Author(s): Priyanka Sawant, Prerna Nikam, Kusum Lad, Shweta Bhosale, Archana Magdum, Ansar Patel

Email(s): priyankasawant8371@gmail.com

DOI: 10.52711/0975-4385.2025.00035   

Address: Priyanka Sawant, Prerna Nikam, Kusum Lad, Shweta Bhosale, Archana Magdum, Ansar Patel
Sant Gajanan Maharaj College of Pharmacy, Mahagaon Site Chinchewadi.
*Corresponding Author

Published In:   Volume - 17,      Issue - 3,     Year - 2025


ABSTRACT:
Plumbago zeylanica, commonly known as Ceylon leadwort, is a traditional medicinal plant with diverse applications in various indigenous systems of medicine. This review article aims to give outline about the botanical, pharmacological, and therapeutic properties of Plumbago zeylanica, highlighting its significant role in modern and traditional medicine. It also include different method of extraction of Plumbago zeylanica. The study explores the extraction methods of bioactive compounds from the bark and leaves of Plumbago zeylanica. Different solvents, including petroleum ether, ethyl acetate, and 70% methanol, were used for extracting compounds from the plant material through soxhlet extraction. The extracts were then purified and dried, and their yield was determined. The physical evaluation of Plumbago zeylanica extracts involved determining various parameters such as ash value, loss on drying, and extractive values. These evaluations provide essential information for quality control and standardization of the plant material. The plant is known for its rich chemical composition, primarily consisting of bioactive compounds such as plumbagin, a potent naphthoquinone with antioxidant, anti-inflammatory, anticancer, and antimicrobial properties. Several studies have demonstrated the plant’s therapeutic potential in treating ailments such as wounds, fever, arthritis, and gastrointestinal disorders. Additionally, its applications in enhancing cognitive function, as well as its promising anti-cancer and anti-diabetic effects, are discussed to encouraging and making attention of scientist for producing new drugssubstances and substantial use of the plants.


Cite this article:
Priyanka Sawant, Prerna Nikam, Kusum Lad, Shweta Bhosale, Archana Magdum, Ansar Patel. Plumbago zeylanica: A Review of its Traditional Uses, Phytochemistry, and Pharmacological Activities. Research Journal of Pharmacognosy and Phytochemistry. 2025; 17(3):214-8. doi: 10.52711/0975-4385.2025.00035

Cite(Electronic):
Priyanka Sawant, Prerna Nikam, Kusum Lad, Shweta Bhosale, Archana Magdum, Ansar Patel. Plumbago zeylanica: A Review of its Traditional Uses, Phytochemistry, and Pharmacological Activities. Research Journal of Pharmacognosy and Phytochemistry. 2025; 17(3):214-8. doi: 10.52711/0975-4385.2025.00035   Available on: https://rjpponline.org/AbstractView.aspx?PID=2025-17-3-5


REFERENCES:
1.    Yuvaraj D. Mandavkar and Sunil S. Jalalpure. A comprehensive review on Plumbago zeylanica Linn. African Journal of Pharmacy and Pharmacology. 2011; Dec 5(25): 2738-2747. doi: 10.5897/AJPP11.739
2.    Pulok K. Mukherjee, et. al. Plants of Indian origin in drug discovery. Expert opinion on Drug Discovery. 2007; Jun 2(5): 633-657.doi: https://doi.org/10.1517/17460441.2.5.633.
3.    Arpita Roy and Navneeta Bhardavaja. Silver Nanoparticles Synthesis from a Pharmaceutically Important Medicinal Plant Plumbago Zeylanica. MOJ Bioequivalence and Bioavailability. 2017; Aug 3(5): 00046. doi: 10.15406/mojbb.2017.03.00046
4.    Kumar, R. et.al. Hepatoprotective activity of aerial parts of Plumbago zeylanica linn against carbon tetrachloride-induced hepatotoxicity in rats. International Journal of Pharmacy and Pharmaceutical Sciences. 2009; 1(1): 171-175.
5.    Vineet Mittal.et.al. A comparative study of analgesic activity of Plumbago zeylanica Linn. callus and root extracts in experimental mice. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 2011; 1(4): 830-836.
6.    Kumar Ganesan, Sharmila Banu Gani. Ethnomedical and Pharmacological Potentials of Plumbago zeylanica L-A Review.American Journal of Phytomedicine and Clinical Therapeutics. 2013; 1(3):  313-337.
7.    Paras Jain. et. al. Pharmacological Profiles of Ethno-Medicinal Plant: Plumbago zeylanica l.- A Review. International Journal of Pharmaceutical Sciences Review and Research. 2013; 24(1): 157-163.
8.    Chetty, K. Madhava et. al. Pharmaceutical Studies and Therapeutic Uses of Plumbago Zeylanica L. Roots (Chitraka, Chitramulamu). Ethnobotanical Leaflets. 2006: 1: Article 33.
9.    BabitaShukla, et.al. Phytochemistry and pharmacological studies of Plumbago zeylanica L.: a medicinal plant review. Clinical Phytoscience. 2021April 7: 34 https://doi.org/10.1186/s40816-021-00271-7
10.    Dheeraj Dubey. et. al. Phytochemical and in-vitro study of flavonoids isolated from barks of plumbago zeylanica for the treatment of anti-inflamation and anti-arthritic Neuro Quantology. 2022Dec 20; 22: 58-76. doi: 10.48047/nq.2022.20.22. NQ10002
11.    Rahul Checker. et. al. Anti-inflammatory effects of plumbagin are mediated by inhibition of NF-kappa B activation in lymphocytes. IntImmunopharmacol. 2009 Jul; 9(7-8): 949-58. doi: 10.1016/j.intimp.2009.03.022.
12.    Napalchyal KS, et al. Clinical evaluation of ChitrakadiChurnav combined with the Kshar Vasti in the management of Amavata (Rheumatoid Arthritis). Journal of Ayurveda. 2013; 7(3): 73-80
13.    Shweta S, Dubey S. Antimicrobial Activity of Leaves Extract of Plumbago zeylanica Plant against Known Drugs. International Journal of Research Studies in Biosciences. 2015; 3(6): 1-6.
14.    Sunil C, et al. Antidiabetic effect of plumbagin isolated from Plumbago zeylanica L. root and its effect on GLUT4 translocation in streptozotocin-induced diabetic rats. Food and Chemical Toxicology. 2012; 50(12): 4356-63
15.    Sankara Aditya et. al. In-vitro anti-cancer activities of few plant extracts against MCF-7 and HT-29 cell lines. International Journal of Pharma Sciences. 2013; 3(2):185-188.
16.    Shen L, et.al. Proapoptotic and Growth-inhibitory Effects of Plumbagin on Human Gastric Cancer Cells Via Suppression of Signal Transducer and Activator of Transcription 3 and Protein Kinase B. Alternative Therapies, Health and Medicine. 2017; 5382
17.    Jyothi VA, Fathima. Phytochemical evaluation and pharmaceutical screening of wound healing and antioxidant activity of Plumbago zeylanica. International Journal of Pharmacy and Technology. 2013; 5: 5879-5891.
18.    Kumar P, et al. Effects of Limited Access Dressing in Chronic Wounds: A Biochemical and Histological Study. Indian Journal of Plastic Surgery. 2015; 22-28.
19.    Barasa M Maniafu et.al. Larvicidal activity of extracts from three Plumbagospp against Anopheles. gambiae. Memorias do Instituto Oswaldo Cruz. 2009; 104(6): 813-817. 
20.    Patil CD, et. al. Bioefficacy of Plumbagozeylanica (Plumbaginaceae) and Cestrum nocturnum (Solanaceae) plant Extracts against Aedesaegypti (Diptera: Culicide) and- Poeciliareticulata. Parasitol. Res., 2011; 108(5): 1253-1263
21.    Ajayi Gabriel O. et.al. Free radical scavenging activities of extracts and bioactive constituents from the roots of Plumbago zeylanica (Linn.). European Journal of Biology and Medical Science Research. 2019; 7(2):  21-33.
22.    K.D. Falang et. al. Anti-ulcer activity of Plumbago Zeylanica linn root extract Journal of Natural Product and Plant Resources. 2012, 2(5): 563-567J. 
23.    Ankita Sharma and Nimali Singh. A Multifarious Potent Herb: Plumbago zeylanica – A Mini Review. International Journal of Recent Scientific Research. 2015; 6(6): 4825-4829, 
24.    Kanchana N, Sadiq AM. Hepatoprotective effect of Plumbago zeylanica on paracetamol induced liver toxicity in rats. International Journal of Pharmacy and Pharmaceutical Science. 2011; 3(1): 151-154

Recomonded Articles:

Author(s): Mr. Avinash B. Thalkari, Mr. Pawan N. Karwa, Ms. Pallavi S. Shinde, Chandrakant S. Gawli, Priyanka S. Chopane

DOI: 10.5958/0975-4385.2020.00006.0         Access: Open Access Read More

Author(s): Anshuman Singh, Bhupendra Vyas

DOI: 10.5958/0975-4385.2018.00052.3         Access: Open Access Read More

Author(s): Bapu R. Thorat

DOI: 10.5958/0975-4385.2018.00017.1         Access: Open Access Read More

Author(s): S.D Mankar, M.S. Bhosale, Mohini Shelke, Pankaj Sonawane

DOI: 10.5958/0975-4385.2021.00007.8         Access: Open Access Read More

Author(s): Shifali Thakur, Bhawna Walia, Gitika Chaudhary

DOI: 10.52711/0975-4385.2021.00024         Access: Open Access Read More

Author(s): Baviskar H. P., Dhake G. T., Kasai M. A., Chaudhari N. B., Deshmukh T. A.

DOI: 10.5958/0975-4385.2017.00024.3         Access: Open Access Read More

Author(s): Kavitha M, Vadivu R, Radha R

DOI: 10.5958/0975-4385.2015.00037.0         Access: Open Access Read More

Author(s): Punita R. Maurya, Swati R. Dhande, Yadunath M. Joshi, Vilasrao J. Kadam

DOI:         Access: Open Access Read More

Author(s): AV Bhosale, MM Abhyankar, SJ Pawar, Khan Shoeb, Naresh Patil

DOI:         Access: Open Access Read More

Author(s): U. S. Jijith, C. R. Sudhakaran Nair, K. C. Ajithkumar, K. Pramod

DOI: 10.5958/0975-4385.2016.00017.0         Access: Open Access Read More

Author(s): Alimuddin Saifi, Rajani Chauhan, J Dwivedi

DOI:         Access: Open Access Read More

Author(s): Nishendu P. Nadpara, Jagruti P. Vaghela, Parula B. Patel

DOI:         Access: Open Access Read More

Author(s): S C Baviya, R Radha, N Jayshree

DOI: 10.5958/0975-4385.2015.00038.2         Access: Open Access Read More

Author(s): Praveen S Nayak, Shweta Nayak, Ranjan Shety, P Das

DOI:         Access: Open Access Read More

Author(s): Kalpana Patil, Swati Dhande, Vilasrao Kadam

DOI:         Access: Open Access Read More

Author(s): Raje VN, Yadav AV, Shelar PA

DOI:         Access: Open Access Read More

Author(s): Chandrakant P. Rathod, Mahavir H. Ghante

DOI: 10.52711/0975-4385.2021.00022         Access: Open Access Read More

Author(s): Vidula Salvi, Yadunath Joshi, Swati Dhande , Vilasrao Kadam

DOI:         Access: Open Access Read More


Recent Articles




Tags