ABSTRACT:
Cassia auriculata are safer, more effective, and have less adverse effects than modern treatment, herbal remedies are preferred. Growing throughout India and other Asian countries, Cassia auriculata is an evergreen plant. For many years, chronic illnesses have been treated using C. auriculata in medicine. Typically, the entire plant is chopped and dug out, and occasionally herbicides are employed for control. On the other hand, it possesses excellent medicinal qualities that are widely employed in India and well-liked in traditional medical systems like Ayurveda and Siddha. Herbal medicine has had exponential growth in the past several years and is becoming more and more popular in both developed and developing nations due to its natural origins and low negative effects. A thorough analysis was carried out to gather data regarding herbal remedies used to treat diabetes mellitus. It is a metabolic endocrine system condition that affects around 10% of the global population, and the number of people affected is rising daily. Hyperglycemia and altered protein, carb, and lipid metabolism are hallmarks of diabetes mellitus. In most developed nations, 90% of all diabetics have type-2 diabetes, with developing nations bearing roughly 80% of the burden. The most common medications for diabetes are insulin and other oral hypoglycemics, but they also come with a number of negative effects. It has been discovered that many medicinal herbs can be utilized to effectively control diabetes. A traditional remedy for diabetes mellitus is Cassia auriculata Linn, also known by its colloquial name, Avartaki. The current investigation aims to determine Cassia auriculata Linn's phytochemical evaluation. Throughout the world, cassia is widely used to treat a variety of illnesses. Research conducted on a variety of Cassia species shows promise in the management of diabetic mellitus. This review outlines the potential of plants belonging to the Cassia species that have been shown to have antidiabetic properties.
Cite this article:
Jondhale Tejal Ankush, Varpe Tanmay Rajendra. Studies on Antidiabetic Botanical Drug: Cassia auriculata. Research Journal of Pharmacognosy and Phytochemistry. 2025; 17(1):75-9. doi: 10.52711/0975-4385.2025.00013
Cite(Electronic):
Jondhale Tejal Ankush, Varpe Tanmay Rajendra. Studies on Antidiabetic Botanical Drug: Cassia auriculata. Research Journal of Pharmacognosy and Phytochemistry. 2025; 17(1):75-9. doi: 10.52711/0975-4385.2025.00013 Available on: https://rjpponline.org/AbstractView.aspx?PID=2025-17-1-13
REFERENCES:
1. Mukherjee PK, Maiti K, Mukherjee K, Houghton PJ. Leads from Indian medicinal plants with hypoglycemic potentials. Journal of Ethnopharmacology. 2006; 106(1):1-28.
2. Gaikwad SB, Krishna MG, Sandhya RM. Phytochemicals for diabetes management. Pharmaceutical Crops. 2014; 5(1): 11-28.
3. Khandelwal KR. Practical Pharmacognosy Techniques and Experiments. Nirali Publication, Pune, 2001, 149-156.
4. Cao Z, Wang Z, Shang Z, Zhao J. Classification and identification of Rhodobryum roseum Limpr. And its adulterants based on fourier-transform infrared spectro.
5. Francis G, Kerem Z, Makkar HP, Becker K. The biological action of saponins in animal systems: a review. British Journal of Nutrition. 2002; 88(6):587-605.
6. Lee KT, Sohn IC, Kim DH, Choi JW, Kwon SH, Park HJ. Hypoglycemic and hypolipidemic effects of tectorigenin and kaikasaponin III in the streptozotocin-induced diabetic rat and their antioxidant activity in vitroArchives of Pharmacal Research. 2000; 23(5):461-6.
7. Yoshikawa M, Murakami T, Kishi A, Kageura T, Matsuda H. Medicinal flowers. III. Marigold. (1): hypoglycemic, gastric emptying inhibitory, and gastroprotective principles and new oleanane-type triterpene oligoglycosides, calendasaponins A, B, C, and D from Egyptian Calendula officinalis. Chemical and Pharmaceutical Bulletin. 2001; 49(7):863-70.
8. Bhavsar SK, Singh S, Giri S, Jain MR, Santani DD. Effect of saponins from Helicteres isora on lipid and glucose metabolism regulating genes expression. Journal of Ethnopharmacology. 2009; 124(3):426-33.
9. Dhar ML, Dhar MM, Dhawan BN, Mehrotra BN, Ray C. Screening of Indian plants for biological activity. Indian J Exp Biol 1968; 6: 232-247.
10. Satyavati GV, Neeraj T, Madhu S. Indigenous plant drugs for diabetes mellitus. J Ethnopharmacol. 1989; 12:23-8.
11. Davis SN. Insulin, oral hypoglycemic agents, and the pharmacology of the endocrine pancreas. In: Brunton LL, ed. Goodman and Gilman‟s. The pharmacological basis of therapeutics, 11th ed. New York: McGraw-Hill, 2000:1411.
12. King H, Aubert RE, Herman WH. Global burden of diabetes, 1995-2025: Prevalence, numerical estimates, and projections. Diabetic Care. 1998; 21:1414-43.
13. Garg M, Garg C. Scientific alternative approach in diabetes-An overview. Pharmacognosy Rev. 2008; 2:284-301.
14. Nagarajan S, Jain HC, Aulakh GS. Indigenous plants in the control of diabetes. New Delhi: Publ Inform Dir CSIR, 1987:586.
15. Rajasekharan S, Tuli SN. Vijaysar (Petrocarpus marsupium) in the treatment of Madhumeha (Diabetes mellitus): a clinical trial. J Res Indian Med Yoga Homeopathy 1976; 9:76-8.
16. Tsay HS, Agrawal DC. Tissue Culture Technology of Chinese Medicinal Plant Resources in Taiwan and their Sustainable Utilization. Int J App Sci Eng. 2005; 3:215-223.
17. Sofowora A. Medicinal Plants and Traditional Medicine in Africa Johnwiley, New York, 1984, 256-257.
18. Bailey CJ, Day C. Traditional plants medicines as treatments for diabetes. Diabetes Care. 1989; 12(8):552-556.
19. Huang THW, Peng G, Kota BP, Li GQ, Yamahara J, Roufogalis BD et al. Anti-diabetic action of Punica granatum flower extract: activation of PPAR-c and identification of an active component. Toxicol App Pharmacol. 2005; 207:160-169.
20. Kumar P, Clark M. Diabetes Mellitus and Other Disorders of Metabolism. In: Clinical Medicine, Sunders, WB (Eds.). 2nd ed. Elsevier, London; 2002, 1069-1071.
21. Cooper EL, “eCAM: clinical analyses and increasing visibility,” Evidence-Based Complementary and Alternative Medicine. 2009; 6, 1: 1–2.
22. Patwardhan B, Vaidya ADB, Chorghade M. Ayurveda and natural products drug discovery. Current Science. 2004; 86: 6: 789–799.
23. Patwardhan B, Mashelkar RA. Traditional medicine-inspired approaches to drug discovery: can Ayurveda show the way forward? Drug Discovery Today. 2009; 14; 804–811.
24. Rupeshkumar M, Kavitha K, Haldar PK. Role of herbal plants in the diabetes mellitus therapy: An overview. International Journal of Applied Pharmaceutics. 2014;6(3):1-3.
25. Goldman P. Herbal medicines today and the roots of modern pharmacology. Annals of Internal Medicine 2001; 135: 594–600.
26. Pugsley MK, Authier S, Curtis MJ. Principles of safety pharmacology. British Journal of Pharmacology. 2008; 154:1382–1399.
27. Oliver-Bever B. Medicinal plants in tropical West Africa. London: Cambridge University Press; 1986: 245-267.
28. Rhemann AU and Zaman K. Medicinal plants with hypoglycemic activity. J Ethnopharmacol. 1989; 26: 1-55.
29. Manickam M, Ramanathan M, Farboodinary Jahromi MA, Chansouria JPN and Ray AB. Antihyperglycemic activity of phenolic from Pterocarpus marsupium. J Natural Product. 1997; 60:609-610.
30. Sheetal V, Singh SP. Current and future status of herbal medicines. Veterinary World. 2000; 1(11): 347-350.
31. Joshi SG. Cesalpinaceae - Cassia auriculata. Text Book of Medicinal Plants. 2000: 119.