M. B. Narkhede, P. V. Ajmire, A. E. Wagh, M. R. Bhise, G. D. Mehetre, H. J. Patil
M. B. Narkhede*, P. V. Ajmire, A. E. Wagh, M. R. Bhise, G. D. Mehetre, H. J. Patil
Indira Bhuuddeshiya Shikshan Shantha’s College of Pharmacy, Malkapur
Volume - 4,
Issue - 1,
Year - 2012
Vetiveria zizanioides belonging to the family Gramineae, is widely used as a traditional plant as refrigerant that cools and calms the entire body. The current study was focused to evaluate the antipyretic (yeast-induced pyrexia in albino rats) potential of the hexane extract (HEVZ) and methanol extract (MEVZ) of Vetiveria zizanioides root. The yeast-induced pyrexia method was standardized by subcutaneous injection of yeast suspension (10 ml /kg body wt.) which increased rectal temperature after 17 hours followed by recording of rectal temperature at regular interval. Both extract at 75mg, 150mg and 300mg/kg dose significantly (P< 0.05) reduced yeast-induced elevated temperature. Also the effect of extracts on normal body temperature was evaluated. Rectal temperature of rodents was recorded at a time interval of 1hrs, 2hrs, 3hrs, 4hrs and 5hrs after drug administration. Reduction is in a dose dependent manner.The anti-pyretic effect of HEVZ and MEVZ was comparable to that of a standard antipyretic agent paracetamol (150 mg / kg body wt, p.o).
Cite this article:
M. B. Narkhede, P. V. Ajmire, A. E. Wagh, M. R. Bhise, G. D. Mehetre, H. J. Patil. An evaluation of anti-pyretic potential of Vetiveria zizanioides (Linn.) root. Research J. Pharmacognosy and Phytochemistry 2012; 4(1): 11-13.