Author(s): Gulam Muheyuddeen, Shishant Rav Divya, Stuti Verma, Sachin Kumar Gautam, Sujeet Kumar Gupta

Email(s): gulammuheyuddeen7860@gmail.com

DOI: 10.52711/0975-4385.2023.00010   

Address: Gulam Muheyuddeen1*, Shishant Rav Divya2, Stuti Verma3, Sachin Kumar Gautam4, Sujeet Kumar Gupta5 1Research Scholar M. Pharm. (Pharmaceutical Chemistry), Hygia Institute of Pharmaceutical Education and Research, Lucknow, Uttar Pradesh.
2Professor and Head Pharmaceutical Chemistry, Hygia Institute of Pharmaceutical Education and Research, Lucknow, Uttar Pradesh.
*Corresponding Author

Published In:   Volume - 15,      Issue - 1,     Year - 2023


ABSTRACT:
Lawsonia inermis (Family: Lythraceae) contained carbohydrates, phenolic, flavonoids, saponins, proteins, alkaloids, terpenoids, quinones, coumarins, xanthones, fat, resin and tannins. It also contained 2-hydroxy-1,4-naphthoquinone (lawsone). Many alkaloids, naphthoquinone derivatives, phenolics and flavonoids were isolated from different parts of Lawsonia inermis. The pharmacological studies showed that Lawsonia inermis showed antibacterial, antifungal, antiparasitic, molluscicidal, antioxidant, hepatoprotective, central nervous, analgesic, anti-inflammatory, antipyretic, wound and burn healing, immunomodulatory, antiurolithiatic, antidiabetic, hypolipidemic, antiulcer, antidiarrhoeal, diuretic, anticancer and many other pharmacological effects. The current review will highlight the chemical constituents and pharmacological effects of Lawsonia inermis.


Cite this article:
Gulam Muheyuddeen, Shishant Rav Divya, Stuti Verma, Sachin Kumar Gautam, Sujeet Kumar Gupta. Lawsonia inermis Linnaeus: Pharmacological Peculiarity and Modern Progression. Research Journal of Pharmacognosy and Phytochemistry. 2023; 15(1):63-6. doi: 10.52711/0975-4385.2023.00010

Cite(Electronic):
Gulam Muheyuddeen, Shishant Rav Divya, Stuti Verma, Sachin Kumar Gautam, Sujeet Kumar Gupta. Lawsonia inermis Linnaeus: Pharmacological Peculiarity and Modern Progression. Research Journal of Pharmacognosy and Phytochemistry. 2023; 15(1):63-6. doi: 10.52711/0975-4385.2023.00010   Available on: https://rjpponline.org/AbstractView.aspx?PID=2023-15-1-10


REFERENCE:
1.    Kumar S, Singh YV, Singh M. Agro-history, uses ecology and distribution of Henna (Lawsonia inermis L. syn. Alba Lam). Henna: cultivation. Improvement and Trade (2005)11–12.
2.    Chaudhary G, Goyal S, Poonia PX. Lawsonia inermis Linnaeus: a phytopharmacological review. International Journal of Pharmaceutical Sciences and Drug Research (2005) 2, 91–98.
3.    Babula P, Mikelova R, Potesil D, Adam V, Kizek R, Havel L, Sladky Z. Simultaneous determination of 1, 4-naphthoquinones, lawsone, juglone, and plumbagin by liquid chromatography with UV detection. Biomed Pap, (2005) ,149:25–28.
4.    Saeed SM, Sayeed SA, Ashraf S, Naz S, Siddiqi R, Ali R, Mesaik MA. A new method for the isolation and purification of lawsone from Lawsonia inermis and its ROS inhibitory activity. Pak. J. Bot. 2013 Jul;45(4):1431-6.
5.    Muhammad HS, Muhammad S. The use of Lawsonia inermis Linn.(henna) in the management of burn wound infections. African Journal of Biotechnology. 2005;4(9).
6.    Hosein HK, Zinab D. Phenolic compounds and antioxidant activity of henna leaves extracts (Lawsonia inermis). World Journal of Dairy & Food Sciences. 2007;2(1):38-41.
7.    This report can be accessed in https://www.itis.gov/servlet/SingleRpt/SingleRpt?search_topic=TSN&search_value=503345#null PDF, 29/01/2022, 06:15 PM.
8.    "Lawson, Isaac.  Dictionary of National Biography. London: Smith, Elder & Co. 1885–1900. Linnaeus dedicated the genus Lawsonia to Isaac Lawson (d. 1747).
9.    Borade AS, Kale BN, Shete RV. A phytopharmacological review on Lawsonia inermis (Linn.). Int J Pharm Life Sci. 2011 Jan;2(1):536-41.
10.    Kokate CK, Purohit AP, Gokhale SB. A Textbook of Pharmacognosy (natural drug &their synonyms in various language). Nirali Prakashan,56 edition, September 2019, A.15.
11.    Ali NA, Jülich WD, Kusnick C, Lindequist U. Screening of Yemeni medicinal plants for antibacterial and cytotoxic activities. Journal of ethnopharmacology. 2001 Feb 1; 74(2):173-9.
12.    Singh RP, Narke R. Preparation and evaluation of phytosome of Lawson. (2015)
13.    Singh DK, Luqman S. Lawsonia inermis (L.): a perspective on anticancer potential of mehndi/henna. Biomedical Research and Therapy. 2014 Oct;1(4):1-9.
14.    Castro FAV, Mariani D, Panek AD, Eleuthero ECA, Pereira MD. Cytotoxicity mechanism of two naphthoquinones (menadione and plumbagin) in Saccharomyces cerevisiae. PLoS ONE, (2008), 3(12):e3999.
15.    Rates SM. Plants as source of drugs. Toxicon. 2001 May 1;39(5):603-13.
16.    Aggarwal R, Birkbeck AA, de Koning CB, Giles RG, Green IR, Li SH, Oosthuizen FJ. The importance of peri-interactions in determining the half-chair conformation of the dihydropyran ring in 2-benzopyrans. Stereochemical consequences. Tetrahedron letters. 2003 Jun 9;44(24):4535-8.
17.    Skibo EB, Xing C, Dorr RT. Aziridinyl quinone antitumor agents based on indoles and cyclopentane [b] indoles: structure-activity relationships for cytotoxicity and antitumor activity. Journal of medicinal chemistry, (2001). 44(22), 3545-3562.
18.    dos Santos AF, Ferraz PA, de Abreu FC, Chiari É, Goulart MO, SantAna AE. Molluscicidal and trypanocidal activities of lapachol derivatives. Planta medica. 2001;67(01):92-3.
19.    Ferreira VF, Jorqueira A, Souza AM, da Silva MN, de Souza MC, Gouvêa RM, Rodrigues CR, Pinto AV, Castro HC, Santos DO, Araújo HP. Trypanocidal agents with low cytotoxicity to mammalian cell line: a comparison of the theoretical and biological features of lapachone derivatives. Bioorganic & medicinal chemistry. 2006 Aug 15;14(16):5459-66.
20.    Da Silva Jr, EN Menna-Barreto, R F.Maria do Carmo, FR. Silva, RS. Teixeira, DV. de Souza, MCB, Pinto AV. Naphthoquinoidal [1, 2, 3]-triazole, a new structural moiety active against Trypanosoma cruzi. European Journal of Medicinal Chemistry, (2008). 43(8), 1774-1780.
21.    Almeida ER. Preclinical and clinical studies of lapachol and beta-lapachone. The Open Natural Products Journal. 2009 Apr 14;2(1).
22.    Gafner S, Wolfenden JL, Niangua M, Stoeckli-Evans H, Hostettmann K. Antifungal and antibacterial naphthoquinones from Newbouldia laevis roots. Phytochemistry, (1996), 42(5), 1315-1320.
23.    Tabata M, Tsukada M., Fukui H. Antimicrobial activity of quinone derivatives from callus culture of Echium lycopsids. Planta Med, (1982),44, 234-236.
24.    C. N. Pinto, A. P. Dantas, K. C. G. de Moura, F. S. Emery, P. F. Polequevitch, M. D. Pinto, S. L. Castro and A. V. Pinto, Arzneim. Forsc., 2000, 50, 1120-1128.
25.    C. O. Salas, M. Faundez, A. Morello, J. D. Maya, and R. A. Tapia, “Synthesis of new N, S-acetal analogs derived from juglone with cytotoxic activity against Trypanosoma cruzi” Curr. Med. Chem., 2011, 18, 144-161.
26.    Musa AE, Madhan B, Madhulatha W, Rao JR, Gasmelseed GA, Sadulla S. Coloring of leather using henna-Natural alternative material for dyeing. Journal of the American Leather Chemists Association. 2009 May 1;104(05):183-90.
27.    Raza A, Iqbal N, Mahmood S, Parveen S, Azeem M, Nawaz M, Javed MT, Noman A. Harnessing natural colorants for sustainable textile dyeing an eco-friendly approach using sweet cane (Saccharum bengalense Retz.) inflorescence. Brazilian Archives of Biology and Technology. 2018 Nov 14;61.
28.    Ashtanga A, Shiri A. Isolation and characterization of 2-hydroxyl-1, 4-naphthoquinone (lawsone) from the powdered leaves of henna plant marketed in Ahwaz city of Ira. IJ Chemtech Res, 3, 1941-1944.
29.    Dhiman A, Sharma K, Goyal J, Garg M, Sharma A. Determination of lawsone content in fresh and dried leaves of Lawsonia inermis Linn. and its quantitative analysis by HPTLC. Journal of Pharmaceutical and Scientific Innovation (JPSI). 2012;1(2).
30.    Rahmoun N, Boucherit-Otmani Z, Boucherit K, Benabdallah M, Choukchou-Braham N. Antifungal activity of the Algerian Lawsonia inermis (henna). Pharmaceutical biology. 2013 Jan 1;51(1):131-5.
31.    Habbal O, Hasson SS, El-Hag AH, Al-Mahrooqi Z, Al-Hashmi N, Al-Bimini, Z, Al-jabri AA. Antibacterial activity of Lawsonia inermis Linn (henna) against Pseudomonas aeruginosa. Asian Pac J Trop Biomed, (2011), 1, 173–176.
32.    Sharma VK. Tuberculostatic activity of henna (Lawsonia inermis Linn.). Tubercle. 1990 Dec 1;71(4):293-5.
33.    Muhammad HS, Muhammad S. The use of Lawsonia inermis Linn .(henna) in the management of burn wound infections. African Journal of Biotechnology. 2005;4(9).
34.    Klaus V, Hartmann T, Gambini J, Graf P, Stahl W, Hartwig A, Klotz LO. 1, 4-Naphthoquinones as inducers of oxidative damage and stress signaling in HaCaT human keratinocytes. Archives of biochemistry and biophysics. 2010 Apr 15;496(2):93-100.
35.    Foury F. Human genetic diseases: a cross-talk between man and yeast. Gene, (1997), 195:1–10.
36.    Anaissi-Afonso L, Oramas-Royo S, Ayra-Plasencia J, Martín-Rodríguez P, García-Luis J, Lorenzo-Castrillejo I, Fernández-Pérez L, Estévez-Braun A, Machin F. Lawsone, juglone, and β-lapachone derivatives with enhanced mitochondrial-based toxicity. ACS Chemical Biology. 2018 Jun 7;13(8):1950-7.
37.    EVM. Santos, JWM. Carneiro, VF. Ferreira. Quantitative structure-activity relationship in aziridinyl-1, 4-naphthoquinone antimalarials: a study of theoretical correlations by the PM3 method. Bioorg. Med. Chem., 2004, 12, 87-93.
38.    Hickman JA. Apoptosis and tumourigenesis. Current opinion in Genetics and Development. 2002 Feb 1;12(1):67-72.
39.    Esteves-Souza A, Figueiredo DV Esteves A, Camara CA, Vargas MD, Pinto AC, Echevarria A. Cytotoxic and DNA-topoisomerase effects of lapachol amine derivatives and interactions with DNA. Brazilian Journal of Medical and Biological Research, (2007), 40(10), 1399-1402.
40.    Jordao AK, Vargas MD, Pinto AC, da Silva FD, Ferreira VF. Lawsone in organic synthesis. RSC advances. 2015;5(83):67909-43.
41.    Hughes LM, Lanteri CA, O Neil MT, Johnson J D, Gribble GW, Trumpower BL. Design of anti-parasitic and anti-fungal hydroxyl - naphthoquinones that are less susceptible to drug resistance. Molecular and biochemical parasitology, (2011), 177(1), 12-19.
42.    Nohynek GJ, Fautz R, Benech-Kieffer F, Toutain H. Toxicity and human health risk of hair dyes. Food and Chemical Toxicology. 2004 Apr 1;42(4):517-43.
43.    Majoie IL, Bruynzeel DP. Occupational immediate-type hypersensitivity to henna in a hairdresser. American Journal of Contact Dermatitis. 1996 Mar 1;7(1):38-40.
44.    To access the report SCCNFP/0583/02 see http://ec.europa.eu/food/fs/sc/sccp/out177_en.pdf.
45.    Kok A. N, Ertekin M. V, Ertekin V. İ. L. D. A. N, & Avci  B, “Henna (Lawsonia inermis Linn.) Induced hemolytic anemia in siblings”. International Journal of Clinical Practice, (2004), 58(5), 530-532.
46.    S. Katar, C. Devecioglu, M. N. Ozbek and S. Ecer, Clin. Exp. Dermatol., 2006, 32, 325-236.
47.    Leong A. Is there a need for neonatal screening of glucose-6-phosphate dehydrogenase deficiency in Canada? McGill Journal of Medicine: MJM. 2007 Jan;10(1):31.
48.    Rahmoun NM, Boucherit-Otmani Z, Boucherit K, Benabdallah M, Villemin D, Choukchou-Braham N. Antibacterial and antifungal activity of lawsone and novel naphthoquinone derivatives. Medecine et Maladies Infectieuses. 2012 Jun 1;42(6):270-5.
49.    Klaus V, Hartmann T, Gambini J, Graf P, Stahl W, Hartwig A, Klotz LO. 1, 4-Naphthoquinones as inducers of oxidative damage and stress signaling in HaCaT human keratinocytes. Archives of Biochemistry and Biophysics. 2010 Apr 15;496(2):93-100.
50.    This report can be accessed in http://www.vkm.no/dav/d63ccd25cf.pdf
51.    Watkinson AC, Brian KR, Walters KA. J. Hadgraft. Int. J. Cosmet. Sci. 1992, 14, 265- 275.
52.    A. Kosmalska, M. Zaborski, A. Masek, Przem. Chem., 2010, 89, 420-424.
53.    Ostovari A, Hoseinieh SM, Peikari M, Shadizadeh SR, Hashemi SJ. Corrosion inhibition of mild steel in 1 M HCl solution by henna extract: A comparative study of the inhibition by henna and its constituents (Lawsone, Gallic acid, α-d-Glucose and Tannic acid). Corrosion Science. 2009 Sep 1;51(9):1935-49.
54.    Doong RA, Lai YJ. Dechlorination of tetrachloroethylene by palletized iron in the presence of humic acid. Water Research, (2005), 39(11), 2309-2318.
55.    Jelly R.,Lewi SW, Lennard C, Limw KF, J. Almog, Chem. Commun., 2008, 3513-3515.
56.    Mangini A. Some complex compounds of hydroxyl quinines. Gazz Chim Ital, (1931), 61, 820-826.
57.    Casanova I, Sousa-Pedrares A, Viqueira J, Durán ML, Romero J, Sousa A, García-Vázquez JA. Electrochemical synthesis and structural characterization of homoleptic and heteroleptic cobalt, nickel, copper, zinc and cadmium compounds with the 2-hydroxy-1, 4-naphthoquinone ligand. New Journal of Chemistry. 2013;37(8):2303-16.
58.    Valle-Bourrouet G, Ugalde-Saldívar VM, Gómez M, Ortiz-Frade LA, González I, Frontana C. Magnetic interactions as a stabilizing factor of semiquinone species of lawsone by metal complexation. Electrochimica acta. 2010 Dec 1;55(28):9042-50.
59.    de Lima CG, Flávio F, de Araujo T, DuFresne A, Knudsen JM. Mössbauer studies of Fe (II) and Fe (III) chelates of some 2-hydroxy-1, 4-naphthoquinones. Inorganic and Nuclear Chemistry Letters. 1971 Jun 1;7(6):513-7.
60.    Bodini ME, Bravo PE.  Arancibia MV. volumetric and spectroscopic study of the iron (II) complexes with the semiquinone of 2-hydroxy-1,4-naphthoquinone(lawsone) in an aprotic medium. Polyhedron, 1994, 13, 497-503.
61.    Salunke-Gawali S, Rane SY, Puranik VG, Guyard-Duhayon C, Varret F. Three dimensional hydrogen-bonding network in a copper complex of 2-hydroxy-1, 4-naphthoquinone: structural, spectroscopic and magnetic properties. Polyhedron. 2004 Oct 20;23(16):2541-7.
62.    S. Oramas-Royo, C. Torrejon, I. Cuadrado, R. Hernandez-Molina, S. Hortelano, A. EstevezBraun and B. de Las Heras. synthesis and cytotoxic activity of metallic complex of lawsone. Bioorg. Med. Chem., 2013, 21, 2471-2477.
63.    Singh YV, Rao SS, Roy PK, Regar PL, Chand K, Jangid BL, Singh M. Henna (Lawsonia Inermls L.) A Promising Dye Yielding Shrub. Central Arid Zone Research Institute Jodhpur. 342 003, India. 2005 Jun:67.
64.    Singh YV, Regar PL, Rao SS, Jangid BL, Chand K. Potential of Planting Configuration and Water Harvesting in Improving the Production of Henna in Arid Fringes. Henna, Cultivation, Improvement and Trade. Central Arid Zone Research Institute. Regional Research Station. Pali-Mawar, India. 2005:28-30.
65.    Nayak BS, Isitor G, Davis EM, Pillai GK. The evidence based wound healing activity of Lawsonia inermis Linn. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives. 2007 Sep;21(9):827-31.
66.    Rahmoun N, Boucherit-Otmani Z, Boucherit K, Benabdallah M., ChoukchouBraham N. Antifungal activity of the Algerian Lawsonia inermis (henna). Pharmaceutical Biology 2013,51, 131–135.
67.    Ali NA, Jülich WD, Kusnick C, Lindequist U. Screening of Yemeni medicinal plants for antibacterial and cytotoxic activities. Journal of ethnopharmacology. 2001 Feb 1;74(2):173-9.
68.    Iyer MR, Pal SC, Kasture VS, Kasture SB. Effect of Lawsonia inermis on memory and behaviour mediated via monoamine neurotransmitters. Indian journal of pharmacology. 1998 May 1;30(3):181.
69.    Philip JP, Madhumitha G, Mary SA. Free radical scavenging and reducing power of Lawsonia inermis L. seeds. Asian Pacific Journal of Tropical Medicine. 2011 Jun 1;4(6):457-61.
70.    Nagaraja S, Ankri S. Target identification and intervention strategies against amebiasis. Drug Resistance Updates. 2019 May 1;44:1-4.
71.    Nithya V. Antimicrobial activity of medicinal plants.
72.    Malekzadeh F. Antimicrobial activity of Lawsonia inermis L. Applied microbiology. 1968 Apr;16(4):663-4.
73.    Tripathi RD, Srivastava HS, Dixit SN. A fungitoxic principle from the leaves ofLawsonia inermis Lam. Experientia. 1978 Jan;34(1):51-2.
74.    Akbar S. Lawsonia inermis L.(Lythraceae). InHandbook of 200 Medicinal Plants 2020 (pp. 1085-1093). Springer, Cham.
75.    Ali NA, Jülich WD, Kusnick C, Lindequist U. Screening of Yemeni medicinal plants for antibacterial and cytotoxic activities. Journal of ethnopharmacology. 2001 Feb 1;74(2):173-9.
76.    Ahmad I, Beg AZ. Antimicrobial and phytochemical studies on 45 Indian medicinal plants against multi-drug resistant human pathogens. Journal of ethnopharmacology. 2001 Feb 1;74(2):113-23.
77.    Gao Y, Chen Y, Cao Y, Mo A, Peng Q. Potentials of nanotechnology in treatment of methicillin-resistant Staphylococcus aureus. European journal of medicinal chemistry. 2021 Mar 5;213:113056.
78.    Silva LE, Confortin C, Swamy MK. Antibacterial and Antifungal Plant Metabolites from the Tropical Medicinal Plants. InBioactive Natural Products for Pharmaceutical Applications 2021 (pp. 263-285). Springer, Cham.
79.    Aqil F, Ahmad I. Antibacterial properties of traditionally used Indian medicinal plants. Methods and findings in experimental and clinical pharmacology. 2007 Mar 1;29(2):79-92.
80.    Singh DK, Luqman S, Mathur AK. Lawsonia inermis L.–A commercially important primaeval dying and medicinal plant with diverse pharmacological activity: A review. Industrial Crops and Products. 2015 Mar 1;65:269-86.
81.    Al-Rubiay KK, Jaber NN, Al-Mhaawe BH, Alrubaiy LK. Antimicrobial efficacy of henna extracts. Oman medical journal. 2008 Oct;23(4):253.
82.    Rajput M, Kumar N. Medicinal plants: A potential source of novel bioactive compounds showing antimicrobial efficacy against pathogens infecting hair and scalp. Gene Reports. 2020 Dec 1;21:100879.
83.    Abulyazid I, Mahdy EM, Ahmed RM. Biochemical study for the effect of henna (Lawsonia inermis) on Escherichia coli. Arabian Journal of Chemistry. 2013 Jul 1;6(3):265-73.
84.    Singh DK, Luqman S, Mathur AK. Lawsonia inermis L.–A commercially important primaeval dying and medicinal plant with diverse pharmacological activity: A review. Industrial Crops and Products. 2015 Mar 1;65:269-86.
85.    Jeyaseelan EC, Jenothiny S, Pathmanathan M., Jeyadevan J. Antibacterial activity of sequentially extracted organic solvent extracts of fruits, flowers, and leaves of Lawsonia inermis L. from Jaffna. Asian Pac. J. Trop. Biomed. 2012, 2, 798–802.
86.    Rahmoun N, Boucherit-Otmani Z, Boucherit K, Benabdallah M., ChoukchouBraham N. Antifungal activity of the Algerian Lawsonia inermis (henna). Pharmaceut. Biol. 2013a, 51, 131–135.
87.    Rahmoun NM.,Atmani ZB ,Benabdallah M ,Boucherit K.,Villemin D , Noureddine Braham NC. Antimicrobial activities of the henna extract and some synthetic naphthoquinones derivatives. Am. J. Med. Biol. Res. 2013b, 1, 16–22.
88.    Hsouna, BA., Culioli, MG., Blache, Y., Jaoua, S., 2011. Antioxidant constituents from Lawsonia inermis leaves isolation, structure elucidation, and antioxidative capacity. Food Chem. 125, 193–200.
89.    Rahmat A, Edrini S, Ismail P, Yap T, Hin Y, Bakar MA. Chemical constituents, antioxidant activity and cytotoxic effects of essential oil from Strobilanthes crispus and Lawsonia inermis. J Biol Sci. 2006;6(6):1005-10.
90.    Guha G, Rajkumar V, Kumar RA, Mathew L. Antioxidant activity of Lawsonia inermis extracts inhibits chromium (VI)-induced cellular and DNA toxicity. Evidence-Based Complementary and Alternative Medicine. 2011 Jan 1;2011.
91.    Ling LT, Radhakrishnan AK, Subramaniam T, Cheng HM, Palanisamy UD. Assessment of antioxidant capacity and cytotoxicity of selected Malaysian plants. Molecules. 2010 Apr;15(4):2139-51.
92.    Ling LT, Radhakrishnan AK, Subramaniam T, Cheng HM, Palanisamy UD. Assessment of antioxidant capacity and cytotoxicity of selected Malaysian plants. Molecules. 2010 Apr;15(4):2139-51.
93.    Mikhaeil BR, Badria FA, Maatooq GT, Amer MM. Antioxidant and immunomodulatory constituents of henna leaves. Zeitschrift für Naturforschung C. 2004 Aug 1;59(7-8):468-76.
94.    Li Q, Gao W, Cao J, Bi X, Chen G, Zhang X, Xia X, Zhao Y. New cytotoxic compounds from flowers of Lawsonia inermis L. Fitoterapia. 2014 Apr 1;94:148-54.
95.    Prakash D, Upadhyay G, Pushpangadan P, Gupta C. Antioxidant and free radical scavenging activities of some fruits. Journal of Complementary and Integrative Medicine. 2011 Jun 14;8(1):1-6.
96.    Nayak BS, Isitor G, Davis EM, Pillai GK. The evidence based wound healing activity of Lawsonia inermis Linn. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives. 2007 Sep;21(9):827-31.
97.    Sakarkar, D.M., Sakarkar, U.M., Shrikhande, V.N., Vayas, J.V., Mandavgade, S., Jaiswal, S.B., Purohit, R.N., 2004. Wound healing properties of henna leaves. Nat. Prod. Radiance 3, 406–412.
98.    Nithaya, V., Anusha, B., 2011. A preclinical study on wound healing activity of Lawsonia alba L. Res. J. Phytochem. 5, 123–129.
99.    Liou JR, El-Shazly M, Du YC, Tseng CN, Hwang TL, Chuang YL, Hsu YM, Hsieh PW, Wu CC, Chen SL, Hou MF. 1, 5-Diphenylpent-3-en-1-ynes and methyl naphthalene carboxylates from Lawsonia inermis and their anti-inflammatory activity. Phytochemistry. 2013 Apr 1;88:67-73.
100.    Endrini S, Rahmat A, Ismail P, Hin TY. Anticarcinogenic properties and antioxidant activity of henna (Lawsonia inermis). J Med Sci. 2002;2(4):194-7.
101.    Dasgupta T, Rao AR, Yadava PK. Modulatory effect of henna leaf (Lawsonia inermis) on drug metabolising phase I and phase II enzymes, antioxidant enzymes, lipid peroxidation and chemically induced skin and forestomach papillomagenesis in mice. Molecular and Cellular Biochemistry. 2003 Mar;245(1):11-22.
102.    Ozaslan M, Karagoz ID, Lawal RA, Kilic IH, Cakir A, Odesanmi OS, Guler I, Ebuehi OA. Cytotoxic and anti-proliferative activities of the Tetrapleura tetraptera fruit extract on ehrlich ascites tumor cells.
103.    Endrini, S., Rahmat, A., Ismail, P., Taufiq, Y.H., Othman, F., 2011. Effects of Henna (Lawsonia inermis) on the apoptotic pathway of human liver carcinoma cell lines. J. Appl. Sci. Res. 7, 321–326.
104.    Ong CY, Ling SK, Ali RM, Chee CF, Samah ZA, Ho AS, Teo SH, Lee HB. Systematic analysis of in vitro photo-cytotoxic activity in extracts from terrestrial plants in Peninsula Malaysia for photodynamic therapy. Journal of Photochemistry and Photobiology B: Biology. 2009 Sep 4;96(3):216-22.
105.    Sauriasari R, Wang DH, Takemura Y, Tsutsui K, Masuoka N, Sano K, Horita M, Wang BL, Ogino K. Cytotoxicity of lawsone and cytoprotective activity of antioxidants in catalase mutant Escherichia coli. Toxicology. 2007 Jun 3;235(1-2):103-11.
106.    Pradhan, R., Dandawate, P., Vyas, A., Padhye, S., Biersack, B., Schobert, R., Ahmad, A., Sarkar, F.H., 2012. From body art to anticancer activities: perspectives on medicinal properties of henna. Curr. Drug Targets 13, 1777–1798.
107.    Priya R, Ilavenil S, Kaleeswaran B, Srigopalram S, Ravikumar S. Effect of Lawsonia inermis on tumor expression induced by Dalton’s lymphoma ascites in Swiss albino mice. Saudi Journal of Biological Sciences. 2011 Oct 1;18(4):353-9.
108.    Singh DK, Luqman S. Lawsonia inermis (L.): a perspective on anticancer potential of mehndi/henna. Biomedical Research and Therapy. 2014 Oct;1(4):1-9.
109.    Alia, B.H., Bashi, r,A.K., Tanira,M.O.M., 1995.Anti-inflammatory, antipyretic, and analgesic effects of Lawsonia inermis L. (Henna) in rats. Pharmacology 51, 356–363.
110.    Gupta A, Saifi AQ, Modi NT, Mishra N. Anti-inflammatory activity of some active principles of Lawsonia inermis leaves. Indian Journal of Pharmacology. 1986 Apr 1;18(2):113.
111.    KJ K, Shete RV, Desai NV. Anti-Arthritic activity of hydroalcoholic extract of Lawsonia Innermis. Int. J. Drug Dev. & Res. 2011 Oct;3(4):217-24.
112.    Sultana S, Khosru KH. Analgesic and antidiarrhoeal activities of Lawsonia inermis. International Journal of Pharmaceutical Sciences and Research. 2011 Dec 1;2(12):3183.
113.    Hemalatha K, Natraj HN, Kiran AS. Hepatoprotective activity of leaves of Lawsonia alba. Indian J Nat Prod. 2004;20(4):14-7.Latha, P.G., Suja, S.R., Shyamal, S., Rajasekharan, S., 2005. Some hepatoprotective garden plants. Nat. Prod. Radiance 4, 278–279.
114.    Ahmed S, Rahman A, Alam A, Saleem M, Athar M, Sultana S. Evaluation of the efficacy of Lawsonia alba in the alleviation of carbon tetrachloride-induced oxidative stress. Journal of Ethnopharmacology. 2000 Feb 1;69(2):157-64.
115.    Bhandarkar, M., Khan, A., 2003. Protective effect of Lawsonia alba L.against carbon tetrachloride-induced hepatic damage in albino rats. Indian J. Exp. Biol. 41, 85–87.
116.    Anand KK, Singh B, Chand D, Chandan BK. An evaluation of Lawsonia alba extract as hepatoprotective agent. Planta Medica. 1992 Feb;58(01):22-5.
117.    Jalalpure SS, Patil MB, Jabshetti MS. Effect of Lawsonia alba leaf extracts on carbon tetrachloride-induced hepatic damage in albino rats. Journal of Natural Remedies. 2003 Jan 1;3(1):97-100.
118.    Reddy, Y., Kalyan, C., Sandya, L., Sandeep, D., Salomi, R., Nagarjuna, S., Reddy, P., 2011. Evaluation of the diuretic activity of aqueous and ethanolic extracts of Lawsonia inermis leaves in rats. Asian J. Plant Sci. Res. 1, 28–33.
119.    Yogisha S, Samiulla DS, Prashanth D, Padmaja R, Amit A. Trypsin inhibitory activity of Lawsonia inermis. Fitoterapia. 2002 Dec 1;73(7-8):690-1.
120.    Singh DK, Luqman S, Mathur AK. Lawsonia inermis L.–A commercially important primaeval dying and medicinal plant with diverse pharmacological activity: A review. Industrial Crops and Products. 2015 Mar 1;65:269-86.
121.    Sultana N, Choudhary MI, Khan A. Protein glycation inhibitory activities of Lawsonia inermis and its active principles. Journal of Enzyme Inhibition and Medicinal Chemistry. 2009 Feb 1;24(1):257-61.
122.    Abdillah, S., Budiady, I., Winarno, H., 2008. Hypoglycaemic and Antihyperlipidemic Effects of Henna Leaves Extract (Lawsonia inermis L.) on Alloxan Induced Diabetic Mice. Jordan J. Pharm. Sci. 1, 100–102.
123.    Arayne MS, Sultana N, Mirza AZ, Zuberi MH, Siddiqui FA. In vitro hypoglycemic activity of methanolic extract of some indigenous plants. Pak J Pharm Sci. 2007 Oct 1;20(4):268-73.
124.    Mail KA, Ibrahim AN, Ahmed MA, Hetta MH. Comparison between the effect of Lawsonia inermis and flubendazole on Strongyloides species using scanning electron microscopy. J Parasit Dis 2016;40:415-22.
125.    Babili FE, Bouajila J, Valentin A, Chatelain C. Lawsonia inermis: Its anatomy and its antimalarial, antioxidant and human breast cancer cells MCF7 activities. Pharm Anal Acta 2013; 1:203.
126.    Suleiman MM, Umar R, Mika’il HG, Tauheed AM, Mamman M. Tropical Journal of Natural Product Research 2019.
127.    Marimuthu S, Rahuman AA, Santhoshkumar T, Jayaseelan C, Kirthi AV, Bagavan A, et al. Lousicidal activity of synthesized silver nanoparticles using Lawsonia inermis leaf aqueous extract against pediculus humanus capitis and bovicola ovis. Parasitol Res 2012;111:2023-33.
128.    Kuppusamy E, Dhamodharan KI, Jayakumar S. Role of plants and plant based products towards the control of insect pests and vectors: A novel review. Journal of Coastal Life Medicine. 2016;4(11):902-17.
129.    Mozaffari E, Abai MR, Khanavi M, Vatandoost H, Sedaghat MM, Moridnia A, Saber-Navaei M, Sanei-Dehkordi A, Rafi F. Chemical composition, larvicidal and repellency properties of Cionura erecta (L.) Griseb. against malaria vector, Anopheles stephensi Liston (Diptera: Culicidae). Journal of Arthropod-Borne Diseases. 2014 Dec;8(2):147.
130.    Al-Snafi AE. A review on Lawsonia inermis: A potential medicinal plant. International Journal of Current Pharmaceutical Research. 2019;11(5):1-3.
131.    Kapadia GJ, Rao GS, Sridhar R, Ichiishi E, Takasaki M, Suzuki N, et al. Chemoprevention of skin cancer: effect of Lawsonia inermis L (henna) leaf powder and its pigment artifact, lawsone in the epstein-barr virus early antigen activation assay and in two-stage mouse skin carcinogenesis models. Anticancer Agents Med Chem 2013; 13:1500-7.
132.    Nakashima S, Oda Y, Nakamura S, Liu J, Onishi K, Kawabata M, et al. Inhibitors of melanogenesis in B16 melanoma 4A5 cells from flower buds of Lawsonia inermis (Henna). Bioorg Med Chem Lett 2015; 25:2702-6.
133.    Ong CY, Ling SK, Ali RM, Chee CF, Samah ZA, Ho AS, et al. Systematic analysis of in vitro photocytotoxic activity in extracts from terrestrial plants in Peninsula Malaysia for photodynamic therapy. J Photochem Photobiol B Biol 2009; 96:216-22.
134.    Yogisha S, Samiulla DS, Prashanth D, Padmaja R, Amit A. Trypsin inhibitory activity of Lawsonia inermis. Fitoterapia 2002; 73:690-1.
135.    Abdelgadir EH, Ahmed RH, Adam SI, Husein AM. Evaluation of toxicological activity (acute and sub-chronic toxicities) of the aqueous extract of Lawsonia inermis seeds on wistar rats. J Pharmacol Toxicol 2010; 5:324-33.
136.    Scientific Committee on Consumer Safety, SCCS. Lawsonia inermis (henna). SCCS/1511/13, 19 09; 2013.
137.    Singh VK, Pandey DK. Fungitoxic studies on bark extract of Lawsonia inermis against ringworm fungi. Hindustan Antibiot Bull 1989; 31:32-5.
138.    Agabna NME, Shaddad SAI, Mudathir AK. Safety of Lawsonia inermis ethanolic seeds extract. J Pharm BiomedSci2014;04:303-9.
139.    Khine YY. Acute kidney injury following Ingestion of henna leaf extract: a case report from Myanmar. Blood Purif 2017;44 Suppl 1:41-5.

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