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Research Journal of Pharmacognosy and Phytochemistry
ISSN: 0975-4385(Online), 0975-2331(Print)
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Antidiabetic Activity of Marsilea quadrifolia linn in Alloxan-Diabetic Rats
Dongare SS*, Maske AP, Patil SM, Umbare RP and Mate GS
ASPM’s K. T. Patil. College of Pharmacy, Osmanabad, India
The different extracts of the Marsilea quadrifolia linn (Family- Marsileaceae) were tested for anti-diabetic activity, by normal rats and alloxan induced diabetic rats. Aqueous and methanol extracts had shown significant protection and lowered the blood glucose level. In alloxan induced diabetic rats the maximum reduction in blood glucose was observed after 72h at a dose level of 200mg/kg body weight. In short term treatment of alloxan induced diabetic rats was determined by measuring blood glucose levels on 0,24,48 and 72h. Both the extracts showed a significant anti- diabetic activity comparable with that of glibenclamide. These results indicate that the Marsilea quadrifolia linn plant possess significant anti–diabetic activity.
Antidiabetic activity; Marsilea quadrifolia; glucose; glibenclamide
Dongare SS, Maske AP, Patil SM, Umbare RP ,Mate GS. Antidiabetic Activity of Marsilea quadrifolia linn in Alloxan-Diabetic Rats. Research J. Pharmacognosy and Phytochemistry 2009; 1(1):15-17.
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