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Research Journal of Pharmacognosy and Phytochemistry
ISSN: 0975-4385(Online), 0975-2331(Print)
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Evaluation of the Diuretic activity of the Methanolic Extract of Bougainvillea spectabilis
N.V.L Suvarchala Reddy V
Ganga Raju M
N.V.L Suvarchala Reddy V1, Alekhya B2, Ganga Raju M2
1Senior Assistant Professor, Department of Pharmacology, GRCP, Bachupally, Hyderabad.
2Department of Pharmacology, Gokaraju Rangaraju College of pharmacy, Hyderabad
Although Bougainvillea spectabilisis very popular and attractive ornamental plants in most areas with warm climates belonging to the family Nyctaginaceae. The plants belonging to this family possess diuretic activity. Therefore, the aim of the present study was to evaluate the diuretic activity of the methanolic extract of Bougainvilea spectabilis of aerial parts. Bougainvillea spectabiliswas orally administered to adult male albino rats at 200 and 400 mg/kg, and its diuretic activity was evaluated and compared to the reference drug furosemide (20 mg/kg, administered i.p.). Acute toxicity of the extract was assessed. Compared to control rats, there was significant higher urinary output, as well as sodium and potassium ion excretion, in animals administered the methanolic extract of Bougainvillea spectabilis. The diuretic activity of aerial parts of Bougainvillea spectabilis has been attributed to the presence of flavonoids. This could be responsible for the effect demonstrated herein, which was similar to that produced by the reference drug furosemide. The mechanism of action of furosemide is by inducing a loss of water through the inhibition of NaCl reabsorption. The results suggest that this receptor-mediated mechanism may account for the diuretic effect of Bougainvillea spectabilis as well.
Bougainvilea spectabilis, Nyctaginaceae, Diuretic activity.
N.V.L Suvarchala Reddy V, Alekhya B, Ganga Raju M. Evaluation of the Diuretic activity of the Methanolic Extract of Bougainvillea spectabilis. Res. J. Pharmacognosy and Phytochem. 2019; 11(1): 38-41.
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