Author(s): Sankalesh G. Khamkar, Bhagyashri A. Kharade, Kiran P. Korade, Ganesh D. Barkade, Ramesh L. Sawant

Email(s): swatikhamkar1213@gmail.com

DOI: 10.52711/0975-4385.2024.00036   

Address: Sankalesh G. Khamkar, Bhagyashri A. Kharade, Kiran P. Korade, Ganesh D. Barkade, Ramesh L. Sawant
Department of Pharmaceutical Chemistry, Dr. Vithalrao Vikhe Patil Foundation’s College of Pharmacy, Vilad-Ghat, Ahmednagar, Maharashtra, India 414111.
*Corresponding Author

Published In:   Volume - 16,      Issue - 3,     Year - 2024


ABSTRACT:
Pigmentation is the process in which the skin pigments are entirely gets tanned and turns into black color. Exposure to ultraviolet radiation is produce selective effects for vitamin D synthesis, which causes melanin synthesis and pigmentation. Skin pigmentation is nowadays becoming a major problem. Due to this we used depigmenting agents which makes skin fairer. In present study we used the herbal materials which are having the anti-inflammatory and anti-oxidant activity which helps to reduce pigmentation. So, to overcome from the skin pigmentation we made the herbal cream which having a such type ingredients that which helps to reduce pigmentation and makes skin fair. For reduction of pigmentation, we formulated herbal cream by using Papaya Pulp, Aloe Vera, Pomegranate Peel Powder as well as Orange Peel Powder. These ingredients can reduce pigmentation by inhibiting tyrosine which is responsible for melanin secretion. The daily use of our herbal cream can reduce melanin quickly.


Cite this article:
Sankalesh G. Khamkar, Bhagyashri A. Kharade, Kiran P. Korade, Ganesh D. Barkade, Ramesh L. Sawant. Formulation and Evaluation of Herbal Cream for Depigmentation. Research Journal of Pharmacognosy and Phytochemistry. 2024; 16(3):191-6. doi: 10.52711/0975-4385.2024.00036

Cite(Electronic):
Sankalesh G. Khamkar, Bhagyashri A. Kharade, Kiran P. Korade, Ganesh D. Barkade, Ramesh L. Sawant. Formulation and Evaluation of Herbal Cream for Depigmentation. Research Journal of Pharmacognosy and Phytochemistry. 2024; 16(3):191-6. doi: 10.52711/0975-4385.2024.00036   Available on: https://rjpponline.org/AbstractView.aspx?PID=2024-16-3-9


REFERENCES:
1.    Jablonski NG, Chaplin G. Human skin pigmentation as an adaptation to UV radiation. Proceedings of the National Academy of Sciences. 2010 May 5; 107(supplement_2):8962–8. doi:10.1073/pnas.0914628107
2.    Lin JY, Fisher DE. Melanocyte Biology and skin pigmentation. Nature. 2007 Feb;445(7130):843–50. doi:10.1038/nature05660
3.    Rouzaud F, Kadekaro AL, Abdel-Malek ZA, Hearing VJ. MC1R and the response of melanocytes to ultraviolet radiation. Mutation Research/ Fundamental and Molecular Mechanisms of Mutagenesis. 2005 Apr 1; 571(1–2): 133–52. doi:10.1016/j.mrfmmm.2004.09.014
4.    Tsatmali M, Ancans J, Thody AJ. Melanocyte function and its control by melanocortin peptides. Journal of Histochemistry Cytochemistry. 2002 Feb; 50(2): 125–33. doi:10.1177/002215540205000201
5.    Park HY, Kosmadaki M, Yaar M, Gilchrest BA. Cellular mechanisms regulating human melanogenesis. Cellular and Molecular Life Sciences. 2009 Jan 21; 66(9): 1493–506. doi:10.1007/s00018-009-8703-8
6.    Schallreuter KU, Kothari S, Chavan B, Spencer JD. Regulation of melanogenesis – controversies and new concepts. Experimental Dermatology. 2008 Apr 7; 17(5): 395–404. doi:10.1111/j.1600-0625.2007.00675.x
7.    Slominski A, Tobin DJ, Shibahara S, Wortsman J. Melanin pigmentation in mammalian skin and its hormonal regulation. Physiological Reviews. 2004 Oct; 84(4): 1155–228. doi:10.1152/physrev.00044.2003
8.    Stremnitzer C, Manzano-Szalai K, Willensdorfer A, Starkl P, Pieper M, König P, et al. Papain degrades tight junction proteins of human keratinocytes in vitro and sensitizes C57BL/6 mice via the skin independent of its enzymatic activity or TLR4 activation. Journal of Investigative Dermatology. 2015 Jul; 135(7): 1790–800. doi:10.1038/jid.2015.58
9.    Kahramanoglu I, Usanmaz S. Pomegranate production and marketing. 2016 Apr 5; doi:10.1201/b20151
10.    Phytochemical analysis, antibacterial and antioxidant activities of pomegranate (punicagranatum L.) peel extracts. International Journal of Biosciences (IJB). 2020 Jun 16; doi:10.12692/ijb/16.6.35-44
11.    Ojewole JA. Analgesic, antiinflammatory and hypoglycaemic effects of ethanol extract ofZingiberofficinale (Roscoe) rhizomes (Zingiberaceae) in mice and rats. Phytotherapy Research. 2006; 20(9): 764–72. doi:10.1002/ptr.1952
12.    Khare CP. Citrus medica Linn. Indian Medicinal Plants. 2007;1–1. doi:10.1007/978-0-387-70638-2_363
13.    Glória MBA. Sweeteners | others. Encyclopedia of Food Sciences and Nutrition. 2003; 5695–702. doi:10.1016/b0-12-227055-x/01404-8
14.    Castangia I, Caddeo C, Manca ML, Casu L, Latorre AC, Díez-Sales O, et al. Delivery of liquorice extract by liposomes and hyalurosomes to protect the skin against oxidative stress injuries. Carbohydrate Polymers. 2015 Dec; 134: 657–63. doi:10.1016/j.carbpol.2015.08.037
15.    Mostafa DM, Ammar NM, Abd El-Alim SH, El-anssary AA. Transdermal microemulsions of Glycyrrhiza glabra L.: Characterization,  stability and evaluation of antioxidant potential. Drug Delivery. 2013 Sept 12; 21(2): 130–9. doi:10.3109/10717544.2013.834419
16.    Kang M-C, Kim SY, Kim YT, Kim E-A, Lee S-H, Ko S-C, et al. In vitro and in vivo antioxidant activities of polysaccharide purified from aloe vera (aloe barbadensis) gel. Carbohydrate Polymers. 2014 Jan;99:365–71. doi:10.1016/j.carbpol.2013.07.091
17.    Vaughn AR, Branum A, Sivamani RK. Effects of turmeric (Curcuma longa) on skin health: A systematic review of the clinical evidence. Phytotherapy Research. 2016 May 23;30(8):1243–64. doi:10.1002/ptr.5640
18.    Nelson KM, Dahlin JL, Bisson J, Graham J, Pauli GF, Walters MA. The Essential Medicinal Chemistry of Curcumin. Journal of Medicinal Chemistry. 2017 Jan 11; 60(5): 1620–37. doi:10.1021/acs.jmedchem.6b00975
19.    Tayyem RF, Heath DD, Al-Delaimy WK, Rock CL. Curcumin content of turmeric and curry powders. Nutrition and Cancer.  2006 Jul; 55(2): 126–31. doi:10.1207/s15327914nc5502_2
20.    Khan S, Patel A, Bhise KS. Antioxidant activity of pomegranate peel powder. Journal of Drug Delivery and Therapeutics. 2017 Mar 15; 7(2). doi:10.22270/jddt.v7i2.1380
21.    Preparation-and-characterization-of-the-poly-herbal-antiageing-cream
22.    Nayak B, Pinto Pereira LM. Catharanthus roseus flower extract has wound-healing activity in Sprague Dawley Rats. BMC Complementary and Alternative Medicine. 2006 Dec; 6(1). doi:10.1186/1472-6882-6-41
23.    S. S. Khadabadi, S.L. Deore, B.A. Baviskar. (2014), Pharmacognosy and Phytochemistry, A Comprehensive Approach, Published by Pharma Med Press, 1st edition, p.p.8.4.
24.    Preethi, KC, Kuttan, R. Wound healing activity of flower extract of calendula offlcinalis. Journal of Basic and Clinical Physiology and Pharmacology. 2009 Mar; 20(1): 73–80. doi:10.1515/jbcpp.2009.20.1.73
25.    Prasad V, Dorle AK. Evaluation of ghee based formulation for wound healing activity. Journal of Ethnopharmacology. 2006 Aug; 107(1): 38–47. doi:10.1016/j.jep.2006.02.006
26.    Sanmathi. B.S., Kalpesh K. Mehta, Anshu Gupta (2016). Dispensing Pharmacy a Practical Manual (p.p. 389-399). Pharma Med Press.
27.    PP Sharma. Cosmetics-formulation, manufacturing and quality control, Cap. VII. 5th edition Vandana Publications, Delhi, India; 2014. p. 181-91.
28.    Ravindra RP, Muslim PK. Comparison of physical characteristics of vanishing Cream base. cow ghee and shata-dhautaghrita as per pharmacopoeial standards. International Journal of Pharma and Biosciences. 2013; 4(4):14 – 21.
29.    Prashanth GK, Krishnaiah GM. Chemical composition of the leaves of Azadirachtaindica Linn (Neem). International Journal of Advancement in Engineering and Technology, Management and Applied Science, 2014 Oct; 1(3): 21-31.
30.    Prasanna A. Datar. Formulation and evaluation of polyherbal gel prepare using Carbopol 934 for treating skin disease in comparison with ointment using emulsifying ointment. Research and Reviews: Journal of Pharmaceutics and Nanotechnology, 2013; 1(1): 20- 21.
31.    SK. Uddandu Saheb, Aduri Prakash Reddy, K. Rajitha, B. Sravani, B. Vanitha. Formulation and Evaluation of Cream from containing plant extracts, World Journal of Pharmacy and Pharmaceutical Sciences. 2018; 7(5): 851-862.
32.    N. R. Patel, H. U. Momin, R.L. Dhumal, K, L. Mohite. Preparation and evaluation of multipurpose herbal cream, Adv Pharm Life sci Res. 2017; 5(1): 27-32.
33.    Himaja, N. Formulation and Evaluation of Herbal Cream from AzadirachtaindicaEthanolic Extract. Int J Res Drug Pharm Sci, 2017;  1(1): 23-6.
34.    Mukherjee PK. Plant Metabolomics and quality evaluation of Herbal Drugs. Quality Control and Evaluation of Herbal Drugs. 2019; 629–53. doi:10.1016/b978-0-12-813374-3.00017-x
35.    The Theory and Practice of Industrial Pharmacy. Leon Lachman, Herbert Lieberman, and Joseph Kanig, Editors. The Journal of Clinical Pharmacology and The Journal of New Drugs. 1970 Nov 12; 10(6):420–420. doi:10.1177/009127007001000614

Recomonded Articles:

Author(s): Anshuman Singh, Bhupendra Vyas

DOI: 10.5958/0975-4385.2018.00052.3         Access: Open Access Read More

Author(s): Kavitha M, Vadivu R, Radha R

DOI: 10.5958/0975-4385.2015.00037.0         Access: Open Access Read More

Author(s): Praveen S Nayak, Shweta Nayak, Ranjan Shety, P Das

DOI:         Access: Open Access Read More

Author(s): Debjit Bhowmik, Chiranjib, Pankaj, KK Tripathi, MR Chandira, KP Sampath Kumar

DOI:         Access: Open Access Read More

Author(s): Puneet Kumar Rai, Dev Raj Sharma, Amit Sharma

DOI: 10.5958/0975-4385.2015.00029.1         Access: Open Access Read More

Author(s): Vidula Salvi, Yadunath Joshi, Swati Dhande , Vilasrao Kadam

DOI:         Access: Open Access Read More

Author(s): Kalpana Patil, Swati Dhande, Vilasrao Kadam

DOI:         Access: Open Access Read More

Author(s): Raje VN, Yadav AV, Shelar PA

DOI:         Access: Open Access Read More

Author(s): K Mekala, R Radha

DOI: 10.5958/0975-4385.2015.00035.7         Access: Open Access Read More

Author(s): Shirisha K, Priyanka B, Habibur Rahman, Dipankar Bardalai, Fulchan Ali

DOI:         Access: Open Access Read More

Author(s): AK Meena, Uttam S Niranjan, AK Yadav, Brijendra Singh, AK Nagaria, A Gaurav, MM Rao

DOI:         Access: Open Access Read More

Author(s): Mohd Asif, Mohd Wasim Ahmed, Shahidul Khair, Murugeswaran R, Rampratap Meena, Mokhtar Alam, Shoeb Ahmed Ansari, Mohd Tariq, Rakesh Kumar Negi

DOI: 10.5958/0975-4385.2019.00035.9         Access: Open Access Read More

Author(s): Umesh Annappan, Vijaya Bharathi Rajkishore, Radha Ramalingam

DOI: 10.5958/0975-4385.2015.00034.5         Access: Open Access Read More

Author(s): Nikhat F, D Satyanarayana, Subhramanyam EVS

DOI:         Access: Open Access Read More

Author(s): Priya Dongare, Swati Dhande, Vilasrao Kadam

DOI:         Access: Open Access Read More

Author(s): Chandrakant P. Rathod, Mahavir H. Ghante

DOI: 10.52711/0975-4385.2021.00022         Access: Open Access Read More

Author(s): Ravindra Singh, Aakanksha Tiwari

DOI: 10.5958/0975-4385.2017.00009.7         Access: Open Access Read More

Author(s): Dhanya Rajan, J. Suresh, N. Paramakrishnan, A. Sri Vasavi Reddy, M Nayeem

DOI:         Access: Open Access Read More


Recent Articles




Tags