Author(s):
Pooja Bagdi, Gaurav Kumar
Email(s):
gaurav.soni@lordsuni.edu.in , pooja.bagdi2001@gmail.com
DOI:
10.52711/0975-4385.2026.00032 
Address:
Pooja Bagdi1, Gaurav Kumar2
1Principal, Trinity Educational Institute, Ramgarh, Jharkhand, India.
2Professor, Lords University Alwar, Rajasthan, India.
*Corresponding Author
Published In:
Volume - 18,
Issue - 3,
Year - 2026
ABSTRACT:
Objective: To comparatively evaluate the anti-urolithiatic and antioxidant potential of hydroalcoholic leaf and fruit extracts of Ziziphus nummularia using in vitro models. Methods: Anti-urolithiatic activity was assessed by calcium oxalate dissolution and nucleation inhibition using spectrophotometric and titrimetric methods. Antioxidant activity was evaluated using DPPH and superoxide radical-scavenging assays. Cystone was used as the reference. Data are expressed as mean±SEM. Results: The fruit extract exhibited significant CaOx crystallization inhibition (87.34%), comparable to Cystone (87.06%), whereas the leaf extract showed 72.05% inhibition. In antioxidant assay leaves exhibited stronger DPPH and Superoxide radical scavenging activity than the fruit extract, reflected by lower IC50 values. Conclusion: Hydroalcoholic extracts of Z. nummularia possess notable anti-urolithiatic and antioxidant activities. The fruit extract showed superior anti crystallization potential, while the leaf extract exhibited stronger antioxidant activity. These findings support the traditional use of Ziziphus nummularia in urolithiasis management and warrant further in vivo investigations.
Cite this article:
Pooja Bagdi, Gaurav Kumar. To Compare the Anti-Urolithiatic and Antioxidant Potentials of Hydroalcoholic Leaf and Fruit Extracts of Ziziphus nummularia. Research Journal of Pharmacognosy and Phytochemistry. 2026; 18(3):228-2. doi: 10.52711/0975-4385.2026.00032
Cite(Electronic):
Pooja Bagdi, Gaurav Kumar. To Compare the Anti-Urolithiatic and Antioxidant Potentials of Hydroalcoholic Leaf and Fruit Extracts of Ziziphus nummularia. Research Journal of Pharmacognosy and Phytochemistry. 2026; 18(3):228-2. doi: 10.52711/0975-4385.2026.00032 Available on: https://rjpponline.org/AbstractView.aspx?PID=2026-18-3-2
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