Author(s): Manjunatha E, R. Nandeesh, Syed Mansoor Ahmed

Email(s): manjupharma@gmail.com

DOI: 10.52711/0975-4385.2022.00009   

Address: Manjunatha E1*, R. Nandeesh2, Syed Mansoor Ahmed3
1Department of Pharmaceutical Chemistry, Sree Siddaganga College of Pharmacy, Tumkur.
2Department of Pharmacognosy, Sree Siddaganga College of Pharmacy, Tumkur.
3Department of Pharmacology, Sree Siddaganga College of Pharmacy, Tumkur.
*Corresponding Author

Published In:   Volume - 14,      Issue - 1,     Year - 2022


ABSTRACT:
Ulcers are open sores on the skin or mucus membrane characterized by a superficial loss of tissue. Ulcers are mainly occurs due to the disturbance of the normal equilibrium caused by either enhanced aggression or diminished mucosal resistance to possible ulcerative agents. Main adverse effects were reported for synthetic medicines available in market, involve the gastrointestinal tract discomfort. Plant based traditional medicines are commonly used all over the world since years as they found safe and effective. Many Medicinal plants and their parts (root, rhizome, bark, leaves and fruits) are currently being used for ulcer treatment. The aim of this review was to report the parts of the plants used for Extract preparation, active constituents present in them and Antiulcer models used for the evaluation. Many Medicinal plants have the potential for the prevention and treatment of ulcers. Detailed investigation, chemical studies, isolation and further studies need to be conducted to identify the active components and elucidate the exact mechanisms of action.


Cite this article:
Manjunatha E, R. Nandeesh, Syed Mansoor Ahmed. Antiulcer and Ulcer Healing Potential of Some Medicinal Plants: A Review. Research Journal of Pharmacognosy and Phytochemistry. 2022; 14(1):37-2. doi: 10.52711/0975-4385.2022.00009

Cite(Electronic):
Manjunatha E, R. Nandeesh, Syed Mansoor Ahmed. Antiulcer and Ulcer Healing Potential of Some Medicinal Plants: A Review. Research Journal of Pharmacognosy and Phytochemistry. 2022; 14(1):37-2. doi: 10.52711/0975-4385.2022.00009   Available on: https://rjpponline.org/AbstractView.aspx?PID=2022-14-1-9


REFERENCES:
1.    Marshall BJ. "Helicobacter Pioneers: Firsthand accounts from the scientists who discovered helicobacter. Edn 3, Vol. I, Blackwell Science Asia Pty Ltd., Victoria, 2002, 1882–1992.
2.    Peery AF, Crockett SD, Barritt AS Burden of gastrointestinal, liver, and pancreatic diseases in the United States. Gastroenterology. 2015; 149: 1731-1741
3.    Doll, R F Avery Jones, Pygott F. Effect of smoking on the production and maintenance of gastricand duodenal ulcers. Lancet. 1958; 1: 657-662.
4.    Bharathi D P, Jegad E and Kavimani S. Antiulcer activity of aqueous extract of fruits of Momordica cymbalaria Hook f. in Wistar rats. Pharmacognosy Res. 2010; 2(1):58-61.
5.    Divya Sharma, Shailendra Bhatt. A comprehensive review on ulcer healing potential of medicinal plants. Int J Pharm Pharm Sci.2014; 6(10) :03-11
6.    Chan FK, Graham DY. Prevention of non-steroidal anti-inflammatory drug gastrointestinal complications reviews and recommendation based on risk assessment. Aliment Pharmacol Ther. 2004; 19(10): 1051-1061.
7.    Kirsner J.B. The problem of peptic ulcer.Am. J. Med. 1952; 13: 615
8.    Piper DW. A comparative overview of the adverse effects of antiulcer drugs. Drug Saf. 1995; 12(2):120‐138.
9.    Martin F. Sucralfate suspension 1 g four times per day in the short-term treatment of active duodenal ulcer. Am J Med. 1989; 86: 104-107
10.    Harish k, Shamena Begam J. Treatment of peptic ulcer by home remedies. International Journal of Advances in Science Engineering and Technology. 2014; 4(3):94-97
11.    Kinoshita Y, Ishimura N, Ishihara S. Advantages and Disadvantages of Long-term Proton Pump Inhibitor Use. J Neurogastroenterol Motil 2018; 24:182-196.
12.    Abhinav Mishra P, Ankit Bajpai and Suresh Chandra. A Comprehensive Review on the Screening Models for the Pharmacological Assessment of Antiulcer Drugs.Current Clinical Pharmacology 2019; 14(3):175-196
13.    Ashok Naik E, Shankar M, Sowjanya R, Sireesha B, Yudharaj P, Jasmine Priyadarshini R. Methods on employed in screening of antiulcer drugs – an overview. Int J Novel Trends in Pharm Sci 2016; 6:111-116
14.    Ratika Umre, Aditya Ganeshpurkar, Ankit Ganeshpurkar, Stuti Pandey, Vikas Pandey, Abhishek Shrivastava, Nazneen Dubey. In vitro, In vivo and in silico antiulcer activity of ferulic acid. Future J Pharm sci 4 (2018) 248–253
15.    Michael Buenor, Adinortey, Charles Ansah, Isaac Galyuon and Alexander Nyarko. In Vivo Models Used for Evaluation of Potential Antigastroduodenal Ulcer Agents. Ulcers 2013; 1:1-12
16.    Meena D K, Jayanthi M. In-Vivo Models Used for Pre-Clinical Evaluation of Anti-Ulcer Activity. Austin Pharmacol Pharm. 2018; 3(2): 1-5.
17.    Richard Jewell, Antiulcer Agents, Editor(s): S.J. Enna, David B. Bylund, xPharm: The Comprehensive Pharmacology Reference, Elsevier, 2007; Pages 1-6.
18.    Barnes, P. M.; Powell-Griner, E.; McFann, K.; Nahin, R. L. In Complementary and Alternative Medicine Use among Adults: United States, 2002, Seminars in Integrative Medicine, Elsevier: 2004; 54–71.
19.    Rates, S. M. K.; . Plants as Source of Drugs. Toxicon: Official Journal of the International Society on Toxinology 2001; 39:603–613.
20.    Dharmani P, Palit G. Exploring Indian Medicinal Plants for Antiulcer Activity. Indian Journal of Pharmacology 2006; 38(2): 95-99.
21.    Noumi E. Dibakto T. Medicinal Plants Used for Peptic Ulcer in the Bangangte Region, Western Cameroon. Fitoterapia 2000; 71: 406–412
22.    Gürbüz I. Üstün O. Yesilada E. Sezik E. Kutsal O. Anti-Ulcerogenic Activity of Some Plants Used as Folk Remedy in Turkey. J Ethnopharmacol 2003; 88: 93–97
23.    Bahmani, M. Zargaran, A. Rafieian-Kopaei, M. Identification of Medicinal Plants of Urmia for Treatment of Gastrointestinal Disorders. Revista Brasileira De Farmacognosia 2014; 24(4): 468–480.
24.    Sen S. Chakraborty R. De B, Mazumder J. Plants and Phytochemicals for Peptic Ulcer: An Overview. Pharmacog Rev 2009; 3(9): 270-289
25.    Warrier PK, Nambiar VP, Raman KC. Indian medicinal plants: A compendium of 500 species. Hyderabad: Orient Longman Publisher; 1994.
26.    Parmar NS, Parmar S. Anti-ulcer potential of flavonoids. Indian J Physiol Pharmacol 1998; 42:343–51.
27.    Kokate CK, Purohit AP, Gokhale SB. Pharmacognosy. 13th ed. Pune: Nirali Prakashan Publisher; 2007.
28.    Das S K, Roy C. The Protective Role of Aegle Marmelos on Aspirin-Induced Gastro-Duodenal Ulceration in Albino Rat Model: A Possible Involvement of Antioxidants. Saudi J Gastroenterol. 2012; 18:188-199
29.    Verma, M. Investigation on Antiulcer Activity of Aegle Marmelos Root as Experimental, Biochemical and Histological Study. J Pharm Res. 2010; 3: 2523–2528
30.    Garaniya N, Bapodra A. Ethno botanical and Phytophrmacological potential of Abrus precatorius L.: A review. Asian Pac J Trop Biomed. 2014; 4:27-34.
31.    Lalita Nagda, Chandra Prakash Joshi, Jyoti Menaria. Antioxidant and Antiulcer activity of Abrus precatorius leaf extract against acetic acid-induced gastric ulcer in rats. Asian J Pharm Clin Res. 2019; 12(7): 218-220.
32.    Rakhesh KV and Ashalatha S Nair. Phytochemical quantification in various plant parts of Aphanamixis polystachya (Wall.). J Pharmacognosy and Phytochem. 2019; 8(4): 422-426.
33.    Hemant Nagar, Pankaj Tiwari, Deepak Kumar Jain and H.S. Chandel. Evaluation of Anti-ulcer Activity of Stem Bark Extract of Aphanmixis Polystachyain Experimental Rats. Ind J Pharm Edu Res.2012; 46(3):222- 227
34.    Dash SP, Dixit S, Sahoo S Phytochemical and Biochemical Characterizations from Leaf Extracts from Azadirachta Indica: An Important Medicinal Plant. Biochem Anal Biochem. 2017; 6 (2): 1-4
35.    Atawodi SE, Atawodi JC: Azadirachta indica (neem): a plant of multiple biological and pharmacological activities.
36.    Phytochem Rev 2009; 8: 601–620.
37.    Pranjit Santonu Bhajoni, Girish Gulab Meshram, Mangala Lahkar. Evaluation of the Antiulcer Activity of the Leaves of Azadirachta indica:An Experimental Study. Integr Med Int. 2016; 3:10–16
38.    Tamboli FA, More HN. Evaluation of antiulcer and antioxidant activity of Barleria gibsoni Dalz. leaves. Phcog Res 2016; 8:226-30.
39.    Jagtap MJ, Deore AB. Antiulcer Activity of Methanolic Extract of Roots of Beta vulgaris, Chenopodiaceae. Int. J. Pharm. Sci. Drug Res. 2018; 10(6): 454-459
40.    Kadiri Sunil Kumar, Avanapu Srinivasa Rao. Evaluation of Antiulcer activity of Plant Chrozophora Plicata. Int J Pharm. 2013; 3(4): 774-778.
41.    Jayachitra, C., Karthika, K., Paulsamy, S. Phytochemical screening and in vitro antimicrobial activity of methanolic extract of Cissus setosa Roxb. Int. Res. J.Pharm.2013; 4: 166–168.
42.    Chinnamaruthu Jayachitra, Senguttuvan Jamuna, Mohammad Ajmal Ali, Subramaniam Paulsamy,Fahad M.A. Al-Hemaid. Evaluation of traditional medicinal plant, Cissus setosa Roxb. (Vitaceae)for antiulcer property. Saudi J Biol Sci.2018; 25: 293–297
43.    Dwivedi Vivek, Chander B.Semwal, Narayan H Yadav. Evaluation of anti-ulcer activity of Clitorea ternatea Leaves (Linn) extract in Wistar rats. Indian J Res Pharmacy and Biotech. 2014; 2(3):1225-1229.
44.    Jayaprakasha G.K., Jagan L., Rao M., Sakariah K.K. Chemistry and biological activity of Curcuma longa. Trend Food Sci. Technol. 2005; 16:533–548.
45.    Mau J., Lai E.Y.C., Wang N.P., Chen C.C., Chang C.H., Chyau C.C. Composition and antioxidant activity of the essential oil from Curcuma zedoaria. Food Chem. 2003; 82:583–591.
46.    Lobo R., Prabhu K.S., Shirwaikar A. Curcuma zedoaria Rosc (white turmeric): A review of its chemical, pharmacological and ethnomedicinal properties. J. Pharm. Pharmacol. 2009; 61:13–21.
47.    Abdelhak Rouibi, Soraya Boukrita. Phytochemical Characterization, Anti-inflammatory and Anti-ulcer Activity of a Spontaneous Succulent Delosperma Reseii. Universal J Agricultural Res. 2018; 6(3): 113-117
48.    Noraziah Nordin, Suzy Munir Salama, Shahram Golbabapour, Maryam Hajrezaie, Pouya Hassandarvish2, Behnam Kamalidehghan, Nazia Abdul Majid, Najihah Mohd Hashim, Hanita Omar, Mehran Fadaienasab, Hamed Karimian, Hairin Taha, Hapipah Mohd Ali, Mahmood Ameen Abdulla. Anti-Ulcer Activity of Enicosanthellum pulchrum (King) Heusden.2014; 9 (11):1-13.
49.    Rios MY, Aguilar-Guadarrama AB and Navarro V: Two new benzofuranes from Eupatorium aschenbornianum and their antimicrobial activity. Planta Med. 2003; 69:967–970.
50.    Garcia S, Lopez R, Torres R and Pacheco M: A revision of Eupatorium (Compositae om Eupatorieae) from Michoacan. Phyton (B Aires). 2011; 80:139–146.
51.    José Miguel Flores Fernández, Eduardo padilla camberos, Ofelia Fernández flores, Nestor Emmanuel Diaz Martínez, Carla Patricia Barragán Álvarez, Patricia Berenice Ramírez Rodríguez. Gastroprotective activity and Pharmacological safety evaluation of Eupatorium aschenbornianum. Exp Therapeu Medicine. 2019; 18: 4467-4472.
52.    Estella Tembe Fokunang, Jessica Ketchemen Pougoue1, Borgia Njunkio, Joseph Ngoupayo2, Donatien Gatsing 3, Paul Tomkins4 and Charles Ntungwen Fokunang. Phytochemical screening and in vivo evaluation of antiulcer properties of secondary metabolites in aqueous extracts of Ficus. thonningii Blume tested on Wistar rats. Int. J. Biol. Chem. Sci. 2019; 13(1): 475-492.
53.    Egwu, Eni Ogbonnia, Finbarrs-Bello Elizabeth, Okoronkwo, Samuel Okafor, Folawiyo, Moshood Abiola and Aduga Ikechukwu Kelly. Curative Potential of Hyptis suaveolens Aqueous Extract on Ethanol-Induced Gastric Ulcer in Albino Wistar Rats. Int J Med Res and Health Sci. 2018; 7(11): 197-205.
54.    Hammad Saleem, Irshad Ahmad, M Ashraf, M Shoaib Ali Gill, Muhammad Faisal Nadeem, M Nabeel Shahid, Kashif Barkat. In vitro Studies on Anti-diabetic and Anti-ulcer Potentials of Jatropha gossypifolia (Euphorbiaceae) Trop J Pharm Res. 2016; 15(1): 121-125
55.    Smeeta M Mohod, Subhash L Bodhankar. Antiulcer activity of aqueous extract of leaves of Madhuca indica J. F. Gmel against naproxen induced gastric mucosal injury in rats. J Acute Disease; 2013: 127-133.
56.    Prabhu K and Rajan S. Assessment of Antiulcer Activity of Ethanolic Extract of Mangifera indica Seed Kernel Using Acid Ethanol Induced Ulcer Model. Int.J Curr Microbiol App.Sci. 2015; 4(4): 854-860
57.    Amin, K., Akhtar, S., and Ismail, T. Nutritional and Organoleptic Evaluation Of Functional Bread Prepared From Raw And Processed Defatted Mango Kernel Flour. J Food Processing and Preservation. 2018; 42(4):13570–13579.
58.    Hussain Raza, Qamar Abbas, Mubashir Hassan, Seong-Hui Eo, Zaman Ashraf, Daeyoung Kim, Abdul Rehman Phull, Song Ja Kim, Sung Kwon Kang and Sung-Yum Seo. Isolation, characterization, and in-silico, in-vitro and in-vivo antiulcer studies of isoimperatorin crystallized from Ostericum koreanum, Pharm Biol. 2017; 55:1, 218-226.
59.    Lakshmanan K, Arumugam M, and Mani R. In vitro analysis of phytochemical screening and antimicrobial activity of parthenium hysterophorus L. against pathogenic microorganisms. Asian J Pharm and Clin Res.2013; 5:41-44.
60.    Sankar N S and Dipak P. Antioxidant potentials of Parthenium hysterophorus L. leaf extracts. Scientific Research Journal of India. 2014; 3(2):80-86.
61.    Ananda Kumar. Chettupalli, Vasudha B, Krishna Sanka. Pharmacological and Phytochemical Evaluation of Gastric Anti-Ulcer Activity of Parthenium hysterophorus in Different Models. Int J Pharmacog Phytochem Res. 2017; 9(4): 449-455.
62.    Saroj Kumar Sahoo, Himanshu Bhusan Sahoo, D. Priyadarshini, G. Soundarya, Ch. Kishore Kumar, K. Usha Rani. Antiulcer Activity of Ethanolic Extract of Salvadora indica (W.) Leaves on Albino Rats. Journal of Clinical and Diagnostic Research. 2016; 10(9):07-10.
63.    Salmah Al-Radahe, Khaled Abdul-Aziz Ahmed, Suzy Salama, Mahmood Ameen Abdulla, Zahra A. Amin, Saad Al-Jassabi1 and Harita Hashim. Anti-ulcer activity of Swietenia mahagoni leaf extract in ethanol-induced gastric mucosal damage in rats J Med Plants Res. 2013; 7(16):988-997.
64.    Kalra P, Sharma S, Suman, Kumar S. Antiulcer effect of the methanolic extract of Tamarindus indica seeds in different experimental models. J Pharm Bioall Sci 2011; 3:236-41.
65.    Gupta RK, Krishnamurti M, Parthasarathi J. Purpurin, a flavanone from Tephrosia purpurea seeds. Phytochemistry. 1980; 19:1264.
66.    Pelter A, Ward RS, Rao EV, Ranga E, Raju N. Substituted flavonoids and 30-substituted 7-oxygenated chalcones from Tephrosia purpurea. J Chem Soc, Perkin Trans. 1981; 1:2491–2498
67.    S.S. Deshpande, G.B. Shah, N.S. Parmar. Antiulcer activity of Tephrosia purpurea in rats. Indian J Pharmacology. 2003; 35: 168-172.
68.    Farombi EO, Owoeye O. Antioxidative and chemopreventive properties of Vernonia amygdalina and Garcinia biflavonoid. Int J Environ Res Public Health. 2011; 8(6):2533-55.
69.    Wahyudi, Edy Suwarso, Marline Nainggolan. Anti-ulcer activity of african leaves (vernonia amygdalina del.) Ethanol extract on male rat. Asian J Pharm Clin Res.2018; 11(3): 375-378
70.    Manjunatha E, Murugan Vedigounder, Geetha K M, R Nandeesh, Syed Mansoor Ahmed. Antioxidant and Antiulcer activity of Ziziphus rugosa Lam. bark. Research J. Pharm. and Tech.2020; 13 (10):4720-24
71.    Manjunatha E, Murugan Vedigounder, Geetha K M, R Nandeesh. Phytochemical and GC-MS analysis of Ziziphus rugosa bark. Int. J. Pharm. Res. 2020; 12(Suppl 1); 1886-91
72.    Manjunatha E, Murugan Vedigounder, Geetha K M, R Nandeesh, M N Palaksha. Review on A Wild Medicinal Plant: Ziziphus Rugosa. Int. J. Pharm. Sci. Rev. Res.2020; 62(2); 40-44.
73.    Amit Kishore Singha, Sandeep Kumar Singha, Prem Pratap Singha, Akhileshwar Kumar Srivastavaa, Kapil D. Pandeya, Ajay Kumara, Himanshu Yadavb A.K. Biotechnological aspects of plants metabolites in the treatment of ulcer: A new prospective. Biotechnology Reports. 2018; 18:1-7.
74.    D.A. Dias, S. Urban, U. Roessner. A Historical Overview of Natural Products in Drug Discovery. Metabolites. 2012; 2: 303–336.
75.    R Nandeesh, E Manjunatha, Vijay S Kumar. Evaluation of antioxidant and antimicrobial activity of various extracts of Buxus wallichiana Baill wood. Res J Pharmacognosy and Phytochem. 2017; 9(2):69
76.    Prashanth KH, Nandeesh R, Kaveri HV, Vidyashree M, Manjunatha E, Veerapur VP, Desai PP, Vijayakumar S. Pharmacognostic and Preliminary Phytochemical Screening of Sesbania grandiflora root. Res J Pharmacog and Phytochem. 2018; Oct 1; 10(4):285-90.
77.    MN Palaksha, TT Mani, E Manjunatha, GP Kumar. Comparative study of In-Vivo effects of Glipizide and Metformin HCl on plasma concentration of Aminophylline in healthy rabbits. Asian J of Pharm Res. 2020; 10(2):62-66


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