Research Journal of Pharmacognosy and Phytochemistry

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0975-4385 (Online)
0975-2331 (Print)


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An evaluation of anti-pyretic potential of Vetiveria zizanioides (Linn.) root

Author(s): M. B. Narkhede, P. V. Ajmire, A. E. Wagh, M. R. Bhise, G. D. Mehetre, H. J. Patil

Email(s): maheshnark@gmail.com

DOI: Not Available

Address: M. B. Narkhede*, P. V. Ajmire, A. E. Wagh, M. R. Bhise, G. D. Mehetre, H. J. Patil
Indira Bhuuddeshiya Shikshan Shantha’s College of Pharmacy, Malkapur
*Corresponding Author

Published In:   Volume - 4,      Issue - 1,     Year - 2012

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ABSTRACT:
Vetiveria zizanioides belonging to the family Gramineae, is widely used as a traditional plant as refrigerant that cools and calms the entire body. The current study was focused to evaluate the antipyretic (yeast-induced pyrexia in albino rats) potential of the hexane extract (HEVZ) and methanol extract (MEVZ) of Vetiveria zizanioides root. The yeast-induced pyrexia method was standardized by subcutaneous injection of yeast suspension (10 ml /kg body wt.) which increased rectal temperature after 17 hours followed by recording of rectal temperature at regular interval. Both extract at 75mg, 150mg and 300mg/kg dose significantly (P< 0.05) reduced yeast-induced elevated temperature. Also the effect of extracts on normal body temperature was evaluated. Rectal temperature of rodents was recorded at a time interval of 1hrs, 2hrs, 3hrs, 4hrs and 5hrs after drug administration. Reduction is in a dose dependent manner.The anti-pyretic effect of HEVZ and MEVZ was comparable to that of a standard antipyretic agent paracetamol (150 mg / kg body wt, p.o).


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Cite this article:
M. B. Narkhede, P. V. Ajmire, A. E. Wagh, M. R. Bhise, G. D. Mehetre, H. J. Patil. An evaluation of anti-pyretic potential of Vetiveria zizanioides (Linn.) root. Research J. Pharmacognosy and Phytochemistry 2012; 4(1): 11-13.

Cite(Electronic):
M. B. Narkhede, P. V. Ajmire, A. E. Wagh, M. R. Bhise, G. D. Mehetre, H. J. Patil. An evaluation of anti-pyretic potential of Vetiveria zizanioides (Linn.) root. Research J. Pharmacognosy and Phytochemistry 2012; 4(1): 11-13.   Available on: https://rjpponline.org/AbstractView.aspx?PID=2012-4-1-4


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DOI: 10.5958/0975-4385 

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Research Journal of Pharmacognosy and Phytochemistry (RJPP) (ISSN: print-0975-2331, Online-0975-4385) is an international, peer-reviewed journal, devoted to pharmacognosy. The aim of RJPP is to increase the impact of pharmacognostic research both in academia and industry, with strong emphasis on quality and originality. RJPP publishes Original Research Articles, Short Communications, Review Articles in all areas of Pharmacognosy and Phytochemistry.

The journal is published quaterly every year in last week of March, June, September and December.    
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