription conveyance frameworks. It plans to give a complete comprehension of different perspectives, including the presentation and clarification of Phytosome, the advantages and detriments related with this conveyance methodology, significant properties to consider, strategies for planning, portrayal procedures, and the wide cluster of uses it offers in the field of medication. It is trusted that this extended substance will help perusers in procuring a more profound comprehension of Phytosome development and its likely ramifications in further developing medication conveyance proficiency.
Cite this article:
Rachana Gautre, Sakshi Gorle. Phytosomes: An Emerging Drug Delivery System. Research Journal of Pharmacognosy and Phytochemistry. 2024; 16(3):168-4. doi: 10.52711/0975-4385.2024.00032
Cite(Electronic):
Rachana Gautre, Sakshi Gorle. Phytosomes: An Emerging Drug Delivery System. Research Journal of Pharmacognosy and Phytochemistry. 2024; 16(3):168-4. doi: 10.52711/0975-4385.2024.00032 Available on: https://rjpponline.org/AbstractView.aspx?PID=2024-16-3-5
REFERENCES:
1. Jadhav AI, Wadhave AA, Arsul VA, Sawarkar HS. Phytosomes: A novel approach in herbal drug delivery system. International Journal of Pharmaceutics and Drug Analysis. 2014; 2(5): 478-86.
2. Patel J, Patel R, Khambholja K, Patel N. An overview of phytosomes as an advanced herbal drug delivery system. Asian J Pharm Sci. 2009 Apr;4(6):363-71.
3. Dubey D, Shrivastava S, Kapoor S, Dubey PK. Phytosome: a novel dosage structure. Pharmaceutical Review. 2007:1-8.
4. Sharma S, Roy RK. Phytosomes: an emerging technology. Int J Pharm Res Dev. 2010;2(5):1-7.
5. Kidd P, Head K. A review of the bioavailability and clinical efficacy of milk thistle phytosome: a silybin-phosphatidylcholine complex (Siliphos). Alternative Medicine Review. 2005 Sep 1;10(3).
6. Jadhav AI, Wadhave AA, Arsul VA, Sawarkar HS. Phytosomes: A novel approach in herbal drug delivery system. International Journal of Pharmaceutics and Drug Analysis. 2014;2(5):478-86.
7. Jain N, Gupta BP, Thakur N, Jain R, Banweer J, Jain DK, Jain S. Phytosome: a novel drug delivery system for herbal medicine. Int J Pharm Sci Drug Res. 2010 Oct;2(4):224-8.
8. Habbu P, Hullatti P. Phytosomes as Novel Drug Delivery System for Herbal Medicine-A Review. Systematic Reviews in Pharmacy. 2017 Jan 1;8(1).
9. Dhir S, Khar RK, Chakraborthy GS, Saurabh M. Phytosomes: a brief overview. Journal of Pharmaceutical Research. 2016 Jun 26:56-62.
10. Barzaghi N, Crema F, Gatti G, Pifferi G, Perucca E. Pharmacokinetic studies on IdB 1016, a silybin-phosphatidylcholine complex, in healthy human subjects. European Journal of Drug Metabolism and Pharmacokinetics. 1990 Oct; 15: 333-8.
11. Malviya V, Arya A, Burange P, Gajbhiye K, Rathod G, Tawar M. To evaluate the cardioprotective effect of hydroalcoholic extract of Matricaria chamomilla linn in isoproterenol induced myocardial infarction in wistar rats. Research Journal of Pharmacy and Technology. 2022; 15(9): 3887-92.
12. Pawar HA, Bhangale BD. Phytosome as a novel biomedicine: a microencapsulated drug delivery system. Journal of Bioanalysis & Biomedicine. 2015 Jan 5;7.
13. Bombardelli E, Curri SB, Della Loggia RO, Del Negro P, Gariboldi P, Tubaro A. Complexes between phospholipids and vegetal derivates of biological interest.
14. Saini V, Bala R, Arora S. Formulation and Evaluation of Phyto-phospholipid complex of Methanolic Extract of leaves of Andrographis paniculate. Research Journal of Pharmacy and Technology. 2023 Feb 28; 16(2):830-4.
15. Pahwa R, Saroha K, Bhardwaj BY, Kumar M, Singh I. Insights into various approaches of Phytosomes for Enhanced Therapeutic Potential of Bioactives. Research Journal of Pharmacy and Technology. 2022;15(9):4277-82.
16. Kalita B, Das MK, Sharma AK. Novel phytosome formulations in making herbal extracts more effective. Research Journal of Pharmacy and Technology. 2013;6(11):1295-301.
17. Kharwade M, Deshkar S, Halyali A, Satpute A. Phytopharmaceutical delivery through skin: Recent updates on delivery by Vesicular carriers. Research Journal of Pharmacy and Technology. 2020; 13(10): 5018-25.
18. Pande SD, Wagh AS, Bhagure LB, Patil SG, Deshmukh AR. Preparation and evaluation of phytosomes of pomegrane peels. Research Journal of Pharmacy and Technology. 2015;8(4):416-22.
19. Pahwa R, Saroha K, Bhardwaj BY, Kumar M, Singh I. Insights into various approaches of Phytosomes for Enhanced Therapeutic Potential of Bioactives. Research Journal of Pharmacy and Technology. 2022; 15(9): 4277-82.
20. Pahwa R, Saroha K, Bhardwaj BY, Kumar M, Singh I. Insights into various approaches of Phytosomes for Enhanced Therapeutic Potential of Bioactives. Research Journal of Pharmacy and Technology. 2022; 15(9): 4277-82.
21. Malviya V. Preparation and evaluation of emulsomes as a drug delivery system for bifonazole. Indian Journal of Pharmaceutical Education and Research. 2021 Jan 1; 55(1): 86-94.
22. Upase AU, Bhusnure OG, Gholve SB, Giram PS, Wattamwar PB. A review on Phytosome loaded with novel herbal drug and their formulation, standardization and applications. Journal of Drug Delivery and Therapeutics. 2019 Jun 15; 9(3-s): 765-9.
23. Mane K, Baokar S, Bhujbal A, Pharande S, Patil G, Patil R, Jain P, Pandey A. Phyto-phospholipid complexes (phytosomes): a novel approach to improve the bioavailability of active constituents. Journal of Advanced Scientific Research. 2020 Aug 10; 11(3): 68-78.
24. Kareparamban JA, Nikam PH, Jadhav AP, Kadam VJ. Phytosome: a novel revolution in herbal drugs. IJRPC. 2012; 2(2): 299-310.
25. Malviya, Vedanshu, Mukund Tawar, Prashant Burange, and Rahul Jodh. "A brief review on resveratrol." 2022: 157-162..
26. Nimbalkar CK, Hatware K. Phytosomes-novel drug delivery system. Indian Journal of Drugs. 2017; 5(1):16-36.
27. Allen Jr, Loyd V. Pharmaceutical Dosage Forms and Drug Delivery Systems. 1990: 2150-2150.
28. Malviya V, Ladhake V, Gajbiye K, Satao J, Tawar M. Design and characterization of phase transition system of zolmitriptan hydrochloride for nasal drug delivery system. International Journal of Pharmaceutical Sciences and Nanotechnology (IJPSN). 2020 May 31; 13(3): 4942-51.
29. Susilawati Y, Chaerunisa AY, Purwaningsih H. Phytosome drug delivery system for natural cosmeceutical compounds: Whitening agent and skin antioxidant agent. Journal of Advanced Pharmaceutical Technology & Research. 2021 Oct; 12(4): 327.
30. Sharma N, Singh S, Laller N, Arora S. Application of central composite design for statistical optimization of trigonella foenum-graecum phytosome-based cream. Research Journal of Pharmacy and Technology. 2020; 13(4): 1627-32.
31. Malviya V, Burange P, Thakur Y, Tawar M. Enhancement of solubility and dissolution rate of atazanavir sulfate by nanocrystallization. Indian Journal of Pharmaceutical Education and Research. 2021 Jul 1; 55(3): S672-80.
32. Malviya V, Pande S. Development and Evaluation of Fast dissolving Film of Fluoxetine hydrochloride. Research Journal of Pharmacy and Technology. 2021; 14(10): 5345-50.
33. Andishmand H, Yousefi M, Jafari N, Azadmard-Damirchi S, Homayouni-Rad A, Torbati M, Hamishehkar H. Designing and fabrication of colloidal nano-phytosomes with gamma-oryzanol and phosphatidylcholine for encapsulation and delivery of polyphenol-rich extract from pomegranate peel. International Journal of Biological Macromolecules. 2024 Jan 1; 256: 128501.
34. Malviya VR, Pande SD, Bobade NN. Preparation and evaluation of sustained release beads of zolmitriptan hydrochloride. Research Journal of Pharmacy and Technology. 2019; 12(12): 5972-6.3.
35. Malviya V. Investigation of In-Vitro Antidiabetic Study, Antioxidant Activity and Anthelminthic Property of Various Extracts of Bitter Cumin Seeds: Antidiabetic Study, Antioxidant Activity, and Anthelminthic Property of Bitter Cumin Seeds. International Journal of Pharmaceutical Sciences and Nanotechnology (IJPSN). 2023 Jul 31; 16(4): 6855-74.
36. Nashaat D, Elsabahy M, Hassanein KM, El-Gindy GA, Ibrahim EH. Development and in vivo evaluation of therapeutic phytosomes for alleviation of rheumatoid arthritis. International Journal of Pharmaceutics. 2023 Sep 25; 644:123332.
37. Talaat SM, Elnaggar YS, El-Ganainy SO, Gowayed MA, Allam M, Abdallah OY. Self-assembled Fisetin-phospholipid complex: fisetin-integrated phytosomes for effective delivery to breast cancer. European Journal of Pharmaceutics and Biopharmaceutics. 2023 Jun 19.
38. Hosseinian SA, Mehrzad J, Mirhafez SR, Saeidi J, Zhiani R, Sahebkar A. Evaluation of the effect of phytosomal curcuminoids on oxidative stress and inflammatory markers in NAFLD: A randomized double-blind placebo-controlled trial. Journal of Functional Foods. 2022 Sep 1; 96: 105202.
39. Dundar AN, Ozdemir S, Uzuner K, Parlak ME, Sahin OI, Dagdelen AF, Saricaoglu FT. Characterization of pomegranate peel extract loaded nanophytosomes and the enhancement of bio-accessibility and storage stability. Food Chemistry. 2023 Jan 1; 398: 133921.
40. Safta DA, Bogdan C, Moldovan ML. Vesicular nanocarriers for phytocompounds in wound care: Preparation and characterization. Pharmaceutics. 2022 May 5; 14(5): 991.
41. Malviya V, Tawar M, Burange P, Bairagi R. Preparation and Characterization of Gastroreten-tive Sustained Release In-situ Gel of Lafutidine. International Journal of Pharmaceutical Sciences and Nanotechnology (IJPSN). 2022 Dec 12; 15(6): 6216-28.
42. Malviya VR, Tawar MG. Preparation and evaluation of oral dispersible strips of teneligliptin hydrobromide for treatment of diabetes mellitus. International Journal of Pharmaceutical Sciences and Nanotechnology (IJPSN). 2020 Jan 31; 13(1): 4745-52.
43. Nanavati B. Phytosome: a novel approach to enhance the bioavailability of phytoconstituent. Asian Journal of Pharmaceutics (AJP). 2017 Oct 11; 11(3).
44. Tung BT, Hai NT, Son PK. Hepatoprotective effect of Phytosome Curcumin against paracetamol-induced liver toxicity in mice. Brazilian Journal of Pharmaceutical Sciences. 2017 Apr 20; 53.
45. Barzaghi N, Crema F, Gatti G, Pifferi G, Perucca E. Pharmacokinetic studies on IdB 1016, a silybin-phosphatidylcholine complex, in healthy human subjects. European Journal of Drug metabolIsm and Pharmacokinetics. 1990 Oct; 15: 333-8.
46. Bombardelli E, Curri SB, Della Loggia R, Del Negro P, Gariboldi P, Tubaro A. Anti-inflammatory activity of 18-Ăź-glycyrrhetinic acid in phytosome form. Fitoterapia. 1989; 60:29-37.
47. Bombardelli E, Cristoni A, Morazzoni P. Phytosome® s in functional cosmetics. Fitoterapia (Milano). 1994;65(5):387-401.
48. Andishmand H, Yousefi M, Jafari N, Azadmard-Damirchi S, Homayouni-Rad A, Torbati M, Hamishehkar H. Designing and fabrication of colloidal nano-phytosomes with gamma-oryzanol and phosphatidylcholine for encapsulation and delivery of polyphenol-rich extract from pomegranate peel. International Journal of Biological Macromolecules. 2024 Jan 1; 256: 128501.
49. Peanparkdee M, Yooying R. Enhancement of solubility, thermal stability and bioaccessibility of vitexin using phosphatidylcholine-based phytosome. NFS Journal. 2023 Jun 1; 31:28-38.
50. Malviya V, Pande S. Design and Characterization of pH Dependent Phase Transition System of Almotriptan Malate for Nasal Drug Delivery System by Employing Factorial Design. Ind. J. Pharm. Edu. Res. 2024; 58(1): 76-90.