Volume No. :   10

Issue No. :  3

Year :  2018

ISSN Print :  0975-2331

ISSN Online :  0975-4385


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Phytochemistry and Pharmacology of the Echinops integrifolius



Address:   U. T. Karimov1,2, Zhao Hai Qing2, H.A. Aisa2
1Institute of the Chemistry of Plant Substances AS RUz, Tashkent 100170, Uzbekistan
2Key Laboratory of Chemistry of Plant Resources in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China
*Corresponding Author
DOI No: 10.5958/0975-4385.2018.00035.3

ABSTRACT:
For the first time investigated the sum of alkaloids of plant Echinops integrifolius, which totaled 0.186% of the dry weight of the plant. By column chromatography was isolated and identified eight substances: three triterpenoids, umbelliferone, isoprenoid ?-lactone-4,8,12,16- tetrametilheptadekan -4-olide, dibuthyl phthalate. There have been studies of antidiabetic properties of isolated compounds, and obtained extracts. It was investigated the antidiabetic, and antimicrobial activity, influence of umbelliferone on tyrosinase activity and melanin in the cells of the model B16 (OD475).
KEYWORDS:
ethanol, extract, lupeol, lupeol acetate, umbelliferone, antidiabetic activity, tyrosinase, melanine.
Cite:
U. T. Karimov, Zhao Hai Qing, H.A. Aisa. Phytochemistry and Pharmacology of the Echinops integrifolius. Res. J. Pharmacognosy and Phytochem. 2018; 10(3): 216-220.
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