Author(s):
Pankaj Prabhakar Dhone, Anjali Wankhade, Vivek Paithankar, J. V. Vyas
Email(s):
pankajdhone4139@gmail.com
DOI:
10.52711/0975-4385.2026.00020 
Address:
Pankaj Prabhakar Dhone*, Anjali Wankhade, Vivek Paithankar, J. V. Vyas
Department of Pharmacology, Vidhyabharti College of Pharmacy, Sant Gadge Baba Amravati University Amravati – 444601, Maharashtra, India.
*Corresponding Author
Published In:
Volume - 18,
Issue - 2,
Year - 2026
ABSTRACT:
Cayratia trifolia (L.) Domin (Family: Vitaceae) is a perennial climber with a long history of use in traditional and folk medicine systems across Asia for treating a variety of ailments, including diabetes, ulcers, tumors, and inflammation. This review aims to provide a comprehensive and updated summary of the ethnobotanical, phytochemical, and pharmacological properties of C. trifolia to highlight its therapeutic potential and identify future research directions. A systematic review of scientific literature confirms that the plant is a rich source of bioactive secondary metabolites, most notably stilbene oligomers (e.g., pallidol, resveratrol, e-viniferin) and flavonoids (e.g., quercetin, kaempferol). Preclinical in-vivo and in-vitro studies have validated many of its traditional uses, demonstrating potent antidiabetic (via a-glucosidase inhibition and enhanced glucose uptake), antioxidant, anti-inflammatory, hepatoprotective, and antimicrobial activities. Furthermore, emerging research on its isolated stilbene compounds has revealed significant cytotoxic effects against various human cancer cell lines. Acute toxicity studies suggest a wide margin of safety. However, despite the extensive preclinical data, there is a complete lack of human clinical trials. Future research should focus on bioactivity-guided isolation of lead compounds, elucidating molecular mechanisms, and conducting clinical studies to translate its therapeutic potential into modern medicine.
Cite this article:
Pankaj Prabhakar Dhone, Anjali Wankhade, Vivek Paithankar, J. V. Vyas. A Comprehensive Review of The Ethnobotany, Phytochemistry and Pharmacological properties of Cayratia trifolia (L.) Domin. Research Journal of Pharmacognosy and Phytochemistry. 2026; 18(2):143-8. doi: 10.52711/0975-4385.2026.00020
Cite(Electronic):
Pankaj Prabhakar Dhone, Anjali Wankhade, Vivek Paithankar, J. V. Vyas. A Comprehensive Review of The Ethnobotany, Phytochemistry and Pharmacological properties of Cayratia trifolia (L.) Domin. Research Journal of Pharmacognosy and Phytochemistry. 2026; 18(2):143-8. doi: 10.52711/0975-4385.2026.00020 Available on: https://rjpponline.org/AbstractView.aspx?PID=2026-18-2-5
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