A review on Black Pepper as Antidiabetic agent: Black- Not always bad

S.D. Mankar; M.S. Bhosale Pankaj Sonawane; Mohini Shelke

doi:10.52711/0975-4385.2022.00006

Research Journal of Pharmacognosy and Phytochemistry

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0975-4385 (Online)
0975-2331 (Print)

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A review on Black Pepper as Antidiabetic agent: Black- Not always bad

Author(s): S.D. Mankar, M.S. Bhosale Pankaj Sonawane, Mohini Shelke

Email(s): sdmankar655@gmail.com

DOI: 10.52711/0975-4385.2022.00006

Address: S.D. Mankar, M.S. Bhosale Pankaj Sonawane, Mohini Shelke
Pravara Rural College of Pharmacy, Pravaranagar A/P Loni - 413736 Tal - Rahata, Dist- Ahmednagar.
*Corresponding Author

Published In: Volume - 14, Issue - 1, Year - 2022

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ABSTRACT:
Because of their broad pharmacological potentials and lower side effects in biological systems, medicinal plants are particularly popular in numerous traditional medical systems. Piper nigrum L. (Family Piperaceae) is a well-known spice known as "The King of Spices" among many others. It includes the pungent alkaloid ‘‘piperine," which is thought to have a variety of pharmacological effects. By blocking many metabolizing enzymes, it increases the bioavailability of a variety of medicines and minerals.Anti-hypertensive, anti-platelet, antioxidant, anti-tumor, anti-asthmatics, analgesic, anti-inflammatory, anti-diarrheal, antispasmodic, antidepressants, immunomodulatory, anticonvulsant, anti-thyroids, antibacterial, antifungal, hepato-protective, insecticidal, and larvicidal activities are just a few of the pharmacological properties Black pepper has traditionally been used to treat diarrhea, dyspepsia, cholera, and gastrointestinal problems.It contains alkaloids, flavones, steroids, and terpenes, among other active phytochemicals. Piperine is the main alkaloid contained in black pepper, accounting for around 4-6 percent of the total. Piperine has recently been discovered to be a PPAR-agonist, a ligand-activated transcription factor found in adipocytes and macrophages that promotes adipocyte development and insulin sensitivity. As a result, piperine could be used as an anti-diabetic medication. Essential oils, acids, esters, alcohol, and phenols make up this mixture. The essential oils that give it its distinct flavor are primarily made up of a group of chemical molecules known as terpenes. Black pepper's antibacterial properties are due to terpenes. Black pepper also has the ability to stimulate saliva secretion, HCL acid, digestive fluid, bile, and mucus, all of which contribute to immune stability. This study aims to give a review of the literature on pharmacognosy, pharmacological activity, and novel piperine.

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Cite this article:
S.D. Mankar, M.S. Bhosale Pankaj Sonawane, Mohini Shelke. A review on Black Pepper as Antidiabetic agent: Black- Not always bad. Research Journal of Pharmacognosy and Phytochemistry. 2022; 14(1):26-8. doi: 10.52711/0975-4385.2022.00006

Cite(Electronic):
S.D. Mankar, M.S. Bhosale Pankaj Sonawane, Mohini Shelke. A review on Black Pepper as Antidiabetic agent: Black- Not always bad. Research Journal of Pharmacognosy and Phytochemistry. 2022; 14(1):26-8. doi: 10.52711/0975-4385.2022.00006 Available on: https://rjpponline.org/AbstractView.aspx?PID=2022-14-1-6

REFERENCES:
1.    Damanhouri ZA and Ahmad A: A review on therapeutic potential of Piper nigrum L. (Black Pepper): The King of Spices. Medicinal and Aromatic Plants. 2014; 3(3): 1-6.
2.    Meghwal M and Goswami TK: Piper nigrum and piperine: An Update. Phytotherapy Research. 2013; 27:1121-1130.
3.    Park UH, Jeong HS, Jo EY, Park T, Yoon SK, Kim EJ, Jeong JC and Um SJ: Piperine, a component of Black Pepper, inhibits adipogenesis by antagonizing PPARγ activity in 3T3-L1 Cells. J. Agrc. Food Chem. 2012; 60: 3853-3860.
4.    Ahmad N, Fazal H, Abbasi BH, Farooq S, Ali M and Khan MA: Biological role of Piper nigrum L. (Black pepper): A review. Asian Pacific Journal of Tropical Biomedicine. 2012; 1945-1953
5.    Parganiha R, Verma S, Chandrakar S, Pal S, Sawarkar HA, Kashyap P (2011) In vitro anti- asthmatic activity of fruit extract of Piper nigrum (Piperaceae). Inter J Herbal Drug Res 1:15-18.
6.    Li S, Wang C, Wang M, Li W, Matsumoto K, et al. (2007) Antidepressant like effects of piperine in chronic mild stress treated mice and its possible mechanisms. See comment in PubMed Commons below Life Sci 80: 1373-1381.
7.    Matsuda H, Ninomiya K, Morikawa T, Yasuda D, Yamaguchi I, et al. (2008) Protective effects of amide constituents from the fruit of Piper chaba on D-galactosamine/TNF-alpha-induced cell death in mouse hepatocytes. See comment in PubMed Commons below Bioorg Med Chem Lett 18: 2038-2042.
8.    Johnson JJ, Nihal M, Siddiqui IA, Scarlett CO, Bailey HH, et al. (2011) Enhancing the bioavailability of resveratrol by combining it with piperine. See comment in PubMed Commons below MolNutr Food Res 55: 1169-1176.
9.    Wattanathorn J, Chonpathompikunlert P, Muchimapura S, Priprem A, Tankamnerdthai O (2008) Piperine, the potential functional food for mood and cognitive disorders. See comment in PubMed Commons below Food ChemToxicol 46: 3106-3110
10.    Parmar VS, Jain SC, Bisht KS, Jain R, Taneja P, Jha A, et al.(1997) Phytochemistry of the genus Piper. Phytochemistry46:597-673.
11.    Khan M, Siddiqui M (2007) Antimicrobial activity of Piper fruits. Nat prod Rad 6:111-113.
12.    Kumar KP, Gnanajobitha G, Vanaja M, Kumar SR, Malarkodi C, Pandian K, et al.(2014) Piper nigrum Leaf and Stem Assisted Green Synthesis of Silver Nanoparticles and Evaluation of its Antibacterial Activity against Agricultural Plant Pathogens. Scientific World Journal: 829894.
13.    Vijayakumar RS, Surya D, Nalini N (2004) Antioxidant efficacy of black pepper (Piper nigrum L.) and piperine in rats with high fat diet induced oxidative stress. See comment in PubMed Commons below Redox Rep 9: 105-110.
14.    Athavale, V.B. (1978) Piper longum in asthmatic bronchitis. Paper presented at International Pediatric Conference in New Delhi, India.
15.    Dahanukar, S.A. et al. (1984, June) Efficacy of Piper longum in childhood asthma. Indian Drugs. 384-386
16.    L. Wang, B. Waltenberger, E. Pferschy-Wenzig, M. Blunder, X. Liu, C. Malainer, T. Blazevic, S. Schaiger, J. M., Rollinger, E. H. Heiss, D. Schuster, B. Kopp, R. Bauer, H. Stuppner, V. M. Dirsch, and A. G. Atanasov, “Natural product agonists of peroxisome proliverator-activated receptor gamma (PPAR): a review”, Biochem. Pharmacol., vol. 92, pp. 73-89, Nov. 2014.
17.    P. Ferré, “The biology of peroxisome proliferator-activated receptors”, Diabetes, vol. 53 (suppl 1), pp. S43-S50, 2004.
18.    T. M. Larsen, S. Toubro, and A. Astrup, “PPARgamma agonists in the treatment of type II diabetes: is increased fatness commensurate with long-term efficacy?”, International Journal of Obesity, vol. 27, pp. 147-161, 2003.
19.    J. Berger and D. E. Moller, “The Mechanism of Action of PPARs”, Ann. Rev. Med., vol. 53, pp. 409-453, 2002.
20.    L. Guo, L. Zhang, Y. Sun et al., “Differences in hepatotoxicity and gene expression profiles by anti-diabetic PPAR γ agonists on rat primary hepatocytes and human HepG2 cells,” Molecular Diversity, vol. 10, no. 3, pp. 349–360, 2006.
21.    M. Meghwal and T.K. Goswami, “Piper nigrum and piperine: an update”, Phytother. Res., vol. 27, pp. 1121-1130, 2013.
22.    Singh J, Dubey RK, Atal CK (1986) Piperine-mediated inhibition of glucuronidation activity in isolatedepithelial cells of the guinea-pig small intestine: evidence that piperine lowers the endogeneous UDP-glucuronic acid content. J Pharmacol Exp Ther 236(2): 488–493.
23.    Suresh D, Srinivasan K (2006) Influence of curcumin, capsaicin, and piperine on the rat liver drug-metabolizing enzyme system in vivo and in vitro. Can J Physiol Pharmacol 84(12): 1259–1265.
24.    Bhardwaj RK, Glaeser H, Becquemont L, Klotz U, Gupta SK, et al. (2002) Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4. J Pharmacol Exp Ther 302(2):45–650.
25.    Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, et al. (1998) Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med 64(4): 353–356.
26.    Suresh D, Srinivasan K (2010) Tissue distribution & elimination of capsaicin, piperine and curcumin following oral intake in rats. Indian J Med Res 131: 682–691.
27.    Singh DV, Godbole MM, Misra K (2013) A plausible explanation for enhanced bioavailability of P-gp substrates in presence of piperine: simulation for next generation of P-gp inhibitors. J Mol Model 19(1):227–238.
28.    Volak LP, Ghirmai S, Cashman JR, Court MH (2008) Curcuminoids inhibit multiple human cytochromes P450, UDP-glucuronosyltransferase, and sulfotransferase enzymes, whereas piperine is a relatively selective CYP3A4 inhibitor. Drug Metab Dispos 36(8): 1594–1605.
29.    Trinder P (1969) Determination of blood glucose using 4-amino phenazone as oxygen acceptor. J Clin Pathol 22(2): 246