Author(s): Mohini Shelke, Avesh Tamboli, Pankaj Sonawane, Priyanka Sadaphal, S.D. Mankar

Email(s): Email ID Not Available

DOI: 10.52711/0975-4385.2021.00035   

Address: Mohini Shelke, Avesh Tamboli, Pankaj Sonawane, Priyanka Sadaphal, S.D. Mankar
Pravara Rural College of Pharmacy, Pravaranagar A/p Loni 413736 Tal – Rahata, Dist – Ahmednagar.
*Corresponding Author

Published In:   Volume - 13,      Issue - 4,     Year - 2021


ABSTRACT:
Carica papaya has been used for centuries in many non-Western medical practices (e.g., Ayurveda, Traditional Chinese and Vietnamese, Unani) for its homeostatic and health-promoting properties. Anecdotal reports have recently surfaced indicating the daily consumption of tea extract made from C. papaya has been related to cancer remission, including remission from certain advanced solid tumor cancers. As a result, we set out to investigate C. papaya leaf extract's in vitro effects on human cancer cells as well as its in vivo effects in cancer patients using scientific methodologies.The phytochemical composition of C. papaya leaf extract was determined using liquid chromatography-mass spectroscopy (LC-MS), immune-modulatory and anti-cancer properties were analyzed in peripheral blood mononuclear cells and various solid tumor cell lines, and clinical laboratory measurements were examined in 116 cancer patients who obtained capsules of C. papaya leaf extract.Our findings suggest that C. papaya has a lot of promise as an adjuvant therapy for certain cancers, and further research is required. In cultured cancer cells, papaya extract tends to be toxic, meaning that it may be used as a drug. For the first time, scientists discovered that papaya leaf extract increases the development of Th1-type cytokines, which are important signaling molecules. In addition to papaya's direct anti-tumor effect on a variety of cancers, this immune system control indicates potential cancer-fighting therapeutic strategies. Th1-type cytokines are important signaling molecules that are increased by papaya leaf extract. Researchers subjected 10 different types of cancer cell cultures to four strengths of papaya leaf extract and assessed the effect after 24 hours, preventing a typical and destructive outcome of many cancer therapy regimens. In every society, papaya inhibited tumor growth.


Cite this article:
Mohini Shelke, Avesh Tamboli, Pankaj Sonawane, Priyanka Sadaphal, S.D. Mankar. A Review on Pharmacognosy and Pharmacological Activity of Carica papaya Leaf. Research Journal of Pharmacognosy and Phytochemistry. 2021; 13(4):200-4. doi: 10.52711/0975-4385.2021.00035

Cite(Electronic):
Mohini Shelke, Avesh Tamboli, Pankaj Sonawane, Priyanka Sadaphal, S.D. Mankar. A Review on Pharmacognosy and Pharmacological Activity of Carica papaya Leaf. Research Journal of Pharmacognosy and Phytochemistry. 2021; 13(4):200-4. doi: 10.52711/0975-4385.2021.00035   Available on: https://rjpponline.org/AbstractView.aspx?PID=2021-13-4-9


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