Author(s): Pooja, Anil Kumar

Email(s): poojakumari3491@gmail.com

DOI: 10.52711/0975-4385.2023.00028   

Address: Pooja*, Anil Kumar
Dept. of Biotechnology, GOVT. V.Y.T. PG. Auto. College, Durg (C.G.)
*Corresponding Author

Published In:   Volume - 15,      Issue - 2,     Year - 2023


ABSTRACT:
Ocimum tenuiflorum Linn. is an Ayurvedic herb commonly regarded as Tusli or Holy Basil. The plant has a long traditional medicinal history. In India Tulsi is worshipped by Hindus and is abundantly found in all regions. Each part of a plant like stems, roots, seeds, leaves, flowers, and fruits have their own curative properties and functions reported by many researchers. The varieties of active chemical constituents; terpenoids, phenols, flavonoids, phenylpropanoids, fatty acid derivatives, essential oil, fixed oil, and steroids are extracted from the Ocimum tenuiflorum plant and are determined of great therapeutic activities. The therapeutic actions of Tulsi compounds recreate their remedial attention and in the standardization of their medicinal results. Eugenol, Oleanolic Acid, Linalool, Ursolic Acid, Beta-Caryophyllene, Rosemarinic Acid, Estragole, Carvacrol, Methyl Cinnamate are the major compounds which are leads to various actions against diseases. This review article summarizes researchers validated various pharmacological actions of these active chemical constituents that have great potential against, antidiabetic, antioxidant, anti- inflammatory, antimicrobial, antiviral (especially against Covid-19/Coronavirus, helpful in the current scenario of “pandemic”), cardioprotective, antihypertensive, and other activities as well. This will be useful for developing new active principles and therapeutics or new life-saving drugs by researchers, practitioners, and students who were implicated in the field of ethnopharmacology.


Cite this article:
Pooja, Anil Kumar. A Systemic Review of Tulsi (Ocimum tenuiflorum or Ocimum sanctum): Phytoconstituents, Ethnobotanical and Pharmacological Profile. Research Journal of Pharmacognosy and Phytochemistry. 2023; 15(2):179-8. doi: 10.52711/0975-4385.2023.00028

Cite(Electronic):
Pooja, Anil Kumar. A Systemic Review of Tulsi (Ocimum tenuiflorum or Ocimum sanctum): Phytoconstituents, Ethnobotanical and Pharmacological Profile. Research Journal of Pharmacognosy and Phytochemistry. 2023; 15(2):179-8. doi: 10.52711/0975-4385.2023.00028   Available on: https://rjpponline.org/AbstractView.aspx?PID=2023-15-2-14


REFERENCES:
1.    Khurana, P. A Review On Medicinal Uses of Ocimum Tenuiflorum Linn (TULSI).
2.    Singh, N., Hoette, Y., and Miller, D. R. (2002). Tulsi: The mother medicine of nature. International Institute of Herbal Medicine.
3.    Pandey, G., and Madhuri, S. (2010). Pharmacological activities of Ocimum sanctum (tulsi): a review. Int J Pharm Sci Rev Res, 5(1), 61-66.
4.    Cohen M. M. (2014). Tulsi - Ocimum sanctum: A herb for all reasons. Journal of Ayurveda and integrative medicine, 5(4), 251–259.
5.    Kumar, K. P., Bhowmik, D., Tripathi, K. K., and Chandira, M. (2010). Traditional Indian Herbal Plants Tulsi and Its Medicinal Importance. Research Journal of Pharmacognosy and Phytochemistry, 2(2), 93-101.
6.    Pattanayak P, Behera P, Das D, Panda SK. Ocimum sanctum Linn. A reservoir plant for therapeutic applications: An overview. Pharmacogn Rev. 2010 Jan;4(7):95-105.
7.    Singh, E., Sharma, S., Dwivedi, J., and Sharma, S. (2012). Diversified potentials of Ocimum sanctum Linn (tulsi): an exhaustive survey. Journal of Natural Product and Plant Resources, 2(1), 39-48.
8.    Bhooshitha, A. N., Ghosh, A. R., Chandan, H. M., Nandhini, H. S., Pramod, B. R., and Krishna, K. L. (2020). Review On Nutritional, Medicinal and CNS Activities of Tulsi (Ocimum. Sanctum). Journal of Pharmaceutical Sciences and Research, 12(3), 420-426.
9.    Evans, W. C. (1996). Phenols and phenolic glycosides. Trease and Evans Pharmacognosy, 14th ed. Noida: Gopsons Papers Limited, 218.
10.    Sajjadi, S. E. (2006). Analysis of the essential oils of two cultivated basil (Ocimum basilicum L.) from Iran. DARU Journal of Pharmaceutical Sciences, 14(3), 128-130.
11.    Kumar, P. K., Kumar, M. R., Kavitha, K., Singh, J., and Khan, R. (2012). Pharmacological actions of Ocimum sanctum–review article. International Journal of Advances in Pharmacy, Biology and Chemistry, 1(3), 2277-4688.
12.    Wangcharoen, W., and Morasuk, W. (2007). Antioxidant capacity and phenolic content of holy basil. Songklanakarin J Sci Technol, 29(5), 1407-1415.
13.    Atal, C. K., and Kapur, B. M. (1982). Cultivation and utilization of medicinal plants. Jammu- Tawi: Regional Research Laboratory, Council of Scientific and Industrial Research.
14.    Gupta, P. A Review on Medicinal Uses of Ocimum Tenuiflorum LINN (TULSI).
15.    Prajapati, N. D., Purohit, S. S., Sharma, A. K., and Kumar, T. (2003). A handbook of medicinal plants: A complete source book. In A handbook of medicinal plants: a complete source book (pp. 554-554).
16.    Gupta, S. K., Prakash, J., and Srivastava, S. (2002). Validation of traditional claim of Tulsi, Ocimum sanctum Linn.as a medicinal plant.
17.    Tewari, D., Sah, A. N., Pandey, H. K., Meena, H. S., Meena, R., Ramaswamy, R. S., ... and Murthy, P. H. (2012). A review on phytoconstituents of Ocimum (Tulsi). International Journal of Ayurvedic Medicine, 3(1), 1-9.
18.    Chauhan, N. S. (1999). Medicinal and aromatic plants of Himachal Pradesh. Indus publishing.
19.    Shah, C. S., and Qadry, J. S. A Textbook of Pharmacognosy. 1998. Back to cited text, (32), 216.
20.    Yanpallewar, S. U., Rai, S., Kumar, M., and Acharya, S. B. (2004). Evaluation of antioxidant and neuroprotective effect of Ocimum sanctum on transient cerebral ischemia and long- term cerebral hypoperfusion. Pharmacology Biochemistry and Behavior, 79(1), 155-164.
21.    Nair, A. R., Gunasegaran, R., and Joshi, B. S. (1982). Chemical investigation of certain south Indian plants. Indian Journal of Chemistry Section B-Organic Chemistry Including MEDICINAL Chemistry, 21(10), 979-980.
22.    Patani, A. (2002). Indian Herbal Pharmacopoeia. Mumbai: Indian Drug Manufactures Association.
23.    Singh, S., Majumdar, D. K., and Rehan, H. M. S. (1996). Evaluation of anti-inflammatory potential of fixed oil of Ocimum sanctum (Holybasil) and its possible mechanism of action. Journal of Ethnopharmacology, 54(1), 19-26.
24.    Rucinque, D. S., Ferreira, P. F., Leme, P. R. P., Lapa-Guimarães, J., and Viegas, E. M. M. (2021). Ocimum americanum and Lippia alba essential oils as anaesthetics for Nile tilapia: Induction, recovery   of   apparent   unconsciousness   and   sensory    analysis    of fillets. Aquaculture, 531, 735902.
25.    Zengin, G., Ferrante, C., Gnapi, D. E., Sinan, K. I., Orlando, G., Recinella, L., ... and Menghini, L. (2019). Comprehensive approaches on the chemical constituents and pharmacological properties of flowers and leaves of American basil (Ocimum americanum L). Food Research International, 125, 108610.
26.    Sen, S. K., and Behera, L. M. (2008). Ethnomedicinal plants used by the tribals of Bargarh district to cure diarrhoea and dysentery.
27.    Shah, A., and Rahim, S. (2017). Ethnomedicinal uses of plants for the treatment of malaria in Soon Valley, Khushab, Pakistan. Journal of ethnopharmacology, 200, 84-106.
28.    Selvi, M. T., Thirugnanasampandan, R., and Sundarammal, S. (2015). Antioxidant and cytotoxic activities of essential oil of Ocimum canum Sims. from India. Journal of Saudi Chemical Society, 19(1), 97-100.
29.    Adomako-Bonsu, A. G., Chan, S. L., Pratten, M., and Fry, J. R. (2017). Antioxidant activity of rosmarinic acid and its principal metabolites in chemical and cellular systems: Importance of physico-chemical characteristics. Toxicology in vitro, 40, 248-255.
30.    Oyedemi, S. O., Oyedemi, B. O., Coopoosamy, R. M., Prieto, J. M., Stapleton, P., and Gibbons, S. (2017). Antibacterial and norfloxacin potentiation activities of Ocimum americanum L. against methicillin resistant Staphylococcus aureus. South African Journal of Botany, 109, 308-314.
31.    Pandey, R., Chandra, P., Kumar, B., Dutt, B., and Sharma, K. R. (2016). A rapid and highly sensitive method for simultaneous determination of bioactive constituents in leaf extracts of six Ocimum species using ultra high performance liquid chromatography-hybrid linear ion trap triple quadrupole mass spectrometry. Analytical Methods, 8(2), 333-341.
32.    Dhama, K., Sharun, K., Gugjoo, M. B., Tiwari, R., Alagawany, M., Iqbal Yatoo, M., ... and Farag, M. R. (2021). A Comprehensive Review on Chemical Profile and Pharmacological Activities of Ocimum basilicum. Food Reviews International, 1-29.
33.    Surburg, H., and Panten, J. Common Fragrance and Flavor Materials.
34.    Chiang, L. C., Ng, L. T., Cheng, P. W., Chiang, W., and Lin, C. C. (2005). Antiviral activities of extracts and selected pure constituents of Ocimum basilicum. Clinical and Experimental Pharmacology and Physiology, 32(10), 811-816.
35.    Hussain, A. I., Anwar, F., Sherazi, S. T. H., and Przybylski, R. (2008). Chemical composition, antioxidant and antimicrobial activities of basil (Ocimum basilicum) essential oils depends on seasonal variations. Food chemistry, 108(3), 986-995.
36.    Baytop, T. (1984). Therapy with Medicinal Plants in Turkey (Past and Present) No: 3255. Istanbul: Publications of the Istanbul University, 359.
37.    Mondello, L., Zappia, G., Cotroneo, A., Bonaccorsi, I., Chowdhury, J. U., Yusuf, M., and Dugo, G. (2002). Studies on the essential oil‐bearing plants of Bangladesh. Part VIII. Composition of some Ocimum oils O. basilicum L. var. purpurascens; O. sanctum L. green; O. sanctum L. purple; O. americanum L., citral type; O. americanum L., camphor type. Flavour and fragrance journal, 17(5), 335-340.
38.    Viña, A., and Murillo, E. (2003). Essential oil composition from twelve varieties of basil (Ocimum spp) grown in Colombia. Journal of the Brazilian chemical society, 14(5), 744- 749.
39.    Kéita, S. M., Vincent, C., Schmit, J. P., and Bélanger, A. (2000). Essential oil composition of Ocimum basilicum L., O. gratissimum L. and O. suave L. in the Republic of Guinea. Flavour and fragrance journal, 15(5), 339-341.
40.    Charles, D. J., and Simon, J. E. (1992). Essential oil constituents of Ocimum kilimandscharicum Guerke. Journal of essential oil Research, 4(2), 125-128.
41.    Barker, C., Dunn, H. C., and Hilditch, T. P. (1950). African drying oils. V. Some Nigerian and Sudanese drying oils. Journal of the Society of Chemical Industry, 69(3), 71-75.
42.    Sastri, B. N. (1962). The Wealth of India. A Dictionary of Indian Raw Materials and Industrial Products. Raw Materials, Vol. 6: LM. The Wealth of India. A Dictionary of Indian Raw Materials and Industrial Products. Raw Materials, Vol. 6: LM.
43.    Soni, N., Gill, D., Sagar, B. S., Raheja, S., and Agrawal, S. (2012). Ocimum kilimandscharicum: A systematic review. Journal of Drug Delivery and Therapeutics, 2(3).
44.    Ntezurubanza, L. J. J. C., Scheffer, J. J. C., Looman, A., and Svendsen, A. B. (1984). Composition of Essential Oil of Ocimum kilimandscharicum Grown in Rwanda1. Planta medica, 50(05), 385-388.
45.    Prakash, P. A. G. N., and Gupta, N. (2005). Therapeutic uses of Ocimum sanctum Linn (Tulsi) with a note on eugenol and its pharmacological actions: a short review. Indian journal of physiology and pharmacology, 49(2), 125.
46.    Nadkarni, K., and Nadkarni, A. K. (1976). Indian Materia Medica, Popular Prakashan Pvt. Ltd., Bombay, 1, 799.
47.    Warrier, P. K., Nambiar, V. P. K., Ramankutty, C., and Indian Medi-cinal Plants, A. (1995). A compendium of 500 species. Indian Medicinal Plants. Orient Longman Publisher, 4, 157-168.
48.    Kweka, E. J., Mosha, F. W., Lowassa, A., Mahande, A. M., Mahande, M. J., Massenga, C. P., ... and Temu, E. A. (2008). Longitudinal evaluation of Ocimum and other plants effects on the feeding behavioral response of mosquitoes (Diptera: Culicidae) in the field in Tanzania. Parasites and Vectors, 1(1), 1-8.
49.    Singh, P., Kalunke, R. M., Shukla, A., Tzfadia, O., Thulasiram, H. V., and Giri, A. P. (2020). Biosynthesis and tissue-specific partitioning of camphor and eugenol in Ocimum kilimandscharicum. Phytochemistry, 177, 112451.
50.    Awogbindin, I. O., Tade, O. G., Metibemu, S. D., Olorunsogo, O. O., and Farombi, E. O. (2014). Assessment of flavonoid content, free radical scavenging and hepatoprotective activities of Ocimum gratissimum and Spondias mombin in rats treated with dimethylnitrosamine. Arch Basic Appl Med, 2, 45-54.
51.    Dubey, N. K., Tiwari, T. N., Mandin, D., Andriamboavonjy, H., and Chaumont, J. P. (2000). Antifungal properties of Ocimum gratissimum essential oil (ethyl cinnamate chemotype). Fitoterapia, 71(5), 567-569.
52.    Akinmoladun, A. C., Ibukun, E. O., Afor, E., Obuotor, E. M., and Farombi, E. O. (2007). Phytochemical constituent and antioxidant activity of extract from the leaves of Ocimum gratissimum. Scientific Research and Essays, 2(5), 163-166.
53.    Dhawan, B. N., Patnaik, G. K., Rastogi, R. P., Singh, K. K., and Tandon, J. S. (1977). Screening of Indian plants for biological activity: part VI.
54.    Rabelo, M., Souza, E. P., Soares, P. M. G., Miranda, A. V., Matos, F. J. A., and Criddle, D. N. (2003). Antinociceptive properties of the essential oil of Ocimum gratissimum L. (Labiatae) in mice. Brazilian Journal of Medical and Biological Research, 36(4), 521- 524.
55.    Edeoga, H. O., Omosun, G., and Uche, L. C. (2006). Chemical composition of Hyptis suaveolens and Ocimum gratissimum hybrids from Nigeria. African Journal of Biotechnology, 5(10).
56.    Charles, D. J., Simon, J. E., and Wood, K. V. (1990). Essential oil constituents of Ocimum micranthum Willd. Journal of agricultural and food chemistry, 38(1), 120-122.
57.    Sacchetti, G., Medici, A., Maietti, S., Radice, M., Muzzoli, M., Manfredini, S., ... and Bruni, R. (2004). Composition and functional properties of the essential oil of Amazonian basil, Ocimum micranthum Willd., Labiatae in comparison with   commercial   essential oils. Journal of Agricultural and Food Chemistry, 52(11), 3486-3491.
58.    Vieira, P. R., de Morais, S. M., Bezerra, F. H., Ferreira, P. A. T., Oliveira, Í. R., and Silva, M. G. V. (2014). Chemical composition and antifungal activity of essential oils from Ocimum species. Industrial Crops and Products, 55, 267-271.
59.    de Vasconcelos Silva, M. G., Matos, F. J. A., Machado, M. I. L., and de Oliveira Silva, F. (2004). Essential Oil Composition of the Leaves of Ocimum micranthum Willd. Journal of Essential Oil Research, 16(3), 189-190.
60.    Caamal-Herrera, I. O., Carrillo-Cocom, L. M., Escalante-Réndiz, D. Y., Aráiz-Hernández, D., and Azamar-Barrios, J. A. (2018). Antimicrobial and antiproliferative activity of essential oil, aqueous and ethanolic extracts of Ocimum micranthum Willd leaves. BMC complementary and alternative medicine, 18(1), 1-9.
61.    Sen, P. (1993). Therapeutic potentials of Tulsi: from experience to facts. Drugs News and Views, 1(2), 15-21.
62.    Hasan, S. B., and Deo, P. S. (1994).   Ocimum   sanctum   seeds   for   mosquito control. International pest control, 36(1), 20-21.
63.    Mukherjee, P. K., Maiti, K., Mukherjee, K., and Houghton, P. J. (2006). Leads from Indian medicinal plants with hypoglycemic potentials. Journal of ethnopharmacology, 106(1), 1- 28.
64.    Jena, J., Ranjan, R., Ranjan, P., and Sarangi, M. K. (2012). A study on natural anticancer plants. Int J Pharmaceut Chem Sci, 1(1), 365-8.
65.    Nadkarni, K. M. (1996). [Indian materia medica]; Dr. KM Nadkarni's Indian materia medica: with Ayurvedic, Unani-Tibbi, Siddha, allopathic, homeopathic, naturopathic and home remedies, appendices and indexes. 1 (Vol. 1). Popular Prakashan.
66.    Ngassoum, M. B., Ousmaila, H., Ngamo, L. T., Maponmetsem, P. M., Jirovetz, L., and Buchbauer, G. (2004). Aroma compounds of essential oils of two varieties of the spice plant Ocimum canum Sims from northern Cameroon. Journal of Food Composition and Analysis, 17(2), 197-204.
67.    Martins, A. P., Salgueiro, L. R., Vila, R., Tomi, F., Cañigueral, S., Casanova, J., ... and Adzet, T. (1999). Composition of the essential oils of Ocimum canum, O. gratissimum and O. minimum. Planta medica, 65(02), 187-189.
68.    Ravid, U., Putievsky, E., Katzir, I., and Lewinsohn, E. (1997). Enantiomeric composition of linalol in the essential oils of Ocimum species and in commercial basil oils. Flavour and fragrance journal, 12(4), 293-2
69.    Euloge, S. A., Kouton, S., Dahouenon-Ahoussi, E., Sohounhloue, D. C. K., and Soumanou, M. M. (2012). Antifungal activity of Ocimum canum essential oil against toxinogenic fungi isolated from peanut seeds in post-harvest in Benin. International Research Journal of Biological Sciences, 1(7), 20-26.
70.    Dewangan, A., Sahu, B. P., and Meher, B. (2020). Review on Pharmacological Potential of Ocimum sanctum L. Advanced Journal of Bioactive Molecules, 17-24.
71.    Madhuri, S., and Govind, P. (2010). Effect of ProImmu, a herbal drug on estrogen caused uterine and ovarian cytotoxicity. Biomed, 5(1), 57-62.
72.    Saija, A., Scalese, M., Lanza, M., Marzullo, D., Bonina, F., and Castelli, F. (1995). Flavonoids as antioxidant agents: importance of their interaction with biomembranes. Free Radical Biology and Medicine, 19(4), 481-486.
73.    Chattopadhyay, R. R. (1993). Hypoglycemic effect of Ocimum sanctum leaf extract in normal and streptozotocin diabetic rats. Indian journal of experimental biology, 31(11), 891-893.
74.    Hannan, J. M. A., Marenah, L., Ali, L., Rokeya, B., Flatt, P. R., and Abdel-Wahab, Y. H. A. (2006). Ocimum sanctum leaf extracts stimulate insulin secretion from perfused pancreas, isolated islets and clonal pancreatic β-cells. Journal of Endocrinology, 189(1), 127-136.
75.    Nagarajan, S., Jain, H. C., and Aulakh, G. S. (1987). Indigenous plants used in the control of diabetes. Publication and Information Directorate, CSIR, New Delhi, 586.
76.    Parasuraman, S., Balamurugan, S., Christapher, P. V., Petchi, R. R., Yeng, W. Y., Sujithra, J., and Vijaya, C. (2015). Evaluation of antidiabetic and antihyperlipidemic effects of hydroalcoholic extract of leaves of Ocimum tenuiflorum (Lamiaceae) and prediction of biological activity of its phytoconstituents. Pharmacognosy research, 7(2), 156.
77.    Geeta Vasudevan, D. M., Kedlaya, R., Deepa, S., and Ballal, M. (2001). Activity of Ocimum sanctum (the traditional Indian medicinal plant) against the enteric pathogens. Ind. J. Med. Sci, 55(8), 434-438.
78.    Khan, A., Ahmad, A., Manzoor, N., and Khan, L. A. (2010). Antifungal activities of Ocimum sanctum essential oil and its lead molecules. Natural Product Communications, 5(2), 1934578X1000500235.
79.    Prashar, R., and Kumar, A. (1995). Chemopreventive action of Ocimum sanctum on 2, 12- dimethylbenz (a) anthracene   DMBA-induced   papillomagnesis   in   the   skin   of mice. International journal of pharmacognosy: a journal of crude drug research.
80.    Prakash, J., and Gupta, S. K. (2000). Chemopreventive activity of Ocimum sanctum seed oil. Journal of ethnopharmacology, 72(1-2), 29-34.
81.    Uma Devi, P., Ganasoundari, A., Vrinda, B., Srinivasan, K. K., and Unnikrishnan, M. K. (2000). Radiation protection by the ocimum flavonoids orientin and vicenin: mechanisms of action. Radiation research, 154(4), 455-460.
82.    Karthikeyan, K., Gunasekaran, P., Ramamurthy, N., and Govindasamy, S. (1999). Anticancer activity of Ocimum sanctum. Pharmaceutical biology, 37(4), 285-290.
83.    Aruna, K., and Sivaramakrishnan, V. M. (1992). Anticarcinogenic effects of some Indian plant products. Food and Chemical Toxicology, 30(11), 953-956.
84.    Devi, P. U. (2001). Radioprotective, anticarcinogenic and antioxidant properties of the Indian holy basil, Ocimum sanctum (Tulasi).
85.    Karthikeyan, K., Ravichandran, P., and Govindasamy, S. (1999). Chemopreventive effect of Ocimum sanctum on DMBA-induced hamster buccal pouch carcinogenesis. Oral oncology, 35(1), 112-119.
86.    Prashar, R., Kumar, A., Hewer, A., Cole, K. J., Davis, W., and Phillips, D. H. (1998). Inhibition by an extract of Ocimum sanctum of DNA-binding activity of 7, 12- dimethylbenz [a] anthracene in rat hepatocytes in vitro. Cancer letters, 128(2), 155-160.
87.    Somkuwar, A. P. (2003). Studies on anticancer effects of Ocimum sanctum and Withania somnifera on experimentally induced cancer in mice (Doctoral dissertation, Jawaharlal Nehru Krishi Viswavidyalaya; Jabalpur).
88.    Devi, P. U., and Ganasoundari, A. (1995). Radioprotective effect of leaf extract of Indian medicinal plant Ocimum sanctum. Indian Journal of Experimental Biology, 33(3), 205- 208.
89.    Ganasoundari, A., Devi, P. U., and Rao, B. S. S. (1998). Enhancement of bone marrow radioprotection and reduction of WR-2721 toxicity by Ocimum sanctum. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 397(2), 303-312.
90.    Chattopadhyay, R. R., Sarkar, S. K., Ganguly, S., Medda, C., and Basu, T. K. (1992). Hepatoprotective activity of Ocimum Sanctum leaf extract against Paracetamol included Hepatic damage in rats.
91.    Seethalakshmi, B., Narasappa, A. P., and Kenchaveerappa, S. (1982). Protective effect of Ocimum sanctum in experimental liver injury in albino rats. Indian J Pharmacol, 14, 63.
92.    Ahmed, M., Ahamed, R. N., Aladakatti, R. H., and Ghosesawar, M. G. (2002). Reversible anti-fertility effect of benzene extract of Ocimum sanctum leaves on sperm parameters and fructose content in rats. Journal of Basic and Clinical Physiology and Pharmacology, 13(1), 51-60.
93.    Singh, S., Taneja, M., and Majumdar, D. K. (2007). Biological activities of Ocimum sanctum L. fixed oil—An overview.
94.    Srinivas, N., Sali, K., and Bajoria, A. A. (2016). Therapeutic aspects of Tulsi unraveled: A review. Journal of Indian Academy of oral medicine and radiology, 28(1), 17.
95.    Bhargava, K. P., and Singh, N. (1981). Anti-stress activity of Ocimum sanctum Linn.
96.    Singh, S., and Majumdar, D. K. (1999). Evaluation of the gastric antiulcer activity of fixed oil of Ocimum sanctum (Holy Basil). Journal of ethnopharmacology, 65(1), 13-19.
97.    Singh, S., Rehan, H. M. S., and Majumdar, D. K. (2001). Effect of Ocimum sanctum fixed oil on blood pressure, blood clotting time and pentobarbitone-induced sleeping time. Journal of ethnopharmacology, 78(2-3), 139-143.
98.    Shah, S. M. A., Akram, M., Riaz, M., Munir, N., and Rasool, G. (2019). Cardioprotective potential of plant-derived molecules: a scientific and medicinal approach. Dose- response, 17(2), 1559325819852243.
99.    Sharma, M., Kishore, K., Gupta, S. K., Joshi, S., and Arya, D. S. (2001). Cardioprotective potential of Ocimum sanctum in isoproterenol induced myocardial infarction in rats. Molecular and cellular biochemistry, 225(1), 75-83.
100.    Kelm, M. A., Nair, M. G., Strasburg, G. M., and DeWitt, D. L. (2000). Antioxidant and   cyclooxygenase   inhibitory   phenolic   compounds   from   Ocimum   sanctum Linn. Phytomedicine, 7(1), 7-13.
101.    Kapewangolo, P., Kandawa-Schulz, M., and Meyer, D. (2017). Anti-HIV activity of Ocimum labiatum extract and isolated pheophytin-a. Molecules, 22(11), 1763.
102.    Ling, A. P., Khoo, B. F., Seah, C. H., Foo, K. Y., Cheah, R. K., Chye, S. M., and Koh, R. Y. (2014, August). Inhibitory activities of methanol extracts of Andrographis paniculata and Ocimum sanctum against dengue-1 virus. In International Conference on Biological Environmental and Food Engineering: Bali, Indonesia (pp. 4-5).
103.    Hemalika, D. V. D., and Chandrika, U. G. Anti-dengue effects of medicinal plants: A review.
104.    Shree P, Mishra P, Selvaraj C, Singh SK, Chaube R, Garg N, Tripathi YB. Targeting COVID-19 (SARS-CoV-2) main protease through active phytochemicals of ayurvedic medicinal plants - Withania somnifera (Ashwagandha), Tinospora cordifolia (Giloy) and Ocimum sanctum (Tulsi) - a molecular docking study. J Biomol Struct Dyn. 2020 Aug 27:1-14. doi: 10.1080/07391102.2020.1810778. Epub ahead of print. PMID: 32851919; PMCID: PMC7484581.
105.    Singh, S., and Majumdar, D. K. (1995). Analgesic activity of Ocimum sanctum and its possible mechanism of action. International journal of Pharmacognosy, 33(3), 188-192.
106.    Mediratta, P. K., Sharma, K. K., and Singh, S. (2002). Evaluation of immunomodulatory potential of Ocimum sanctum seed oil and its possible mechanism of action. Journal of Ethnopharmacology, 80(1), 15-20.
107.    Mondal, S., Varma, S., Bamola, V. D., Naik, S. N., Mirdha, B. R., Padhi, M. M., ... and Mahapatra, S. C. (2011). Double-blinded randomized controlled trial for immunomodulatory effects of Tulsi (Ocimum sanctum Linn.) leaf extract on healthy volunteers. Journal of ethnopharmacology, 136(3), 452-456.
108.    Mediratta PK, Dewan V, Bhattacharya SK, Gupta VS, Maiti PC, Sen P. Effect of Ocimum sanctum Linn. on humoral immune responses. Indian J Med Res. 1988 Apr;87:384-6. PMID: 3169894.
109.    Jeba, C. R., Vaidyanathan, R., and Rameshkumar, G. (2011). Immunomodulatory activity of aqueous extract of Ocimum sanctum in rat. Int J Pharm Biomed Res, 2(1), 33- 8.
110.    Sharma, P., Kulshreshtha, S., and Sharma, A. L. (1998). Anti-cataract activity of Ocimum sanctum on experimental cataract. Indian journal of pharmacology, 30(1), 16.
111.    Kadian, R., and Parle, M. (2012). Therapeutic potential and phytopharmacology of tulsi. International Journal of Pharmacy and Life Sciences, 3(7).
112.    Singh, S., and Majumdar, D. K. (1996). Effect of fixed oil of Ocimum sanctum against   experimentally   induced   arthritis   and    joint    edema    in    laboratory animals. International Journal of Pharmacognosy, 34(3), 218-222.
113.    Kadian, R., and Parle, M. (2012). Therapeutic potential and phytopharmacology of tulsi. International Journal of Pharmacy and Life Sciences, 3(7).
114.    Upadhyay, R. K. (2017). Tulsi: A holy plant with high medicinal and therapeutic value. International Journal of Green Pharmacy (IJGP), 11(01).
115.    Singh, M., Hamid, A. A., Maurya, A. K., Prakash, O., Khan, F., Kumar, A., ... and Bawankule, D. U. (2014). Synthesis of diosgenin analogues as potential anti-inflammatory agents. The Journal of steroid biochemistry and molecular biology, 143, 323-333.

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