ABSTRACT:
Herbs and herbal compounds are of tremendous research interest due to their numerous therapeutic applications. Several folk evidences have been documented in the formulations of the ancient world's pharmaceutical system, which have drawn researchers for scientific validation. Several herbal substances have been found and demonstrated therapeutic efficacy against pathophysiological diseases. Recently, attempts have been made to use these herbal components to synthesize nanoparticles for biomedical uses. Green synthesis is the method of creating nanoparticles using herbal/biogenic materials, and it has produced numerous metallic nanoparticles. The metal nanoparticle-herb combination may show better efficacy against different pathophysiological conditions. This review tries to put forward the different metal nanoparticles formed from different herbal resources and their role in health and diseases. Although green synthesis of nanoparticle is an emerging area of research but very few data are available regarding their physiological effects, compatibility and toxicity. This review is an effort to elaborate in detail the role of medicinally important herbs in synthesizing metal nanoparticles, their physiological compatibility and therapeutic efficacy. Further, considerations and discussions are also made on limitations (toxicity) of the green synthesis of nanoparticles along with their future prospects in health and diseases. This review opens door to a completely new dimension in medicinal plant research combining the nanotechnology with herbs i.e., Herbonanoceuticals.
Cite this article:
Ashish Londhe, S.D. Mankar. Herbonanoceuticals: A Newer approach for Delivering Herbal Drugs-A Review. Research Journal of Pharmacognosy and Phytochemistry. 2022; 14(2):136-1. doi: 10.52711/0975-4385.2022.00026
Cite(Electronic):
Ashish Londhe, S.D. Mankar. Herbonanoceuticals: A Newer approach for Delivering Herbal Drugs-A Review. Research Journal of Pharmacognosy and Phytochemistry. 2022; 14(2):136-1. doi: 10.52711/0975-4385.2022.00026 Available on: https://rjpponline.org/AbstractView.aspx?PID=2022-14-2-14
REFERENCES:
1. Khan SB, Faisal M, Rahman MM, Jamal A (2011) Exploration of CeO2 nanoparticles as a chemisensor and photo-catalyst for environmental applications. Sci Total Environ 409(15):2987–2992 Khan I, Saeed K, Khan I (2017) Nanoparticles: properties, applications and toxicities. Arab J Chem.
2. Singh RP, Singh SG, Naik H, Jain D, Bisla S. Herbal excipients in novel drug delivery system. Int J Compr Pharm 2011; 2:1-7.
3. Bairwa NK, Sethiya NK, Mishra SH. Protective effect of stem bark of Ceiba pentandra linn. against paracetamolinduced hepatotoxicity in rats. Pharmacognosy Res 2010; 2:26-30
4. Wu XY, Lee PI. Preparation and characterization of thermal- and pH-sensitive nanospheres. Pharm Res 1993; 10:1544-7
5. Yadav D, Suri S, Choudhary AA, Sikender M, Hemant K, Beg NM, et al. Novel approach: Herbal remedies and natural products in pharmaceutical science as nano drug delivery systems. Int J Pharm Tech 2011; 3:3092-116
6. Characteristics of Particles – Particle Size Categories. Available from: http://www.epa.gov/apti/ bces/module3/category/category.htmtt. [Last accessed on 2015 Sep 01
7. Vollath D. Nanomaterials – An introduction to synthesis, properties and application. Environ Eng Manage J 2008; 7:865-70.
8. Sun L, Chow LC, Frukhtbeyn SA, Bonevich JE. Preparation and properties of nanoparticles of calcium phosphates with various Ca/P ratios. J Res Natl Inst Stand Technol 2010; 115:243-255
9. Lue JT. Physical properties of nanomaterials. Encylopedia of Nanoscience and Nanotechnology. Los Angeles: American Scientific Publishers; 2003
10. van Vlerken LE, Amiji MM. Multi-functional polymeric Figure 8: Haircare products Mamillapalli, et al.: Nanoparticles for herbal extracts Asian Journal of Pharmaceutics • Apr-Jun 2016 (Suppl) • 10 (2) | S60 nanoparticles for tumour-targeted drug delivery. Expert Opin Drug Deliv 2006; 3:205-16.
11. Tashima T. Multifunctionality of drug’s pharmacophores within an organism. Drug Des 2014; 3:3.
12. Karaman R. The future of prodrugs designed by computational chemistry. Drug Des 2012; 1:1. 13. Pawar HS, Bhangale BD. Phytosome as a novel biomedicine: A microencapsulated drug delivery system. J Bioanal Biomed 2015; 7:1.
13. Giacomazza D, Carlo MD. Insulin as therapeutic agent against Alzheimer’s disease. Drug Des 2012; 1:3.
14. Petralia S, Barbuzzi T, Ventimiglia G (2012) Polymerase chain reaction efficiency improved by water soluble β-cyclodextrins capped platinum nanoparticles. Mater Sci Eng C 32(4): 848–850
15. Yadav L, Tripathi RM, Prasad R, Pudake RN, Mittal J (2017) Antibacterial activity of cu nanoparticles against E. coli, Staphylococcus aureus and Pseudomonas aeruginosa. Nano Biomed Eng 9(1): https://doi.org/10.5101/nbe.v9i1.p9-14
16. Galib BM, Mashru M, Jagtap C, Patgiri BJ, Prajapati PK (2011) Therapeutic potentials of metals in ancient India: a review through Charaka Samhita. J Ayurveda Integr Med 2:55–63
17. Gomes A, Ghosh S, Sengupta J, Datta P, Gomes A (2014) Herbonanoceuticals: a new step towards herbal therapeutics. Med Aromat Plants 3:162
18. Pavani T, Chakra CS, Rao KV (2013) A green approach for the synthesis of nano-sized iron oxide, by Indian Ayurvedic modified bhasmikaran method. Am J Pharm Sci 1:1–7
19. Pal D, Sahu CK, Haldar A (2014) Bhasma: the ancient Indian nanomedicine. J Adv Pharm Technol Res 5:4–12.
20. Iravani S (2011) Green synthesis of metal nanoparticles using plants. Green Chem 13:2638–2650 Jain AN (2004) Ligand-based structural hypotheses for virtual screening. J Med Chem 47(4):947–961.
21. SD Mankar, N Bhanage, P Salunke, P Thorve - Research Journal of Pharmacognosy and Phytochemistry, 2021, Vol-13, Issue-03 -126-130