Volume No. :   8

Issue No. :  3

Year :  2016

ISSN Print :  0975-2331

ISSN Online :  0975-4385


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Preparation and Evaluation of Phytocontituent Based Mucoadhesive Antifungal Vaginal Gel

Address:   Ananta Choudhury*, Amit Roy, Suman Saha, Sanjib Bahadur
Department of Pharmaceutics, Columbia Institute of Pharmacy, Tekari, Raipur, C.G.
*Corresponding Author
DOI No: 10.5958/0975-4385.2016.00021.2

The present experimental work has been designed with an aim to develop a phytoconstitute based mucoadhesive antifungal vaginal gel for wide range of fungal infections. This topic of research has been selected addressing the clinical status of the women’s health related problems. Around 75% of world women population experience acute episodes of vaginal candidasis at least once during their life time and if not treated properly may prove life threatening. All the formulations were prepared incorporating optimized concentration of curcumin and fluconazole as active constituents. Antifungal activities of Phyto-combination were screened based on In-Vitro antifungal study. Mucoadhesive polymers like Carbopol 940 and HPMC K4M were used to prepared gel base. In-vitro evaluation such as determination of pH, viscosity, spreadability, mucoadhesive study, Drug content, drug release study and In-Vivo study like RVI (rabbit vaginal irritation test) were performed to evaluate the performance of prepared formulations. Based on the result it was concluded that prepared formulations were safe, effective and overall performances were found satisfactory. Among the several preparations, F2 formulations that contain 1:4 ratios of curmumin and fluconazole shows better result.
Mucoadhesive gel, antifungal vaginal formulation, vaginal drug delivery, Curcumin as antifungal, Phytoconstituent based formulation, Fluconazole gel.
Ananta Choudhury, Amit Roy, Suman Saha, Sanjib Bahadur. Preparation and Evaluation of Phytocontituent Based Mucoadhesive Antifungal Vaginal Gel. Res. J. Pharmacognosy and Phytochem. 2016; 8(3): 116-120.
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