Zingiber officinale the Herbal and Traditional Medicine and Its Therapeutically Importance

 

Debjit Bhowmik*, Chiranjib, Pankaj, KK Tripathi, MR Chandira and     KP Sampath Kumar

Rajiv Gandhi College of Pharmacy, Nautanwa, Maharajganj, Uttar Pradesh

Department of Pharmaceutical Sciences, Coimbatore Medical Sciences, Coimbatore

 

 

ABSTRACT:

Ginger is a perennial herb, with underground branching stems (rhizomes) which are swollen and tough. The leaves and rhizomes of ginger have a characteristic fragrance when cut or bruised. Rhizomes are dug out after the leafy parts are dried. Ginger, the underground stem, or rhizome, of the plant Zingiber officinale has been used as a medicine in Asian, Indian, and Arabic herbal traditions since ancient times. Ginger is considered an herbal remedy in many cultures. Over the years, it has been used to reduce inflammation, help with digestion, improve cardiovascular health and even historically to ward off diseases like the plague. The rhizome can be sliced, chopped, minced or served fresh but will always carry the trademark "heat" that has made it a medicinal mystery. Historically, people used ginger to fight disease and cure a fever since people would sweat when they would eat the root. Although that helps, since it gets the metabolism racing and warms the body, we now realize that ginger offers additional medicinal benefits. Consumption of ginger helps with blood circulation and has anti-inflammatory qualities that ease arthritis and other body aches and pains. It increases the body's production of saliva and other digestive fluids, which relieves an upset stomach and supports healthy digestion. Speeding up digestion helps clean the kidneys and bowels to remove toxins from the body. It also helps ease morning sickness, nausea and motion sickness. Ginger is said to improve digestion and has been known to pep up the appetite, promote saliva production, combat dyspepsia and relieve flatulent colic . It is also thought to be helpful for stomach cramps, alcoholic gastritis and hangover. The shogaol content in Ginger increases the activity of the digestive tract and is particularly helpful in digesting rich, fatty foods. Ginger has been used to cleanse the body of toxins through the skin by stimulating and increasing perspiration and has also been useful in breaking fevers. It is slightly diuretic and further cleanses the body by strengthening kidney function and increasing kidney filtration

 

 

INTRODUCTION:

Ginger is an herb indigenous to southeastern Asia. It is cultivated in the U.S., India, China, West Indies and tropical regions. Ginger is a creeping perennial on a thick tuberous rhizome. In the first year, a green, erect, reed-like stem about 60 cm high grows from this rhizome. The plant has narrow, lanceolate to linear-lanceolate leaves 15 to 30 cm long, which die off each year. The flower scape grows directly from the root and terminates in a long, curved spike. A white or yellow flower grows from each spike. Ginger root is used today to provide relief for symptoms of motion sickness including sweating, vomiting, dizziness, and nausea. No conclusive results were found when studies compared commercial medications with ginger. Signs of similar results between the two did seem apparent in the studies. Ginger has other uses including relieving arthritis pain, ulcerative colitis, menstrual discomfort, headaches, fevers from flu and colds, and sore throats.


Gastrointestinal problems including heartburn and gas can also be treated with ginger. The muscles of the gastrointestinal tract can be strengthened by the use of garlic. Ginger is also used to treat arthritis, both rheumatoid and osteoarthritis. It is thought that garlic can also provide relief for toothaches, but no scientific evidence exists to support this. In herbal Medicine, garlic has been traditionally used for asthma, deafness leprosy, bronchial congestion, arteriosclerosis that is hardening of arteries- fevers, worms and liver gall bladder trouble. Garlic is good for the heart, a food for the hair a stimulant to appetite, a strength-giving ,used in Leucoderma, leprosy, piles, worms, Catarrhal disorder, asthma and cough. In recent times ,experiments have confirmed several ancient beliefs about the healing value of this herb. These experiments have in fact proven much greater power of garlic than known previously. The unpleasant odour in garlic is due to its sulphur content. This mineral is content to a greater degree in its volatile oil, which has remarkable medicinal values. Chest diseases:Garlic has proved effective in certain diseases of the chest. It reduces stinking of the breath in pulmonary gangrene. Garlic is also useful in the treatment of tuberculosis. In Ayurveda a decoction of garlic boiled in milk is considered a wonderful drug for tuberculosis. One gram of garlic , 250ml of milk and a liter of water are boiled together till it reduces to one fourth of the decoction. It should be taken thrice a day .Taken in sufficient quantities, it is marvelous remedy for pneumonia. Three cloves of garlic boiled in milk can be used every night with excellent results in asthma. A pod of garlic is peeled ,crushed and boiled in 120ml pure malt vinegar .It is strained after cooling and an equal quantity of honey is mixed and preserve in a clean bottle. One or two teaspoon of this syrup can be taken with fenugreek decoction in the evening and before retiring. This has been found effective in reducing the severity of asthmatic attacks. Digestive disorders: Garlic is one of the most important herbs for the digestive systems. , It stimulates peristaltis or movement of the intestines and the secretion of the digestive juices. High Blood Pressure: Garlic is one of the most effective remedies for lowering blood pressure; Pressure and tension are reduced because it has the power to ease the spasm of the small arteries. It also modifies the pulse and modifies the heart rhythm. In Russia garlic is used extensively in the treatment of rheumatism and associated diseases .Even in Britain, garlic is recommended for Rheumatic afflictions.  Garlic helps to break up cholesterol in the blood vessels, thereby preventing any hardening of arteries which leads to high blood pressure and heart attack If a patient takes garlic after a heart attack, the cholesterol level comes down .Though the earlier damage may not be repaired ,the chances of new attacks are reduced. Blood Disorders: The herb is regarded as a rejuvenator. It has been found to help remove toxins revitalise the blood, stimulate circulation and promote intestinal flora, or colony of bacteria that prevent infection by harmful bacteria. Skin Disorder: Garlic has been used successfully for a variety of skin disorders. Pimples disappear without a scar when rubbed with raw garlic several times a day. Even very persistance forms of acne in some adults, have been healed with garlic. Garlic rubbed over ringworm, gives quick relief. The area is burnt by the strong garlic and later the skin peels off and the ring worm is cured.

 

 

CHEMICAL PROPERTIES:1

The active ingredients in ginger root include volatile oils and pungent phenol compounds known as gingerols, sesquiterpenoids, and shogaols. Ginger oil represents 3 percent of the ginger plant, and it is the oil that causes the spicy fragrance. Recent studies show that ginger has strong antioxidant properties. In addition, ginger reduces inflammation by inhibiting prostaglandin biosynthesis, specifically cyclooxygenase-1 and cyclooxygenase-2. These effects make ginger comparable to those of non-steroidal anti-inflammatory medications although ginger does not cause the side effects characteristic of non-steroidal anti-inflammatory medications. Ginger also suppresses the immune system's production of proinflammatory cytokines and chemokines, reducing disease severity in patients with rheumatoid arthritis.

 

ACTIVE COMPOUNDS:

The dried rhizome of ginger contains approximately 1-4% volatile oils. These are the medically active constituents of ginger; they are also responsible for ginger's characteristic odor and taste. The aromatic principles include zingiberene and bisabolene, while the pungent principles are known as gingerols and shogaols.

Volatile Oil:

Components can vary greatly, depending on the country of origin. The main components of the volatile oil are:

Ø  ( -)-zingiberene and arcurcumene

Ø  beta-bisabolene and arcurcumene

Ø  neral and geranial

Ø  D-camphor

Ø  beta-phellandrene

Ø  geranial

Ø  neral and linalool

Ø  (E)-alpha-farnesene, important as aroma carrier                zingiberol (mixture of cis- and trans-beta-eudesmol)

Ø  Arylalkane - Pungent Substances

 

HISTORY:2,3

Medicinal use of ginger dates back to ancient China and India; references to its use are found in Chinese pharmacopoeias, the Sesruta scriptures of Ayurvedic medicine as well as Sanskrit writings. Once its culinary properties were discovered in the 13th century, use of this herb became widespread throughout Europe. In the Middle Ages, it held a firm place in apothecaries for travel sickness, nausea, hangovers, and flatulence. Traditionally, ginger is used as an acrid bitter to strengthen and stimulate digestion. Modern uses include prophylaxis for nausea and vomiting (associated with motion sickness, hyperemesis gravidarum, and surgical anesthesia),dyspepsia, lack of appetite, anorexia, colic, bronchitis, and rheumatic complaints.Ginger is in the official pharmacopoeias of Austria, China, Egypt, Great Britain, India, Japan, the Netherlands, and Switzerland. It is approved as a nonprescription drug in Germany and as a dietary supplement in the US. Only scraped or un-scraped, unbleached ginger is accepted as a medicinal-grade drug, medicinal grade containing greater than or equal to 1.5% volatile oil. Langner, et al consider Jamaican and Cochin ginger to be the best varieties. and report the Japanese plant to be of inferior quality and do not recommend it for medicinal use. Standards of quality for ginger can be found in The United States Pharmacopeia National Formulary.

 

 

BOTANY :-

A native of tropical Asia, this perennial is cultivated in tropical climates such as Australia, Brazil, China, India, Jamaica, West Africa, and parts of the US.The term "root" is actually a misnomer because it is the rhizome that is used medicinally and as a culinary spice. Cultivation with natural manuring is thought to increase the spiciness of the rhizome and is therefore preferred to wild crafting.The rhizome is harvested between 6 and 20 months; taste and pungency increase with maturity.The plant carries a green purple flower in terminal spikes; the flowers are similar to orchids.

 

DOSAGE:

Ginger is commonly found in 500 mg (0.5 gram) capsules. The daily dose should not exceed 4 grams of fresh root or 3.0 ml of tincture. For arthritis pain, 2-4 grams of ginger juice or powder can be used daily. Ginger can also be used as a compress or paste and applied directly to inflamed joints. For colds, menstrual cramps, and headache 2 tbsp or several slices of fresh ginger can be added to boiled water can be consumed 2-3 times daily. Fresh ginger root can also be sliced and steamed and the vapors inhaled. For nausea and indigestion, 2-4 grams of ginger can be used daily. Alternately a ¼ oz piece of raw or crystallized ginger can be chewed. As with many herbal preparations, it can take up to two months before the full effects are noticed.

 

INTERACTIONS:

Because ginger can interfere with blood clotting, it should be used cautiously in patients on anticoagulant therapies such as coumadin or heparin. Ginger may reduce the toxic effects of the chemotherapeutic agent cyclophosphamide.Although ginger is very effective for nausea and morning sickness and is used to reduce the effects of several chemotherapeutic agents, the use of ginger capsules is not recommended for pregnancy. Ginger is also contraindicated in patients with biliary disease because of its tendency to cause bile release from the gallbladder.

 

MEDICAL BENEFITS OF GINGER:5-,7

Ginger root is used today to provide relief for symptoms of motion sickness including sweating, vomiting, dizziness, and nausea. No conclusive results were found when studies compared commercial medications with ginger. Signs of similar results between the two did seem apparent in the studies.Ginger has other uses including relieving arthritis pain, ulcerative colitis, menstrual discomfort, headaches, fevers from flu and colds, and sore throats. Gastrointestinal problems including heartburn and gas can also be treated with ginger. The muscles of the gastrointestinal tract can be strengthened by the use of garlic. Ginger is also used to treat arthritis, both rheumatoid and osteoarthritis. It is thought that garlic can also provide relief for toothaches, but no scientific evidence exists to support this.


THERAPEUTIC USES OF GINGER6,7

Ginger's most common use may be as a treatment for digestive problems, including gas, bloating, cramps, and even colic in babies (if it's diluted). Research has shown that it's also more effective than Dramamine for nausea. It has been used successfully against seasickness, airsickness, and even morning sickness in pregnant women. Because it's a warming herb, it also has a diaphoretic effect (meaning it causes sweating) that's used by some herbalists to help their patients develop a fever and recover more quickly from a cold or the flu. Simmer the ginger root in water, then strain the water, soak a cloth in it, and apply the cloth to the affected area. Mix ginger juice with olive or sesame oil and massage it into the skin. This oil can also be applied to the scalp as a remedy for dandruff, or put on a cotton ball which is then inserted into the external ear canal to help an earache.


The essential oil of ginger is also useful against colds, coughs, sore throats, arthritis, and has even been used occasionally as an aphrodisiac. And don't forget the obvious - you can cook with ginger frequently to enjoy its flavor as well as its medicinal benefits. It's great added to meat, because it helps make the meat easier to digest.

 

Motion Sickness

Several studies suggest that ginger may be more effective than placebo in reducing symptoms associated with motion sickness. In one trial of 80 novice sailors (prone to motion sickness), those who took powdered ginger experienced a significant reduction in vomiting and cold sweating compared to those who took placebo. Similar results were found in a study with healthy volunteers. While these results are promising, other studies suggest that ginger is not as effective as medications in reducing symptoms associated with motion sickness. In a small study of volunteers who were given ginger (fresh root and powder form), scopolamine (a medication commonly prescribed for motion sickness), or placebo, those receiving the medication experienced significantly fewer symptoms compared to those who received ginger.

 

Conventional prescription and nonprescription medicines that decrease nausea may also cause unwanted side effects, such as dry mouth and drowsiness. Given the safety of ginger, many people find it a welcome alternative to these medications to relieve motion sickness.

 

Pregnancy Related Nausea and Vomiting

Human studies suggests that 1 gram daily of ginger may be safe and effective for pregnancy-associated nausea and vomiting when used for short periods (no longer than 4 days). Several studies have found that ginger is more effective than placebo in relieving nausea and vomiting associated with pregnancy. In a small study of 30 pregnant women with severe vomiting, those who ingested 1 gram of ginger every day for 4 days reported more relief from vomiting than those who received placebo. In a larger study of 70 pregnant women with nausea and vomiting, those who received a similar dosage of ginger felt less nauseous and experienced fewer vomiting episodes than those who received placebo.

 

Chemotherapy nausea

Evidence from a few studies suggests that ginger reduces the severity and duration of nausea (but not vomiting) during chemotherapy. More research is needed to confirm these results and establish safety.

 

Nausea and vomiting following surgery

Research has produced mixed results regarding the use of ginger in the treatment of nausea and vomiting following surgery. Two studies found that 1 gram of ginger root before surgery reduced nausea as effectively as a leading medication. In one of these two studies, women who received ginger also required fewer nausea-relieving medications following surgery. Other studies, however, have failed to find the same positive effects. In fact, one study found that ginger may actually increase vomiting following surgery. More research is needed to determine whether ginger is safe and effective for the prevention and treatment of nausea and vomiting following surgery.

 

Inflammation

In addition to providing relief from nausea and vomiting, ginger extract has long been used in traditional medical practices to reduce inflammation. In fact, many health care professionals use ginger to help treat health problems associated with inflammation, such as arthritis and ulcerative colitis. In a study of 261 people with osteoarthritis (OA) of the knee, those who received a ginger extract twice daily experienced less pain and required fewer pain-killing medications compared to those who received placebo. Although a few studies have shown a benefit of ginger for arthritis, one trial found that the herb was no more effective than ibuprofen (a medication frequently used to treat OA) or placebo in reducing symptoms of OA.


CAUTIONS

Ginger can keep platelets from clumping, so it can act as a blood thinner, which means it should not be used by someone who is taking other anticoagulants. It's also not recommended for people with gallstones, or those who are taking digoxin, phenothiazines, tetracycline, or sulfa drugs. And it may interfere with the absorption of iron and fat-soluble vitamins, so it's best not to take them at the same time as a ginger supplement.


Ginger is generally safe for short-term use during pregnancy, for easing morning sickness. But it should not be used by pregnant women who have gallstones.

 

TRADITIONAL APPLICATIONS IN HERBAL MEDICINE:10-12

Aromatic, carminative, stimulant to the gastro- intestinal tract, diaphoretic, expectorant, antiemetic, and stomachic, also sialagogue and digestive; Externally, a local stimulant and rubefacient. Ginger is given in dyspepsia and flatulent colic excellent to add to bitter infusions; specially valuable in alcoholic gastritis; of use for diarrhoea from relaxed bowel where there is no inflammation. Ginger Tea is a hot infusion very useful for stoppage of the menses due to cold, externally it is a rubefacient. Essence of Ginger should be avoided, as it is often adulterated with harmful ingredients.


Digestive System Actions:

Ginger is a classic tonic for the digestive tract. Classified as an aromatic bitter, it stimulates digestion. It also keeps the intestinal muscles toned. This action eases the transport of substances through the digestive tract, lessening irritation to the intestinal walls. Ginger may protect the stomach from the damaging effect of alcohol and non steroidal anti-inflammatory drugs (such as ibuprofen) and may help prevent ulcers.

Allergies and asthma:

Dried ginger can help in the management of allergies and asthma by offsetting the effect of the platelet-activating factor (PAP). PAP initiates inflammatory processes in allergy and asthma. It was found to become more active after changes in blood chemistry that occur in a high-fat diet.

Atherosclerosis and high cholesterol:

Arthritis, bursitis, fibrocystic breasts, lymphedema, and pain. Ginger inhibits the production of immune-system components called cytokines. These chemicals are believed to create a long-term tendency toward inflammation. Ginger also stimulates blood circulation. These effects of ginger are taken advantage of in treating a number of disorders marked by swelling and pain, such as arthritis. Studies have also shown that ginger can relieve pain without the side effects typically found when using nonsteroidal anti-inflammatory drugs (NSAIDs) and steroids.


Anti-nausea/Anti-vomiting Actions:

Research is inconclusive as to how ginger acts to alleviate nausea. Ginger may act directly on the gastrointestinal system or it may affect the part of the central nervous system that causes nausea. It may be that ginger exerts a dual effect in reducing nausea and vomiting.


Parasitic infection:

 Ginger contains a chemical called zingibain that dissolves parasites and their eggs. In laboratory trials, ginger extracts have been shown to kill the anisakid worm (a parasite occasionally found in raw fish) within sixteen hours. Ginger tea is useful as a supplement in treating schistosomiasis, a parasitic disease.


Seizure disorders:

Ginger protects the body from the hepatotoxic effects of valproic acid (Depakene), a common treatment for seizure disorders. Ginger, when used on a daily basis,  was found to improve the elevated levels of the liver enzymes alanine amino- transferase (ALT) and aspartate aminotransferase (AST). 


Action and Uses in Ayurveda and Siddha:

Ginger is an important herb used in Ayurveda. Ayurveda takes advantage of the following medicinal properties for ginger: Analgesic, anti-emetic, aromatic, aphrodisiac, carminative, diaphorelic, digestive, expectorant, nervine, sialagogue, stimulant. Ayurvedic practitioners consider ginger to be a truly a wonder drug, having so many healing properties. It was called the universal medicine. Taken with rock salt it reduces vayu; with rock candy it reduces Pitta; with honey it reduces Kapha. Thus it can be used to influence all tridoshas. Ginger is used in the following ayurvedic remedies: katu rasam, ushna veeryam, vata-kapha-haram, katu- vipaka, lagu, snigdam, pachanam, ruchyam, vrishyam, swaryam, vibhanda haram, in grahani agnimanthyam. amavatham, chardhi, swasam, soolam, arsas, anaham, hrith-rogam, udhara rogam. It is used externally in kapha, swellings, headache. Perhaps the most versatile of all herbs, fresh ginger can be topically applied as a warm fomentation to relieve spasms pain and cramps. Simply cut several slices of the fresh root and place them in a pan of boiling water. Saturate a flannel cloth with the tea and apply it topically as warm as the body will bear. This is an ideal treatment for stiff neck and shoulders. The herb is cooked with meat to aid its assimilation and detoxify it. Fresh ginger tea is the most ideal herb to use for the first signs of mucus, cold, cough, and so on. To make it taste better, add honey. Drinking ginger tea with meals will greatly aid digestion and assimilation and is useful for those with weak, cold digestion.

 

SAFETY:15

Ginger is one of the most widely available and widely used herbal remedy on the planet. Billions of people use ginger safely daily as food and medicine. A few precautions should be followed, though. Ginger should not be used by those with heat signs in the lungs or stomach. Side effects of ginger are rare when used as recommended. However, some people may be sensitive to the taste or may experience heartburn. Persons with a history of gallstones should consult a nutritionally oriented doctor before using ginger. Ginger can prolong the sleeping time induced by barbiturates. Use ginger with extreme caution if you are taking any kind of medication to induce sleep. Ginger is contraindicated in morning sickness. Because of its cholagogic effect, ginger should not be taken in the presence of gallstone conditions except under the supervision of a doctor. The daily consumption of ginger root may interfere with the absorption of dietary iron and fat-soluble vitamins. Avoid taking ginger for two weeks prior to undergoing elective surgery.


Short-term use of ginger for nausea and vomiting during pregnancy appears to pose no safety problems; however, long-term use during pregnancy is not recommended.


Ginger can increase the potency of prescription medications used to prevent blood clots, such as aspirin, clopidogrel (Plavix), ticlopidine (Ticlid), or warfarin (Coumadin). Combining ginger with these medications could result in unexpected bleeding. Discuss with your physician before taking ginger to control nausea after surgery. If bleeding is a major


GINGER AND ITS BENIFITS17-19

Ginger is regarded as the oldest and most common kitchen spice that has been used since ages especially in Asia ginger is said to be the best plant for health. Often ginger is taken in various forms in dried form as well as fresh ginger is useful for treating various ailments. here are some from granny's treasure box some of the important uses of ginger :-

 

1) Mix a teaspoon of fresh ginger juice with a cup of fenugreek decoction and to it add 1tsp honey to make an excellent expectorant for the treatment of asthma. it give relief to the ailing patient

2) Ginger seems to improve the body's ability to sweat, It helps in blood circulation and help us get rid of cold symptoms and the flu. mothers used ginger to treat children when they got cold and cough with basil juice and honey .In fact, researchers are investigating ginger as a means to reduce the chance of cardiovascular disease. It’s not known that these benefits are because of an improved circulatory system or something else is improving heart functions

3) Cut a small piece of ginger and boil it with a cup of water. Add some green tealeaves. strain and drink hot. It is effective in fever resulting from the cold.

4) Pound a piece of fresh ginger and boil with a cup of water and add a little honey. Drink it hot two or three times a day for a month. The pain-relieving and anti-cramping compounding ginger effectively helps to relieve painful menstruation cramps (dysmenorrhoea). In the absence of menstruation in women in the reproductive age (amenorrhoea), this concoction can also help induce menstruation.

5) Ginger protects your body from radiation, possibly in conjunction with its antioxidant capabilities

6) Ginger attributes a number of health and fitness promoting properties. It’s found to be 
useful in reducing the cardiovascular risk as well as improvement of heart's performance during exercise, it possess smooth and relaxing effect on the body, resulting in a better stress fighting capacity.

7) Young ginger rhizomes are juicy and fleshy with a very mild taste. They are often pickled in vinegar or sherry as a snack or just cooked as an ingredient in many dishes, it is said to release (vayu) from one’s body and thus good for related problem such as sciatica and gas.

8) Powdered dry ginger root (ginger powder) is typically used to spice gingerbread and other recipes and is used to make tea which taste awesome when ginger is added to it .

9) Ginger is also made into candy; often candies for throat aliments are easily available over the counter at the chemist shops

10) Ginger powder is particularly given to expecting women and feeding mothers with milk.

11) Its stimulant and carminative properties are used frequently for dyspepsia and colic. It is frequently employed to disguise the taste of medicines.

12) Ginger compounds are active against diarrhea which is the leading cause of infant death .Ginger has been found effective in multiple studies for treating nausea caused by sea and morning sickness, and chemotherapy though ginger was not found superior over a placebo for post-operative nausea. Apart from its benefits it also have certain side effects such as Allergic reactions sometimes result in rashes, although they are not harmful, sometimes use of ginger can cause heartburn, bloating, gas, belching and nausea, especially if taken in powdered form. Unchewed fresh ginger may result in intestinal blockage and choke your throat and individuals who have had ulcers, inflammatory bowel disease or blocked intestines may react badly to large quantities of fresh ginger Ginger can also adversely affect individuals with gallstones. There are also suggestions that ginger may affect blood pressure, clotting, and heart.

 

GINGER ROOT SIDE EFFECTS:22,21,24

Most of us are familiar with the health benefits of ginger root and its culinary uses. However, like any other herb, high doses or overuse of ginger may result in some side effects. The following are some of the ginger root side effects.

Ø  The most common side effects of ginger root includes, heartburn, diarrhea and irritation of the mouth.

Ø  In some people, prolonged use of ginger root may lead to dry and scaly rashes, which develop on the face and may move downward with time.

Ø  Another ginger root side effect, associated with its long term use is visual sensitivity to bright light.

Ø  Ginger root consumption is not recommended for people with gallstones, as this herb increases bile production. The same applies to those, who are taking blood thinning medications or is preparing for surgery.

Ø  Ginger should be avoided by people with bleeding disorders, ulcers and inflammatory bowel diseases.

Ø  It has also been noticed that some people with allergies, develop ginger root side effects, like rashes. In some rare cases, eye irritation and pink eye has also been associated with consumption of ginger.

Ø  There are also reports that suggest that ginger may also affect the blood pressure and heart rhythms.

 

There are very few reports of ginger root side effects in people, who take low doses of this herb. Most of the reported cases are either associated with intake of ginger powder as compared to fresh form, prolonged use of ginger root or its overuse. It may also interact with other drugs, herbs or supplements and create complications. Hence, it is very important to seek the opinion of your doctor before using this herb for medicinal purposes. It is also advisable to undergo a herbal treatment under the supervision of a qualified herbal practitioner.

 

PHARMACOLOGY:

Important chemical constituents are thought to be the phenolic compounds (e.g, gingerols, shogaols) and essential oils (primarily the sesquiterpenes such as zingiberene, zingiberol, and curcumene). Ginger and isolated constituents, primarily gingerols, have been studied in many animal and in vitro experiments; the details of these studies have been extensively reviewed. In summary, ginger was found to enhance gastrointestinal motility in some (but not all) animal studies, and to de crease chemotherapy-induced vomiting. It reduces experimentally induced gastric lesions, and enhances bile excretion. In vitro, ginger is an antioxidant; inhibits formation of inflammatory prostaglandins and leukotrienes and inhibits platelet aggregation.

 

CLINICAL TRIALS: 26,27,31,33

Ginger root, primarily in doses of 0.5-1 g, has been well-studied for motion sickness and as an antiemetic; results of controlled trials are generally positive, but are not all consistent. Ginger was more effective than placebo and dimenhydrinate (Dramamine) in an initial single-blind experiment for motion sickness, measuring the tolerance of students in a rotating chair. Although one small, placebo-controlled study also reported an antivertigo effect to caloric stimulation of the vestibular apparatus, three subsequent controlled studies of experimental motion sickness (using a rotating chair or turntable) found ginger to be no more effective than placebo. Better results were found in "real-life" clinical studies of motion sickness. Ginger was reported to help prevent or reduce sea-sick ness on ocean vessels in three double-blind, randomized controlled trials (RCTs). In naval cadets, a single dose of ginger reduced vomiting and cold sweats more effectively than placebo. 17 In 60 cruise passengers, ginger had equivalent effects to standard doses of antiemetic antihistamines when given every 4 hours, and in 1741 tourists on whale safaris when given in two doses shortly before and after departure. In a separate RCT of 28 children (ages 4-8) prone to travel sickness, 0.25 g every 4 hours reduced symptoms of travel sickness more effectively, and with less side effects, than dimenhydrinate. Mixed results were found for postsurgical nausea following laparoscopic gynecologic procedures in four large double-blind RCTs; results were positive in two studies and negative in the other two. In the positive studies, 1 g of a ginger root product before surgery reduced the incidence of nausea as effectively as a standard dose of metoclopramide, and decreased the need for postoperative medications. In the other two studies, there

 

Adverse Effects:

Ginger has no known clinical adverse effects other then rare heartburn.

 

Side Effects and Interactions:

Drug interactions have not been studied or reported in humans. In a rat model, ginger did not interact with warfarin's activity on blood coagulation.

 

Cautions:

Although ginger has antiprostaglandin and antiplatelet effects in vitro, increased risk of bleeding has not been demonstrated with oral doses up to 4 g daily, and there have been case reports of bleeding. Because doses greater than 4 g/day may affect platelet function, it would be prudent to recommend lower doses for patients who are taking anticoagulant drugs or are otherwise at high bleeding risk. Despite its widespread use in foods, ingestion of ginger during pregnancy is controversial. Ginger extract and isolated ginger constituents have mutagenic and antimutagenic properties, depending on the in vitro experimental test. Embryotoxic effects have been described in pregnant rats. In the two controlled clinical trials of pregnant women (totaling 59 women who received ginger), there were no significant adverse effects detected on pregnancy outcome. Based on the experience of its wide-spread use in foods, it is unlikely that ginger has detrimental effects during pregnancy; nevertheless, it would be prudent to be cautious and to avoid higher doses (> 2 g daily).

 

DOSES OF GINGER:26,28

Pediatric:

Ginger should not be used by children under 2 years of age. Ginger may be used by children over 2 years of age to treat nausea, digestive cramping, and headaches. Adjust the recommended adult dose to account for the child's weight. Most herbal dosages for adults are calculated on the basis of a 150 lb (70 kg) adult. Therefore, if the child weighs 50 lb (20 - 25 kg), the appropriate dose of ginger for this child would be 1/3 of the adult dosage.

 

Adult:

In general, ginger intake should not exceed 4 grams daily (this includes the ginger obtained through diet such as from ginger ale, ginger snaps, and ginger bread). Usually, food sources contain no more than 0.5% ginger. Standardized dose: Take 75 - 2,000 mg in divided doses with food, standardized to contain 4% volatile oils or 5% total pungent compounds including 6-gingerol or 6-shogaol.For nausea, gas, or indigestion: 2 - 4 grams of fresh root daily (0.25 - 1.0 g of powdered root) or 1.5 - 3.0 mL (30 - 90 drops) liquid extract daily. To prevent vomiting, take 1 gram of powdered ginger (1/2 tsp) or its equivalent, every 4 hours as needed (not to exceed 4 doses daily), or 2 ginger capsules (1 gram), 3 times daily. You may also chew a 1/4 oz piece of fresh ginger when needed. For pregnancy-induced vomiting, use 250 mg 4 times daily. To relieve arthritis pain: Take fresh ginger juice, extract, or tea, 2 - 4 grams daily. Topical ginger oil may also be rubbed into a painful joint. Fresh ginger root may also be placed in a warm poultice or compress and apply to painful areas. For cold and flu symptoms, sore throat, headache and menstrual cramps: Steep 2 tbsp of freshly shredded ginger in hot water, 2 - 3 times daily. A drop of ginger oil or a few slices of fresh rhizome may also be placed in steaming water and inhaled.

Preparations and Doses:

Common preparations include powdered ginger capsules, liquid extracts, tinctures, and candies. The doses examined in various clinical trials range from 0.2 to 1 g of dried ginger root, usually administered in capsules, as a single dose or repeated every 4 hours or q.i.d. depending on the study, Doses recommended by herbal authorities are similar, usually 0.5-1 g two to four times a day, up to 4 g daily. Larger daily doses of up to 9 g of fresh or dried ginger are often used in traditional Chinese medicine. Substantial ginger content is found in highly spiced meals or strong ginger ales and teas.

 

Food Value of Ginger:

Ginger is available in two forms, fresh and dried Both the forms contain effective food value. As the taste of ginger is not very palatable, subtle means are adopted to use it in certain ways. It is put in vegetables. The dried ginger, which may be scraped or peeled before drying, constitute the spice, and is esteemed for its flavor, pungency, aroma and medicinal value.

 

Food Value

Minerals and Vitamins

Moisture - 80.9%

Calcium - 20 mg

Protein - 2.3%

Phosphorus - 60 mg

Fat - 0.9%

Iron - 2.6 mg

Vitamin C - 6 mg

Fibre - 2.4%

Small amount of Vitamin B Complex

Minerals - 1.2%

* Values per 100 gm's edible portion

Carbohydrates - 12.3%

Calorific Value - 67

 

Natural Benefits and Curative Properties of Ginger:

Ginger is being used as medicine in India from Vedic period and is called Mahaaushidhi, meaning the great medicine. Ancient physicians used ginger as a carminative and anti fermenting medicine. Galen, the Greek physician, used ginger as a medicine to rectify the defective humors of the body. He used ginger in the treatment of paralysis caused by phlegmatic imbalance in the body. Aviceena, another Greek physician used it as an aphrodisiac. Pomose, yet another Greek physician also used ginger in the treatment of gout centuries ago. Ginger is now widely used in local medicines in India and the far East. Taken internally, it is a stimulating carminative and locally it is used as a rubefacient and counter irritant. Like many other spices, ginger is believed to have aphrodisiac properties.


The ginger yields an essential oil, but this lacks the pungent principle, it is used in the manufacture of flavoring essence and in perfumery An oleoresin - i.e. mixture of oil and resin - is also extracted, in which the full pungency of the spice is preserved; it is used for flavoring and also for medicinal purposes.

 

Digestive System Disorders:-

Ginger is a valuable drug for disorders of the digestive system. It is extremely useful in dyspepsia, flatulence, colic, vomiting, spasms and other painful affections bf the stomach and the bowels. Chewing a piece of fresh ginger after meals regularly is an insurance against these ailments. This protective action is attributable to excessive secretion of saliva, distaste enzyme and volatile oil. 


Half a teaspoon of fresh ginger juice, mixed with one teaspoonful of each of fresh lime juice and fresh mint juice and a tablespoonful of honey, constitutes an effective medicine for dyspepsia, nausea and vomiting due. To biliousness, indigestion caused by intake of heavy non-vegetarian and fried fatty food, morning sickness, jaundice and piles. This mixture should be sucked thrice daily in the treatment of these conditions.

 

Cough and Cold :-

Ginger is an excellent remedy for coughs and colds. Extracted juice of ginger with honey should be taken three or four times a day in case of coughs. In case of colds, ginger should be cut into small pieces and boiled in a cup of water. It should then' be strained and half a teaspoon of sugar added to it should be drunk while hot. Ginger tea, prepared by adding few pieces of ginger into boiled water before adding tea leaves, is also an effective remedy for colds and for fevers resulting from cold

 

Respiratory Disorders:-

A teaspoonful of the fresh ginger juice mixed with a cupful of fenugreek decoction and honey to taste is an excellent diaphoratic mixture which increases sweating to reduce fever in influenza. It acts as an expectorant in bronchitis, asthma, whooping cough and tuberculosis of the lungs.

 

Aches and Pains :-

Ginger is an excellent pain killer. It can cure all types of pain. In headache, ginger ointment made by rubbing dry ginger with a little water and applied to the forehead affords relief. It allays tooth ache when applied to the face. In case of earache, a few drops of ginger juice will give relief.

 

Sexual Debility:-

Ginger juice is a valuable aphrodisiac. It is highly beneficial in the treatment of sexual weakness For better results, half a teaspoon of ginger juice should be taken with a half-boiled egg and honey, once, daily at night for a month. It tones up the sex centers and cures impotency, premature ejaculation, spermatorrhoea.

 

Menstrual Disorders:-

Ginger is also useful in menstrual disorders. A piece of fresh ginger should be pounded and boiled in a, cupful of water for few minutes. The infusion sweetened with sugar should be taken thrice daily after meals as a medicine for dysmenorrhoea, and amenorrhea due to exposure to cold winds and taking cold bath

 

Medicinal Value of Ginger:

Traditional medicinal uses of ginger root included its use in treating cold, cough, digestive disorders, menstrual cramps, etc. This herb is believed to have aphrodisiac powers, and is mentioned in 'Kama Sutra'. Ginger is used to relieve motion sickness and morning sickness. It has anti-inflammatory properties and is used to relieve pain and reduce inflammation associated with arthritis, rheumatism and muscle cramps. Ginger is also used to expel the phlegm accumulated in the lungs and so, is found to be effective in treating respiratory diseases, like, asthma and bronchitis. It can stimulate blood circulation and is also useful in removing toxins from the body. This herb has blood thinning and cholesterol lowering properties, which are beneficial for lowering the risk of heart disease. Ginger root health benefits is believed to be due to its active components, like, gingerols, zingibain, bisabolenel, oleoresins, starch, mucilage and essential oil (zingiberene, zingiberole, camphene, cineol, borneol). 

 

Ginger Root Side Effects:

Most of us are familiar with the health benefits of ginger root and its culinary uses. However, like any other herb, high doses or overuse of ginger may result in some side effects. The following are some of the ginger root side effects.

Ø  The most common side effects of ginger root includes, heartburn, diarrhea and irritation of the mouth.

Ø  In some people, prolonged use of ginger root may lead to dry and scaly rashes, which develop on the face and may move downward with time.

Ø  Another ginger root side effect, associated with its long term use is visual sensitivity to bright light.

Ø  Ginger root consumption is not recommended for people with gallstones, as this herb increases bile production. The same applies to those, who are taking blood thinning medications or is preparing for surgery.

Ø  Ginger should be avoided by people with bleeding disorders, ulcers and inflammatory bowel diseases.

Ø  It has also been noticed that some people with allergies, develop ginger root side effects, like rashes. In some rare cases, eye irritation and pink eye has also been associated with consumption of ginger.

Ø  There are also reports that suggest that ginger may also affect the blood pressure and heart rhythms.

 

There are very few reports of ginger root side effects in people, who take low doses of this herb. Most of the reported cases are either associated with intake of ginger powder as compared to fresh form, prolonged use of ginger root or its overuse. It may also interact with other drugs, herbs or supplements and create complications. Hence, it is very important to seek the opinion of your doctor before using this herb for medicinal purposes. It is also advisable to undergo a herbal treatment under the supervision of a qualified herbal practitioner.

 

CONCLUSION:

Ginger serves as a powerful natural anti-inflammatory and stimulates improved blood circulation. One modern study of patients with rheumatoid arthritis, osteoarthritis and muscular discomfort found taking powdered ginger relieved pain in over 75% of rheumatoid arthritis sufferers and all patients with muscular discomfort benefitted. Pointing to the safety of the medicinal use of ginger compared to steroids and nonsteroidal anti-inflammatory drugs, not one patient reported a single adverse side effect by the end of the three year study. Ginger is frequently served with sushi to combat parasites as well as offer a complementary dish. The chemical zingibain found in ginger dissolves many parasites and their eggs, including the anisa kid worm sometimes found in raw fish. Ginger tea has also been found helpful in the treatment of the parasitic disease schistosomiasis contracted by visitors to some lesser developed tropical areas. The ginger compound shagaol kills cold viruses at a concentration found in ordinary raw ginger making ginger an effective cold remedy. Ginger’s pain relieving properties bring relief to flu and strep throat sufferers. As a diaphoretic, ginger even induces sweating to help the body remove toxins and reduce mucous congestion. Ginger has other uses including relieving arthritis pain, ulcerative colitis, menstrual discomfort, headaches, fevers from flu and colds, and sore throats. Gastrointestinal problems including heartburn and gas can also be treated with ginger. The muscles of the gastrointestinal tract can be strengthened by the use of garlic. Ginger is also used to treat arthritis, both rheumatoid and osteoarthritis.

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Received on 05.12.2009

Accepted on 12.03.2010   

© A&V Publication all right reserved

Research Journal of Pharmacognosy  and Phytochemistry. 2(2): March -April 2010, 102-110