Author(s): Chandrasekar R, R. Pavithra, B. Vandana, R. Babitha, S. Tejoprasanna, B. Sandeep, G. Deepika, M. Niranjan Babu

Email(s): chandrumnrcop@gmail.com

DOI: 10.52711/0975-4385.2022.00028   

Address: Chandrasekar R1*, R. Pavithra, B. Vandana, R. Babitha, S. Tejoprasanna, B. Sandeep, G. Deepika, M. Niranjan Babu2
1Associate Professor, Department of Pharmacognosy, Seven Hills College of Pharmacy, Venkatramapuram, Tirupati, Chittoor, Andhrapradesh, India.
2Professor, Department of Pharmacognosy, Seven Hills College of Pharmacy, Venkatramapuram, Tirupati, Chittoor, Andhrapradesh, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 3,     Year - 2022


ABSTRACT:
Urolithiasis is a common disease, affecting a large number of people worldwide, affecting all the age groups from youngsters to old people. Urolithiasis is one of the most severe urologic disorders which are most prevalent in developed and developing countries. Lagerstroemia speciosa, belongs to the group of Lythraceae family, commonly called as crape myrtle is a medicinal plant that has traditionally been used as an antidiabetic, lowering blood glucose levels in the body. Banaba is the common name of Lagerstroemia speciosa. The current study was investigated for the in vitro antiurolithiatic potential of Langerstromia specoisa leaf extract (LSEE) against calcium oxalate (CaOx) urolithiasis. The mechanism of stone formation involves supersaturation, crystal nucleation, precipitation, crystal growth and aggregation of crystals. The CaOx crystal was characterized by FT-IR analysis. LSEE significantly inhibited the stone formation, nucleation, growth and aggregation of CaOx crystals. FT-IR characterization was used for analyzing the formation of calcium oxalate crystals, which will be used in growth and aggregation assays. LSEE has significant antiurolithiatic activity in vitro against CaOx urolithiasis, which could be attributed to its flavonoids, polyphenolic content, saponins and tannins.


Cite this article:
Chandrasekar R, R. Pavithra, B. Vandana, R. Babitha, S. Tejoprasanna, B. Sandeep, G. Deepika, M. Niranjan Babu. Evaluation of in vitro Antiurolithiatic Potential of Ethanolic Leaf Extract of Langerstromia specoisa. Research Journal of Pharmacognosy and Phytochemistry. 2022; 14(3):150-4. doi: 10.52711/0975-4385.2022.00028

Cite(Electronic):
Chandrasekar R, R. Pavithra, B. Vandana, R. Babitha, S. Tejoprasanna, B. Sandeep, G. Deepika, M. Niranjan Babu. Evaluation of in vitro Antiurolithiatic Potential of Ethanolic Leaf Extract of Langerstromia specoisa. Research Journal of Pharmacognosy and Phytochemistry. 2022; 14(3):150-4. doi: 10.52711/0975-4385.2022.00028   Available on: https://rjpponline.org/AbstractView.aspx?PID=2022-14-3-2


REFERENCES:
1.    Thongprayoon C, Krambeck AE, Rule AD. Determining the true burden of kidney stone disease. Nat Rev Nephrol. 2020 doi: 10.1038/s41581-020-0320-7.
2.    Sorokin I, Mamoulakis C, Miyazawa K, Rodgers A, Talati J, Lotan Y. Epidemiology of stone disease across the world. World J Urol. 2017; 35:1301–20.
3.    Lohiya A, Kant S Kapil A, Gupta SK, Misra P, Rai SK. Population-based estimate of urinary stones from Ballabgarh, northern India. Natl Med J India. 2017; 30:198–200.
4.    Romero V, Akpinar H and Assimos D G, Kidney stones: A global picture of prevalence, incidence, and associated risk factors, Rev Urol, 2010, 12(2-3), e86–e96.
5.    Parmar MS, Kidney stones, BMJ, 2004, 328(7453), 1420–1424.
6.    Custer CD, Ranelle RA, Josephine LDY, Amelia SA and Elmer-Rico EM: Hypoglycemic acyivity of irradiated Banaba (Lagerstroemia speciosa Linn.) Leaves, Journal of Applied Science Research 2005; 1(1): 95-98.
7.    Mukherjee PK. Quality Control of Herbal Drugs. Business Horizon Pharmaceutical Publications, New Delhi, 2008, 187-191.
8.    Sofowora, A. (1993) Phytochemical Screening of Medicinal Plants and Traditional Medicine in Africa Edition. Spectrum Books Ltd., Nigeria, 150-156.
9.    Trease, G.E. and Evans, M.D., (1989). A text book of Pharmacognosy. 13th Ed. Builler Trindall and Canssel London. Pp 176-180.
10.    Harborne, J.B. (1998) Textbook of Phytochemical Methods. A Guide to Modern Techniques of Plant Analysis. 5th Edition, Chapman and Hall Ltd, London, 21-72.
11.    Venkatachalam Sasikala Singanallur Ramu Radha Bavaniamma Vijayakumari In vitro evaluation of Rotula aquatica Lour. for antiurolithiatic activity Journal of Pharmacy Research 2013, 6(3):378-382
12.    Dulce María González Mosquera et al. Antiurolithiatic activity of Boldoa purpurascens aqueous extract: An in vitro and in vivo study J Ethnopharmacol. 2020.10; 253:112691.
13.    Bawari S, Sah AN, Tewari D. Antiurolithiatic Activity of Daucus carota: An in vitro Study. Pharmacog J. 2018; 10(5):880-4.
14.    Yenduri Suvarna, S K. Abdul Rahaman. In Vitro – In Vivo Evaluation of Antiurolithiatic activity of piperine from Piper nigrum. Research J. Pharm. and Tech. 2020; 13(1):63-68.
15.    Spandana. K, Shivani. M, Himabindhu. J, Ramanjaneyulu. K. Evaluation of In Vitro Antiurolithiatic Activity of Vigna radiata. Research J. Pharm. and Tech 2018; 11(12): 5455-5457.
16.    Neeraja Kamakshi. U, Ganga Rao. B, Venkateswara Rao. B. Comparison of In vitro Antiurolithiatic Activity of Aerva lanata, Sphaeranthus indicus, Merremia emarginata. Research J. Pharm. and Tech. 2017; 10(6): 1653-1656.
17.    Kushagra D, Rajiv S, Ruchi G, Neelesh M. In-Vitro Evaluation of Anti-Urolithic Activity of Leaves Extract of Costus igneus. Research J. Pharm. and Tech 2020; 13(3):1289-1292.
18.    Sathish Babu. P, Gokula Krishnan, Anand Babu.K, Chitra. K. In silico and In vitro Evaluation of Anti-urolithiatic Activity of Ethanolic Extract of Syzygium cumini Stem Bark. Research J. Pharm. and Tech. 2017; 10(5): 1317-1321.
19.    Anshuman Rai, Anamika Gautam, Sakshi Panchal, Ankita Sood, Pankaj Prashar, Narendra Kumar Pandey, Indu Melkani, Bimlesh Kumar. Protective effect of Ethanolic extract of Terminalia arjuna bark against Ethylene Glycol induced Urolithiasis in male rats: In-Vitro and In-Vivo Evaluation. Research J. Pharm. and Tech. 2020; 13(12):6132-6139.
20.    Pradnya N. Jagtap, Bhagyashri R. Vyapari, Yashashri H. Nimbalkar, Sitaram V. Kale, Ganesh B. Nigade. Evaluation of Antiurolithiatic activity of Polyherbal formulation (Lithout Tablets) by In-vitro inhibition of Calcium Oxalate Crystallization. Research J. Pharm. and Tech. 2019; 12(11): 5477-5478.

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