Author(s): Sneha Anarthe, Sanjay Chaudhari

Email(s): sneha.pharma@yahoo.co.in

DOI: Not Available

Address: Sneha Anarthe1* and Sanjay Chaudhari2
1Department of Pharmacognosy, Gokaraju Rangaraju College of Pharmacy, Bachupally, Hyderabad, India
2Amrutvahini College of Pharmacy, Sangamner, Tal- Sangamner, Dist- Ahmednagar, Maharashtra, India.
*Corresponding Author

Published In:   Volume - 3,      Issue - 1,     Year - 2011


ABSTRACT:
The hypoglycaemic and antihyperglycemic activity of methanolic and ethyl acetate extracts of Leucas linifolia were investigated for in-vitro alpha amylase inhibitory activity and hypoglycaemic activity on normal rats and alloxan induced diabetic rats. The methanolic and ethyl acetate extracts of Leucas linifolia showed good in-vitro alpha amylase inhibitory activity as compare to standard acarbose with IC50 value of 27.13 and 33.61. The methanolic extract (300mg/kg) and ethyl acetate extract (300mg/kg) of Leucas linifolia reduced the normal blood glucose level from 78.2 ± 3.126 to 57 ± 4.266 mg/dl and 82.4 ± 1.208 to 61.2 ± 4.630, 2h after oral administration of the extract (P<0.01). In case of alloxan induced hypoglycaemic activity, the blood glucose levels were measured at 0, 7th 15th and 21st day after the extract treatment. Both methanolic (300mg/kg) and ethyl acetate (300mg/kg) extracts also significantly lowered the blood glucose level in alloxan induced diabetic rat from 311.16 ± 8.356 to 241.0 ± 6.812 mg/dl and 309.5 ± 9.674 to 242.5 ± 9.882 mg/dl, 21 day after oral administration of extract (P<0.001). The antihyperglycemic activity of Leucas linifolia was compared to standard drug glibenclamide (0.25mg/kg), an oral hypoglycaemic activity. Besides total phenolic and total flavonoid contents were also investigated for methanolic and ethyl acetate extracts.


Cite this article:
Sneha Anarthe, Sanjay Chaudhari. Hypoglycemic Activity of Leucas linifolia (Lamiaceae) Spreng. Research J. Pharmacognosy and Phytochemistry 2011; 3(1): 34-37.

Cite(Electronic):
Sneha Anarthe, Sanjay Chaudhari. Hypoglycemic Activity of Leucas linifolia (Lamiaceae) Spreng. Research J. Pharmacognosy and Phytochemistry 2011; 3(1): 34-37.   Available on: https://rjpponline.org/AbstractView.aspx?PID=2011-3-1-8


Recomonded Articles:

Author(s): Praveen S Nayak, Shweta Nayak, Ranjan Shety, P Das

DOI:         Access: Open Access Read More

Author(s): S. Mohan Raj*, Shahid Mohammed, Vinoth Kumar S, Santhosh Kumar C, Subal Debnath

DOI:         Access: Open Access Read More

Author(s): Priya Dongare, Swati Dhande, Vilasrao Kadam

DOI:         Access: Open Access Read More

Author(s): Anosike Chioma Assumpta, Obidoa Onyechi, Nwodo Okwesilieze Fredrick C., Joshua Parker Elijah.

DOI:         Access: Open Access Read More

Author(s): Sandeep R Kane, Rahul S Adnaik, Vishvesh A Apte, Chandrakant S Magdum

DOI:         Access: Open Access Read More

Author(s): Sawarkar DJ, Vijaya C, Turaskar AO, Shende VS, Chatap VK, Sawant VA, Borkar SN

DOI:         Access: Open Access Read More

Author(s): L. Kavitha, B. Kumaravel, G. Sriram Prasath, S. Subramanian

DOI:         Access: Open Access Read More

Author(s): Sharda Sonawane, Deepak Bharati, Undale VR , Bhosale AV

DOI:         Access: Open Access Read More

Author(s): Preeti Tiwari, Rakesh K. Patel, T.S. Eashwari

DOI:         Access: Open Access Read More

Author(s): M. B. Narkhede, P. V. Ajmire, A. E. Wagh, M. R. Bhise, G. D. Mehetre, H. J. Patil

DOI:         Access: Open Access Read More

Author(s): Ena Gupta, Abubakar Mohammed, Shalini Purwar, Syed Ibrahim Rizvi, Shanthy Sundaram

DOI: 10.5958/0975-4385.2017.00030.9         Access: Open Access Read More

Author(s): V.I. Zalavadiya, V.K. Shah, N.R. Sheth, Sumit Chakraborty

DOI:         Access: Open Access Read More

Author(s): VDN Srinivas, G Sumalatha, PPV Jagannath, D Siva Kishore, P Madhu Kiran ,,M Jhansi Rani

DOI:         Access: Open Access Read More

Author(s): Atanu Bhattacharjee, Shastry Chakrakodi Shashidhara, Santanu Saha

DOI:         Access: Open Access Read More

Author(s): B Suneetha, K V S R G Prasad, P Deepthi Nishanthi2, B R Soumya, B Sampath Kumar

DOI:         Access: Open Access Read More

Author(s): K. Selvaraju, K.S.G. Arulkumaran, K. Karthick, K. Vengadesh Prabhu, J. Padma Preetha, R. Arrivukkarasu

DOI:         Access: Open Access Read More

Research Journal of Pharmacognosy and Phytochemistry (RJPP) is an international, peer-reviewed journal, devoted to pharmacognosy...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0975-4385 


Recent Articles




Tags