Volume No. :   3

Issue No. :  3

Year :  2011

ISSN Print :  0975-2331

ISSN Online :  0975-4385


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A Review on Pharmacological Profile for Phytomedicine Known as Gloriosa superba Linn.



Address:   Hemant Badwaik*, Tapan Kumar Giri , D.K. Tripathi , Mukesh Singh and Abdul Hanif Khan
Rungta College of Pharmaceutical Sciences and Research, Bhilai (C.G)
*Corresponding Author
DOI No:

ABSTRACT:
Application indigenous natural products has been alternative way to replace synthetic medicine Gloriosa superba is a well known ethnomedicinal plant which is used in Ayurveda. Photochemical studies of G. superba shows presence of colchicin, b-siltosterol, long chain fatty acids, b and g-lumiccolchicines, 2-hydroxy-6-methoxy benzoic, luterlin, N-formyl-deacetyl colchicines and new colchicine glycoside, 3-O-demethylcolchicine-3-O-alpha-D- glucopyranoside. FDA-approved use of Colchicine is to treat gout (it is one of the active ingredients of anti-gout tablets marketed by Merck & Co.). It is also used as an anticancer, antimicrobial, antifungal, anticoagulant, antilipoxygenase agent and antidote in snake bite. However, ingestion of all parts of the plant is extremely poisonous and can be fatal. The commonest clinical presentation of poisoning is severe gastroenteritis with nausea, vomiting, diarrhoea with b leading to dehydration, hypovolaemic shock and acute renal failure. Gloriosa superba usually multiply by corm and seeds but due to low germination capability it restricts for the regeneration. Therefore, in order to safeguard and preserve this important plant biotechnological approachs would be very useful. Micropropagation of Gloriosa superba meets ever increasing demands for colchicine. The availability from both wild and cultivated sources make the plant of Gloriosa superba a potential source of Colchicine in India.
KEYWORDS:
Gloriosa superba Linn., 3-O-demethylcolchicine-3-O-alpha-D- glucopyranoside, antitumor, gout, gastroenteritis.
Cite:
Hemant Badwaik, Tapan Kumar Giri , D.K. Tripathi , Mukesh Singh, Abdul Hanif Khan. A Review on Pharmacological Profile for Phytomedicine Known as Gloriosa superba Linn. Research J. Pharmacognosy and Phytochemistry 2011; 3(3): 103-107.
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