Author(s): Sonali S Gadge

Email(s): sonaligadge94@gmail.com

DOI: 10.52711/0975-4385.2021.00014   

Address: Sonali S Gadge
P R Patil Institute of Pharmacy, Talegaon (SP), Dist-Wardha (MS), India- 442202.
*Corresponding Author

Published In:   Volume - 13,      Issue - 2,     Year - 2021


ABSTRACT:
The COVID-19 has spread all over the world and there is no single drug or medicine for the prevention and the treatment of this deadly disease. One can get prevention from this disease by boosting the immune system. Persons with weak immune system e.g. children, elder patients or patients with preexisting diseases affect rapidly due to coronavirus. This novel coronavirus attacks mainly on the person immunity. For the centuries the herbal medicinal plants have many beneficial effects against deadly viruses. Herbal medicines provide a rich resource for new antiviral drug development. These natural agents interact with the life cycle of virus such as virus entry, replication, assembly and release. In this review, the importance, immunomodulator, antiviral and pharmacological activities of some medicinal plants, namely, Allium Sativum, Zingiber Officinalis, Cinnamomum zeylanicum, Curcuma longa, Ocimum sanctum, Glycyrrhiza glabra, Ginseng, Black pepper, Emblica officinalis, Withania somnifera, Tinospora cordifolia, Echinacea purpurea, Azadirachta indica, Piper betel, Eugenia caryophyllata, Cinchona calisaya, Nigella sativa, Cuminum cyminum are highlighted. These medicinal plants have many phytoconstituents like alkaloids, glycosides, terpenoids, flavonoids, lactones, polysaccharides, volatile oils, tannins, resins, etc which are helpful for boosting immunity and will help in the prevention and in the management of COVID-19. Several types of research attempted to use herbal medicines against COVID-19.


Cite this article:
Sonali S Gadge. Antiviral and Immunity-modulating Natural Herbs in the Prevention of COVID-19. Research Journal of Pharmacognosy and Phytochemistry. 2021; 13(2):81-4. doi: 10.52711/0975-4385.2021.00014

Cite(Electronic):
Sonali S Gadge. Antiviral and Immunity-modulating Natural Herbs in the Prevention of COVID-19. Research Journal of Pharmacognosy and Phytochemistry. 2021; 13(2):81-4. doi: 10.52711/0975-4385.2021.00014   Available on: https://rjpponline.org/AbstractView.aspx?PID=2021-13-2-5


REEFERENCES:
1.    Gadge SS, Game MD, Salode VL. Review on COVID-19 and its impact on Indian Economy. International Journal of Pharmacy and Biomedical Research. 2020; 7(3): 25-32.
2.    Pilau MR, Alves SH, Weiblen R, Arenhart S, Cueto AP, Lovato LT. Antiviral Activity of the Lippia graveolens (Mexican Oregano) Essential Oil and its Main Compound Carvacrol Against Human and Animal Viruses. Brazilian Journal of Microbiology. 2011; 42(4): 1616-1624.
3.    Kumar A, Chawla A, Gaganpreet, Diksha. A Valuable Insight to the Novel Deadly COVID-19: A Review. Research Journal of Pharmacology and pharmacodyanamics. 2020; 12(3): 111-116.
4.    Dewagan V, Sahu R, Satapathy T, Roy A. The Exploring of Current Development Status and the Unusual Symptoms of Coronavirus Pandemic (COVID-19). Research Journal of Pharmacology and Pharmacodyanamics. 2020; 12(4): 172-176.
5.    Chidgey SM, Broadley KJ. Respiratory Syncytial Virus Infections: Characteristics and Treatment. Journal of Pharmacy and Pharmacology. 2005; 57(11): 1371-1381.
6.    Ball LA, Knipe DM and Howley PM. Virus replication strategies in field of virology. Lippincott Williams and Wilkims. USA. 2007.
7.    Patil PA, Jain RS. Theoretical Study and Treatment of Novel COVID-19. Research Journal of Pharmacology and Pharmacodyanamics. 2020; 12(2): 71-72.
8.    Rokade M, Khandagale P. Coronavirus Disease: A Review of a New Threat to Public Health. Asian Journal of Pharmaceutical Research. 2020; 10(3): 241-244.
9.    Naresh BV. A Review of the 2019 Novel Coronavirus (COVID-19) Pandemic. Asian Journal of Pharmaceutical Research. 2020; 10(3): 233-238.
10.    Debnath S, Chakravorty R, Devi D. A Review on Role of Medicinal Plants in Immune System. Asian Journal of Pharmacy and Technology. 2020; 10(4): 273-277.
11.    Chan JF, Kok KH, Zhu Z, Chu H, To KK, Yuan S, Yelen KY. Genomic Characterization of the 2019 Novel Human-Pathogenic Coronavirus Isolated from A Patient with Atypical Pneumonia After Visiting Wuhan. Emerging Microbes and Infections. 2020; 9(1): 221-236.
12.    Durouiche S. Current Review on Herbal Pharmaceutical Improve Immune Responses Against COVID-19 Infection. Research Journal opf Pharmaceutical Dosage Forms and Technology. 2020; 12(3): 181-184.
13.    Sharma L. Indian Spices: Hidden Treasure to Manage Ailments. EPRA Journals. International Journal of Multidisciplinary Research. 2017; 3(3): 226-230.
14.    Khokra SL, Parashar B, Dhamijia HK, Bala M. Immunomodulators: Immune System Modifiers. Research Journal of Pharmacy and Technology. 2012; 5(2): 169-174.
15.    Patil SB, Awale VB. Some Medicinal Plants Used by People of Sangli District, Maharashtra. Asian Journal of Pharmaceutical Research. 2011; 1(2): 42-43.
16.    Block, Eric. Garlic and other Alliums: The Lore and the Science. Royal Society of Chemistry.
17.    Butt MS, Sultan MT, Buitt MS, Iqbal J. Garlic: Nature’s Protection Against Physiological Treats. Critical Reviews in Food Science and Nutrition. 2009; 49(6): 538-555.
18.    Shang A, Cao SY, Xu XY, Gan RY, Tang GY, et al. Bioactive Compounds and Biological Functions of Garlic (Allium sativum L). Foods. 2019; 8(7): 246.
19.    Tsai Y, Cole LL, Davis LE, Lockwood SJ, Simmons V, Wild GC. Antiviral Properties of Garlic: In Vitro Effects on Influenza B, Herpes Simplex and Coxsackie Viruses. Planta Medica. 1985; 51(5): 460-461.
20.    Nantz MP, Rowe CA, Muller CE, Creasy RA, Stanilka JM, Percival SS. Supplementation with Aged Garlic Extract Improves Both NK and δ-T Cell Function and Reduces the Severity of Cold and Flu Symptoms: A Randomized, Double-blind, Placebo-Controlled Nutrition Intervention. Clinical Nutrition. 2012; 31(3): 337-344.
21.    Chandrashekhar PM, Prashanth KV, Venkatesh YP. Isolation, Structural Elucidation and Immunomodulatory Activity of Fructons from Aged Garlic Extract. Phytochemistry. 2011; 72(2-3): 255-264.
22.    Sultan MT, Buttxs MS, Qayyum MN, Suleria AR. Immunity: Plants as Effective Mediators. Critical Reviews in Food Science and Nutrition. 2014; 54(10): 1298-1308.
23.    Wu XJ, Hu Y, Lamy E, Sundermann VM. Apoptosis Induction in Human Lung Adenomacarcinoma Cells by Oil-Soluble Allyl Sulfides: Triggers, Pathways and Modulators, Environmental and Molecular Mutagenesis. 2009; 50(3): 266-275.
24.    Altonsy MO, Andrews SC. Diallyl Disulphide, A Beneficial Component of Garlic Oil, Causes A Redistribution of Cell-Cycle Growth Phases, Induces Apoptosis, and Enhances Butyrate-Induced Apoptosis in Colorectal Adenomacarcinoma Cells (HT-29). Nutrition and Cancer. 2011; 63(7): 1104-1113.
25.    Chen CY, Huang CF, Tseng YT, Kuo SY. Diallyl Disulphide Induces (Ca2+) Mobilization in Human Colon Cancer Cell Line SW480. Archives of Taxicology. 2012; 86: 231-238.
26.    Schoeman, Fielding BC. Coronavirus Envelope Protein: Current Knowledge. Virology Journal. 2019; 16: 69.
27.    Mashhadi NS, Ghiasvand R, Askari G, Hariri M, et al. Anti-oxidative and Anti-inflammatory Effects of Ginger in Health and Physical Activity, Review of Current Evidence. International Journal of Preventive Medicine. 2013; 4 (Suppl 1): S36-42.
28.    Da Silveira e Sa Rde C, Andrade LN, deSousa DP. Sesquiterpenes from Essential Oils and Inflammatory Activity. Natural Product Communications. 2015; 10(10): 1767-1774.
29.    Chang JS, Wang KC, Yeh CF, Shieh DE, Chiang LC. Fresh Ginger (Zingiber officinale) has Antiviral Activity against Human Respiratory Tract Cell Lines. Journal of Ethanopharmacology. 2013; 145(1): 146-151.
30.    Bode AM and Dong Z. The amazing and mighty ginger. Boca Raton (FL) : CRC Press-Taylor and Francis. 2011.
31.    Townsend EA, Siviski ME, Zhang Y, Xu C, Hoonjan B, Emala CW. Effects of Ginger and Its Constituents on Airway Smooth Muscle Relaxation and Calcium Regulation. American Journal of Respiratory Cell and Molecular Biology. 2013; 48(2): 157-163.
32.    Cifci A, Tayman C, Yakut I, Halil H. Ginger (Zingiber officinale) Prevents Severe Damage to the Lungs Due to Hyperoxia and Inflammation. Turkish Journal of Medical Sciences. 2018; 48(4): 892-900.
33.    Srivastava AK, Chaurasia JP, Khan R, Dhand C, Verma S. Role of Medicinal Plants of Traditional Use in Recuperating Devastating COVID-19 Situation. Medicinal and Aromatic plants. 2020; 9 (359): 1-16.
34.    Kannappan R, Gupta SC, Kim JH, Reuter S and Aggrawal BB. Neuroprotection by Spice-Derived Neutraceuticals: You Are What You Eat! Molecular Neurobiology. 2011; 44(2): 142-159.
35.    Rani MP, Padmakumari KP, Sankarikutty B, Cherion OL, Nisha VM, Raghu KG. Inhibitory Potential of Ginger Extracts against Enzymes Linked to Type II Diabetes, Inflammation and Induced Oxidative Stress. International Journal of Food Science and Nutrition. 2011; 62(2): 106-110.
36.    Bhat SA, Rather SA, Iqbal A, Qureshi HA, Islam N. Immunomodulators for curtailing COVID-19: A Positive Approach. Journal of Drug Delivery and Therapeutics. 2020; 10(3-S): 286-294.
37.    Brochot A, Guilbot A, Haddioui L, Roques C. Antibacterial, Antifungal and Antiviral effects of Three Essential Oil Blends. Microbiology Open. 2017; 6(4): e00459.
38.    Fauvelle C, Lmbotin M, Heydmann L, et al. A cinnamon Derived Procyanidin Type A Compound Inhibits Hepatitis C Virus Cell Entry. Hepatology International. 2017; 11(5): 440-445.
39.    Mritynjaya M, Pavitra V, Janhavi P, Neelam R, Halami PM, Ravindra PV. Immune-boosting, Antioxidant and Anti-inflammatyory Food Supplements Targeting Pathogenesis of COVID-19. Frontiers in Immunology. 2020; 11: 2337.
40.    Hewlings SJ, Kalman DS. Curcumin: A Review of Its Effects on Human Health. Foods. 2017; 6(92): 1-11.
41.    Nadkarni KM and Nadkarni AK. Indian Materia Medica. Popular Prakashan Pvt Ltd. Bombay. 1976
42.    Lelli D, Sahebkar A, JohnstonTP, Pedone C. Curcumin Use in Pulmonary Diseases: State of the Art and Future Perspectives. Pharmacological Research. 2017; 115: 133-148.
43.    Shakibai M, Jhon T, Tanzil GS, Lehmann I, Mobasheri A. Suppression of NF-KB Activation by Curcumin Leads to Inhibition of Cyclo-oxygenax-2 and Matrix Metalloproteinase-9 in Human Articular Chondrocytes: Implicvations for the Treatment of Osteoarthritis. Biochemical Pharmacology. 2007; 73(9): 1434-1445.
44.    shankhdhar PK, Mishra P, Kannojia P, Joshi H. Turmeric: Plant Immunobooster Against COVID-19. Research Journal of Pharmacognosy and Phytochemistry. 2020; 12(3): 174-177.
45.    De R, Kundu P, Swarnakar S, Ramamurthy T, et al. Antimicrobial Activity of Curcumin Against Helicobacter pylori Isolates from India and During Infections in Mice. Antimicrobial Agents and Chemotherapy. 2009; 53(4): 1592-1597.
46.    Singh RK, Rai D, Yadav D, Bhargava A, Balzarini J, De Cleroq E. Synthesis, Antibacterial and Antiviral Properties of Curcumin Bioconjugates Bearing Dipeptide, Fatty Acids and Folic acid. European Journal of Medicinal Chemistry. 2010; 45(3): 1078-1086.
47.    Voduganthan M, Vardeny O, Michel T, McMurray, et al. Renin-Angiotensin-Aldosterone System Inhibitors in Patients with COVID-19. The New England Journal of medicine. 2020; 382(17): 1653-1659.
48.    Nugraha RV, Ridwansyah H, Ghozali M, Khairani AF, Atik N. Traditional Herbal Medicine Candidates as Complementary Treatments for COVID-19: A Review of Their Mechanisms, Pros and Cons. Evidence-based Complementary and Alternative Medicine. 2020: 1-12.
49.    Cohen MM. Tulsi-Ocimum sanctum: A herb for All Reasons. Journal of Ayurveda and Integrative Medicine. 2014; 5(4): 251-259.
50.    Godhwani S, Godhwani JL, Vyas DS. Ocimum sanctum: An Experimental Study Evaluating its Anti-Inflammatory, Analgesic and Antipyretic Activity in Animals. Journal of Ethanopharmacology. 1987; 21(2): 153-63.
51.    Goothy SSK, Goothy S, Chaoudhary A, Potety CG, Chakraborty H, Kumar AHS, et al. Ayurveda’s Holistic Lifestyle Approach for the Management of Coronavirus disease (COVID-19): Possible Role of Tulsi. International Journal of Research in Pharmaceutical Sciences. 2020; 11(Suppl 1): 16-18.
52.    Ravi V, Parida S, Desai A, Chandramuki A, Gourie-Devi M, Grau GE. Correltaion of Tumour Necrosis Factor Levels in the Serum and Cerebrospinal Fluid with Clinical Outcome in Japanese Encephalitis Patients. Journal of Medical Virology. 1997; 51 (2): 132-136.
53.    Sangeetha P, Poornamathy JJ. In Vitro Assessment of Anti-inflammatory Activity of Ocimum sanctum (Karunthulasi leaves). International Journal of Pharma and Bio Sciences. 2015; 6(2): 1387-1391.
54.    Khaerunnisa S, Kurniawan H, Awaluddin R, Suhartati S, Soetjipto S. Potential Inhibitor COVID-19 Main Protease (Mpro) from Several Medicinal Plant Compounds by Molecular Docking Study. 2020.
55.    Yang R, Wang LQ, Yuan BC, Liu Y. The Pharmacological Activities of Licorice. Planta Medica. 2015; 81(18): 1654-1669.
56.    Wang L, Yang R, Yuan B, Liu Y, Liu C. The Antiviral and Antimicrobial Activities of Licorice, a Widely Used Chinese Herb. Acta Pharmaceutica Sinica B. 2015; 5(4): 310-315.
57.    Damle M. Glycyrrhiza glabra (Liquorice)- A Potent Medicinal Herb. International Journal of Herbal Medicine. 2014; 2(2): 132-136.
58.    Matsumoto Y, Matsuura T, Aoyagi H, Matsuda M, Hmwe SS, Date T. Antiviral activity of glycyrrhizin against hepatitis C virus in vitro. PLoS One. 2013; 8(7): e68992.
59.    Ashfaq UA, Masoud MS, Nawaz Z, Riazuddin S. Glycyrrhizin as Antiviral Agent Against Hepatitis C Virus. Journal of Translational Medicine. 2011; 9:112.
60.    Srivastava AK, Chaurasia JP, Khan R, Dhand C, Verma S. Role of Taditional Plants of Medicinal Use in Recuperating Devastating COVID-19 Situation. Medicinal and Aromatic Plants. 2020; 9(5): 359.
61.    Ratan ZA, Haidere MF, Hong YH, Park SH, Lee JO, Lee J, et al. Pharmacological Potential of Ginseng and its Major Component Ginsenosides. Journal of Ginseng Research. 2020.
62.    Im K, Kim J, Min H. Ginseng, the Natural Effectual Antiviral: Protective Effect of Korean Red Ginseng against Viral Infection. Journal of Ginseng Research. 2016; 40(4): 309-314.
63.    Kumar R, Grover SK, Divekar HM, Gupta AK, Shyam R, Srivastava KK. Enhanced Thermogenesis in Rats by Panax ginseng, Multivitamins and Minerals. International Journal of Biometeorology. 1996; 39(4): 187-191.
64.    Block KI, Mead MN. Immune System Effects of Echinacea, Ginseng and Astragalus: A Review. Integrative Cancer Therapies. 2003; 2(3): 247-267.
65.    Iqbal H, Rhee DK. Ginseng Alleviates Microbial Infections of the Respiratory Tract: A Review. Journal of Ginseng Research. 2020; 44(2): 194-204.
66.    Lee JS, Hwang HS, Ju-Ko, Lee YN, et al. Immunomodulatory Activity of Red Ginseng Against Influenza A virus Infection. Nutrients. 2014; 6(2): 517-529.
67.    Luxita Sharma. Immunomodulatory Effect and Supportive Role of Traditional Herbs, Spices and Nutrients in Management of COVID-19. Journal of PeerScientist. 2020; 3(2): 1-8.
68.    Bang JS, Oh DH, Choi HM, Sur B-J, Lim S-J, Kim JY, et al. Anti-inflammatory and Antiarthritic Effects of Piperine in Human Interleukin Beta-Stimulated Fibroblast-like Synoviocytes and in Rat Arthritis Models. Arthritis Research and Therapy. 2009; 11(2): R49.
69.    Ahmad N, Fazal H, Abbasi BH, Farooq S, Ali M, Khan MA. Biological Role of Piper nigrum L (Black pepper): A review. Asian Pacific Journal of Tropical Biomedicine. 2012; 2:1945-1953.
70.    Takoori H, Aumeeruddy MZ, Rengasamy KR, et al. A Systemic Review on Black Pepper (piper nigrum L): from Folk Uses to Pharmacological Applications. Critical Reviews in Food Science and Nutrition. 2019; 59(1): 210-243.
71.    Mittal R, Gupta RL. In Vitro Antioxidant Activity of Piperine. Methods and Findings in Experimental and Clinical Pharmacology. 2000; 22 (5): 271-274.
72.    Mittal B, Chand T. Global Care through Ayurveda in Pandemic of COVID-19. International Journal of Health Sciences and Research. 2020; 10(6): 165-172.
73.    Baliga MS, Dsouza JJ. Amla (Emblica officinalis Gaertn), A Wonder Berry in the Treatment and Prevention of Cancer. European Journal of Cancer Prevention. 2011; 20(3): 225-239.
74.    Saini A, Sharma S, Chibber S. Protective Efficacy of Emblica officinalis against Klebsiella Pneumonia Induced Pneumonia in Mice. Indian Journal of Medical Research. 2008; 128(2): 188-193.
75.    Khare CP. Indian medicinal plants - An illustrated Dictionary. Springer Science+ business media, New York. 2007.
76.    Tiwari R, Chakraborty S, Saminathan M, Dhama K, Singh SV. Ashwagandha (Withania somnifera): Role in Safeguarding Health, Immunomodulatory Effects, Combating Infections and Therapeutic Applications: A review. Journal of Biological Sciences. 2014; 14(2): 77-94.
77.    Singh N, Bhalla M, Jager P, Gilca M. An overview on ashwagandha: A Rasayana (Rejuvenator) of Ayurveda. African Journal of Traditional, Complementary and Alternative Medicines. 2011; 8(5 Suppl): 208-213.
78.    Shah VV, Shah ND, Patrekar PV. Medicinal Plants from Solanaceae family. Research Journal of Pharmacy and Technology. 2013; 6(2): 143-151.
79.    Bhattacharya SK, Goel RK, Kaur R, Ghosal S. Anti-stress Activity of Sitoindosides VII and VIII. New Acylsterylglucosides from Withania somnifera. Phytotherapy Research. 1987; 1(1): 32-37.
80.    Cai Z, Zang G, Tang B, Liu Y, Fu X, Zhang X. Promising Anti-influenza Properties of Active Constituent of Withania somnifera Ayurvedic Herb Targeting Neuroaminidase of H1N1 Influenza: Computational study. Cell Biochemistry and Biophysics. 2015; 72(3): 727-739.
81.    Mikolai J, Erlandson A, Murison A, Gregory WL, et al., In Vivo Effects of Ashwagandha (Withania somnifera) Extract on the Activation of Lymphocytes. The journal of Alternative and Complementary Medicine. 2009; 15(4): 423-430.
82.    Vuksan, Sievenpipper, Vladimir, et al. Current Clinical Evidence for Korean Red Ginseng in management of Diabetes and Vascular Disease: a Toronto’s Ginseng Clinical Testing Program. Journal of Ginseng Research. 2010; 34(4): 264-273.
83.    Gautam M, Diwanay SS, Gairola S, Shinde YS, Jadhav SS, Patwardhan BK. Immune Response Modulation to DPT Vaccine by Aqueous Extract of Withania somnifera in Experimental System. International Immunopharmacology. 2004; 4(6): 841-849.
84.    Ashish Kumar, Jnanesha AC and Saudamalla Nagaraju. Cultivation and medicinal properties of Giloy [Tinospora cordifolia (Thunb) Miers]. Medicinal and Aromatic Plants. 2019; 18(1): 57-58.
85.    Upadhyay AK, Kumar K, Kumar A, Mishra HS. Tinospora cordifolila (Wild.) Hook.f. and Thoms. (Guduchi)- Validation of the Ayurvedic Pharmacology through Experimental and Clinical Studies. International Journal of Ayurveda Research. 2010; 1(2): 112-121.
86.    Nadig PD, Revankar RR, Dethe SM, Narayanswamy SB, Aliyar MA. Effect of Tinospora cordifolia on Experimental Diabetic Neuropathy. Indian Journal of Pharmacology. 2012; 44(5): 580-583.
87.    Singh D, Chaudhari PK. Chemistry and Pharmacology of Tinospora cordifolia. Natural Product Communications. 2017; 12(2): 299-308.
88.    Antul K, Amandeep P, Gurwinder S Chaudhary. Review on Pharmacological profile of Medicinal vine: Tinospora cordifolia. 2019; 35(5): 1-11.
89.    Hartmann HT, Kester DE, Davies FT and Geneve RL. Plant Propogation Principles and Practices. Prentice-Hall of India Pvt. Ltd., New Delhi. 1997.
90.    Saha S, Ghgosh S. Tinospora cordifolia: One plant, Many Roles. Ancient Science of Life. 2012; 31(4): 151-159.
91.    Nair PK, Rodriguezs, Ramachandran R, Alamo A, Melnick SJ, Escalon E, et al. Immune stimulating Properties of a Novel Polysaccharides from the Medicinal Plant Tinospora cordifolia. International Immunopharmacol. 2004; 4(13): 1645-1659.
92.    Sachan S, Dhama K, Latheef SK, Samad HA, Mariappan AK, Manuswamy P, et al. Immunomodulatory Potential of Tinospora cordifolia and CpG ODN (TLR 21 Agonist) against the Very Virulent Infectious Bursal disease virus in SPF chicks. Vaccines (Basel). 2019; 7(3): 106.
93.    Srivastava N, Saxena V. A Review on Scope of Immunomodulatory Drugs in Ayurveda for Prevention and Treatment of COVID-19. Plant Science Today. 2020; 7(3): 417-423.
94.    Srivastava AK, Chaurasia JP, Khan R, Dhand C, Verma S. Role of Medicinal Plants of Traditional Use in Recuperating Devastating COVID-19 Situation. Medicinal and Aromatic plants. 2020; 9(5): 1-16.
95.    Hudson J, Vimalnathan S. Echinacea- A Source of Potent Antivirals for Respiratory Virus Infections. Pharmaceuticals. 2011; 4(7): 1019-1031.
96.    Srivastava N, Saxena V. A Review on Scope of Immunomodulatory Drugs in Ayurveda for Prevention and Treatment of COVID-19. Plant Science Today. 2020; 7(3): 417-423.
97.    Bhowmik D, Chiranjib, Yadav J, Tripathi KK and Kumar KP. Herbal Remedies of Azadirachta indica and its Medicinal Applications. Journal of Chemical and Pharmaceutical Research. 2010; 2: 62-72.
98.    Islas JF, Acosta E, Buentello ZG, Delgado JL, et al. An Overview of Neem (Azadirachta indica) and its Potential Impact on Health. Journal of Functional Foods. 2020; 74: 1-13.
99.    Alzohairy MA. Therapeutics Role of Azadirachta indica (Neem) and their Active Constituents in Diseases Prevention and Treatment. Evidence-based Complementary and Alternative Medicine. 2016.
100.    Subapriya R, Nagini S. Medicinal Properties of Neem Leaves: A Review. Current Medicinal Chemistry- Anti-cancer Agents. 2005; 5(2): 149-156.
101.    Biswas K, Chattopadhyay I, Banerjee RK, Bandopadhyay U. Biological Activities and Medicinal Properties of Neem (Azadirachta indica). Current Science. 2002; 82(11): 1336-1345.
102.    Udeinya I, Mbah A, Chijioke C, Shu E. An Antimalarial Extract from Neem Leaves. Transactions of the Royal Society of Tropical Medicine and Hygiene. 2004; 98(7): 435-437.
103.    Baildya N, Khan AA, Ghosh NN, Tanmoy Dutta T, Chattopadhyay AP. Screening of Potential Drug from Azadirachta indica (Neem) Extracts for SARS-CoV-2: An Insight from Molecular Docking and MD-Simulation Studies. Journal of Molecular Structure. 2020.
104.    Madhumita M, Guha P, Nag A. Bio-actives of Betel Leaf (Piper betel L.): A Comprehensive Review on Extraction, Isolation, Characterization and Biological Activity. Phytotherapy Research. 2020; 34(10): 1-19.
105.    Sengupta R, Banik JK. A Review on Betel Leaf (PAN). International Journal of Pharmaceutical Sciences and Research. 2013; 4(12): 4519-4524.
106.    Chauhan ES, Aishwarya J, Akriti Singh A, Tiwari A. A Review: Neutraceuticals Properties of Piper Betel (Paan). American Journal of Phytomedicine and Clinical Therapeutics. 2016; 4(02): 28-41.
107.    Ramji N, Iyer R, Chandrasekaran S. Phenolic Antibacterials from Piper Betel in the Prevention of Halitosis. Journal of Etanopharmacology. 2002; 83(1-2): 149-152.
108.    Arujothi S, Uma C, Sivagurunathan P. Comparative Evaluation on the Antibacterial Activity of Kapoori Variety Piper Betel Leaves against Certain Bacterial Pathogens. International Journal of Science and Research Methodology. 2016; 3(3): 35-45.
109.    Akaike T, Noguchi Y, Ijiri S, Setoguchi K, Suga M, Zheng YM, Dietzschold B, Maedah H. Pathogenesis of Influenza Virus-induced Pneumonia: Involvement of both Nitric Oxide and Oxygen Radicals. Proceedings of the National Academy of Sciences of the United States of America. 1996; 93(6): 2448-2453.
110.    Lakshmi BS, Naidu KC. Comparative morphoanatomy of Piper Betel L. Cultivars in India. Annals of Biological Research. 2010; 1(2): 128-134.
111.    Dibazar SP, Fateh S, Daneshmandi S. Immunomodulatory Effects of Clove (Syzygium aromaticum) Constituents on Macrophages: In Vitro Evaluations of Aqueous and Ethanolic Components. Journal of Immunotoxicology. 2015; 12(2): 124-131.
112.    Gulcin I, Elmastas M, Aboul-Enein HY. Antioxidant Activity of Clove Oil-A Powerful Antioxidant Source. Arabian Journal of Chemistry. 2012; 5(4): 489-499.
113.    Ghorab AE, Massry KF. Free Radical Scavenging and Anti-oxidant Activity of Volatile Oils of Local Clove [Syzygium aromaticum] and Cinnamon [Cinnamomum zeylanicum] Isolated by Supercritical Fluid Extraction. Journal of Essential Oil Bearing Plants. 2003; 6(1): 9-20.
114.    Lee KG, Shibamato T. Antioxidant Property of Aroma Extract Isolated from Clove Buds [Syzygium aromaticum (L.) Merr. et Perry]. Food Chemistry. 2001; 74(4): 443-448.
115.    Jie An, Minie M, Sazaki T, Woodward JJ, Elkon KB. Antimalarial Drugs as Immune Modulators: New Mechanism for Older Drugs. Annual Review of Medicine. 2017; 68: 317-330.
116.    Maraunder A, Ganzera M. Quantitative Determination of Major Alkaloids in Cinchona Bark by Supercritical Fluid Chromatography. Journal of Chromatography A. 2018; 1554: 177-122.
117.    Rizk JG, Zadeh KK, Mandeep R Mehra MR, Lavie CJ, Rizk Y, Forthal DN. Pharmaco-Immunomodulatory Therapy in COVID-19. Drugs. 2020; 80: 1267-1292.
118.    Majdalawiech AF, Hmaidan R, Carr RI. Nigella Sativa Modulates Splenocyte Proliferation, Th1/Th2 Cytokine Profile, Macrophage Function and NK Anti-tumour Activity. Journal of Ethanopharmacology. 2010; 131(2): 268-275.
119.    El-Hack MA, Alagawany M, Farag MR, Tiwari R, Kumaragurubaran K, Dhama K. Nutritional, Healthical and Therapeutic Efficacy of Black cumin (Nigella sativa) in Animals, Poultry and Humans. International Journal of Pharmacology. 2016; 12(3): 232-248.
120.    Ahmad A, Husain A, Mujeeb M, Khan SA, et al. A Review on Therapeutic Potential of Nigella sativa: A Miracle Herb. Asian Pacific Journal of Tropical Biomedicine. 2013; 3(5): 337-352.
121.    Al- Jassir MS. Chemical Composition and Microflora of Black Cumin (Nigella sativa L.) Seeds Growing in Saudi Arabia. Food Chemistry. 1992; 45: 239-242.
122.    Kulyar MF, Rongrong Li, Mehmood K, Waqas M, Kun Li, Jiakui Li. Potential influence of Nigella Sativa (Black cumin) in Reinforcing Immune System: A hope to decelerate the COVID-19 Pandemic. Phytomedicine. 2020.
123.    Salem EM, Yar T, Bamosa AO, Al-Quorain A, Yasawy MI, Alsulamain RM, et al. Comparative Study of Nigella sativa and Triple Therapy in Eradication of Helicobacter Pylori in Patients with Non-ulcer Dyspepsia. The Saudi Journal of Gastroenterology. 2010; 16(3): 207-214.
124.    Molla S, Azad MAK, Hasib MAAA, Hossain MM, Ahammed MS, Rana S, Islam MT. A review on Antiviral Effects of Nigella sativa. Pharmacologyonline. 2019; 2: 47-53.
125.    Maideen NM. Prophetic Medicine-Nigella sativa (Black cumin seeds)-Potential Herb for COVID-19? Journal of Pharmacopuncture. 2020, 23(2): 62-70.
126.    Ashraf S, Ashraf S, Ashraf M, Imran MA, Kalsoom L, Siddiqui UN, et al. Honey and Nigella sativa against COVID-19 in Pakistan (HNS-COVID-PK): A Multi-center Placebo-controlled Randomized Clinical Trial. 2020.
127.    Snafi AE. The Pharmacological Activities of Curcumin cyminum-A review. IOSR Journal of Pharmacy. 2016; 6(6): 46-65.
128.    Srinivasana K. Cumin (Cuminum cyminum) and Black cumin (Nigella sativa) seeds: Traditional Uses, Chemical Constituents and Nutraceutical Effects. Food Quality and Safety. 2018; 2(1): 1-16.
129.    Johri RK. Cuminum cyminum and Carum carvi: An update. Pharmacognosy Reviews. 2011; 5(9): 63-72.
130.    Wei J, Zhang X, Bi Y, Miao R, Zhang Z, Su H (2015). Anti-inflammatory Effects of Cumin Essential Oil by Blocking JNK, ERK, and NF-kb Signaling Pathways in LPS-stimulated RAW 264.7 cells. Evidence-Based Complementary and Alternative Medicine. 2015: 474509.
131.    Chauhan PS, Satti NK, Suri KA, Amina M, Bani S. Stimulatory Effects of Cuminum cyminum and Flavonoid Glycoside on Cyclosporine-A and Restraint Stress Induced Immune-suppression in Swiss Albinomice. Chemico- Biological Interactions. 2010; 185(1): 66-72.
132.    Zandi K, Teoh BT, Sam SS, Fong WP, Mustafa MR, Sazaly A. Novel Antiviral Activity of Baicalein against Dengue Virus. BMC Complementary and Alternative Medicine. 2012; 12: 214.

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