Nem Kumar Jain, Rituparna Roy, Hero Khan Pathan, Aditi Sharma, Shakhi Ghosh, Santosh Kumar
Nem Kumar Jain1*, Rituparna Roy1, Hero Khan Pathan1, Aditi Sharma1, Shakhi Ghosh1, Santosh Kumar2
1School of Pharmacy, ITM University, Gwalior, MP, India.
2Department of Life Sciences, ITM University, Gwalior, MP, India.
Volume - 12,
Issue - 3,
Year - 2020
Mouth ulcers often cause pain and irritation of the sores by salty, spicy and sour food items and may cause discomfort while healing occurs due to the use of chemical formulations. This project focuses on the preparation of a herbal mouth ulcer healing gel because of better cultural acceptability, better compatibility with human body and lesser side effects. The gel was prepared by using alcoholic extract of Psidium guajava, and betel leaves and aqueous extract of liquorice. Developed formulations were transparent, homogeneous and pH ranges from 6.8-7. Formulation showed acceptable rheological behaviour with applicable Spreadability and Extrudability properties. Anti-fungal studies of formulations showed excellent efficacy against Aspargilious aureus, Candida albicans. Therefore, developed formulations have potential to treat mouth ulcers. However, further clinical studies are required to establish clinical efficacy of prepared herbal gels.
Cite this article:
Nem Kumar Jain, Rituparna Roy, Hero Khan Pathan, Aditi Sharma, Shakhi Ghosh, Santosh Kumar. Formulation and Evaluation of Polyherbal Aqueous Gel from Psidium guajava, Piper betel and Glycerrhiza glabra Extract for Mouth Ulcer Treatment. Res. J. Pharmacognosy and Phytochem. 2020; 12(3):145-148. doi: 10.5958/0975-4385.2020.00024.2
Nem Kumar Jain, Rituparna Roy, Hero Khan Pathan, Aditi Sharma, Shakhi Ghosh, Santosh Kumar. Formulation and Evaluation of Polyherbal Aqueous Gel from Psidium guajava, Piper betel and Glycerrhiza glabra Extract for Mouth Ulcer Treatment. Res. J. Pharmacognosy and Phytochem. 2020; 12(3):145-148. doi: 10.5958/0975-4385.2020.00024.2 Available on: http://rjpponline.org/AbstractView.aspx?PID=2020-12-3-4
1. Rad F, Yaghmaee R, Mehdi Abadi P, Khatibi R. A comparative clinical trial of topical triamcinolone (adcortyle) and a herbal solution for the treatment of minor aphthous stomatitis. Armaghane-danesh 2010;15(3):191-8.
2. Aslani A, Zolfaghari B, Davoodvandi F. Design, Formulation and Evaluation of an Oral Gel from Punica Granatum Flower Extract for the Treatment of Recurrent Aphthous Stomatitis. Adv Pharm Bull. 2016;6(3):391–398.
3. Shaikh S, Shete A, Doijad R; Formulation and Evaluation Pharmaceutical aqueous gel of powdered Guava Leaves for Mouth Ulcer Treatment; Pharma Tutor; 2018; 6(4); 32-38; http:// dx.doi.org/10.29161/PT. v6.i4.2018.32
4. Rezvaninejad R, Navabi N, Khoshroo MR, Torabi N, Atai Z. Herbal Medicine in Treatment of Recurrent Aphthous Stomatitis: A Literature Review. J Islam Dent Assoc Iran. 2017; 29(3):127-134. DOI: 10.30699/jidai.29.3.127 (Review)
5. Jain NK, Jha V, Shrivastava N, Sihare V, Jain A. An Experimental Evaluation of Ipomoea Carnea Leaves Extract as Anti-Furuncle Modality: A Preliminary Study. Indo Am J pharm. 2017; 7(08):656-660.
6. Khayrollah and Zyoud. Formulation and Clinical Effect Study of Rue Extract as Mouth Paste in The Treatment-of Mouth Ulcers. Arab J Pharm Sci. 2004;2(8).
7. Thombre, K. P.; Sharma, D. and Lanjewar, A. M. (2018). Formulation and evaluation pharmaceutical aqueous gel of powdered Cordia dichotoma leaves with guava leaves. Am. J. Pharmatech. Res., 8:268-277.
8. Sengupta R and Banik JK: A review on betel leaf (pan). Int J Pharm Sci Res 2013; 4(12): 4519-24.
9. Messier C, Epifano F, Genovese S, Grenier D. Licorice and its potential beneficial effects in common oro-dental diseases. Oral Dis. 2012 Jan;18(1):32-9. doi: 10.1111/j.1601-0825.2011.01842.x. Epub 2011 Aug 18.
10. Martin MD, Sherman J, van der Ven P, Burgess J. A controlled trial of a dissolving oral patch concerning glycyrrhiza (licorice) herbal extract for the treatment of aphthous ulcers. Gen Dent. 2008 Mar-Apr;56(2):206-10; quiz 211-2, 224.
11. Das SK, Das V, Gulati AK, Singh VP. Deglycyrrhizinated liquorice in aphthous ulcers. J Assoc Physicians India. 1989 Oct;37(10):647. PMID: 2632514.
12. Jadhav ST. Formulation and Evaluation Pharmaceutical Aqueous Gel of Powdered Guava, Aloe Vera and Acacia Leaves for Treatment of Mouth Ulcer.
Int J Sci Res. 2019; 8(5): 1693-1697.
13. Pirbalouti AG, Koohpayeh A, Karimi I. The wound healing activity of flower extracts of punica granatum and achillea kellalensis in wistar rats. Acta Pol Pharm 2010;67(1):107-10.