Author(s):
Anyash Basnett, Sushilta Pradhan
Email(s):
pradhansushilta98@gmail.com , basnettanyash@gmail.com
DOI:
10.52711/0975-4385.2026.00021 
Address:
Anyash Basnett1, Sushilta Pradhan2*
1Assistant Professor, Department of Pharmacognosy, Himalayan Pharmacy Institute, Majitar, Rangpo 737136, East Sikkim, India.
2Research Scholar, Department of Pharmaceutical Technology, North Bengal University, Siliguri 734013, West Bengal, India.
*Corresponding Author
Published In:
Volume - 18,
Issue - 2,
Year - 2026
ABSTRACT:
Aim of the study: The Heracleum genus holds 94 identified compounds, all of which suggest essential biological functions. With this, this literature study aims to focus on a particular species of the Heracleum genus, “Tetrataenium nepalense”, which belongs to the family Umbelliferae. Commonly found in Sikkim and the Darjeeling district of India. The study aims to explore the available literature data on this plant, as ethnomedicinal evidence suggests that it possesses essential biological functions, including anti-inflammatory, carminative, wound-healing, antibacterial, anti-diarrheal, tonic, digestive, analgesic, and anticonvulsant properties. Material and Method: A Literature survey was conducted using various search databases, including SpringerLink, PubMed, Google Scholar, ScienceDirect, and Web of Science. Papers from 1975 to the latest paper from 2025 were referred to for this review article. Result: The goal of this review was to organise up-to-date and thorough information on the pharmacology, phytochemistry, and ethnobotanical uses of Tetrataenium nepalense to create new avenues for future research, including potential applications as functional components in foods. Conclusion: From the review study of Tetrataenium nepalense it could be concluded that this plant Tetrataenium nepalense, is being traditionally used as medicinal plants by the local people of the Himalayan region, as its chemical constituents reveal that due to the presence of numerous compounds like Furanocoumarins, including bergapten, byakangelicol, phellopterin, xanthotoxin, isopimpinellin, imperatorin, primary phytochemicals like alkaloids, terpenoids, steroids, flavonoid, glycoside, saponins make it ideal for the its pharmacological activity.
Cite this article:
Anyash Basnett, Sushilta Pradhan. Phytochemical and Pharmacological Insights into Tetrataenium nepalense: An Integrative Review. Research Journal of Pharmacognosy and Phytochemistry. 2026; 18(2):149-5. doi: 10.52711/0975-4385.2026.00021
Cite(Electronic):
Anyash Basnett, Sushilta Pradhan. Phytochemical and Pharmacological Insights into Tetrataenium nepalense: An Integrative Review. Research Journal of Pharmacognosy and Phytochemistry. 2026; 18(2):149-5. doi: 10.52711/0975-4385.2026.00021 Available on: https://rjpponline.org/AbstractView.aspx?PID=2026-18-2-6
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24. Dash S, Nath L, Bhise S, Kar P, Bhattacharya S. Stimulation of immune function activity by the alcoholic root extract of Heracleum nepalense D. Don. Indian Journal of Pharmacology. 2006; 38(5): 336-40.
25. Dugrand-Judek A, Olry A, Hehn A, Costantino G, Ollitrault P, Froelicher Y, et al. The distribution of coumarins and furanocoumarins in Citrus species closely matches Citrus phylogeny and reflects the organization of biosynthetic pathways. PLOS one. 2015; 10(11): e0142757.
1. Asgary S, Sahebkar A, Afshani MR, Keshvari M, Haghjooyjavanmard S, Rafieian‐Kopaei M. Clinical evaluation of blood pressure lowering, endothelial function improving, hypolipidemic and anti‐inflammatory effects of pomegranate juice in hypertensive subjects. Phytotherapy Research. 2014; 28(2): 193-9.
2. Haq I. Safety of Medicinal Plants. Pak J Med Res. 2004; 43(4): 203-10.
3. Hosseinzadeh Z, Ramazani A, Razzaghi-Asl N. Plants of the Genus Heracleum as a Source of Coumarin and Furanocoumarin. Journal of Chemical Reviews. 2019; 1(2): 78-98.
4. Bahadori MB, Dinparast L, Zengin G. The genus Heracleum: a comprehensive review on its phytochemistry, pharmacology, and ethnobotanical values as a useful herb. Comprehensive Reviews in Food Science and Food Safety. 2016; 15(6): 1018-39.
5. Bose SK, Dewanjee S, Mandal SC. Antibacterial activity of methanol extract of roots of Heracleum nepalense D Don. on bacteria causing diarrhoea. Oriental Pharmacy and Experimental Medicine. 2007; 7(3): 286-9.
6. Rai U, Rai S, Datta S, Sarkar RK. Heracleum nepalense D. Don: An unheeded medicinal shrub of Sikkim and West Bengal Hills.
7. Grover J, Yadav S, Vats V. Medicinal plants of India with anti-diabetic potential. Journal of Ethnopharmacology. 2002; 81(1): 81-100.
8. Manandhar NP. Substitute spices in Nepal. Journal of Herbs, Spices and Medicinal Plants. 1996; 3(4): 71-7.
9. Rai MB. Medicinal plants of Tehrathum district, eastern Nepal. Our nature. 2003; 1(1): 42-8.
10. Dash S, Nath LK, Bhise S. Antioxidant and antimicrobial activities of Heracleum nepalense D Don root. Tropical Journal of Pharmaceutical Research. 2005; 4(1): 341-7.
11. Singh HB, Prasad P, Rai L. Folk medicinal plants in the Sikkim Himalayas of India. Asian Folklore Studies. 2002: 295-310.
12. Shakhmatov EG, Toukach PV, Kuznetsov SP, Makarova EN. Structural characteristics of water-soluble polysaccharides from Heracleum sosnowskyi Manden. Carbohydrate Polymers. 2014; 102: 521-8.
13. Pradhan DK. Inductive Coupled Plasma Analysis of Heracleum Nepalense d. Don (Umbelliferae). Exploratory Animal and Medical Research. 2023; 13.
14. Bose SK, Dewanjee S, Sahu R, Dey SP. Effect of bergapten from Heracleum nepalense root on production of proinflammatory cytokines. Natural Product Research. 2011; 25(15): 1444-9.
15. Subba A, Bharati M, Rai P, Saha D. Phytochemical composition of Heracleum nepalense D. Don fruit extracts and its activity against the larvae of Aedes albopictus (Diptera: Culicidae). International Journal of Tropical Insect Science. 2020; 40(2): 373-83.
16. Basnet A, Kalaunı SK. Phytochemical screening and biological activity analysis of some selected medicinal plants of Ilam district of Nepal. Current Perspectives on Medicinal and Aromatic Plants. 2020; 3(2): 61-73.
17. Pramila K, Bimala S. Antimicrobial and antioxidant properties of fruits of Capsicum annuum var. cerasiforme (Mill.) Irish and Heracleum nepalense D. Don. International Journal of Toxicological and Pharmacological Research. 2017; 9(2): 105-12.
18. Dash S. Chemical and pharmacological evaluation of colebrookea oppositifolia smith and Heracleum nepalence D Don Dc: University of North Bengal; 2006.
19. Nersezashvili M, Berashvili D, Jokhadze M, Gokadze S, Bozhadze A. Chemical Composition and Biological Activity of Species of the Genus Heracleum. Georgian Scientists. 2023; 5(2): 317-40.
20. Luo T, Jia X, Feng W-d, Wang J-y, Xie F, Kong L-d, et al. Bergapten inhibits NLRP3 inflammasome activation and pyroptosis via promoting mitophagy. Acta Pharmacologica Sinica. 2023; 44(9): 1867-78.
21. Kurtul E, Küpeli Akkol E, Karpuz Ağören B, Yaylacı B, Bahadır Acıkara Ö, Sobarzo-Sánchez E. Phytochemical investigation and assessment of the anti-inflammatory activity of four Heracleum taxa growing in Turkey. Frontiers in Pharmacology. 2025; 15: 1494786.
22. Kose TI, Yardimci GB, Kirci D, Polat DC, Demirci B, Eryilmaz M, et al. Bioactivities and chemotaxonomy of four Heracleum species: a comparative study across plant parts. Pharmaceuticals. 2025; 18(4): 576.
23. Subba B, Maharjan S, Biswakarma A, Kathayat NS, Koirala S. Study of in-vitro anti-diabetic activity and antioxidant activity of some selected plants of nepal. International Journal of Pharmaceutical Research. 2021; 13(3).
24. Dash S, Nath L, Bhise S, Kar P, Bhattacharya S. Stimulation of immune function activity by the alcoholic root extract of Heracleum nepalense D. Don. Indian Journal of Pharmacology. 2006; 38(5): 336-40.
25. Dugrand-Judek A, Olry A, Hehn A, Costantino G, Ollitrault P, Froelicher Y, et al. The distribution of coumarins and furanocoumarins in Citrus species closely matches Citrus phylogeny and reflects the organization of biosynthetic pathways. PLOS one. 2015; 10(11): e0142757.