A Review on Polyherbal Antiulcer Formulations

Ravindra Laware; Ganesh Bharskar; Saurav Chavan; Gauri Borude

doi:10.52711/0975-4385.2022.00017

Research Journal of Pharmacognosy and Phytochemistry

ISSN

0975-4385 (Online)
0975-2331 (Print)

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A Review on Polyherbal Antiulcer Formulations

Author(s): Ravindra Laware, Ganesh Bharskar, Saurav Chavan, Gauri Borude

Email(s): ganeshb7748@gmail.com

DOI: 10.52711/0975-4385.2022.00017

Address: Ravindra Laware, Ganesh Bharskar, Saurav Chavan, Gauri Borude
Department of Pharmacy, Pravara Rural College of Pharmacy, Pravaranagar.
*Corresponding Author

Published In: Volume - 14, Issue - 2, Year - 2022

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ABSTRACT:
A peptic ulcer is common gastrointestinal disorder. Peptic ulcers are sores on the stomach, small intestine, or esophageal lining. It is caused by H. pylori infection regular usage of NSAID’s, irregular food habits, stress, Gastric Acid Secretions. Various synthetic drugs are available for the treatment of peptic ulcer. But these are expensive and produce more side effects as compared to herbal drugs. The literature revealed that many herbal drugs and polyherbal formulations are used in the treatment of peptic ulcer. In this review is a compilation of knowledge gathered from the research papers published and review the various herbal drugs and polyherbal formulation used for peptic ulcer.

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Cite this article:
Ravindra Laware, Ganesh Bharskar, Saurav Chavan, Gauri Borude. A Review on Polyherbal Antiulcer Formulations. Research Journal of Pharmacognosy and Phytochemistry. 2022; 14(2):89-7. doi: 10.52711/0975-4385.2022.00017

Cite(Electronic):
Ravindra Laware, Ganesh Bharskar, Saurav Chavan, Gauri Borude. A Review on Polyherbal Antiulcer Formulations. Research Journal of Pharmacognosy and Phytochemistry. 2022; 14(2):89-7. doi: 10.52711/0975-4385.2022.00017 Available on: https://rjpponline.org/AbstractView.aspx?PID=2022-14-2-5

REFERENCES:
1.   Kavitt, R. T., Lipowska, A. M., Anyane-Yeboa, A. and Gralnek, I. M. Diagnosis and Treatment of Peptic Ulcer Disease. The American Journal of Medicine 132, 447–456 (2019).
2.   Sverdén, E., Agréus, L., Dunn, J. M. and Lagergren, J. Peptic ulcer disease. The BMJ 367, 1–8 (2019).
3.   Meshram, N. et al. Significance of Medicinal Plant used for the Treatment of Peptic Ulcer. Asian Journal of Pharmacy and Technology 5, 32 (2015).
4.   Patidar, K. and Patel, N. A Study to assess the Effectiveness of Structured Teaching Programme (STP) on Knowledge regarding risk factors and prevention of Peptic ulcer among the middle age Population in selected urban area at Mehsana City. Asian Journal of Nursing Education and Research 9, 370 (2019).
5.   Anand, S. J. T. and Sara, B. A study to assess the effectiveness of Video Teaching Programme on Diet and Stress Management among patients with Peptic Ulcer Disease in RMMCH, Annamalai University, Chidambaram. Asian Journal of Nursing Education and Research 5, 389 (2015).
6.   Tortora, G. and BRYAN, D. Principles of Anatomy and Physiology. (WileyPLUS, 2017).
7.   Smith, M. E. and Morton, D. G. 4 - The Stomach: Control. in The Digestive System (Second Edition) 51–69 (Churchill Livingstone, 2010).
8.   Mahurkar, N. and Sayeed Ul Hasan, S. M. Synergistic Antiulcer Effect of Melatonin and Esomeprazole Combination in Pylorus Ligation, Ethanol, Aspirin induced Peptic Ulcers. Asian Journal of Pharmaceutical Research 5, 10 (2015).
9.   Goudanavar, P. S., Ramesh, B. and Fattepur, S. R. Gastro retentive dosage forms: An excellent carrier system for treatment of peptic ulcer. Research Journal of Pharmacy and Technology 14, 2316–2320 (2021).
10.   Fan, X. G., Kelleher, D., Fan, X. J., Xia, H. X. and Keeling, P. W. Helicobacter pylori increases proliferation of gastric epithelial cells. Gut 38, 19–22 (1996).
11.   Blaser, M. J. Not all Helicobacter pylori strains are created equal: should all be eliminated? Lancet (London, England) 349, 1020–1022 (1997).
12.   Narayanan, M., Reddy, K. M. and Marsicano, E. Peptic Ulcer Disease and Helicobacter pylori infection. Missouri medicine 115, 219–224 (2018).
13.   Warzecha, Z. et al. Deleterious effect of Helicobacter pylori infection on the course of acute pancreatitis in rats. Pancreatology: official journal of the International Association of Pancreatology (IAP) 2, 386–395 (2002).
14.   Buti, L. et al. Helicobacter pylori cytotoxin-associated gene A (CagA) subverts the apoptosis-stimulating protein of p53 (ASPP2) tumor suppressor pathway of the host. Proceedings of the National Academy of Sciences of the United States of America 108, 9238–9243 (2011).
15.   Thulluru, A. et al. Optimization of HPMC K100M and Sodium Alginate Ratio in Metronidazole Floating Tablets for the Effective Eradication of Helicobacter pylori. Asian Journal of Pharmacy and Technology 9, 195 (2019).
16.   Scarpignato, C. and Hunt, R. H. Nonsteroidal antiinflammatory drug-related injury to the gastrointestinal tract: clinical picture, pathogenesis, and prevention. Gastroenterology clinics of North America 39, 433–464 (2010).
17.   Vane, J. R. and Botting, R. M. Mechanism of action of nonsteroidal anti-inflammatory drugs. The American journal of medicine 104, 2S-8S; 21-22S (1998).
18.   Laine, L., Takeuchi, K. and Tarnawski, A. Gastric mucosal defense and cytoprotection: bench to bedside. Gastroenterology 135, 41–60 (2008).
19.   Griffin, M. R., Piper, J. M., Daugherty, J. R., Snowden, M. and Ray, W. A. Nonsteroidal anti-inflammatory drug use and increased risk for peptic ulcer disease in elderly persons. Annals of internal medicine 114, 257–263 (1991).
20.   Szabo, S. et al. Vascular approach to gastroduodenal ulceration: new studies with endothelins and VEGF. Digestive diseases and sciences 43, 40S-45S (1998).
21.   Aihara, T. et al. Pharmacological control of gastric acid secretion for the treatment of acid-related peptic disease: past, present, and future. Pharmacology and therapeutics 98, 109–127 (2003).
22.   Mahmood, A. A. et al. Enhancement of gastric ulcer by Areca catechu nut in ethanol-induced gastric mucosal injuries in rats. Journal of Medicinal Plants Research 5, 2562–2569 (2011).
23.   Ilavarasan, J. R., Monideen, S. and Vijayalakshmi, M. Antiulcer Activity of Aegle Marmelos Linn. Ancient science of life 21, 256–259 (2002).
24.   Jalilzadeh-Amin, G., Najarnezhad, V., Anassori, E., Mostafavi, M. and Keshipour, H. Antiulcer properties of glycyrrhiza glabra L. Extract on experimental models of gastric ulcer in mice. Iranian Journal of Pharmaceutical Research 14, 1163–1170 (2015).
25.   Bhajoni, P. S., Meshram, G. G. and Lahkar, M. Evaluation of the Antiulcer Activity of the Leaves of Azadirachta indica: An Experimental Study. Integrative Medicine International 3, 10–16 (2016).
26.   Al-Wajeeh, N. S. et al. The antiulcer effect of Cibotium barometz leaves in rats with experimentally induced acute gastric ulcer. Drug Design, Development and Therapy 11, 995–1009 (2017).
27.   Arunachalam, K. et al. Chemical characterization, toxicology and mechanism of gastric antiulcer action of essential oil from Gallesia integrifolia (Spreng.) Harms in the in vitro and in vivo experimental models. Biomedicine and Pharmacotherapy 94, 292–306 (2017).
28.   Jemaї, M. et al. Investigation of Antiulcer and Antioxidant Activity of Juniperus phoenicea L. (1753) Essential Oil in an Experimental Rat Model. Biol Pharm Bull. 2015;38(11):1738-46. doi: 10.1248/bpb.b15-00412.
29.   Prabhu K and Rajan S. Assessment of Antiulcer Activity of Ethanolic Extract of Mangifera indica Seed Kernel Using Acid Ethanol Induced Ulcer Model. Int. J. Curr. Microbiol. App. Sci (2015) 4(4): 854-860
30.   Neelima, N., Sudhakar, M., Patil, M. B. and Lakshmi, B. V. S. Anti-ulcer Activity and HPTLC Analysis of Mangifera indica L. Leaves. International Journal of Pharmaceutical and Phytopharmacological Research 2012, 146–155 (2012).
31.   Saad B. Almasaudi, Nagla A. El-Shitany, Aymn T. Abbas, Umama A. Abdel-dayem, Soad S. Ali, Soad K. Al Jaouni, Steve Harakeh, "Antioxidant, Anti-inflammatory, and Antiulcer Potential of Manuka Honey against Gastric Ulcer in Rats", Oxidative Medicine and Cellular Longevity, vol. 2016, 10 pages, (2016).
32.   Antiulser, A. et al. Antiulcer activity of musa paradisiaca (banana) tepal and skin extracts in ulcer induced albino mice. 20, 1203–1216 (2016).
33.   Raza H, Abbas Q, Hassan M, Eo SH, Ashraf Z, Kim D, Phull AR, Kim SJ, Kang SK, Seo SY. Isolation, characterization, and in silico, in vitro and in vivo antiulcer studies of isoimperatorin crystallized from Ostericum koreanum. Pharm Biol. 2017 Dec;55(1):218-226. doi: 10.1080/13880209.2016.1257641.
34.   Abebaw, M., Mishra, B., and Gelayee, D. A. (2017). Evaluation of anti-ulcer activity of the leaf extract of Osyris quadripartita Decne. (Santalaceae) in rats. Journal of experimental pharmacology, 9, 1–11. https://doi.org/10.2147/JEP.S125383.
35.   Pradeepkumar, B., Bhavyamadhuri, C. P., Padmanabha reddy, Y., Veerabhadrappa, K. V., Narayana, G., Haranath, C., Somasekhar reddy, K., and Sudheer, A. (2017). Evaluation of Antiulcer Activity of Peltophorum Pterocarpum. Journal of clinical and diagnostic research: JCDR, 11(6), FF01–FF03. https://doi.org/10.7860/JCDR/2017/26171.9998.
36.   Mostofa, R., Ahmed, S., Begum, M. M., Sohanur Rahman, M., Begum, T., Ahmed, S. U., Tuhin, R. H., Das, M., Hossain, A., Sharma, M., and Begum, R. (2017). Evaluation of anti-inflammatory and gastric anti-ulcer activity of Phyllanthus niruri L. (Euphorbiaceae) leaves in experimental rats. BMC complementary and alternative medicine, 17(1), 267. https://doi.org/10.1186/s12906-017-1771-7.
37.   Bagheri, S. M. et al. Antiulcer and hepatoprotective effects of aqueous extract of Plantago ovata seed on indomethacin-ulcerated rats. Biomedical Journal 41, 41–45 (2018).
38.   Bhatia, S., Sharma, K., Sharma, A., Nagpal, K. and Bera, T. Anti-inflammatory, Analgesic and Antiulcer properties of Porphyra vietnamensis. Avicenna journal of phytomedicine 5, 69–77 (2015).
39.   Sofidiya, M. O. and Awolesi, A. O. Antinociceptive and antiulcer activities of Pycnanthus angolensis. Revista Brasileira de Farmacognosia 25, 252–257 (2015).
40.   Sahoo, S. K. et al. Antiulcer activity of ethanolic extract of Salvadora indica (W.) leaves on Albino rats. Journal of Clinical and Diagnostic Research 10, FF07-FF10 (2016).
41.   Minaiyan, M., Sajjadi, S.-E. and Amini, K. Antiulcer effects of Zataria multiflora Boiss. on indomethacin-induced gastric ulcer in rats. Avicenna journal of phytomedicine, 408–415 (2018).
42.   Brito, S. A. et al. Antiulcer activity and potential mechanism of action of the leaves of Spondias mombin L. Oxidative Medicine and Cellular Longevity 2018, (2018).
43.   de Almeida, C. L. F. et al. Spondias purpurea L. (Anacardiaceae): Antioxidant and antiulcer activities of the leaf hexane extract. Oxidative Medicine and Cellular Longevity 2017, (2017).
44.   Silva, L. P. et al. Terminalia catappa L.: A medicinal plant from the Caribbean pharmacopeia with anti-Helicobacter pylori and antiulcer action in experimental rodent models. Journal of Ethnopharmacology 159, 285–295 (2015).
45.   Minozzo, B. R. et al. Anti-ulcer mechanisms of polyphenols extract of Euphorbia umbellata (Pax) Bruyns (Euphorbiaceae). Journal of Ethnopharmacology 191, 29–40 (2016).
46.   Kumar, S., Suman, Sharma, S. and Kalra, P. Antiulcer effect of the methanolic extract of Tamarindus indica seeds in different experimental models. Journal of Pharmacy and Bioallied Sciences 3, 236–241 (2011).
47.   Shree, G. K., Parvathi, S., Ramkumar, P. S. S., and Priya, S. S. Pharmacological and phytochemical evaluation of anti-ulcerogenic potential of Solanum nigrum. International Journal of Pharmaceutical Sciences and Research, 3(8), 2837, (2012).
48.   Santhoshkumar, M., Anusuya, N. and Bhuvaneswari, P. Antiulcerogenic effect of resin from Shorea robusta Gaertn. F. on experimentally induced ulcer models. International Journal of Pharmacy and Pharmaceutical Sciences 5, 269–272 (2013).
49.   Ahmad, H., Wadud, A., Jahan, N., Khazir, M. and Sofi, G. Evaluation of Anti-ulcer activity of hydro alcoholic extract of Post Sumaq (Rhus coriaria Linn.) in Ethanol induced Gastric ulcer in experimental Rats. International Research Journal of Medical Sciences 1, 7–12 (2013).
50.   Uduak, E. U. et al. Ulceroprotective Effect of Methanol Extract of Psidium guajava Leaves on Ethanol Induced Gastric Ulcer in Adult Wistar Rats. Asian Journal of Medical Sciences 4, 75–78 (2012).
51.   Gregory, M. et al. Anti-ulcer activity of Ficus religiosa leaf ethanolic extract. Asian Pacific Journal of Tropical Biomedicine 3, 554–556 (2013).
52.   Kumar, K., Mruthunjaya, K., Kumar, S. and Mythreyi, R. Anti ulcer activity of ethanol extract of the stem bark of Careya arborea Roxb. International Current Pharmaceutical Journal 2, 78–82 (2013).
53.   CH. Madhu*, P. Jonathan Brainard, G. Prithvi Raj, J. S. and A. S. S. R. Antiulcer activity of aqueous extract of annona squamosa leaves on rats. IJPSR 3, 4429–4433 (2012).
54.   Vaseem, A., Ali, M. and Afshan, K. Activity of Tulsi leaves (Ocimum sanctum linn) in protecting gastric ulcer in rats by cold restrain method. IJBCP 6, 2343–2347 (2017).
55.   Singh, S., and Majumdar, D. K. (1999). Evaluation of the gastric antiulcer activity of fixed oil of Ocimum sanctum (Holy Basil). Journal of ethnopharmacology, 65(1), 13–19. https://doi.org/10.1016/s0378-8741(98)00142-1.
56.   Lakshmi, M. Pharmacognostical, Phytochemical and Pharmacological evaluation for the antiulcer activity of Polyherbal suspension. Journal of Pharmacognosy and Phytochemistry, 2(3), 128-135 (2013).
57.   Vahalia, M., Vemula, S., Chawada, M. and Thakur, K. Antiulcer activity of Amlapitta Mishran suspension in rats: A pilot study. Ancient Science of Life 32, 112 (2012).
58.   Dasarapu, S. and Alluri, R. Evaluation of Antiulcer Activity of Polyherbal Formulation Against Ethanol Induced Gastric Ulcer in Albino Rats. International Journal of Innovation Sciences and Research 5, 761–765 (2016).
59.   Bahmani, S., Harish, M. S., Iqbal, M. and Rao, K. S. Anti-secretory and anti-ulcer activity of Surasa, a poly herbal formulation in pylorus ligated (Shay) rat model. Biosciences Biotechnology Research Asia 5, 295–300 (2008).
60.   Roopa, G., Bhat, R. S. and Dakshina, M. S. Formulation and evaluation of an antacid and anti-ulcer suspension containing herbal drugs. Biomedical and Pharmacology Journal 3, 01–06 (2010).
61.   al Mofleh, I. et al. Gastroprotective effect of an aqueous suspension of black cumin Nigella sativa on necrotizing agents-induced gastric injury in experimental animals. Saudi Journal of Gastroenterology 14, 128–134 (2008).
62.   al Mofleh, I. A., Alhalder, A. A., Mossa, J. S., Al-Soohalbani, M. O. and Rafatullah, S. Aqueous suspension of anise “Pimpinella anisum” protects rats against chemically induced gastric ulcers. World Journal of Gastroenterology 13, 1112–1118 (2007).
63.   Sameena Alam, Mohammed Mohiuddin, Kumar Linga Swamy, Abdullah Baig1, M. Venkata Reddy, Rajesh Kumar Gupta, S. D. Evaluation of Antiulcer and Antioxidant Activity of Polyherbal Formulation in Wistar Rats. International Journal of Pharmaceutical and Phytopharmacological Research 2, 407–411 (2013).
64.   Dizester Herbal, Dr. Willmar Schwabe India, Accessed January 06, 2022 https://www.schwabeindia.com/
65.   Amlapitta Mishran Suspension, Shree Dhootapapeshwar Ltd., Accessed January 06, 2022 https://sdlindia.com/
66.   Himcocid-SF, Himalaya Wellness Company, Accessed January 06, https://himalayawellness.in/products/himcocid-sf
67.   Ulcercare Capsules, TVS Biotech, Accessed January 06, https://www.tvsbiotech.com/health-wellness-products-suppliers-india.html
68.   Yashtimadhu, Himalaya Wellness Company, Accessed January 06, https://himalayawellness.in/products/yashtimadhu