Dheepa Anand, Chandrasekar R, Sivagami B
Dheepa Anand1*, Chandrasekar R2, Sivagami B3
2Department of Pharmacology, Cherans College of Pharmacy, Coimbatore, Tamilnadu, India.
1Associate Professor, Department of Pharmacognosy, Seven Hills College of Pharmacy, Tirupati, Chitoor, Andhrapradesh, India.
3Associate Professor, Department of Pharmaceutical Analysis, Seven Hills College of Pharmacy, Tirupati.
Volume - 13,
Issue - 2,
Year - 2021
New drugs are introduced in the market every year and new diseases are emerging every year and there is no cure for existing diseases. Though new drugs are being approved by the FDA every year, controlling emerging infections is a global concern. Due to increased side effects and toxicity the modern world is turning towards herbal medicine. Due to few reasons like global warming, food habits and modern life style disease like Urolithiasis places a significant economic burden on the healthcare system, especially in developed and developing countries where, owing to changes in food habits and lifestyle, the prevalence of stone disease has significantly increased over the last few decades; unfortunately, it will probably continue to increase for a number of reasons. Despite considerable improvements in the development of new herbal therapies for the management of urinary stones, the incidence of urolithiasis is increasing worldwide. However, it is evident that crystal retention, cell apoptosis, renal cell injury, and associated stone promoters or inhibitors play important roles for kidney stone formation. In addition, the identification of novel phytoconstituents on the basis of molecular and cellular alterations in relation to stone formation will help develop better herbal remedies. Moreover, better understanding of the mechanisms of urolithiasis associated with stone inhibitors or promoters will be critical for stone-removing medications. This review encompasses different medicinal plants, polyherbal formulations and phytoconstituents used in the treatment of Kidney stones. More interdisciplinary research is needed to develop new plant-derived high-quality natural products to treat and prevent the formation of kidney stones.
Cite this article:
Dheepa Anand, Chandrasekar R, Sivagami B. A Critical Review on Antiurolithiatic Activity of Bioactive Phytoconstituents. Research Journal of Pharmacognosy and Phytochemistry. 2021; 13(2):95-0. doi: 10.52711/0975-4385.2021.00015
Dheepa Anand, Chandrasekar R, Sivagami B. A Critical Review on Antiurolithiatic Activity of Bioactive Phytoconstituents. Research Journal of Pharmacognosy and Phytochemistry. 2021; 13(2):95-0. doi: 10.52711/0975-4385.2021.00015 Available on: http://rjpponline.org/AbstractView.aspx?PID=2021-13-2-6
1. Romero V, Akpinar H and Assimos D G, Kidney stones: A global picture of prevalence, incidence, and associated risk factors, Rev Urol, 2010, 12(2-3), e86–e96.
2. Ghodasara J, Pawar A, Deshmukh C and Kuchekar B, Inhibitory effect of rutin and curcumin on experimentally-induced calcium oxalate urolithiasis in rats, Pharmacogn Res, 2010, 2(6): 388–392.
3. Cloutier J, Villa L, Traxer O and Daudon M, Kidney stone analysis: "Give me your stone, I will tell you who you are!", World J Urol, 2015, 33(2): 157–169.
4. Chaudhary A, Singla S K and Tandon C, In vitro evaluation of terminalia arjuna on calcium phosphate and calcium oxalate crystallization, Indian J Pharm Sci, 2010, 72(3): 340–345.
5. Parmar MS, Kidney stones, BMJ, 2004, 328(7453): 1420–1424.
6. Alelign T and Petros B, Kidney stone disease: An update on current concepts, Adv Urol, 2018, 2018, 1-12.
7. Trinchieri A, Epidemiology of urolithiasis: An update, Clin Cases Miner Bone Metab, 2008, 5(2):101–106.
8. Ziemba J B and Matlaga B R, Epidemiology and economics of nephrolithiasis, Investig Clin Urol, 2017, 58(5): 299–306.
9. Edenberg H J, The genetics of alcohol metabolism: Role of alcohol dehydrogenase and aldehyde dehydrogenase variants, Alcohol Res Health, 2007, 30(1): 5–13.
10. WHO, Quality control methods for medicinal plant materials, 1992, World Health Organization, Geneva.
11. Butterweck V, Khan SR. Herbal medicines in the management of urolithiasis: alternative or complementary? Planta Med. 2009; 75(10):1095-1103.
12. Alelign T, Petros B. Kidney Stone Disease: An Update on Current Concepts. Adv Urol. 2018; 2018:3068365.
13. Chandrasekar. R, Sivagami. B, M. Niranjan Babu. A Pharmacoeconomic Focus on Medicinal Plants with Anticancer Activity. Res. J. Pharmacognosy and Phytochem. 2018; 10(1): 91-100.
14. Jagannath N, Chikkannasetty SS, Govindadas D, Devasankaraiah G. Study of antiurolithiatic activity of Asparagus racemosus on albino rats. Indian J Pharmacol. 2012; 44(5):576-579.
15. Vyas N, Argal A. Antiurolithiatic Activity of Extract and Oleanolic Acid Isolated from the Roots of Lantana camara on Zinc Disc Implantation Induced Urolithiasis. ISRN Pharmacol. 2013 15; 2013:951795.
16. R. Srikaran, S. Salika dulanjali Evaluation of in vitro anti-urolithiatic activity of methanolic extract of cucumis melo seeds on calcium oxalate crystals. Int J Curr Pharm Res, 2014;11 (1): 18-20
17. Dinnimath BM, Jalalpure SS, Patil UK. Antiurolithiatic activity of natural constituents isolated from Aerva lanata. J Ayurveda Integr Med. 2017; 8(4):226-232.
18. Meiouet F, El Kabbaj S, Daudon M. Étude In vitro study of the litholytic effects of herbal extracts on cystine urinary calculi. Prog Urol. 2011; 21(1):40-7.
19. L.Yach S. Benni Z. Alia A. Cheik M.O.B. Idriss M. Draou M. Bouati In vitro litholytic activity of some medicinal plants on urinary stones African Journal of Urology 2018; 24 (3):197-201
20. Ashok P, Koti BC, Vishwanathswamy AH. Antiurolithiatic and antioxidant activity of Mimusops elengi on ethylene glycol-induced urolithiasis in rats. Indian J Pharmacol. 2010; 42(6):380-383.
21. Sharma I, Khan W, Parveen R, Alam MJ, Ahmad I, Ansari MH, Ahmad S. Antiurolithiasis Activity of Bioactivity Guided Fraction of Bergenia ligulata against Ethylene Glycol Induced Renal Calculi in Rat. Biomed Res Int. 2017; 2017:1969525.
22. Ilhan M, Ergene B, Süntar I, Ozbilgin S, Saltan Çitoğlu G, Demirel MA, Keleş H, Altun L, Küpeli Akkol E. Preclinical Evaluation of Antiurolithiatic Activity of Viburnum opulus L. on Sodium Oxalate-Induced Urolithiasis Rat Model. Evid Based Complement Alternat Med. 2014; 2014:578103.
23. Niharika. M, Suchitha. N, Akhila. S, Himabindhu. J, Dr. Ramanjaneyulu. K. Evaluation of in vitro Antiurolithiatic Activity of Gossypium Herbaceum J. Pharm. Sci. and Res. 2018; 10(5):1236-1237
24. Senthil Rajan Dharmalingam, Rajkumar Madhappan, Kumarappan Chidambaram, Srinivasan Ramamurthy, Krishna Gopal, P Swetha and KL Senthil Kumar Anti-Urolithiatic Activity of Melia Azedarach Linn Leaf Extract in Ethylene Glycol-Induced Urolithiasis in Male Albino Rats Tropical Journal of Pharmaceutical Research 2014; 13 (3): 391-397
25. Abu Zarin, M., Tan, J.S., Murugan, P. et al. Investigation of potential anti-urolithiatic activity from different types of Musa pseudo-stem extracts in inhibition of calcium oxalate crystallization. BMC Complement Med Ther 2020; 20, 317.
26. Pawar AT, Vyawahare NS. Anti-urolithiatic activity of standardized extract of Biophytum sensitivum against zinc disc implantation induced urolithiasis in rats. J Adv Pharm Technol Res. 2015; 6(4):176-182.
27. Kaleeswaran B, Ramadevi S, Murugesan R, Srigopalram S, Suman T, Balasubramanian T. Evaluation of anti-urolithiatic potential of ethyl acetate extract of Pedalium murex L. on struvite crystal (kidney stone). J Tradit Complement Med. 2018; 9(1):24-37.
28. Araújo Viel T, Diogo Domingos C, da Silva Monteiro AP, Riggio Lima-Landman MT, Lapa AJ, Souccar C. Evaluation of the antiurolithiatic activity of the extract of Costus spiralis Roscoe in rats. J Ethnopharmacol. 1999; 66(2):193-8.
29. Das M, Malipeddi H. Antiurolithiatic activity of ethanol leaf extract of Ipomoea eriocarpa against ethylene glycol-induced urolithiasis in male Wistar rats. Indian J Pharmacol. 2016; 48(3):270-4.
30. Niharika M., Harshitha V., Ashwini P., Srivinya B., Himabindhu J., Ramanjaneyulu k. Evaluation of in vitro antiurolithiatic activity of chloris barbata Int J Curr Pharm Res, 2018; 10(3): 65-67.
31. Biren N. Shah, Khodidas D. Raiyani and D. C. Modi Antiurolithiatic Activity Studies of Momordica charantia Linn. Fruits International Journal of Pharmacy Research and Technology 2011; 1 (1): 06-11.
32. Vyas B, Vyas R, Joshi S, Santani D. Antiurolithiatic Activity of Whole-Plant Hydroalcoholic Extract of Pergularia daemia in Rats. J Young Pharm. 2011; 3(1):36-40.
33. Das M, Malipeddi H. Antiurolithiatic activity of ethanol leaf extract of Ipomoea eriocarpa against ethylene glycol-induced urolithiasis in male Wistar rats. Indian J Pharmacol. 2016; 48(3):270-274.
34. Sweta Bawari, Archana Negi Sah, Devesh Tewari Antiurolithiatic Activity of Daucus carota: An in vitro Study Pharmacogn J. 2018; 10(5):880-884
35. Mosquera DMG, Ortega YH, Quero PC, Martínez RS, Pieters L. Antiurolithiatic activity of Boldoa purpurascens aqueous extract: An in vitro and in vivo study. J Ethnopharmacol. 2020; 10; 253:112691.
36. Patel VB, Acharya N. Effect of Macrotyloma uniflorum in ethylene glycol induced urolithiasis in rats. Heliyon. 2020; 6(6):e04253.
37. Chandrasekar R Jayanth P C and Niranjan Babu M Protective effect of ethanolic leaf extract of Alphonsea sclerocarpa against ethylene glycol induced urolithiasis in rats Indian Journal of Natural Products and Resources 2019; 10(4): 252-258
38. Sree Lakshmi Namburu, Sujatha Dodoala, Bharathi Koganti, K. V. S. R. G. Prasad Antiurolithiatic activity of Phaseolus vulgaris seeds against ethylene glycol-induced renal calculi in Wistar rats International Journal of Green Pharmacy 2017; 11 (4): 281
39. Khan A, Khan SR, Gilani AH. Studies on the in vitro and in vivo antiurolithic activity of Holarrhena antidysenterica. Urol Res. 2012; 40(6):671-681.
40. Kaushik, J., Tandon, S., Bhardwaj, R. et al. Delving into the Antiurolithiatic Potential of Tribulus terrestris Extract Through –In Vivo Efficacy and Preclinical Safety Investigations in Wistar Rats. Sci Rep 2019; 9, 15969.
41. Korah MC, Rahman J, Rajeswari R, et al. Evaluation of diuretic efficacy and antiurolithiatic potential of ethanolic leaf extract of Annona squamosa Linn. in experimental animal models. Indian J Pharmacol. 2020; 52(3):196-202.
42. Velu, V., Das, M., Raj N, A. et al. Evaluation of in vitro and in vivo anti-urolithiatic activity of silver nanoparticles containing aqueous leaf extract of Tragia involucrata. Drug Deliv. and Transl. Res. 2017; 7, 439–449.
43. R. Naga kishore, T. Mangilal, N. Anjaneyulu, G. Abhinayani and N. Sravya Investigation of anti-urolithiatic activity of brassica oleracea gongylodes and desmostachya bipinnata in experimentally induced urolithiasis in animal models Int J Pharm Pharm Sci, 2014; 6 (6) 602-604
44. Youn SH, Kwon JH, Yin J, Tam LT, Ahn HS, Myung SC, Lee MW. Anti-Inflammatory and Anti-Urolithiasis Effects of Polyphenolic Compounds from Quercus gilva Blume. Molecules. 2017; 5; 22(7):1121.
45. Khan, A., Bashir, S., Khan, S.R. et al. Antiurolithic activity of Origanum vulgare is mediated through multiple pathways. BMC Complement Altern Med 2011; 11, 96.
46. Jarald EE, Kushwah P, Edwin S, Asghar S, Patni SA. Effect of Unex on ethylene glycol-induced urolithiasis in rats. Indian J Pharmacol. 2011; 43(4):466-468.
47. Makasana A, Ranpariya V, Desai D, Mendpara J, Parekh V. Evaluation for the anti-urolithiatic activity of Launaea procumbens against ethylene glycol-induced renal calculi in rats. Toxicol Rep. 2014; 1:46-52.
48. Touhami, M., Laroubi, A., Elhabazi, K. et al. Lemon juice has protective activity in a rat urolithiasis model. BMC Urol 2007; 7, 18.
49. Wang, Rulin et al. “Antiurolithiatic effect of Fucoxanthin on Ethylene Glycol-induced Renal Calculus in Experimental Rats.” Journal of King Saud University - Science 32 (2020): 1896-1901.
50. Shah JG, Patel BG, Patel SB, Patel RK. Antiurolithiatic and antioxidant activity of Hordeum vulgare seeds on ethylene glycol-induced urolithiasis in rats. Indian J Pharmacol. 2012; 44(6):672-677.
51. Patel VB, Acharya N. Effect of Macrotyloma uniflorum in ethylene glycol induced urolithiasis in rats. Heliyon. 2020;6(6): e04253.
52. Olayeriju, O.S., Crown, O.O., Elekofehinti, O.O. et al. Effect of moonseed vine (Triclisia gilletii Staner) on ethane-1,2-diol-induced urolithiasis and its renotoxicity in Wistar albino rats. Afr J Urol 2020; 26, 4.
53. Yenduri Suvarna, S K. Abdul Rahaman. In Vitro – In Vivo Evaluation of Antiurolithiatic activity of piperine from Piper nigrum. Research J. Pharm. and Tech. 2020; 13(1):63-68.
54. Salama AA, El-Kassaby MI, Hassan A. Anti-urolithiatic activity of Solanum nigrum hydroalcoholic extract in ethylene glycol-induced urolithiasis in rats. Egypt Pharmaceut J 2019; 18:311-9.
55. Spandana. K, Shivani. M, Himabindhu. J, Ramanjaneyulu. K. Evaluation of In Vitro Antiurolithiatic Activity of Vigna radiata. Research J. Pharm. and Tech 2018; 11(12): 5455-5457.
56. Neeraja Kamakshi. U, Ganga Rao. B, Venkateswara Rao. B. Comparison of In vitro Antiurolithiatic Activity of Aerva lanata, Sphaeranthus indicus, Merremia emarginata. Research J. Pharm. and Tech. 2017; 10(6): 1653-1656.
57. Kushagra D, Rajiv S, Ruchi G, Neelesh M. In-Vitro Evaluation of Anti-Urolithic Activity of Leaves Extract of Costus igneus. Research J. Pharm. and Tech 2020; 13(3):1289-1292.
58. Sathish Babu. P, Gokula Krishnan, Anand Babu.K, Chitra. K. In silico and In vitro Evaluation of Anti-urolithiatic Activity of Ethanolic Extract of Syzygium cumini Stem Bark. Research J. Pharm. and Tech. 2017; 10(5): 1317-1321.
59. Anshuman Rai, Anamika Gautam, Sakshi Panchal, Ankita Sood, Pankaj Prashar, Narendra Kumar Pandey, Indu Melkani, Bimlesh Kumar. Protective effect of Ethanolic extract of Terminalia arjuna bark against Ethylene Glycol induced Urolithiasis in male rats: In-Vitro and In-Vivo Evaluation. Research J. Pharm. and Tech. 2020; 13(12):6132-6139.
60. Lulat SI, Yadav YC, Balaraman R, Maheshwari R. Antiurolithiatic effect of lithocare against ethylene glycol-induced urolithiasis in Wistar rats. Indian J Pharmacol. 2016; 48(1):78-82.
61. Gupta SK, Baghel MS, Bhuyan C, Ravishankar B, Ashok BK, Patil PD. Evaluation of anti-urolithiatic activity of Pashanabhedadi Ghrita against experimentally induced renal calculi in rats. Ayu. 2012; 33(3):429-434.
62. Kumar Bagepalli Srinivasa A, Kuruba L, Khan S, Saran GS. Antiurolithiatic activity of gokhsuradi churan, an ayurvedic formulation by in vitro method. Adv Pharm Bull. 2013; 3(2):477-9.
63. A. L. Shirfule, C. N. Khobragade, P. Badrinarayan, Y. S. Borse and R. H. Amilkanthwar Phytochemical Analysis and Antiurolithiatic Activity of a Polyherbal Formulation, Journal of Herbs, Spices and Medicinal Plants, 2009; 15:1, 66-72,
64. D G Baheti and S S Kadam; Antiurolithiatic activity of a polyherbal formulation against calcium oxalate induced urolithiasis in rats; J. Adv. Pharm. Edu. and Res. 2013: 3(1): 61-71
65. Shirfule AL, Racharla V, Qadri SS, Khandare AL. Exploring antiurolithic effects of gokshuradi polyherbal ayurvedic formulation in ethylene-glycol-induced urolithic rats. Evid Based Complement Alternat Med. 2013; 2013:763720.
66. Vasanthi AHR, Muthulakshmi V, Gayathri V, Manikandan R, Ananthi S, Kuruvilla S. Antiurolithiatic Effect of Sirupeelai Samoola Kudineer: A Polyherbal Siddha Decoction on Ethylene Glycol-induced Renal Calculus in Experimental Rats. Pharmacogn Mag. 2017; 13(Suppl 2): S273-S279.
67. Albayrak A, Bayir Y, Halici Z, Karakus E, Oral A, Keles MS, Colak S, Zipak T, Dorman E, Uludag K, Yayla N, Gulcan E. The biochemical and histopathological investigation of amlodipine in ethylene glycol-induced urolithiasis rat model. Ren Fail. 2013; 35(1):126-31.
68. Pradnya N. Jagtap, Bhagyashri R. Vyapari, Yashashri H. Nimbalkar, Sitaram V. Kale, Ganesh B. Nigade. Evaluation of Antiurolithiatic activity of Polyherbal formulation (Lithout Tablets) by In-vitro inhibition of Calcium Oxalate Crystallization. Research J. Pharm. and Tech. 2019; 12(11): 5477-5478.