Ekta Khare, Aditi Sharma, Anurima Chowdhury, Shailendra Singh Narwariya
Ekta Khare1*, Aditi Sharma2, Anurima Chowdhury3, Shailendra Singh Narwariya4
1GCRG College of Pharmacy, AKTU, Lucknow UP, India.
2JSS College of Pharmacy, Ooty.
3,4School of Pharmacy, I.T.M. University, Gwalior (M.P.), India.
Volume - 15,
Issue - 4,
Year - 2023
Background: Breast cancer is the most frequent female cancer and one of the leading causes of cancer death in women. There are many chemotherapy agents available for the treatment of breast cancer. Still, the current therapeutic options have not fulfilled the desired outcomes, especially for drug-resistant breast cancer therapy. Thus, there is an urgent need to develop novel anti-breast cancer agents. Objective: This overview targets to portray the new advancement of herbal and artificial derivatives with anti-breast cancer potential, protecting the articles allotted from the ultimate year. Method: We found significant articles of interest in the field of breast cancer and proposed a review based on relevant information. Description of the studies included in the review. Result: Various key components are found in vegetables, fruits, seeds, nuts, coffee, tea, and wine. Therefore, dietary exposure is significant. Natural products having low-cost toxicity, their availability in foods, and their existence in a variety of herbal treatments, caution should be exercised in further assessment of their properties and applications. Conclusion: We tried to analyze the anti-breast cancer potency of quite a few extracts from different plant sources and to compare their antiproliferative efficiency of crude extracts with the action of their purified ingredients while an additional study is required.
Cite this article:
Ekta Khare, Aditi Sharma, Anurima Chowdhury, Shailendra Singh Narwariya. Potential of Natural products for Chemoprevention of Breast Cancer. Research Journal of Pharmacognosy and Phytochemistry. 2023; 15(4):305-0. doi: 10.52711/0975-4385.2023.00048
Ekta Khare, Aditi Sharma, Anurima Chowdhury, Shailendra Singh Narwariya. Potential of Natural products for Chemoprevention of Breast Cancer. Research Journal of Pharmacognosy and Phytochemistry. 2023; 15(4):305-0. doi: 10.52711/0975-4385.2023.00048 Available on: https://rjpponline.org/AbstractView.aspx?PID=2023-15-4-7
1. Veeresham, C. Natural products derived from plants as a source of drugs. J. Adv. Pharm. Technol. Res. 2012; 3: 200–201.
2. Yuan, H.; Ma, Q.; Ye, L.; Piao, G. The traditional medicine and modern medicine from natural products. Molecules 2016; 21: 559.
3. Cragg, G.M.; Pezzuto, J.M. Natural products as a vital source for the discovery of cancer chemotherapeutic and chemopreventive agents. Med. Princ. Pract. 2016; 25 (Suppl 2): 41–59.
4. Newman, D.J.; Cragg, G.M. Natural products as sources of new drugs over the nearly four decades from 01/1981 to 09/2019. J. Nat. Prod. 2020; 83: 770–803.
5. Seca, A.M.L.; Pinto, D.C.G.A. Plant secondary metabolites as anticancer agents: Successes in clinical trials and therapeutic application. Int. J. Mol. Sci. 2018; 19; 263.
6. Kotecha, R.; Takami, A.; Espinoza, J.L. Dietary phytochemicals and cancer chemoprevention: A review of the clinical evidence. Oncotarget 2016; 7: 52517–52529.
7. George, V.C.; Dellaire, G.; Rupasinghe, H.P.V. Plant flavonoids in cancer chemoprevention: Role in genome stability. J. Nutr. Biochem. 2017; 45: 1–14.
8. Thomford, N.E.; Senthebane, D.A.; Rowe, A.; Munro, D.; Seele, P.; Maroyi, A.; Dzobo, K. Natural products for drug discovery in the 21st century: Innovations for novel drug discovery. Int. J. Mol. Sci. 2018; 19: 1578.
9. Kucuk O, Sarkar FH, Sakr W, Djuric Z, Pollak MN, Khachik F, et al. Phase II randomized clinical trial of lycopene supplementation before radical prostatectomy. Cancer Epidemiol Biomarkers Prev. 2001; 10: 861–8.
10. Koh MS, Hwang JS, Moon AR. Lycopene inhibits proliferation, invasion and migration of human breast cancer cells. Biomol Ther. 2010;18:92–8. doi: 10.4062/biomolther.2010; 18:1.092.
11. Wang Y, Cui R, Xiao Y, Fang J, Xu Q. Effect of carotene and lycopene on the risk of prostate cancer: a systematic review and dose-response meta-analysis of observational studies. PLoS One. 2015; 10: e0137427. doi: 10.1371/journal.pone.0137427.
12. Gann PH, Ma J, Giovannucci E, Willett W, Sacks FM, Hennekens CH, et al. Lower prostate cancer risk in men with elevated plasma lycopene levels: results of a prospective analysis. Cancer Res. 1999;59:1225–30.
13. Lin MC, Wang FY, Kuo YH, Tang FY. Cancer chemopreventive effects of lycopene: suppression of MMP-7 expression and cell invasion in human colon cancer cells. J Agric Food Chem. 2011; 59: 11304–18. doi: 10.1021/jf202433f.
14. Lian F, Wang XD. Enzymatic metabolites of lycopene induce Nrf2-mediated expression of phase II detoxifying/antioxidant enzymes in human bronchial epithelial cells. Int J Cancer. 2008; 123: 1262–8. doi: 10.1002/ijc.23696.
15. Ono M, Takeshima M, Nakano S. Mechanism of the anticancer effect of lycopene (tetraterpenoids) Enzymes. 2015;37:139–66. doi: 10.1016/bs.enz.2015.06.002.
16. M, Diederich M. Antioxidant and anti-proliferative properties of lycopene. Free Radic Res. 2011; 45: 925–40. doi: 10.3109/10715762.2011.564168.
17. Petchsak P, Sripanidkulchai B. Momordica cochinchinensis aril extract induced apoptosis in human MCF-7 breast cancer cells. Asian Pac J Cancer Prev. 2015; 16: 5507–13. doi: 10.7314/APJCP.2015.16.13.5507.
18. Teodoro AJ, Oliveira FL, Martins NB, Maia Gde A, Martucci RB, Borojevic R. Effect of lycopene on cell viability and cell cycle progression in human cancer cell lines. Cancer Cell Int. 2012;12:36. doi: 10.1186/1475-2867-12-36.
19. Takeshima M, Ono M, Higuchi T, Chen C, Hara T, Nakano S. Anti-proliferative and apoptosis-inducing activity of lycopene against three subtypes of human breast cancer cell lines. Cancer Sci. 2014; 105: 252–7. doi: 10.1111/cas.12349.
20. Gloria NF, Soares N, Brand C, Oliveira FL, Borojevic R, Teodoro AJ. Lycopene and beta-carotene induce cell-cycle arrest and apoptosis in human breast cancer cell lines. Anticancer Res. 2014; 34: 1377–86.
21. Nahum A, Zeller L, Danilenko M, Prall OW, Watts CK, Sutherland RL, et al. Lycopene inhibition of IGF-induced cancer cell growth depends on the level of cyclin D1. Eur J Nutr. 2006; 45: 275–82. doi: 10.1007/s00394-006-0595-x.
22. Shindo S, Hosokawa Y, Hosokawa I, Ozaki K, Matsuo T. Genipin inhibits MMP-1 and MMP-3 release from TNF-a-stimulated human periodontal ligament cells. Biochimie. 2014; 107 Pt B:391–5. doi: 10.1016/j.biochi.2014.10.008.
23. Koriyama Y, Chiba K, Yamazaki M, Suzuki H, Muramoto K, Kato S. Long-acting genipin derivative protects retinal ganglion cells from oxidative stress models in vitro and in vivo through the Nrf2/antioxidant response element signaling pathway. J Neurochem. 2010; 115: 79–91. doi: 10.1111/j.
24. Yang X, Yao J, Luo Y, Han Y, Wang Z, Du L. P38 MAP kinase mediates apoptosis after genipin treatment in non-small-cell lung cancer H1299 cells via a mitochondrial apoptotic cascade. J Pharmacol Sci. 2013; 121: 272–81. doi: 10.1254/jphs.12234FP.
25. Pons DG, Nadal-Serrano M, Torrens-Mas M, Valle A, Oliver J, Roca P. UCP2 inhibition sensitizes breast cancer cells to therapeutic agents by increasing oxidative stress. Free Radic Biol Med. 2015; 86: 67–77. doi: 10.1016/j.freeradbiomed.2015.04.032.
26. Ayyasamy V, Owens KM, Desouki MM, Liang P, Bakin A, Thangaraj K, et al. Cellular model of Warburg effect identifies tumor promoting function of UCP2 in breast cancer and its suppression by genipin. PLoS One. 2011; 6: e24792. doi: 10.1371/journal.pone.0024792.
27. Chen PH, Peng CY, Pai HC, Teng CM, Chen CC, Yang CR. Denbinobin suppresses breast cancer metastasis through the inhibition of Src-mediated signaling pathways. J Nutr Biochem. 2011; 22: 732–40. doi: 10.1016/j.jnutbio.2010.06.004.]
28. Peiro G, Ortiz-Martínez F, Gallardo A, Pérez-Balaguer A, Sánchez-Payá J, Ponce JJ, et al. Src, a potential target for overcoming trastuzumab resistance in HER2-positive breast carcinoma. Br J Cancer. 2014; 111: 689–95. doi: 10.1038/bjc.2014.327.
29. Liu HE, Chang AS, Teng CM, Chen CC, Tsai AC, Yang CR. Potent anti-inflammatory effects of denbinobin mediated by dual inhibition of expression of inducible no synthase and cyclooxygenase 2. Shock. 2011;35:191–7. doi: 10.1097/SHK.0b013e3181f0e9a8.
30. Tsai AC, Pan SL, Lai CY, Wang CY, Chen CC, Shen CC, et al. The inhibition of angiogenesis and tumor growth by denbinobin is associated with the blocking of insulin-like growth factor-1 receptor signaling. J Nutr Biochem. 2011; 22: 625–33. doi: 10.1016/j.jnutbio.2010.04.014.
31. Chen J, Hou R, Zhang X, Ye Y, Wang Y, Tian J. Calycosin suppresses breast cancer cell growth via ERβ-dependent regulation of IGF-1R, p38 MAPK and PI3K/Akt pathways. PLoS One. 2014;9:912-45. doi: 10.1371 0091245.
32. Huang G, Li M. The role of EphB4 and IGF-IR expression in breast cancer cells. Int J Clin Exp Pathol. 2015; 8: 5997–6004.
33. Kim S, Moon A. Capsaicin-induced apoptosis of H-ras-transformed human breast epithelial cells is Rac-dependent via ROS generation. Arch Pharm Res. 2004; 27: 845–9. doi: 10.1007/BF02980177.
34. Kang HJ, Soh Y, Kim MS, Lee EJ, Surh YJ, Kim HR, et al. Roles of JNK-1 and p38 in selective induction of apoptosis by capsaicin in ras-transformed human breast epithelial cells. Int J Cancer. 2003; 103: 475–82. doi: 10.1002/ijc.10855.