Volume No. :   11

Issue No. :  1

Year :  2019

ISSN Print :  0975-2331

ISSN Online :  0975-4385


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Bio-assay guided Isolation of Bioactive molecules from chloroform extract of fruits of Lantana camara (L.)



Address:   Zekarias Gebre1, Yinebeb Tariku1, Venkatesan Jayakumar2*
1Chemistry Department, College of Natural Sciences, Jimma University, Jimma, Ethiopia,
2Chemistry Department, Shri Vaishnav Institute of Science, SVVV University, Indore, Madhya Pradesh, India.
*Corresponding Author
DOI No: 10.5958/0975-4385.2019.00006.2

ABSTRACT:
Current progress in drug discovery research and search for new novel molecules have intensified the efforts for exploring bioactive lead molecule from herbal and traditional system of medicine around all parts of world. The current study highlights bioassay guided isolation of active phytochemical from bioactive chloroform crude extract of fruits of Lantana camara (L.). Column chromatography separation of chloroform extract leads to the isolation of LC-1 to LC-3 active molecules. The structure of active lead molecules was confirmed with help of IR, 1H-NMR, 13C-NMR, DEPT-135, DEPT-95 spectral techniques. Further antimicrobial assay studies on Pseudomonas aeruginosa, Salmonella thyphimurium, Staphylococcus aureus and Escherichia coli by disc diffusion method found that LC-2 & LC-3 is promisingly active molecule.
KEYWORDS:
Lantana camara (L.), column chromatography, spectral technique, antimicrobial activity.
Cite:
Zekarias Gebre, Yinebeb Tariku, Venkatesan Jayakumar. Bio-assay guided Isolation of Bioactive molecules from chloroform extract of fruits of Lantana camara (L.). Res. J. Pharmacognosy and Phytochem. 2019; 11(1): 27-33.
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