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Volume No. :   2

Issue No. :  1

Year :  2010

ISSN Print :  0975-2331

ISSN Online :  0975-4385


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Screening of Immunomodulatory Activity of Extracts of Seeds of Jatropha curcas Linn. On Human Neutrophils



Address:   DS Hugar1, Sanjeev Heroor1* and Zakir Hussain2
1HKES’s College of Pharmacy, Gulbarga – 585105
2Luqman College of Pharmacy, Gulbarga – 585102
*Corresponding Author
DOI No:

ABSTRACT:
Jatropha curcas Linn. (Euphorbiaceae) traditionally claimed to be used as tonic, tissue builder and stimulant, the present work was undertaken to prove scientifically its tonic property as immunomodulator (immunostimulant) on human neutrophils by some in-vitro models, viz.- Nitroblue tetrazolium (NBT) dye test, phagocytosis of candida albicans and chemotaxis assay at different concentrations – 10?g/ml, 20?g/ml, 40?g/ml, 100?g/ml and 1000?g/ml (undiluted extract) of aqueous and petroleum ether(40-600 c) extracts of seeds of the plant. The extracts at concentrations of 1000?g/ml (undiluted extract) and 100?g/ml showed 70-80% of phagocytic and chemotactic activities when compared to normal and positive controls in the parameters studied. However, the activity was lower at concentrations 40?g/ml, 20?g/ml and 10?g/ml. Preliminary phytochemical investigation showed the presence of flavonoids, tannins, carbohydrates, saponins and amino acids in the extracts; hence these compounds might be responsible for immunomodulatory (immunostimulant) activity.
KEYWORDS:
Jatropha curcas, Immunomodulatory (immunostimulant), NBT, candida albicans, chemotaxis.
Cite:
DS Hugar, Sanjeev Heroor, Zakir Hussain. Screening of Immunomodulatory Activity of Extracts of Seeds of Jatropha curcas Linn. On Human Neutrophils. Research J. Pharmacognosy and Phytochemistry 2010; 2(1): 70-74.
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