Author(s): Preeti Tiwari, Rakesh K.Patel

Email(s): preetitiwari198311@yahoo.com

DOI: Not Available

Address: Preeti Tiwari1* and Rakesh K.Patel2
1Department of Pharmacognosy, Shri Sarvajanik Pharmacy College, Mehsana-384001,Gujarat, India
2Head of Department of Pharmacognosy, Shri S. K. Patel College of Pharmaceutical Education and Research, Kherva-382711,Gujarat, India
*Corresponding Author.

Published In:   Volume - 4,      Issue - 5,     Year - 2012


ABSTRACT:
The objective of the present study was to estimate the total phenolic content as well as flavonoids in Draksharishta-T and Draksharishta-M prepared by traditional and modern methods respectively and in its marketed preparation and also to evaluate the antioxidant activity of these test preparations on two different in vitro antioxidant activity models. Total phenolic content was determined colorimetrically using Folin–Ciocalteu reagent and was found 0.0967 and 0.0961 %w/w gallic acid equivalent in Draksharishta-T and Draksharishta-M respectively. Total flavonoid content was determined by aluminium chloride method and was found 0.01163 and 0.01129 %w/w quercetin equivalent in Draksharishta-T and Draksharishta-M respectively. Super-oxide anion scavenging activity and lipid per-oxidation assay were carried out to evaluate the antioxidant potential of Draksharishta-T and Draksharishta-M. The antioxidant activity of Draksharishta-T and Draksharishta-M was found increased in concentration dependent manner in both the in vitro antioxidant activity models as super-oxide radical scavenging activity and lipid per-oxidation assay. Draksharishta-T and Draksharishta-M showed significant scavenging of super-oxide radical and showed IC50 138.06 and 145.35 µg/ml respectively. Draksharishta-T and Draksharishta-M also inhibited the ferrous sulphate induced lipid per-oxidation in dose dependent manner and showed inhibitory concentration (IC50) 230.03 and 236.11 µg/ml respectively. Marketed Draksharishta also showed a rich concentration of total phenolics and flavonoids and showed dose dependent antioxidant activity in both the models. Thus, the results obtained in this study indicate that Draksharishta-T and Draksharishta-M can be a promising source of natural antioxidant.


Cite this article:
Preeti Tiwari, Rakesh K.Patel. Total Phenolics and Flavonoids and Antioxidant Potential of Draksharishta Prepared by Traditional and Modern Methods. Research J. Pharmacognosy and Phytochemistry 2012; 4(5): 244-249.


Recomonded Articles:

Author(s): Pritesh Shah, Swati Dhande, Yadunath Joshi, Vilasrao Kadam.

DOI:         Access: Open Access Read More

Author(s): Kavitha M, Vadivu R, Radha R

DOI: 10.5958/0975-4385.2015.00037.0         Access: Open Access Read More

Author(s): Baviskar H. P., Dhake G. T., Kasai M. A., Chaudhari N. B., Deshmukh T. A.

DOI: 10.5958/0975-4385.2017.00024.3         Access: Open Access Read More

Author(s): Gomathi B , Anuradha R

DOI:         Access: Open Access Read More

Author(s): Nishendu P. Nadpara, Jagruti P. Vaghela, Parula B. Patel

DOI:         Access: Open Access Read More

Author(s): Chitra Shenoy, M B Patil, Ravi Kumar

DOI:         Access: Open Access Read More

Author(s): S C Baviya, R Radha, N Jayshree

DOI: 10.5958/0975-4385.2015.00038.2         Access: Open Access Read More

Author(s): Shantha Sheela Nagarajan, Muthusamy Periyannan , Radha Ramalingam

DOI: 10.5958/0975-4385.2016.00013.3         Access: Open Access Read More

Author(s): Shruti Srivastava, Jatin Jaiswal, Hemendra Gautam, Sunil Singh, Surabhi Sharma

DOI:         Access: Open Access Read More

Author(s): Lenkalapally Matsyagiri, Kommu Sudhakar, Takkadpelliwar Santoshi, Masna Nagarjuna , N. L. Gowrishankar

DOI:         Access: Open Access Read More

Author(s): Mohammad Shamim Qureshi, A. Venkateshwar Reddy, G.S. Kumar, Lubna Nousheen

DOI: 10.5958/0975-4385.2017.00001.2         Access: Open Access Read More

Author(s): Umesh Annappan, Vijaya Bharathi Rajkishore, Radha Ramalingam

DOI: 10.5958/0975-4385.2015.00034.5         Access: Open Access Read More

Author(s): Mamta Tiwari, Pushpraj S. Gupta, Nisha Sharma

DOI: 10.5958/0975-4385.2018.00014.6         Access: Open Access Read More

Author(s): K Amutha , D Victor Arokia Doss

DOI:         Access: Open Access Read More

Author(s): V. Krishna Murthy Naik, K. Sudhakar Babu, J. Latha, Beulah Kolluru

DOI: 10.5958/0975-4385.2018.00013.4         Access: Open Access Read More

Author(s): Dhanya Rajan, J. Suresh, N. Paramakrishnan, A. Sri Vasavi Reddy, M Nayeem

DOI:         Access: Open Access Read More

Research Journal of Pharmacognosy and Phytochemistry (RJPP) is an international, peer-reviewed journal, devoted to pharmacognosy...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0975-4385 


Recent Articles




Tags