Vikas Gupta, Junaid Niazi, Jatinderjot Kaur Kehal, Parveen Bansal
Vikas Gupta1, Junaid Niazi2*, Jatinderjot Kaur Kehal3 and Parveen Bansal1
1National Institute of Ayurvedic Pharmaceutical Research, Patiala, Punjab.
2Rayat and Bahra Institute of Pharmacy, Hoshiarpur, Punjab.
3PCTE Institute of Pharmacy, Jhande, Ludhiana, Punjab
Volume - 2,
Issue - 3,
Year - 2010
Pandanus tectorius (Pandanaceae) was being used ethnomedically for treatment of diseases like asthma, cough, and bronchitis and locally as analgesic. Chemical constituents of leaves included triterpene, squalene and phytosterols. The study was aimed to evaluate both anti-inflammatory and anti nociceptive activity of the ethanolic extract of fresh leaves of Pandanus tectorius (PTEE) in rats using the carrageenan-induced paw oedema method in rats and tail-flick model in mice at various dose levels. Ceiling effect of the extract was observed at 300 mg/kg in carrageenan test. The effect was equivalent to phenylbutazone (80 mg/kg, p.o.) at 300 mg/kg. Effectiveness of extract in the late phase of inflammation suggests the inhibition of prostagalandins and leukotrienes release. The extract produced marked analgesic activity at 300 mg/kg and the effect was comparable to that of standard drug, Ibuprofen (100 mg/kg, p.o). Preliminary phytochemical screening revealed the presence of tannins, sterols, triterpenes and flavanoids in extract. In conclusion, this study has established the anti-inflammatory activity and analgesic activity of P. tectorius and, thus, justifies the ethnic uses of the plant.
Cite this article:
Vikas Gupta, Junaid Niazi, Jatinderjot Kaur Kehal, Parveen Bansal. Anti-Inflammatory and Anti-Nociceptive Activity of Pandanus tectorius Parkinson. Research J. Pharmacognosy and Phytochemistry 2010; 2(3): 193-195.