Author(s):
Vandana Yadav, Ashish William, Renu Das, Purnima Baghel
Email(s):
anishc@cecbilaspur.ac.in
DOI:
10.52711/0975-4385.2026.00042 
Address:
Vandana Yadav1, Ashish William1, Renu Das2, Purnima Baghel2
1Students, Chouksey School of Pharmacy, CEC, Bilaspur, Chhattisgarh, India.
2Assistant Professor, Chouksey School of Pharmacy, CEC, Bilaspur, Chhattisgarh, India.
*Corresponding Author
Published In:
Volume - 18,
Issue - 3,
Year - 2026
ABSTRACT:
Liver disorders constitute a major global health challenge, and the limitations associated with currently available hepatoprotective agents have intensified interest in plant-derived therapeutics. Madhuca longifolia (Sapotaceae), a medicinal tree extensively used in traditional Indian medicine, has been investigated for its protective effects against experimentally induced liver injury. This review critically evaluates the available literature on the hepatoprotective potential of M. longifolia extracts, with particular emphasis on phytochemical composition, preclinical efficacy, proposed mechanisms of action, toxicological considerations, and the current status of clinical research. Preclinical studies consistently demonstrate that extracts derived from the flowers, bark, leaves, and seeds of M. longifolia mitigate hepatotoxicity induced by agents such as paracetamol, carbon tetrachloride, and D-galactosamine. These effects are evidenced by normalization of serum biochemical markers, restoration of antioxidant defenses, and improvement of histopathological features. Mechanistically, hepatoprotection is largely attributed to antioxidant, anti-inflammatory, and membrane-stabilizing properties mediated by flavonoids, phenolic compounds, triterpenoids, and saponins. Despite compelling experimental data, clinical evidence remains extremely limited, with no well-designed randomized controlled trials directly assessing hepatic outcomes in humans. This review highlights critical gaps in standardization, safety evaluation, and clinical validation, and outlines future research directions necessary for the translational development of M. longifolia as a hepatoprotective agent.
Cite this article:
Vandana Yadav, Ashish William, Renu Das, Purnima Baghel. Hepatoprotective Potential of Madhuca longifolia Extracts: Preclinical Evidence, Mechanisms and Clinical Research Gaps. Research Journal of Pharmacognosy and Phytochemistry. 2026; 18(3):295-9. doi: 10.52711/0975-4385.2026.00042
Cite(Electronic):
Vandana Yadav, Ashish William, Renu Das, Purnima Baghel. Hepatoprotective Potential of Madhuca longifolia Extracts: Preclinical Evidence, Mechanisms and Clinical Research Gaps. Research Journal of Pharmacognosy and Phytochemistry. 2026; 18(3):295-9. doi: 10.52711/0975-4385.2026.00042 Available on: https://rjpponline.org/AbstractView.aspx?PID=2026-18-3-12
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