Author(s):
Dhanashri D. Patil, Darshana M. Patil, Dhanashree V. Patil, Mansi A. Dhankani, Amitkumar R. Dhankani, Sunil Pawar
Email(s):
dhanudp1312@gmail.com
DOI:
10.52711/0975-4385.2026.00034 
Address:
Dhanashri D. Patil*, Darshana M. Patil, Dhanashree V. Patil, Mansi A. Dhankani, Amitkumar R. Dhankani, Sunil Pawar
P.S.G.V.P. Mandal’s College of Pharmacy, Shahada, Dist. Nandurbar, 425409 (M.S), India.
*Corresponding Author
Published In:
Volume - 18,
Issue - 3,
Year - 2026
ABSTRACT:
Clerodendrum phlomidis, a medicinal plant belonging to the Verbenaceae family, is commonly used to treat inflammation and related illnesses. It contains phytochemicals such flavonoids, alkaloids, tannins, and phenolic compounds, which contribute to its anti-inflammatory, analgesic, antibacterial, antioxidant, antipyretic, and wound-healing properties. The purpose of this study was to develop and test a herbal gel containing a chloroform extract of Clerodendrum phlomidis leaves for topical anti-inflammatory activities. The extract was obtained using the maceration process and the gel was formulated with Carbopol 934, propylene glycol, methyl paraben, propyl paraben, and triethanolamine as excipients. Three formulations (F1, F2, and F3) containing varying concentrations of Carbopol 934 were prepared and evaluated for parameters such as appearance, homogeneity, pH, viscosity, spreadability, swelling index, and extrudability. Out of them, F2 demonstrated superior stability and positive outcomes, suggesting its potential as a topical herbal anti-inflammatory formulation.
Cite this article:
Dhanashri D. Patil, Darshana M. Patil, Dhanashree V. Patil, Mansi A. Dhankani, Amitkumar R. Dhankani, Sunil Pawar. Formulation and Evaluation of Herbal Gel containing Clerodendrum phlomidis Leaf Extract. Research Journal of Pharmacognosy and Phytochemistry. 2026; 18(3):238-2. doi: 10.52711/0975-4385.2026.00034
Cite(Electronic):
Dhanashri D. Patil, Darshana M. Patil, Dhanashree V. Patil, Mansi A. Dhankani, Amitkumar R. Dhankani, Sunil Pawar. Formulation and Evaluation of Herbal Gel containing Clerodendrum phlomidis Leaf Extract. Research Journal of Pharmacognosy and Phytochemistry. 2026; 18(3):238-2. doi: 10.52711/0975-4385.2026.00034 Available on: https://rjpponline.org/AbstractView.aspx?PID=2026-18-3-4
REFERENCES:
1. Babu NP, Pandikumar P, Ignacimuthu S. Lysosomal membrane stabilization and anti-inflammatory activity of Clerodendrum phlomidis L.f., a traditional medicinal plant. J Ethnopharmacol. 2011; 135: 779–85.
2. Rabb UN. Critical review on Agnimantha (Premna integrifolia Linn and Clerodendrum phlomidis Linn). 2022; 4(3): 292–8.
3. Kumar V, Abbas AK, Fausto N, editors. Robbins and Cotran pathologic basis of disease. 7th ed. Philadelphia: Elsevier Saunders; 2004. p. 47–86.
4. Anonymous. The wealth of India. Vol. 2. New Delhi: Publications and Information Directorate; 1981.
5. Allen LV, Popovich NG, Ansel HC. Ansel’s pharmaceutical dosage forms and drug delivery systems. 9th ed. Philadelphia: Lippincott Williams and Wilkins; 2011.
6. Metta S, Amir KM, Lakshmi MS, Shruthi PK. A review: Pharmaceutical gels and its types with prominence role of its drug delivery systems. IJRAR. 2023; 10(2).
7. Karamkar PG, Agrawal A, Chatap VK. A review article: Formulation of topical gel by QbD approach. 2023; 11(2):90–101.
8. Mohan MK, Raja MM, Mishra SH. Comprehensive review of Clerodendrum phlomidis: A traditionally used bitter. J Chin Integr Med. 2010; 8(6).
9. Shareef U, Prakash P. A comprehensive review of Clerodendrum phlomidis. World J Pharm Res. 2023; 12(11).
10. Vijayamirtharaj R, Vincent S, Senthilkumar N. Anti-inflammatory activity of chloroform extract of aerial part of Clerodendrum phlomidis Linn. RJPBCS. 2011;2(1):390–5.
11. Das S, Haldar PK, Pramanik G. Formulation and evaluation of herbal gel containing Clerodendron infortunatum leaves extract. Int J PharmTech Res. 2011; 3(1): 140–3.