Akhlaq Mustafa, Anas Iqbal Alvi, Zaki Ahmad Siddiqui, R. P. Meena
Akhlaq Mustafa1*, Anas Iqbal Alvi2, Zaki Ahmad Siddiqui3, R. P. Meena4
1Research Officer (Chemistry) Drug Standardization Research Unit, Central Council for Research in Unani Medicine), New Delhi.
2Research Assistant (Chemistry)) Drug Standardization Research Unit, Central Council for Research in Unani Medicine), New Delhi.
3Research Officer (Unani)) Drug Standardizations Research Unit, Central Council for Research in Unani Medicine), New Delhi.
4Research Officer (Chemistry), Central Council for Research in Unani Medicine),
61-65, Institutional Area, Janakpuri, New Delhi.
Volume - 13,
Issue - 1,
Year - 2021
Microwave digested aqueous extracts of fresh and market samples of some important indigenous drugs, which are traditionally used as an ingredient in the preparation of various reputed compound unani formulations, were utilized for the determination of heavy metals (Mercury, Lead, Cadmium and Arsenic) by Atomic Absorption Spectrophotometer. These formulations are well known to cure a number of human ailments. These plants are Glycyrrhiza glabra Linn. (Root) and Cordia dichotoma Forst. f. (Fruits). Heavy metals Concentrations so obtained of all plant drugs were below the permissible limit. Since Unani system of Medicine uses herbs, animal products as well as minerals to prepare the poly-herbal formulations, so to satisfy the present-day scientific world, it is also necessary to evolve the standards of quality and purity for indigenous drugs to ensure their uniform effectiveness against diseases. Therefore, keeping in view of such a significance ploy of these herbs, a comparative phyto-chemical and physicochemical screening of fresh and market samples of herbal drugs were also carried out.
Cite this article:
Akhlaq Mustafa, Anas Iqbal Alvi, Zaki Ahmad Siddiqui, R. P. Meena. Heavy metals determination in Microwave digested aqueous extracts of fresh and market samples of some Plant origin drugs with reference to their preliminary Comparative Physico-chemical Evaluation. Res. J. Pharmacognosy and Phytochem. 2021; 13(1):11-17. doi: 10.5958/0975-4385.2021.00003.0
Akhlaq Mustafa, Anas Iqbal Alvi, Zaki Ahmad Siddiqui, R. P. Meena. Heavy metals determination in Microwave digested aqueous extracts of fresh and market samples of some Plant origin drugs with reference to their preliminary Comparative Physico-chemical Evaluation. Res. J. Pharmacognosy and Phytochem. 2021; 13(1):11-17. doi: 10.5958/0975-4385.2021.00003.0 Available on: https://rjpponline.org/AbstractView.aspx?PID=2021-13-1-3
1. Anonymous, 2006. National Formulary of Unani Medicine Part I, Ministry of Health and Family Welfare Govt. of India, Page No. 116, 116-117, 115 and 46.
2. Anonymous, 1987. Physicochemical standards of Unani Formulations Part II, CCRUM, Ministry of Health and Family Welfare Govt. of India, Pp. 268-271.
3. Dawson, E. J, Macklin, M. G. (1998): Speciation of heavy metals in flood plain and flood sediments; A reconnaissance survey of the Aire Valley West Yorkshire Great Britain, Environ Geochem Health, 20:67-76.
4. Saper, R. B, Kales, S. N, Paquin, J. Burns, Philips, R. S. (2004): Heavy Metals of Ayurvedic Herbal Medicine products. JAMA 292(23): 2868-873.
5. World Health Organization, Quality Control Methods for Medicinal Plant Materials, WHO, Geneva, Switzerland, 2005.
6. Kokate, C. K, Purohit, A. P, Gokhale, S. B, 2010: Pharmacognosy; Nirali Prakashan, Pune, 45th ed., p.6.19-6.22
7. Anonymous, 1998, Quality Control Methods for Medicinal Plant Materials, World Health Organization, Geneva, PP. 25-28.
8. Trease G. E. and Evans, W. C, 1972, Pharmacognosy, 10th edn, Tindel, London.
9. World Health Organization, Quality Control Methods for Medicinal Plant Materials, WHO, Geneva, Switzerland, 1998.
10. AOAC, Official method of analysis of AOAC International,16th edition, AOAC International, Suite 4000, 2200, Wilson Boulevard, Arlington, Verginea, USA, 1995.
11. Biondi DM, Rocco C, Ruberto G. Dihydrostilbene derivatives from Glycyrrhiza glabra leaves. J Nat Prod. 2005; 68:1099–1102. doi: 10.1021/np050034q.
12. Blumenthal M, Goldberg A, Brinckmann J. Herbal medicine: expanded commission E monographs. Newton, MA: Integrative Medicine Communications; 2000.
13. Davis EA, Morris DJ. Medicinal uses of liquorice through the millennia: the good and plenty of it. Mol. Cell Endocrinol. 1991; 78:1–6. Doi: 10.1016/0303-7207(91)90179-V.
14. Huang M, Wang W, Wei S. Investigation on medicinal plant resources of Glycyrrhiza uralensis in China and chemical assessment of its underground part. J Nat Med. 2010; 63(2):137–146.
15. Huxley A. Dictionary of gardening. New York: Stockton Press; 1992.
16. Kong ND, Chang IK, Lee SI, Kim NJ. Studies on the efficacy of combined preparation of crude drugs: effects of “Bojungikgi-tang” on the digestive system, blood pressure and diuretic actions. Korean J Pharmacog. 1984; 15(3):121–127.
17. Saxena S. Glycyrrhiza glabra: medicine over the millennium. Nat Prod Radiance. 2005; 4(5):358–367.
18. Sheehan MP, Atherton DJ. A controlled trial of traditional Chinese medicinal plants in widespread non-exudative atopic eczema. Br J. Dermatol. 1992; 126(2): 179–184. doi: 10.1111/j.1365-2133.1992.tb07817.x.
19. Shirinyan E, Panosyan A, Barikyan M, Avakyan O. New antistressor compounds from liquorice. Izv Akad Nauk USSR. 1988; 6:932–936.
20. Sokolov S, Zamotayev I. Directory of medicinal plants. Moscow: Medicina; 1985Tsuda T, Kubota K, Yasuda K, Nishikava S, Sugaya A, Sugaya E. Effects of Chinese herbal medicine “Kanbalu-Taiso-To” on trans membrane ionic currents and its local anesthetic action. J. Ethnopharmacol. 1986; 17(3):257–261. doi: 10.1016/0378-8741(86)90113-3
21. Weiss RF, Fintelmann V. Herbal medicine. Stuttgart: Georg Thieme Verlag; 2000.
22. Zhu YP. Chinese materia medica: chemistry, pharmacology and applications. Amsterdam: Harwood Academic Publishers; 1998. Zhu S, Sugiyama R, Batkhuu J, Sanchir C, Zou K, Komatsu K. Survey of Glycyrrhizae Radix resources in Mongolia: chemical assessment of the underground part of Glycyrrhiza uralensis and comparison with Chinese Glycyrrhiza Radix. Phytother Res. 2008; 22(2):141–148. doi: 10.1002/ptr.2295.
23. Sharma V, Agrawal RC (2013) Glycyrrhiza glabra-a plant for the future. J. Pharm Med Scien 2(3):15–20
24. Sharma V, Agrawal RC, Pandey S. Phytochemical screening and determination of anti-bacterial and anti-oxidant potential of Glycyrrhiza glabra root extracts. J Environ Res Dev. 2013; 7(4):1552–1558.
25. Anon Glycyrrhiza glabra. Altern Med Rev. 2005; 10:230–237.
26. Armanini D, Fiore C, Mattarello MJ, Bielenberg J, Palermo M. History of the endocrine effects of licorice. Exp Clin Endocrinol Diabetes. 2002; 110: 257–261. doi: 10.1055/s-2002-3
27. Basu, NG, Ghosal, PK, Thakur S. Structural studies on a polysaccharide fraction from the fruits of Cordia dichofoma Forst. Carbohydr. Res. 1984; 131: 149–155.
28. Vohora, SB. Unani joshandah drugs for common cold, catarrh, cough and associated fevers. J Ethnopharmacol. 1986; 16:201–211.
29. Khond M, Bhosale JD, Arif T, Mandal TK, Padhi MM, Dabur R. Screening of some selected medicinal plants extracts for in-vitro antimicrobial activity. Middle-East J Sci. Res. 2009; 4(4):271–278.
30. Anjaria J, Parabia M, Bhatt G, Khamar R. Ahmedabad: SRITI Innovations; 1997. Nature heals a glossary of selected indigenous medicinal plants of India; P. 23.
31. Hussain N, Kakoti BB. Review on ethno botany and psychopharmacology of Cordia dichotoma. J Drug Deliv Ther. 2013; 3 (1):110–113.
32. Patel AK, Pathak N, Trivedi H, Gavania M, Patel M, Panchal N. Phyto-pharmacological properties of Cordia dichotoma as a potential medicinal tree: an overview. Int. J Inst. Pharm Life Sci. 2011; 1(1):40–51.
33. Parekh J, Chanda, S. In vitro screening of antibacterial activity of aqueous and alcoholic extracts of various Indian plant species against selected pathogens from Enterobacteriaceae. Afr. J. Microbiol. Res. 2007; 1(6):92–99.
34. Sebastian MK, Bhandari MM. Medico-ethno botany of Mount Abu, Rajasthan, India. J Ethno pharmacol. 1984; 12:223–230.
35. Rapisarda, A. Iauk L, Ragusa S. Micro morphological study on leaves of some Cordia Boraginaceae species used in traditional medicine. Econ Bot. 1997; 51(4):385–391.