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Volume No. :   1

Issue No. :  1

Year :  2009

ISSN Print :  0975-2331

ISSN Online :  0975-4385


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Effect of Ethanolic Extract of Borassus flabellifer L. Male Flowers (Inflorescences) on Chemically Induced Inflammation in Wistar Rats.



Address:   Sachin R Patil*1, MB Patil2, Ravi Kumar1 and Mahesh S. Paschapur*3
1 Department of Pharmaceutics, 2 Department of Pharmacognosy,
3 Department of Pharmacology, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, India
*Corresponding Author
DOI No:

ABSTRACT:
Objective: The present study is designed to investigate anti-inflammatory activities of ethanolic extract of male flowers (inflorescences) of Borassus flabellifer L. (Arecaceae). Methods: Acute inflammation models like histamine-induced and egg-albumin-induced rat paw edema model and xylene induced ear oedema in mice were employed to investigate the anti-inflammatory activity. The biochemical parameters like serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), lipid per oxidation and alkaline phosphatase (ALP) were also estimated as supportive study. Results: The extract at doses 150mg/kg b.w. and 300mg/kg b.w. and diclofenac sodium (standard) showed significant anti-inflammatory in all the models, as compared to control (p< 0.0001). The extract and standard drug also showed significant (p<0.0001) results for biochemical parameters. Conclusion: The results of the present further confirm the use of Borassus flabellifer L. traditionally for the treatment of painful inflammatory conditions.
KEYWORDS:
Borassus flabellifer L., inflorescences, male flowers, anti-inflammatory, histamine, egg-albumin, SGOT, SGPT, Lipid per oxidation, ALP.
Cite:
Sachin R Patil, MB Patil, Ravi Kumar, Mahesh S. Paschapur. Effect of Ethanolic Extract of Borassus flabellifer L. Male Flowers (Inflorescences) on Chemically Induced Inflammation in Wistar Rats. Research J. Pharmacognosy and Phytochemistry 2009; 1(1): 59-63.
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