Mohini Shelke, Avesh Tamboli, Pankaj Sonawane, Priyanka Sadaphal, S.D. Mankar
Email ID Not Available
Mohini Shelke, Avesh Tamboli, Pankaj Sonawane, Priyanka Sadaphal, S.D. Mankar
Pravara Rural College of Pharmacy, Pravaranagar A/p Loni 413736 Tal – Rahata, Dist – Ahmednagar.
Volume - 13,
Issue - 4,
Year - 2021
Carica papaya has been used for centuries in many non-Western medical practices (e.g., Ayurveda, Traditional Chinese and Vietnamese, Unani) for its homeostatic and health-promoting properties. Anecdotal reports have recently surfaced indicating the daily consumption of tea extract made from C. papaya has been related to cancer remission, including remission from certain advanced solid tumor cancers. As a result, we set out to investigate C. papaya leaf extract's in vitro effects on human cancer cells as well as its in vivo effects in cancer patients using scientific methodologies.The phytochemical composition of C. papaya leaf extract was determined using liquid chromatography-mass spectroscopy (LC-MS), immune-modulatory and anti-cancer properties were analyzed in peripheral blood mononuclear cells and various solid tumor cell lines, and clinical laboratory measurements were examined in 116 cancer patients who obtained capsules of C. papaya leaf extract.Our findings suggest that C. papaya has a lot of promise as an adjuvant therapy for certain cancers, and further research is required. In cultured cancer cells, papaya extract tends to be toxic, meaning that it may be used as a drug. For the first time, scientists discovered that papaya leaf extract increases the development of Th1-type cytokines, which are important signaling molecules. In addition to papaya's direct anti-tumor effect on a variety of cancers, this immune system control indicates potential cancer-fighting therapeutic strategies. Th1-type cytokines are important signaling molecules that are increased by papaya leaf extract. Researchers subjected 10 different types of cancer cell cultures to four strengths of papaya leaf extract and assessed the effect after 24 hours, preventing a typical and destructive outcome of many cancer therapy regimens. In every society, papaya inhibited tumor growth.
Cite this article:
Mohini Shelke, Avesh Tamboli, Pankaj Sonawane, Priyanka Sadaphal, S.D. Mankar. A Review on Pharmacognosy and Pharmacological Activity of Carica papaya Leaf. Research Journal of Pharmacognosy and Phytochemistry. 2021; 13(4):200-4. doi: 10.52711/0975-4385.2021.00035
Mohini Shelke, Avesh Tamboli, Pankaj Sonawane, Priyanka Sadaphal, S.D. Mankar. A Review on Pharmacognosy and Pharmacological Activity of Carica papaya Leaf. Research Journal of Pharmacognosy and Phytochemistry. 2021; 13(4):200-4. doi: 10.52711/0975-4385.2021.00035 Available on: https://rjpponline.org/AbstractView.aspx?PID=2021-13-4-9
1. Abidina NZ, Omara H, Empungana AJ, Kamalaldinb NA, Yahayab BH and Zubairia SI: Proliferative Activity of Saponin-Reducing Carica papaya L. Leaves Extracts on Human Lung Fibroblast Cell (IMR90). Journal Teknologi November 2016.
2. Agung N, Hesty H, Jae SC and, Hee-Juhn P: Identification and quantification of flavonoids in Carica
3. Ahmad N, Fazal H, Ayaz M, et al. Dengue fever treatment with Carica papaya leaves extracts. Asian Pacific Journal of Tropical Biomedicine. 2011:330-333.
4. Ahmad N: Dengue fever treatment with Carica papaya leaves extracts; Asian Pacific Journal of Tropical Biomedicine 2011; 4: 330-333.
5. Bamisaye FA, Ajani EO, Minari JB. Prospects of ethnobotanicaluses of pawpaw (Carica papaya). J Med Plants. 2013;1(4):171–7.
6. Baskaran C, Rathabai V, Velu S and Kubendiran K: The efficacy of Carica papaya L. leaf extract on some bacterial and a fungal strain by well diffusion method; Asian Pacific Journal of Tropical Disease 2012; 2(2): s658-s662.
7. Bouayed J, Hoffmann L, Bohn T. Total phenolics, flavonoids, anthocyanins and antioxidant activity following simulated gastrointestinal digestion and dialysis of apple varieties: bioaccessibilityand potential uptake. Food Chem. 2011;128(1):14–21.
8. Chavez Quintal P, Gonzalea-Flores T, Rodriguez-Buenfil and Gallegos-Tintore S: Antifungal activity in Ethanolic Extracts of Carica papaya L cv Maradol leaves and seeds; Indian Journal of Microbiology 2011; 51(1): 54-60.
9. Chung-Shih T: New macrolcyclic, Δ1-piperideine alkaloids from papaya leaves: dehydrocarpaine I and II; Phytochemistry 1979; 18(4): 651-652.
10. Cragg GM, Newman DJ. Plants as a source of anti-cancer agents. J Ethnopharmacol. 2005;100(1-2):72–9.
11. Dharmarathna SLCA, Wickramasinghe S, Waduge RN, Rajapakse RPVJ and Kularatne SAM: Does Carica papaya L. leaf extract increase the platelet count? An experimental study in a murine model; Asian Pacific Journal of Tropical Biomedicine 2013; 3(9):720-724.
12. E, et al. Aqueous extract of Carica papaya leaves exhibits anti-tumor activity and immunomodulatory effects. J Ethnopharmacol. Feb 17 2010;127(3):760-767.
13. Focho DA, Newu MC, Anjah MG, Nwana FA and Ambo FB: Ethnobotanical survey of trees in Fundong, Northwest Region, Cameroon. J Ethnobiol Ethnomed. 2009; 5: 17.
14. George M, Venkataraman PR and Pandalai KM: Investigation on plant antibiotics part II; A search for antibiotics substances in some Indian medicinal plants. Journal of Science and Industrial Research. 1947; 6B: 42-46
15. Govindachari TR, Pai BR and Narasimhan NS: Pseudocarpine, a new alkaloid from Carica papaya L. J.Chem. Soc., 1954; 0: 1847-1849.
16. Hu T, Guo YY, Zhou QF, Zhong XK, Zhu L, Piao JH, et al. Optimization of ultrasonic-assisted extraction of total saponins from Eclipta prostrasta L. using response surface methodology. J Food Sci. 2012;77(9):C975–82.
17. Indran M, Mahmood AA, Kuppusamy. 5UR. Protective effect of Carica papaya L leaf extract against alcohol induced acute gastric damage and blood oxidative stress in rats. West Indian Med J. Sep
18. Juarez-Rojop IE: Phytochemical screening and hypoglycaemic activity of Carica papaya L. leaf in streptozotocin- induced diabetic rats. Revista Brasileira de Farmacognosia. 2014; 24(3): 341-347.
19. Krishna KL, Paridhavi M, Patel JA. Review on nutritional, medicinal and pharmacological properties of papaya (Carica papayaLinn.). Nat Prod Radiance. 2008;7(4):364–73.
20. Leader B, Baca QJ, Golan DE. Protein therapeutics: a summary and pharmacological classification. Nat Rev Drug Discov. 2008;7(1)21–39.
21. Longdet IY, Adoga EA. Effect of methanolic leaf extract of Caricapapaya on plasmodium berghei infection in albino mice. Eur J MedPlants. 2017;20(1):1–7.
22. Nguyen TT, Parat MO, Shaw PN, Hewavitharana AK, Hodson MP. Traditional aboriginal preparation alters the chemical profile ofCarica papaya leaves and impacts on cytotoxicity towards humansquamous cell carcinoma. PLoS One. 2016;11(2):1–15.
23. Otsuki N, Dang NH and Morimoto EKASC: Aqueous extract of Carica papaya L. leaves exhibits anti tumor activity and immunomodulatory effects; Journal of Ethnopharmacology 2010; 127(3): 760-767.
24. Otsuki N, Dang NH, Kumagai E, Kondo A, Iwata S, Morimoto C.Aqueous extract of Carica papaya leaves exhibits anti-tumor activity and immunomodulatory effects. J Ethnopharmacol. 2010; 127(3): 760–7.
25. Pandey S, Walpole C, Cabot PJ, Shaw PN, Batra J, Hewavitharana AK. Selective anti-proliferative activities of Carica papaya leafjuice extracts against prostate cancer. Biomed Pharmacother. 2017; 89:515–23.
26. Pandey S, Walpole C, Cabot PJ, Shaw PN, Jyotsna B and Hewavitharana AK: Cancer; Biomedicine and Pharmacotherapy 2017; 89: 515-523.
27. papaya L. leaf and peroxynitrite-scavenging activity; Asian Pacific Journal of Tropical Biomedicine 2017; 7(3):208-213.
28. Patil T, Patil S, Patil A, Patil S. Carica papaya leaf extracts–anEthnomedicinal boon. Int J Pharmacog Phytochem Res. 2014; 6(2): 260–5.
29. Paul BI, Nasreen MA, Sarker AN, Islam MR. Isolation, purificationand modification of papain enzyme to ascertain industrially valuable nature. Int J Biotechnol Res. 2013;3(5):11–22.
30. Rahman S, Imran M, Muhammad N, et al. Antibacetial screening of leaves and stem of Carica papaya. Journal of Medicinal Plants Research. 2011; 5(20):5167-5171.
31. Rahmani AH, Aldebasi YH. Potential role of Carica papaya andtheir active constituents in the prevention and treatment of diseases. Int J Pharm Pharm Sci. 2016;8(1):11–5.
32. Ram PN, Ram VR, Khatri TT, Vyas SJ and Dave PN: XRF analysis of Carica papaya L. leaves of semi arid region of Kachchh. International Letters of Natural Sciences. 2014; 19: 15-24.
33. Ramasawamy AM and Sirsi M: Antituberculosis Activity of Some Chemical Constituents from Higher Plants. Indian J. Pharm 1960; 22: 34-35.
34. Sagnia B, Fedeli D, Casetti R, Montesano C, Falcioni G and Colizzi V: Antioxidant and Anti-Inflammatory Activities of Extracts from Cassia alata, Eleusine indica, Eremomastax speciosa, Carica papaya L. and Polyscias fulva medicinal plants collected in Cameroon; Plos one2014; 9(10).
35. Sarala N, Paknikar SS. Papaya extract to treat dengue: a noveltherapeutic option?. Ann Med Health Sci Res. 2014;4(3):320–4.
36. Saran PL, Choudhary R. Drug bioavailability and traditional medi-caments of commercially available papaya: a review. Afr J AgricRes. 2013;8(25):3216–23.
37. Sathasivam K, Ramanathan S, Mansor SM, et al. Thrombocyte counts in mice after the administrationof papaya leaf suspension. Wiener klinische Wochenschrift. Oct 2009;121 Suppl 3:19-22.
38. Seigler DS, Pauli GF, Nahrstedt A, Leen R. Cyanogenicallosides and glucosides from Passifloraedulis and Carica papaya. Phytochemistry. 2002;60(8):873–82
39. SP Singh, SV Mathan, A Dheeraj, D Tailor, RP Singh, A Acharya.Anticancer effects and associated molecular changes of Caricapapaya against prostate cancer. AACR; Cancer Res. 2019;79(13): Abstract nr 3004.
40. Suwendar PH and Ernasari GI: Analgetic activity of Papaya (Carica papaya L.) leaves extract; Procedia Chemistry 2014; 13: 147-149.
41. Tang CS. Benzyl isothiocyanate of papaya fruit. Phytochemistry 1971;10(1):117–21.
42. Tasqiah: HPLC- based activity profiling for antiplasmodial compounds in the traditional Indonesian medicinal plant Carica papaya L. Journal of Ethnopharmacology. 2014;155(1): 426-434.
43. Thomas E, Vandebroek I, Sanca S and Van Damme P: Cultural significance of medicinal plant families and species among Quechua farmers in Apillapampa, Bolivia. J Ethnopharmacol 2009; 122: 60–67
44. Vij T, Prashar Y. A review on medicinal properties of Carica papaya Linn. Asian Pac J Trop Dis. 2015;5(1):1–6.
45. Vishwanath Z, Prasad DR, Mehul J, Trivedi B andNivsarkar M: Antithrombocytopenic activity of carpaine and alkaloidal extract of Carica papaya Linn. leaves in busulfan induced thrombocytopenic Wistar rats; Journal of Ethanopharmacology 2016; 181(2): 20-25.
46. Wall MM. Ascorbic acid, vitamin a, and mineral composition ofbanana (Musa sp.) and papaya (Carica papaya) cultivars grown in Hawaii. J Food Compos Anal. 2006;19(5):434–45.