Volume No. :   11

Issue No. :  4

Year :  2019

ISSN Print :  0975-2331

ISSN Online :  0975-4385


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Investigation of In vitro Anti-cancer property of Adhatoda vasica in Hela, HepG2, MCF-7, MDAMB-231 Cell Lines



Address:   Sankaradoss Nirmala*1, P Nadana Sabapathi2, M Sudhakar1, Naveen Bathula3, Y Sravanthi1
1Department of Pharmacognosy, Malla Reddy College of Pharmacy (Affiliated OU), Hyderabad - 500014, Telangana, India.
2Aizant Drug Research Solutions, Hyderabad - 500100, Telangana, India
3School of Pharmaceutical Sciences, VISTAS, Chennai.
*Corresponding Author
DOI No: 10.5958/0975-4385.2019.00036.0

ABSTRACT:
The anticancer-cytotoxic activities of ethanolic extract of Adhatoda vasica were tested under in-vitro conditions in different cancer cell lines like MCF-7, MDAMB-231, Hela, HepG2 cell lines. The active constituents carbohydrates, steroids, Alkaloids, Tannins, Flavanoids, Saponins, gums and mucilage. The ethanolic extract of Adhatoda vasica showed a good cytotoxic activity (60%,60%,85% and 65%) in Hela, HepG2, MCF-7, MDAMB-231 cells at 24 hrs respectively. In this in-vitro studies the normal cells are act as a positive control. The ethanolic extract of Adhatoda vasica shows maximum percentage of 85% after 24 hrs. From this study, it can be concluded that the phytoconstituents of Adhatoda vasica have significant anticancer-cytotoxic activity on Hela, HepG2, MCF-7, MDAMB-231 cells.
KEYWORDS:
Investigation of invitro anti-cancer property, Adhatoda vasica.
Cite:
Sankaradoss Nirmala, P Nadana Sabapathi, M Sudhakar, Naveen Bathula, Y Sravanthi. Investigation of In vitro Anti-cancer property of Adhatoda vasica in Hela, HepG2, MCF-7, MDAMB-231 Cell Lines. Res. J. Pharmacognosy and Phytochem. 2019; 11(4):212-216.
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