List of Refereed Journals published by UGC, New Delhi on 11-01-2017-- Research Journal of Pharmacy and Technology (Sr. No.-275); Asian Journal of Management (Sr. No.-3986); Asian Journal of Research in Chemistry (Sr. No.-4008); Research Journal of Engineering and Technology (Sr. No.-31787); Researc (22-Jan-2017)        |

Volume No. :   9

Issue No. :  2

Year :  2017

ISSN Print :  0975-2331

ISSN Online :  0975-4385


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Evaluation of analgesic potential of Boerhavia diffusa roots in albino mice



Address:   Kadiri Sunil Kumar1*, V. Saideepthi2, Shaik Shahajeb2, M. Nandini2, R.Suthakaran3
1Associate Professor, Department of Pharmacology, Vijaya College of Pharmacy, Munaganoor – 501511, Hyderabad, Telangana, India
2B-Pharmacy Final year II Sem, Vijaya College of Pharmacy, Munaganoor – 501511, Hyderabad, Telangana, India
3Principal and Professor, Department of Pharmaceutical Chemistry, Vijaya College of Pharmacy, Munaganoor – 501511, Hyderabad, Telangana, India
*Corresponding Author
DOI No: 10.5958/0975-4385.2017.00020.6

ABSTRACT:
The present research was designed to evaluate the analgesic potential of Boerhavia diffusa root powder 150 mg/kg, p.o in albino mice. Boerhavia diffusa is a popular herb in ayurveda which is also known as Punarnava. Boerhavia diffusa root powder was procured from a local ayurvedic store. The analgesic effect of the root powder was evaluated by using acetic acid induced writhings test in mice. It was found that Boerhavia diffusa root powder at a dose of 150 mg/kg treated for 15 days has significantly inhibited pain induced by acetic acid by decreasing the number of writhing responses such as extension of hind limbs (22±0.77), abdominal constrictions (13±0.08) and trunk twisting (20±0.55) when compared to control treated mice i.e extension of hind limbs (38±0.17), abdominal constrictions (26±1.23) and trunk twisting (24±0.55) in control mice. The results were compared with standard diclofenac sodium (25 mg/kg, p.o) treated mice. Hence it is evident from the above results that boerhavia diffusa at 150 mg/kg possesses significant analgesic potential.
KEYWORDS:
Boerhavia diffusa, analgesic, writhing responses, acetic acid, diclofenac sodium.
Cite:
Kadiri Sunil Kumar, V. Saideepthi, Shaik Shahajeb, M. Nandini, R.Suthakaran. Evaluation of analgesic potential of Boerhavia diffusa roots in albino mice. Res. J. Pharmacognosy and Phytochem. 2017; 9(2): 111-114.
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