Author(s): Ankit Kumar, Rajesh Gupta

Email(s): Ankitwras@gmail.com

DOI: 10.52711/0975-4385.2024.00029   

Address: Ankit Kumar, Rajesh Gupta
Sri Sai College of Pharmacy, Badhani Pathankot.
*Corresponding Author

Published In:   Volume - 16,      Issue - 3,     Year - 2024


ABSTRACT:
Hands are the to begin with mode of transmission of organisms and diseases. Hand cleanliness is a key guideline and work out in the anticipation, control and lessening of contaminations. Due to COVID widespread the require of hand sanitizer has expanded which causes less dryness to hand. Considering the require, we arranged a polyherbal sanitizer utilizing seven plant extricates with other fixings counting isopropyl liquor, camphor, hydrogen peroxide, glycerol and water. The fixings were chosen on the premise of their antimicrobial property. The fixings and sanitizer were assessed for antimicrobial property and appeared strong action against gram positive microbes S. aureus, though blend of extricates appeared strong action against all the bacterial strains utilized but B. cereus. The sanitizer moreover appeared strong action against all the strains utilized in the climbing arrange of Klebsiella spp. > B. cereus > S. aureus > S. pyogenes > P. aeruginosa > Dermatophyte > E. coli and gave zone of hindrance of 18±0.05, 12±0.03, 11±0.01, 10±0.01, 9±0.5, 9±0.01 and 7±0.001 mm separately. The antimicrobial action was compared with other commercial hand sanitizer and greatest movement was appeared against Klebsiella spp. and least against E. coli and P. aeruginosa by all the sanitizer utilized. The adequacy of hand sanitizer was checked on hands of 38 volunteers of research facility specialists, patients and their relatives with composed and verbal assent. The sanitizer decreased or disposed of the development of pathogens confined from hands. Time interim impact was moreover checked at a time crevice of two hours too appeared the impact of hand sanitizer for longer time with diminishment in bacterial development. The sanitizer pH was soluble with great rack, surface and odor. No turbidity was seen when kept at higher temperature for 3 months and appeared no skin dryness with relieving impact after utilizing sanitizer on diverse volunteers.


Cite this article:
Ankit Kumar, Rajesh Gupta. Formulation and Evaluation of Herbal Hand Sanitizer. Research Journal of Pharmacognosy and Phytochemistry. 2024; 16(3):154-8. doi: 10.52711/0975-4385.2024.00029

Cite(Electronic):
Ankit Kumar, Rajesh Gupta. Formulation and Evaluation of Herbal Hand Sanitizer. Research Journal of Pharmacognosy and Phytochemistry. 2024; 16(3):154-8. doi: 10.52711/0975-4385.2024.00029   Available on: https://rjpponline.org/AbstractView.aspx?PID=2024-16-3-2


REFERENCE:
1.    Kolhapure SA, Pratibha MD, Ravi K, Evaluation of the antimicrobial efficacy and safety of Pure Hands as a hand sanitizer: Indian Journal of Clinical Practice. 2005; 15 (10): 19-27.  
2.    National Disease Surveillance Centre. Preventing Food borne Disease: A Focus on the Infected Food Handler. 2004: 17-20.  
3.    Snyder OP, Paul ST, Safe Hand Washing, Hospitality Institute of Technology and Management. 1988: 11-21.
4.    J. M. Boyce and D. Pittet. Guideline for hand hygiene in health care settings. Morbidity Mortality Weekly Report. 2002; 51(16):  1-44.  
5.    R. Hirose, T. Nakaya, Y. Naito, T. Daidoji, R. Bandou, K. Inoue, O. Dohi, N. Yoshida, H. Konishi and Y. Itoh, “Situations leading to reduced effectiveness of current hand hygiene against infectious mucus from Influenza virus infecte patients.  MSphere. 2019; 4(5).   
6.    Y. A. Ali. To study the effect of hand sanitizers used in Kingdom of Saudi Arabia against the common bacterial pathogens. Int Res J Nat Appl Sciences. 2015; 2(2): 2349-4077.
7.    F. Alderees, R. Mereddy R, D. Webber, N. Nirmal and Y. Sultanbawa. Mechanism of action against food spoilage yeasts and bioactivity of Tasmannia Lanceolata, Backhousia citriodora and Tasmannia Lanceolata, Backhousia citriodora. Plant Solvent Extracts Foods. 2018; 11: 179.
8.    P. G. Andrew, C. Dexter and G. Aziz. Hand Sanitizers: A review of ingredients, mechanisms of action, modes of delivery and efficacy against coronaviruses.  Am J Infect Control. 2020.  
9.    G. Kampf and A. Kramer. Epideriologic background of hand hygiene and evaluation of the most important agents for scrubs and rubs.  Clinical Microbiology Review.  2004; 17: 863893.
10.    K. Pedersen, H. Elisabeth, D. J. Jeanne and A. Tove. Short-term effects of alcohol-based disinfectant and detergent on skin irritation. Contact Dermatitis. 2005; 52(2).  
11.    O. M. David. Assessment of soap skin-substantively and other hygiene regimens for skin disinfection. Int J Biosci. 2009;4(2): 89-94.  
12.    https://www.geeknoob.com/hand-santizersadvantages-disadvantages-side-effects.html-17.
13.    https://www.canadianliving.com/health/preventionand-recovery/article/hand-sanitizers-benefits-andlimitations
14.    T. R. Govindachari, G. Suresh, G. Gopalakrishnan, B. Banumathy and S. Masilamani. Identification of antifungal compounds from the seed oil of Azadirachta indica. Phytoparasitica. 1998; 26(2):  109-116.
15.    U.Bandyopadhyay, K. Biswas, A. Sengupta, P. Moitra, P. Dutta, D. Sarkar, P. Debnath, C. K. Gangulyand R. K. Banerjee, “Clinical studies on the effect of Neem (Azadirachta indica) bark extract on gastric secretion and gastroduodenal ulcer. Life Sciences. 2004; 75(24):  2867–2878.
16.    P. E. Ebong, I. J. Atangwho, E. U. Eyong and G. E. Egbung. The antidiabetic efficacy of combined extracts from two continental plants: Azadirachta indica (A. Juss) (Neem) and Vernonia amygdalina (Del.) (African Bitter Leaf). Am J Biochem Biotechnol. 2008; 4(3): 239–244.  
17.    R. Paul, M. Prasad and N. K. Sah. Anticancer biology of Azadirachta indica L (neem): a minireview. Cancer Biol Ther. 2011; 12(6): 467–476.
18.    F. Uwimbabazi, J. Uwimana and J. P. Rutanga. Assessment of antibacterial activity of Neem plant (Azadirachta indica) on Staphylococcus aureus and Escherichia coli. J Med Plants Stud. 2015; 3(4): 85-91.
19.    S. Dipti and S. Kamna. Formulation of an herbal substitute for chemical sanitizer and its evaluation for antimicrobial efficiency. Int J ChemTech Res. 2019;12(3): 114-120.  
20.    S. P. Rutuja and C. Nayan. Formulation of herbal sanitizer and determining their antimicrobial activities against skin Pathogens. Int J Innov Sci Res Technol. 2018; 3(8).    
21.    R. Kumar, A. K. Singh, A. Gupta, A. Bishayee and A. K. Pandey. Therapeutic potential of Aloe vera - A miracle gift of nature. Phytomedicine. 2019;60.  
22.    P. P. Athiban, B. J. Borthakur, S. Ganesan and B. Swathika. Evaluation of antimicrobial efficacy of Aloe vera and its effectiveness in decontaminating gutta percha cones. J Conserv Dent. 2012; 15(3): 246-248.  
23.    B. F. Nejatzadeh.  Antibacterial activities and antioxidant capacity of Aloe vera. Org Med Chem Lett. 2013;3(1).   
24.    S. Patel, V. Sharma, N. S. Chauhan and V. K. Dixit. An updated review on the parasitic herb of CuscutareflexaRoxb. Chin J Integr Med. 2012; 10(3): 249-255.
25.    F. B. Inamdae, R. Oswal, T. V. Chorageand K. Garje. In vitro antimicrobial activity of Cuscutareflexa Roxb.  Int Res J Pharm. 2011; 2(4): 214-216.
26.    A. B. Behrooz, F. T. Yazdi, M. Ali, Z. Fatemeh, M. G. Mohammad and V. Alireza. Effect of aqueous and ethanolic extract of Eucalyptus camaldulensis L. on food infection and intoxication microorganisms in vitro. JPS Summer. 2013; 4(3).  
27.    O. Ayepola and B. deniyi. The antibacterial activity of leaf extracts of Eucalyptus camaldulensis (Myrtaceae). J Appl Sciences Res. 2008; 4(11): 1410-1413.
28.    P. Horvath and J. Koscova. In vitro antibacterial activity of Mentha essential oils against Staphylococcus aureus. Folia Veterinaria. 2017; 61(3): 71-77.
29.    D. Deepak, K. Gaurav, K. P. Rakesh and S. Vinod. Antimicrobial activity of Mentha arvensis against clinical isolates of human cariogenic pathogens - an in vitro study. IJPSR. 2012; 3(5): 1355-1360.
30.    A. Balakrishna, G. Saradindu, Y. Giriraj, S. Kavita, G. Sirsendu and J. Sushil. Formulation, evalution and antibacterial efficiency of water based herbal hand sanitizer gel. 2018.
31.    P. Eswar, C. G. Devaraj and P. Agarwal. Anti-microbial activity of tulsi [Ocimum sanctum (Linn.)] extract on a periodontal pathogen in human dental plaque: An Invitro study. J Clin Diagn Res. 2016;  10(3): ZC53-ZC56.  
32.    F. D. Onajobi. Smoth muscle contracting lipidicsoluble principles in chromatographic fractions of Ocimumgratissimum. J Ethnopharmacol. 1986; 18: 3-11.  
33.    A. M. Janssen, J. J. Scheffer, L. Ntezurubanza and A. Baerheim Svendsen. Antimicrobial activities of some Ocimum species grown in Rwanda. J Ethnophar-Macol. 1989; 26: 57-63.
34.    M. Sainsbury and E. A. Sofowora. Essential oil from the leaves and inflorescence of Ocimumgratissimum.  Phytochemistry. 1971; 10: 3309-3310.
35.    K.D Tripathi. Essential of Medical Pharmacology, Jaypee Publication, Edition 8th, 2019: 237 to 254.
36.    Larché M, Akdis CA, Valenta R. Immunological mechanisms of allergen-specific immunotherapy. Nat Rev Immunol. 2006; 6 (10): 761–771.
37.    S. Azman, M. Sekar, et al. Traditional Medicinal Plants Conferring Protection against Ovalbumin-Induced Asthma in Experimental Animals. J Asthma Allergy. 2021; 14: 641–662.
38.    Lambrecht, B.N.; Hammad, H.; Fahy, J.V. The Cytokines of Asthma. Immunity. 2019, 50, 975–991.
39.    G. Kaufman Asthma: pathophysiology, diagnosis and management. Nurs Stand. 2011; 26(5):48.
40.    M.A Lyengar, Jambaiah KM, Rao GM. Studies on an anti-asthma kada: A Proprietary Herbal Combination Part-I Clinical Study. Indian Drug. 1994; 31(5):183–186.
41.    Brusselle, G.G.; Koppelman, G.H. Biologic Therapies for Severe Asthma. N. Engl. J. Med. 2022, 386, 157–171.
42.    S. Tarek. Towards a deep understanding of bronchial asthma. Egyptian Journal of Bronchology. 2007; 1(1):120-124.
43.    L. Amaral-Machado, et al. Use of Natural Products in Asthma Treatment. Hindawi Evidence-Based Complementary and Alternative Medicine. 2020: 35
44.    A.Sharma Shanker C, Tyagi L, Singh M, Rao CV. Herbal medicine for market potential in India: An Overview. Academic Journal of Plant Sciences. 2008; 1(2): 26-36.
45.    Sastri H, ed. Ashtanga Hridayam. Varanasi, India: Chaukhambha Orientalia; 2002.
46.    Rammanohar P. Clinical Evidence in the Tradition of Avurveda: Evidence-Based Practice in Complementary and Alternative Medicine. Berlin, Germany: Springer-Verlag; 2012:70.
47.    Yadavji T, ed. Caraka Samhita. New Delhi, India: Munshilal Manoharlal Publishers; 1992.

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