Now a day’s pulmonary drug delivery remains the preferred route for administration of various drugs. Pulmonary drug delivery is currently the focus of accelerated research and development because of the potential to produce maximum therapeutic benefit to patients by directly targeting drug to the site of pathology in the lungs. These routes of drug delivery may give the advantages like a small amount of drug, less adverse reaction and rapid onset of action. Drug delivery by the pulmonary route has evolved to be one of the most widely used systemic or local drug delivery approach. Recent progress within biotechnology has generated a group of novel protein and peptide drugs to which administration to the respiratory tract, to obtain systemic delivery seems advantageous compared to e.g. parenteral or gastrointestinal administration (tablets, capsules etc.). A successful pulmonary administration requires a harmonic interaction between the drug formulation, the inhaler device, and the patient. The delivery device plays a major role in the efficiency of pulmonary delivery, and great strides have been made in the development of new devices in recent years. The devices most commonly used for respiratory delivery, including nebulizers, metered-dose inhalers, and dry powder inhalers. the choice of device will depend on the drug, the formulation, the site of action, and the pathophysiology of the lungs. Pulmonary drug delivery system has been widely used in various diseases conditions like asthma, COPD, angina pectoris, diabetes, cancer, migraine, tuberculosis, acute lung injury and other.
Cite this article:
Patidar S., Mandloi R., Pillai S., Birla N.. A Review on Pulmonary Drug Delivery System. Res. J. Pharmacognosy and Phytochem. 2021; 13(1):44-50. doi: 10.5958/0975-4385.2021.00008.X
Patidar S., Mandloi R., Pillai S., Birla N.. A Review on Pulmonary Drug Delivery System. Res. J. Pharmacognosy and Phytochem. 2021; 13(1):44-50. doi: 10.5958/0975-4385.2021.00008.X Available on: http://rjpponline.org/AbstractView.aspx?PID=2021-13-1-8
1. Bhavna, Sharma Deepika and Goyal Kartik “Recent Approaches for Novel Treatment for Pulmonary Diseases” J Pul & Res Sci 2018; 2(4): 001-0010.
2. Singh anupama, Malviya Rishabha, Sharma promod k. “pulmonary drug delivery system: A Novel approach for drug delivery” Current Drug Therapy 2011; 6(2): 137-144.
3. Shaikh Siraj, Najim sayyed, khan Tarique, shaikh afsar, zameeruddin Mohhamad., Quazi AAMER “Recent Advancement in Pulmonary drug delivery System” Int J Appl Pharm 2010; 2(4): 2728.
4. R. Sunitha, K. Surla Prabha and P. Muthu Prasanna “Drug Delivery and Its Developments for Pulmonary System” International Journal of Pharmaceutical, Chemical and Biological Sciences 2011; 1(1): 66-82.
5. Nagoba Shivappa N, Mandurke Arjun D., Bhalekar Rohini V., Ningule Ganesh M “A Review on Pulmonary Drug Delivery System” international journal of pharmacy and pharmaceutical research 2018; 12(4): 440-448.
6. Gangurde H.H., Chordiya M.A., Baste N.S., Tamizharasi S., Upasani C.D. “Approaches and Devices Used in Pulmonary Drug Delivery System: A Review” Asian Journal of Pharmaceutical Research 2012; 4(1): 11-27.
7. K. Dhanya, Dr. Raghavann C. Vijaya, Varghese Vijesh “Pulmonary Drug Delivery Systems – Past and Present Approaches” Journal of Pharmacy Research 2012; 5(10) :5069-5073.
8. Karhale Ashish A, Chaudhari Hiralal S, Ughade Prajkta L, Baviskar Dheeraj T, Jain Dinesh K., “Pulmonary Drug Delivery System”, Int.J. PharmTech Res. 2012; 4(1): 294-297.
9. V.Ravichandiran, K. Masilamani, S. Satheshkumar, D. Joseprakash “DRUG DELIVERY TO THE LUNGS” International Journal of Pharmaceutical Sciences Review and Research 2011; 10(2): 85-86.
10. Pandey Shivanand, Patel Binal, D, Viral, Jivani. N. P “Large, Porous Inhaled Particles: A Potential Approach to Pulmonary Drug Delivery” Journal of Pharmacy Research 2009; 2(7): 1178-1179.
11. P. Anusha, M.C. Vivek, Nethaji Ramalingam, K.R. Vimal “Pulmonary Nano-Drug Delivery Systems for Lung Cancer” Ijppr.Human 2020; 18(4): 728-729.
12. Leja Katarzyna, Lewandowicz Grażyna “Polymers Biodegradation and Biodegradable Polymers – a Review” Polish J. of Environ. Stud. 2010; 19(2): 255-256.
13. Chow Albert H. L., Tong Henry H. Y., Chattopadhyay Pratibhash, Shekunov Boris Y. “Particle Engineering for Pulmonary Drug Delivery” Pharmaceutical Research 2007;24(3): 418-419.
14. Rahimpour Yahya, Hamishehkar Hamed “Lactose Engineering for Better Performance in Dry Powder Inhalers” Advanced Pharmaceutical Bulletin 2012 ;2(2): 183-184.
15. Shende Rajeshri Bhimraj, Dr. Patel Vipul “A Review: General Concept About the Metered Dose Inhaler” JETIR 2020; 7(4): 2131-2132.
16. Deshkar Sanjeevani Shekhar, Vas Alisha Swizal “Recent updates on dry powder for inhalation for pulmonary drug Delivery systems” Int. J. Res. Pharm. Sci. 2019; 10(4):29 47-2948.
17. Sahane SP., Nikhar AK., Bhaskaran S., DR. Mundhada “Dry Powder Inhaler: An Advance Technique for Pulmonary Drug Delivery System” International Journal of Pharmaceutical and Chemical Sciences 2012; 1(3): 1028-1029.
18. Sahiti K. Guna, Prasad Shivani “Nebulizers: A Review Paper” International Journal of Advanced Research in Computer Science 2017; 8(5): 1697-1699.
19. Arı Arzu “Jet, Ultrasonic, and Mesh Nebulizers: An Evaluation of Nebulizers for Better Clinical Outcome” Eurasian J Pulmonol 2014 ;16 :1-2.
20. Chandel Akshay, Goyal Amit K., Ghosh Goutam, Rath Goutam “Recent advances in aerosolised drug delivery” Biomedicine and Pharmacotherapy 2019;112:7-8.
21. Vecellio L. “The mesh nebuliser: A recent technical innovation for Aerosol delivery” Breathe 2006; 2(3): 255-257.
22. Shaikh Siraj, Nazim Syed, Shaikh Afsar, Khan Tarique, Zameeruddin Md., Majaz Quazi, Chalikwar Shailesh “Recent Trends in Applications of Pulmonary Drug Delivery: A Review” International Journal of Pharma Research and Development 2011; 2(12):172-178.
23. Yıldız-Peköz Ayca, Ehrhardt Carsten “Advances in Pulmonary Drug Delivery” Pharmaceutics 2020; 12(10): 911.