Author(s): Vrunda V. Shah, Vipul K. Shah, Krishnkant N. Patel, Navin R. Sheth, M. M. Patel

Email(s): vrundazalavadiya@gmail.com

DOI: 10.5958/0975-4385.2017.00043.7   

Address: Vrunda V. Shah1*, Vipul K. Shah2, Krishnkant N. Patel3, Navin R. Sheth4, M. M. Patel1
1Shree Swaminarayan Sanskar Pharmacy College, Zundal, Gandhinagar-382421, Gujarat, India
2Troikaa Pharmaceuticals Ltd., Ahmedabad, Gujarat, India
3SAL Institute of Pharmaceutical Education and Research, Ahmedabad, Gujarat, India.
4Vice Chancellor of Gujarat Technological University, Ahmedabad, Gujarat, India.
*Corresponding Author

Published In:   Volume - 9,      Issue - 4,     Year - 2017


ABSTRACT:
Liver toxicity is a major health problem of worldwide proportions. Herbal medicines derived from plant extracts are being increasingly utilized to treat a wide variety of clinical diseases. Objective of the present work was to evaluate Hepatoprotective potential of Hydro alcoholic extract of Ipomoea turpethum root. This in vivo efficacy was reinforced by a significant dose dependent hepatoprotection (at 100 mg/kg and 200mg/kg dose) in CCl4 induced Hepatotoxicity using wistar rats five in each groups. In this study extract of plant (100mg/kg and 200mg/kg, orally) was given for 6 days daily and CCl4 (1 ml/kg, 1:1 with liquid paraffin, s.c.) is given at 6th day after 2 hours from dosing. The Hepatoprotective activity is confirmed by decreasing the activity of serum enzymes, SGOT, SGPT, ALKP, Bilirubin, Cholesterol, while it significantly increased the reduced Protein levels in dose dependant manner. The study was also supported by histopathology of liver sections. The Hepatoprotective activity of the extract is being comparable to standards Silymarin (200mg/kg). The results obtained in the present study indicate that Ipomoea turpethum is a potential source of natural Hepatoprotectives.


Cite this article:
Vrunda V. Shah, Vipul K. Shah, Krishnkant N. Patel, Navin R. Sheth, M. M. Patel. Improvement on the Carbon Tetrachloride inducing Hepatotoxicity in rats using Ipomoea turpethum Root. Res. J. Pharmacognosy and Phytochem. 2017; 9(4): 231-234. doi: 10.5958/0975-4385.2017.00043.7


Recomonded Articles:

Author(s): Anshuman Singh, Bhupendra Vyas

DOI: 10.5958/0975-4385.2018.00052.3         Access: Open Access Read More

Author(s): Bapu R. Thorat

DOI: 10.5958/0975-4385.2018.00017.1         Access: Open Access Read More

Author(s): Vidula Salvi, Yadunath Joshi, Swati Dhande , Vilasrao Kadam

DOI:         Access: Open Access Read More

Author(s): Lenkalapally Matsyagiri, Kommu Sudhakar, Takkadpelliwar Santoshi, Masna Nagarjuna , N. L. Gowrishankar

DOI:         Access: Open Access Read More

Author(s): Soosamma John, Madhavi T., Bincy Raj, Jincy Shaji, Vinutha

DOI:         Access: Open Access Read More

Author(s): Shantha Sheela Nagarajan, Muthusamy Periyanna, Radha Ramalingam

DOI: 10.5958/0975-4385.2015.00036.9         Access: Open Access Read More

Author(s): Umesh Annappan, Vijaya Bharathi Rajkishore, Radha Ramalingam

DOI: 10.5958/0975-4385.2015.00034.5         Access: Open Access Read More

Author(s): Kalpana Patil, Swati Dhande, Vilasrao Kadam

DOI:         Access: Open Access Read More

Author(s): Ravindra Singh, Aakanksha Tiwari

DOI: 10.5958/0975-4385.2017.00009.7         Access: Open Access Read More

Author(s): Dhanya Rajan, J. Suresh, N. Paramakrishnan, A. Sri Vasavi Reddy, M Nayeem

DOI:         Access: Open Access Read More

Author(s): Gharge Varsha G., Shelar Pournima A., Ghadge Dhairysheel M., Patil Anup A., Bhandwalkar Omkar S., Yadav Adhikrao V.

DOI: 10.5958/0975-4385.2017.00016.4         Access: Open Access Read More

Author(s): Ravi Dubey, Saba Shaikh, Swati Dhande, Y. M. Joshi, Vilasrao J. Kadam

DOI:         Access: Open Access Read More

Author(s): R Parthasarathy, R Ilavarasan, CM Karrunakaran

DOI:         Access: Open Access Read More

Author(s): AK Meena, Uttam S Niranjan, AK Yadav, Brijendra Singh, AK Nagaria, A Gaurav, MM Rao

DOI:         Access: Open Access Read More

Author(s): Raje VN, Yadav AV, Shelar PA

DOI:         Access: Open Access Read More

Author(s): Vrunda Zalavadiya, Vipul Shah, Devdas Santani, Kanchan Kumari, Surabhi Binawara, Bhumi Raval

DOI:         Access: Open Access Read More

Author(s): Veeresh P Veerapur, Pramod P Desai, S Vijayakumar

DOI: 10.5958/0975-4385.2018.00046.8         Access: Open Access Read More

Author(s): D. Benito Johnson, Neethu. P. Charles, Banshongdor H Mawlieh, Timai Passah, V. Venkatanarayanan

DOI: 10.5958/0975-4385.2016.00020.0         Access: Open Access Read More

Author(s): Sachin R Patil, MB Patil, Ravi Kumar, Mahesh S. Paschapur

DOI:         Access: Open Access Read More

Author(s): Sawarkar DJ, Vijaya C, Turaskar AO, Shende VS, Chatap VK, Sawant VA, Borkar SN

DOI:         Access: Open Access Read More

Research Journal of Pharmacognosy and Phytochemistry (RJPP) is an international, peer-reviewed journal, devoted to pharmacognosy...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0975-4385 


Recent Articles




Tags