Volume No. :   2

Issue No. :  5

Year :  2010

ISSN Print :  0975-2331

ISSN Online :  0975-4385


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Studies on Anti-Inflammatory and Analgesic Properties of Methanol Extract of Aerial Part of Clerodendrum inerme in Experimental Animal Models



Address:   R. Vijay Amirtharaj*, V. Suresh and R. Senthil Kumar
Department of Pharmaceutical chemistry, JKKMMRF College of Pharmacy, Ethirmedu, Komarapalayam 638183, Namakkal Dt, Tamilnadu, India.
*Corresponding Author
DOI No:

ABSTRACT:
The methanol extract of aerial part of Clerodendrum inerme were investigated for anti-inflammatory and analgesic at the dose 200 mg/kg, body weight. The experimental paradigms used were carrageenan, induced pedal edema for anti-inflammatory activity, acetic acid induced writhing methods were used to assess analgesic activity. In acute phase inflammation, a maximum inhibition 60.17% (P < 0.01) was noted at the dose of 200 mg/kg after 3 h of treatment with methanol extract of Clerodendrum inerme (MECI) in carrageenan, induced pedal edema respectively. The extract also produced significant (P < 0.01) analgesic activity in both paradigms. This study exhibits that the methanol extracts of aerial part of Clerodendrum inerme possess anti-inflammatory and analgesic activities.
KEYWORDS:
Clerodendrum inerme, Anti-inflammatory, Analgesic
Cite:
R. Vijay Amirtharaj, V. Suresh , R. Senthil Kumar. Studies on Anti-Inflammatory and Analgesic Properties of Methanol Extract of Aerial Part of Clerodendrum inerme in Experimental Animal Models. Research J. Pharmacognosy and Phytochemistry 2010; 2(5): 421-424.
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