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Volume No. :   3

Issue No. :  2

Year :  2011

ISSN Print :  0975-2331

ISSN Online :  0975-4385


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Hepatoprotective Activity of Vitex quinata Roots against Paracetamol-Induced Hepatic Injury in Rats.



Address:   V. Sreedhar1*, L.K. Ravindra Nath2, N. Madana Gopal1, K. Venu Gopal3, D.Raju1 and K.K. Rajasekhar4
1Department of Pharmacy, Prabhath Institute of Pharmacy, Nandayal, A.P, INDIA
2Department of Chemistry, Srikrishna Devaraya University, Anantapur, A.P, INDIA
3Dept of Pharmacy, Nirmala College of Pharmacy, Kadapa, A.P, INDIA
4Departement Of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupathi-517503, A.P,INDIA
*Corresponding Author
DOI No:

ABSTRACT:
Methanolic extracts of Vitex quinata roots at 200, 400 and 800 mg/kg and silymarin was prepared and tested for its hepatoprotective effect against paracetamol induced hepatitis in rats. Alteration in the level of biochemical markers of hepatic damage like SGOT, SGPT, ALKP, TPL, CHL, TPTN and ALP were tested in both treated and untreated groups. The methanolic extracts of Vitex quinata roots at 200,400 and 800 mg/kg and silymarin showed a significant (P<0.05) decrease in all the elevated SGOT, SGPT, ALKP, TBL, CHL and significant increase (P<0.05) in TPTN and ALB levels produced by the toxicant Paracetamol.
KEYWORDS:
Vitex quinata, Antioxidant activity, Ascorbic acid.
Cite:
V. Sreedhar, L.K. Ravindra Nath, N. Madana Gopal, K. Venu Gopal, D.Raju, K.K. Rajasekhar. Hepatoprotective Activity of Vitex quinata Roots against Paracetamol-Induced Hepatic Injury in Rats. Research J. Pharmacognosy and Phytochemistry 2011; 3(2): 77-81.
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