Antioxidant activity of Gloriosa superba in albino rats

Pradeep Kumar Samal

Research Journal of Pharmacognosy and Phytochemistry

ISSN

0975-4385 (Online)
0975-2331 (Print)

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Antioxidant activity of Gloriosa superba in albino rats

Author(s): Pradeep Kumar Samal

Email(s): samalpharmacology@rediffmail.com

DOI: Not Available

Address: Pradeep Kumar Samal
SLT Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh.
*Corresponding Author:

Published In: Volume - 5, Issue - 6, Year - 2013

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ABSTRACT:
The objective of this study was to investigate the antioxidant activity of Gloriosa superba leaves against carbon tetracholoride (CCl4) induced hepatotoxic model. The plant materials were dried in shade, powdered with help of hand grinder and extracted with alcohol. Preliminary phytochemical test shows the presence of Alkaloids, Carbohydrates, Tannins, Amino acids and Flavanoids. The alcoholic extract of Gloriosa superba (AEGS) showed a significant dose dependent (250 mg and 500 mg/kg p.o.) antioxidant activity. The degree of antioxidant activity was measured by using serum biochemical parameters like hepatic antioxidant enzymes like SOD, CAT, GPX and LPO. AEGS at a dose level of 250mg/kg and 500mg/kg produce significant (P<0.001) antioxidant activity by decreasing the level Malondialdehyde, while it significantly increased the levels of glutathione peroxidase (GPX) , superoxide dismutase (SOD) and Catalase activity (CAT) in a dose dependent manner. The effect of AEGS was comparable to that of standard drug Silymarin.

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Cite this article:
Pradeep Kumar Samal. Antioxidant activity of Gloriosa superba in albino rats. Research J. Pharmacognosy and Phytochemistry 2013; 5(6): 288-292

Cite(Electronic):
Pradeep Kumar Samal. Antioxidant activity of Gloriosa superba in albino rats. Research J. Pharmacognosy and Phytochemistry 2013; 5(6): 288-292 Available on: https://rjpponline.org/AbstractView.aspx?PID=2013-5-6-4