List of Refereed Journals published by UGC, New Delhi on 11-01-2017-- Research Journal of Pharmacy and Technology (Sr. No.-275); Asian Journal of Management (Sr. No.-3986); Asian Journal of Research in Chemistry (Sr. No.-4008); Research Journal of Engineering and Technology (Sr. No.-31787); Researc (22-Jan-2017)        |

Volume No. :   9

Issue No. :  3

Year :  2017

ISSN Print :  0975-2331

ISSN Online :  0975-4385


Registration

Allready Registrered
Click to Login

Application of Seed Polymer extracted from Benincasa hispida for Development of Fast Dissolving Tablet of Carvedilol



Address:   Suresh G. Killedar1*, Durgacharan A. Bhagwat2, Sneha S. Jadhav3
1Department of Pharmacognosy, Bharati Vidyapeeth College of Pharmacy, Kolhapur-416013, Maharashtra, India,
2Department of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Kolhapur-416013, Maharashtra, India,
3Department of Pharmaceutical Technology, Bharati Vidyapeeth College of Pharmacy, Kolhapur-416013, Maharashtra, India
*Corresponding Author
DOI No: 10.5958/0975-4385.2017.00031.0

ABSTRACT:
Natural polymers are preferred over synthetic polymers as they are nontoxic, facilely available at low cost, utilized in low concentration, and are naturally extracted to provide nutritional supplement. Fast dissolving tablets have received ever-increasing demand during the last decade. Aim of present study was to develop fast dissolving tablet of Carvedilol using seed polymer extracted from Benincasa hispida. Prepared tablets were evaluated for pre and post compression parameters. Results of compatibility study using FTIR and DSC showed that Carvedilol is compatible with extracted seed polymer. Pre-compression studies revealed good micromeritic properties of powder blend for direct compression. In-vitro dissolution study showed that, tablet containing seed polymer released 90.67% of drug within 60 min. Study concluded that, natural superdisintegrant extracted from Benincasa hispida can be efficaciously utilized in tablet formulations which exhibit faster drug dissolution and hence may increase bioavailability, thereby, availing in efficacious therapy with improved patient compliance.
KEYWORDS:
Benincasa hispida, seed polymer, natural superdisintegrant, fast dissolving tablet, carvedilol.
Cite:
Suresh G. Killedar, Durgacharan A. Bhagwat, Sneha S. Jadhav. Application of Seed Polymer extracted from Benincasa hispida for Development of Fast Dissolving Tablet of Carvedilol. Res. J. Pharmacognosy and Phytochem. 2017; 9(3): 167-172.
[View HTML]     



Visitor's No. :   95796