Author(s): Narkhede Sachin B., Luhar Shailesh V., Tailor Palak A., Shinde Siddhi S., Saini Shrushti J., Singh Aniket, D., Singh Manish J.

Email(s): bnbswaminarayan@gmail.com

DOI: 10.52711/0975-4385.2024.00013   

Address: Narkhede Sachin B.*, Luhar Shailesh V., Tailor Palak A., Shinde Siddhi S., Saini Shrushti J., Singh Aniket D., Singh Manish J.
Smt. B.N.B. Swaminarayan Pharmacy College, National Highway No 48, Shree Swaminarayan Gurukul, Vapi, District Valsad, Gujarat 396191.
*Corresponding Author

Published In:   Volume - 16,      Issue - 2,     Year - 2024


ABSTRACT:
In a developing nation like India, diabetes has imposed an immense burden on the health care system. There is additionally an alpha-amylase of blood sugar levels in diabetes patients in the numerous treatment approaches. Therefore, it is unquestionably crucial to scientifically screen medicinal plants for their use in treatments to ensure that they are both safe and effective. Our present research investigates the alpha-amylase inhibitory action of methanolic extracts from the Syzygium cuminii seeds, Gymnema sylvestre leaves, and Swertia chirata leaves three indigenous medicinal herbs. With the use of the alpha-amylase model and the 3, 5-dinitro salicylic acid (DNSA) approach, the anti-diabetic action was carried out. The fundamental concept of the DNSA approach is the color-change principle, which is further validated by the colorimeter. The findings demonstrated that the alpha-amylase inhibitory action is present in all three methanolic extracts of Syzygium cuminii seeds, Gymnema sylvestre leaves, and Swertia chirata leaves. Furthermore, we concluded that Syzygium cuminii seed extract is more effective than the other two at inhibiting alpha-amylase activity. Based on the findings of this study, we endorse the use of all three methanolic extracts in the management of diabetes mellitus.


Cite this article:
Narkhede Sachin B., Luhar Shailesh V., Tailor Palak A., Shinde Siddhi S., Saini Shrushti J., Singh Aniket, D., Singh Manish J.. Formulation and Evaluation of Anti-diabetic Herbal Tablet containing Syzygium cuminii, Swertia chirata and Gymnema sylvestre. Research Journal of Pharmacognosy and Phytochemistry. 2024; 16(2):69-2. doi: 10.52711/0975-4385.2024.00013

Cite(Electronic):
Narkhede Sachin B., Luhar Shailesh V., Tailor Palak A., Shinde Siddhi S., Saini Shrushti J., Singh Aniket, D., Singh Manish J.. Formulation and Evaluation of Anti-diabetic Herbal Tablet containing Syzygium cuminii, Swertia chirata and Gymnema sylvestre. Research Journal of Pharmacognosy and Phytochemistry. 2024; 16(2):69-2. doi: 10.52711/0975-4385.2024.00013   Available on: https://rjpponline.org/AbstractView.aspx?PID=2024-16-2-2


REFERENCES:
1.    Kaul K, Tarr JM, Ahmad SI, Kohner EM, Chibber R. Introduction to diabetes mellitus. Diabetes: an old disease, a new insight. Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 771). 2013:1-1. doi: 10.1007/978-1-4614-5441-0_1.
2.    G.S., Sharma, R., Sanodiya, B. S., Pandey, M., Prasad, G.B.K.S., Bisen P.S. Gymnema sylvestre: an alternative therapeutic agent for management of diabetes. Journal of Applied Pharmaceutical Science. 2012 Dec 29; 2(12): 1-6.doi:10.7324/JAPS.2012.21201.
3.    Tiwari P, Mishra BN, Sangwan NS. Phytochemical and pharmacological properties of Gymnema sylvestre: an important medicinal plant. BioMed Research International. 2014 Jan https://:doi.org/10.1155/2014/830285.
4.    Kumar V, Van Staden J. A review of Swertia chirayita (Gentianaceae) as a traditional medicinal plant. Frontiers in Pharmacology. 2016 Jan 12; 6: 308. https://doi/10.3389/fphar.2015.00308.
5.    Chakravarty AK, Mukhopadhyay S, Das B. Swertane triterpenoids from Swertia chirata. Phytochemistry. 1991 Jan 1; 30(12): 4087-92. https://doi.org/10.1016/0031-9422(91)83473-X.
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