Author(s):
Shweta Pandey, Dinesh Jain, Loveleen Kaur, Amarendra Singh
Email(s):
shwetapandey.pandey27@gmail.com , dineshjain90900@gmail.com , loveleenkaurramgarhia16@gmail.com , srsamarendra00@gmail.com
DOI:
10.52711/0975-4385.2026.00011 
Address:
Shweta Pandey1, Dinesh Jain1, Loveleen Kaur1, Amarendra Singh1*
Chandigarh College of Pharmacy, Landran, Mohali, Punjab.
*Corresponding Author
Published In:
Volume - 18,
Issue - 1,
Year - 2026
ABSTRACT:
Tinospora cordifolia, an important plant in traditional healing practices, has attracted interest due to its diverse therapeutic applications. This review examines its cultural significance in various traditional medicine systems. The study explores Tinospora cordifolia’s ability to adapt to different environments and its contribution to sustainable ecosystems, along with its chemical composition, which includes alkaloids, diterpenoids, phenolics, and polysaccharides. This review thoroughly examines its pharmacological activity and highlights recent developments in tissue culture techniques and genetic analysis, which play an important role in preserving genetic diversity and enhancing the synthesis of secondary metabolites.
Cite this article:
Shweta Pandey, Dinesh Jain, Loveleen Kaur, Amarendra Singh. Phytochemistry and Therapeutic Promise of Tinospora cordifolia: An Integrated Perspective. Research Journal of Pharmacognosy and Phytochemistry. 2026; 18(1):68-8. doi: 10.52711/0975-4385.2026.00011
Cite(Electronic):
Shweta Pandey, Dinesh Jain, Loveleen Kaur, Amarendra Singh. Phytochemistry and Therapeutic Promise of Tinospora cordifolia: An Integrated Perspective. Research Journal of Pharmacognosy and Phytochemistry. 2026; 18(1):68-8. doi: 10.52711/0975-4385.2026.00011 Available on: https://rjpponline.org/AbstractView.aspx?PID=2026-18-1-11
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134. Shervani ZA, Mishra PK. Phytochemical study of Tinospora cordifolia grown on three different soil conditions. Res J Life Sci Bioinform Pharm Chem Sci. 2019; 5(2): 810.
135. Paliwal R, Singh R, Choudhury DR, Tiwari G, Kumar A, Bhat KC, et al. Molecular Characterization of Tinospora cordifolia (Willd.) Miers Using Novel g-SSR Markers and Their Comparison with EST-SSR and SCoT Markers for Genetic Diversity Study. Genes. 2022;13(11):2042.
136. Lade S, Pande V, Rana TS, Yadav HK. Estimation of genetic diversity and population structure in Tinospora cordifolia using SSR markers. 3 Biotech. 2020;10(7):310.
137. Girme A, Saste G, Singh R, Mirgal A, Ingavale R, Balasubramaniam AK, et al. Quantitative and rapid quality assessment methods for the multi-class bioactive constituents of Tinospora cordifolia using high-performance liquid and thin layer chromatography analysis with tandem mass spectrometry characterization. Sep Sci Plus. 2022; 5(6):e202200048.
138. Kumar B, Bajpai V, Kumar N. Phytochemistry of Tinospora cordifolia. 1st ed. CRC Press; 2020.
139. Ahmadi S, Askani S, Fathima S, Sumayya MB, Sutramay P, Charan JP, et al. Preliminary phytochemical screening and antibacterial activity of Tinospora cordifolia. J Med Plants Stud. 2023;11(4):80–8.
140. Ahmad F, Ali M, Alam P. New phytoconstituents from the stem bark of Tinospora cordifolia Miers. Nat Prod Res. 2010;24(10):926–34.
141. Sharma A, Arya A, Kumari S, Chatterjee A. Effect of lockdown interventions to control the COVID-19 epidemic in India. arXiv. 2020. arXiv:2009.03168.
142. Polu PR, Nayanbhirama U, Khan S, Maheswari R. Assessment of free radical scavenging and anti-proliferative activities of Tinospora cordifolia Miers (Willd). BMC Complement Altern Med. 2017; 17(1):457.
143. Joshi B, Kumar N, Singh D. DNA barcoding and molecular phylogeny of Tinospora species using ITS and matK markers. Plant Gene. 2019;19:100–9.
144. Singh D, Kumar S, Sharma V. Genetic diversity analysis of Tinospora cordifolia using RAPD markers. Indian J Biotechnol. 2011; 10(2): 212–7.
145. Kumar M, Singh A, Pandey R. Microsatellite marker development and genetic diversity in Tinospora cordifolia. BMC Plant Biol. 2020;20(1):1–14.
146. Lakshmi P, Singh S, Kumari M. Molecular phylogenetic analysis of Tinospora cordifolia using matK gene. Biochem Genet. 2018; 56(1): 47–62.
147. Sharma R, Kumar A, Singh S. Nuclear ribosomal DNA analysis for resolving evolutionary relationships in Tinospora spp. J Phylogenet Evol Biol. 2017:37–42.
148. Rathore R, Sharma V, Singh S. Genetic variability of Tinospora cordifolia using ISSR markers. J Herbal Med. 2018;13:34–40.
149. Pandey R, Sharma P, Kumar M. Chloroplast genome analysis of Tinospora cordifolia: Insights into structural organization. Plant Sci Today. 2020;7(3):187–97.
150. Chandra S, Singh S, Kumar A. AFLP-based genetic variation analysis of Tinospora cordifolia. Indian J Genet Plant Breed. 2014;74(2):151.
151. Meena S, Singh D, Kumar A. Genome-wide SNP discovery in Tinospora cordifolia for marker-assisted selection. Mol Breed. 2019;39(4):1–10.
152. Das A, Sharma P, Kumar A. Expression profiling of antioxidant genes in Tinospora cordifolia under abiotic stress using qPCR. J Plant Interact. 2017; 12(2): 134–44.
153. Prasad A, Patel P, Kumari M, Saxena G, Chakrabarty D, Singh SS. A Literature Update on Strategies for Harnessing and Conserving the Bioactive Phytochemicals from Tinospora cordifolia: Current Status, Challenges, and Future Prospects. In: Plants for Immunity and Conservation Strategies. 2023. p. 1–20.
154. Arunachalam K, Yang X, San TT. Tinospora cordifolia (Willd.) Miers: Protection mechanisms and strategies against oxidative stress-related diseases. J Ethnopharmacol. 2022; 283:114540.
155. Islam MS, Ghosh D, Islam MA. Insight into metabolomic profiling of Tinospora cordifolia and its therapeutic potential. World J Tradit Chin Med. 2024.
156. Krishna P, Krishnamoorthy K. In vitro biological properties and in silico analysis of Tinospora cordifolia. J Pharm Bioallied Sci. 2024.
157. Sharma A, Kumar V, Singh S. Metabolic and molecular characterization of Tinospora cordifolia for its bioactive components. Phytochemistry. 2020; 179: 112514.