Author(s): VDN Srinivas, G Sumalatha, PPV Jagannath, D Siva Kishore, P Madhu Kiran, , M Jhansi Rani

Email(s): vdnsrinivas@gmail.com

DOI: Not Available

Address: VDN Srinivas*, G Sumalatha, PPV Jagannath, D Siva Kishore, P Madhu Kiran and M Jhansi Rani
Department of Pharmacology, Hindu College of Pharmacy, Amaravathi Road, Guntur, Andhra pradesh
*Corresponding Author

Published In:   Volume - 2,      Issue - 1,     Year - 2010


ABSTRACT:
Urolithiasis is a major health problem with its high morbidity, high cost of management and potential for end-stage renal disease. The aim of our study is to cure and prevent the recurrent stone formation. Herbal drugs claim many promising remedies in urolithiasis. An attempt is made in this direction in the current work by using Macrotyloma uniflorum. The experimental model selected for the present study is subcutaneous administration of gentamicin (40mg/kg/day) for 8 days and dietary supplementation with 5% ammonium oxalate starting at day 5 of the treatment regimen to induce calcium oxalate urolithiasis. On administration of aqueous extract of Macrotyloma uniflorum in preventive and curative groups, moderate to few crystals are observed along the mild appearance of edema and dilation in tubules and crystals are present focally indicating the ability of aqueous extract of Macrotyloma uniflorum to dissolve the pre-formed stones. The parameters monitored in the present study are Kidney weight, calcium and oxalate deposition in kidney and the histological studies support the calcium and oxalate deposition data in kidney. Thus aqueous extract of Macrotyloma uniflorum showed significant antinephrolithiatic activity.


Cite this article:
VDN Srinivas, G Sumalatha, PPV Jagannath, D Siva Kishore, P Madhu Kiran ,,M Jhansi Rani. Antinephrolithiatic Potential of Macrotyloma uniflorum Aqueous Extract in Rats. Research J. Pharmacognosy and Phytochemistry 2010; 2(1): 75-78.


Recomonded Articles:

Author(s): S. Mohan Raj*, Shahid Mohammed, Vinoth Kumar S, Santhosh Kumar C, Subal Debnath

DOI:         Access: Open Access Read More

Author(s): Sandeep R Kane, Rahul S Adnaik, Vishvesh A Apte, Chandrakant S Magdum

DOI:         Access: Open Access Read More

Author(s): Anosike Chioma Assumpta, Obidoa Onyechi, Nwodo Okwesilieze Fredrick C., Joshua Parker Elijah.

DOI:         Access: Open Access Read More

Author(s): L. Kavitha, B. Kumaravel, G. Sriram Prasath, S. Subramanian

DOI:         Access: Open Access Read More

Author(s): Sawarkar DJ, Vijaya C, Turaskar AO, Shende VS, Chatap VK, Sawant VA, Borkar SN

DOI:         Access: Open Access Read More

Author(s): Sharda Sonawane, Deepak Bharati, Undale VR , Bhosale AV

DOI:         Access: Open Access Read More

Author(s): Gauthami R, Sudhakara Reddy G, Anoop Austin, T.K. Gopal, C. Uma Maheswara Reddy

DOI:         Access: Open Access Read More

Author(s): Ena Gupta, Abubakar Mohammed, Shalini Purwar, Syed Ibrahim Rizvi, Shanthy Sundaram

DOI: 10.5958/0975-4385.2017.00030.9         Access: Open Access Read More

Author(s): Preeti Tiwari, Rakesh K. Patel, T.S. Eashwari

DOI:         Access: Open Access Read More

Author(s): M. B. Narkhede, P. V. Ajmire, A. E. Wagh, M. R. Bhise, G. D. Mehetre, H. J. Patil

DOI:         Access: Open Access Read More

Author(s): VDN Srinivas, G Sumalatha, PPV Jagannath, D Siva Kishore, P Madhu Kiran ,,M Jhansi Rani

DOI:         Access: Open Access Read More

Author(s): Atanu Bhattacharjee, Shastry Chakrakodi Shashidhara, Santanu Saha

DOI:         Access: Open Access Read More

Author(s): K. Selvaraju, K.S.G. Arulkumaran, K. Karthick, K. Vengadesh Prabhu, J. Padma Preetha, R. Arrivukkarasu

DOI:         Access: Open Access Read More

Author(s): Prasanta Dey1*, Dipankar Bardalai2, Natesh Ramesh Kumar1, Chitra Subramani3, Manidipa Mukherjee4, Tejendra Bhakta4

DOI:         Access: Open Access Read More

Author(s): A.K Meena, M.M Rao, R Sannd, A.K Mangal, G.R Reddy, M.M Padhi, Ramesh Babu

DOI:         Access: Open Access Read More

Author(s): Rakesh K Sindhu, Pradeep Kumar, Inderbir Singh , Sandeep Arora

DOI:         Access: Open Access Read More

Research Journal of Pharmacognosy and Phytochemistry (RJPP) is an international, peer-reviewed journal, devoted to pharmacognosy...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0975-4385 


Recent Articles




Tags