Volume No. :   2

Issue No. :  1

Year :  2010

ISSN Print :  0975-2331

ISSN Online :  0975-4385


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In-Vitro Anthelmintic Activity of Thespesia populnea Linn Roots

Address:   SM Shaheedha*1, R Uma2, Ramya K, CH Phanindra and MD Dhanaraju1
1Research Lab, GIET School of Pharmacy, NH 5, Chaitanya Nagar, Rajahmundry, India-533294
2Dept. of Chemistry, Pachaiyappa’s College, Chennai -600 030, India.
*Corresponding Author

The aim of the proposed study was to evaluate anthelmintic potential of Thespesia populnea root which was extracted with petroleum ether (60°-80°C), chloroform, ethyl acetate and methanol. The extracts were prepared in the percentage of 0.1%, 0.2% and 0.5%. These fractions were tested in the bioassay, which involved the determination of time taken for paralysis and death on the Indian helminthes Pheritima posthuma and Ascaris lumbricoides. Piperazine citrate was included as reference standard and 10% DMSO in normal saline as vehicle. Petroleum ether extract (0.5%) showed significant activity against the Indian varieties Pheritima posthuma, and Ascaris lumbricoides. The time taken for paralysis and death was found to be 9.25 min and 15.8min against Pheritima posthuma and 4.50 min and 9.25 min against Ascaris lumbricoides respectively. The results proved that the extracts were significant at higher concentration (0.5% pet ether) and had almost the same activity as that of the standard Piperazine citrate. The traditional use of the root of Thespesia populnea as an anthelmintic has been confirmed.
Anthelmintic activity, Thespesia populnea, Pheritima posthuma, Ascaris lumbricoides, Piperazine citrate.
SM Shaheedha, R Uma, Ramya K, CH Phanindra ,MD Dhanaraju. In-Vitro Anthelmintic Activity of Thespesia populnea Linn Roots. Research J. Pharmacognosy and Phytochemistry 2010; 2(1): 64-66.
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